Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	2787
Gene name	G protein subunit gamma 5
Gene symbol	GNG5
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1p22.3
Summary	G proteins are trimeric (alpha-beta-gamma) membrane-associated proteins that regulate flow of information from cell surface receptors to a variety of internal metabolic effectors. Interaction of a G protein with its activated receptor promotes exchange of

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miRTarBase ID	miRNA	Experiments	Reference
MIRT023505	hsa-miR-1-3p	Proteomics	18668040
MIRT027504	hsa-miR-98-5p	Microarray	19088304
MIRT028436	hsa-miR-30a-5p	Proteomics	18668040
MIRT051558	hsa-let-7e-5p	CLASH	23622248
MIRT048451	hsa-miR-100-5p	CLASH	23622248
MIRT493755	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT493754	hsa-miR-4513	PAR-CLIP	20371350
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	20371350
MIRT493750	hsa-miR-568	PAR-CLIP	20371350
MIRT493756	hsa-miR-183-5p	PAR-CLIP	20371350
MIRT567437	hsa-miR-4500	PAR-CLIP	20371350
MIRT027504	hsa-miR-98-5p	PAR-CLIP	20371350
MIRT567436	hsa-let-7a-5p	PAR-CLIP	20371350
MIRT567435	hsa-miR-4458	PAR-CLIP	20371350
MIRT567434	hsa-let-7i-5p	PAR-CLIP	20371350
MIRT567433	hsa-let-7g-5p	PAR-CLIP	20371350
MIRT051558	hsa-let-7e-5p	PAR-CLIP	20371350
MIRT567432	hsa-let-7b-5p	PAR-CLIP	20371350
MIRT567431	hsa-let-7c-5p	PAR-CLIP	20371350
MIRT567430	hsa-let-7d-5p	PAR-CLIP	20371350
MIRT567429	hsa-let-7f-5p	PAR-CLIP	20371350
MIRT567428	hsa-miR-8080	PAR-CLIP	20371350
MIRT567427	hsa-miR-6816-3p	PAR-CLIP	20371350
MIRT567426	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT567425	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT567424	hsa-miR-576-3p	PAR-CLIP	20371350
MIRT502289	hsa-miR-3169	PAR-CLIP	20371350
MIRT567423	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT567422	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT493755	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT567421	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT567420	hsa-miR-3919	PAR-CLIP	20371350
MIRT567419	hsa-miR-4756-3p	PAR-CLIP	20371350
MIRT493754	hsa-miR-4513	PAR-CLIP	20371350
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	20371350
MIRT493752	hsa-miR-5589-3p	PAR-CLIP	20371350
MIRT502288	hsa-miR-4740-5p	PAR-CLIP	20371350
MIRT502287	hsa-miR-3152-3p	PAR-CLIP	20371350
MIRT502286	hsa-miR-5095	PAR-CLIP	20371350
MIRT502285	hsa-miR-7151-3p	PAR-CLIP	20371350
MIRT493751	hsa-miR-8074	PAR-CLIP	20371350
MIRT493750	hsa-miR-568	PAR-CLIP	20371350
MIRT567418	hsa-miR-4477b	PAR-CLIP	20371350
MIRT493749	hsa-miR-3149	PAR-CLIP	20371350
MIRT493756	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT502289	hsa-miR-3169	PAR-CLIP	21572407
MIRT493755	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT493754	hsa-miR-4513	PAR-CLIP	21572407
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	21572407
MIRT493752	hsa-miR-5589-3p	PAR-CLIP	21572407
MIRT502288	hsa-miR-4740-5p	PAR-CLIP	21572407
MIRT502287	hsa-miR-3152-3p	PAR-CLIP	21572407
MIRT502286	hsa-miR-5095	PAR-CLIP	21572407
MIRT502285	hsa-miR-7151-3p	PAR-CLIP	21572407
MIRT493751	hsa-miR-8074	PAR-CLIP	21572407
MIRT493750	hsa-miR-568	PAR-CLIP	21572407
MIRT493749	hsa-miR-3149	PAR-CLIP	21572407
MIRT493756	hsa-miR-183-5p	PAR-CLIP	24398324
MIRT502289	hsa-miR-3169	PAR-CLIP	24398324
MIRT493755	hsa-miR-656-3p	PAR-CLIP	24398324
MIRT493754	hsa-miR-4513	PAR-CLIP	24398324
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	24398324
MIRT493752	hsa-miR-5589-3p	PAR-CLIP	24398324
MIRT502288	hsa-miR-4740-5p	PAR-CLIP	24398324
MIRT502287	hsa-miR-3152-3p	PAR-CLIP	24398324
MIRT502286	hsa-miR-5095	PAR-CLIP	24398324
MIRT502285	hsa-miR-7151-3p	PAR-CLIP	24398324
MIRT493751	hsa-miR-8074	PAR-CLIP	24398324
MIRT493750	hsa-miR-568	PAR-CLIP	24398324
MIRT493749	hsa-miR-3149	PAR-CLIP	24398324
MIRT493756	hsa-miR-183-5p	PAR-CLIP	23592263
MIRT493755	hsa-miR-656-3p	PAR-CLIP	23592263
MIRT493754	hsa-miR-4513	PAR-CLIP	23592263
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	23592263
MIRT493752	hsa-miR-5589-3p	PAR-CLIP	23592263
MIRT493751	hsa-miR-8074	PAR-CLIP	23592263
MIRT493750	hsa-miR-568	PAR-CLIP	23592263
MIRT493749	hsa-miR-3149	PAR-CLIP	23592263
MIRT567436	hsa-let-7a-5p	PAR-CLIP	27292025
MIRT567432	hsa-let-7b-5p	PAR-CLIP	27292025
MIRT567431	hsa-let-7c-5p	PAR-CLIP	27292025
MIRT567430	hsa-let-7d-5p	PAR-CLIP	27292025
MIRT051558	hsa-let-7e-5p	PAR-CLIP	27292025
MIRT567429	hsa-let-7f-5p	PAR-CLIP	27292025
MIRT567433	hsa-let-7g-5p	PAR-CLIP	27292025
MIRT567434	hsa-let-7i-5p	PAR-CLIP	27292025
MIRT493756	hsa-miR-183-5p	PAR-CLIP	27292025
MIRT493749	hsa-miR-3149	PAR-CLIP	27292025
MIRT502287	hsa-miR-3152-3p	PAR-CLIP	27292025
MIRT502289	hsa-miR-3169	PAR-CLIP	27292025
MIRT567420	hsa-miR-3919	PAR-CLIP	27292025
MIRT567423	hsa-miR-3927-3p	PAR-CLIP	27292025
MIRT567435	hsa-miR-4458	PAR-CLIP	27292025
MIRT567418	hsa-miR-4477b	PAR-CLIP	27292025
MIRT567437	hsa-miR-4500	PAR-CLIP	27292025
MIRT493754	hsa-miR-4513	PAR-CLIP	27292025
MIRT502288	hsa-miR-4740-5p	PAR-CLIP	27292025
MIRT567419	hsa-miR-4756-3p	PAR-CLIP	27292025
MIRT502286	hsa-miR-5095	PAR-CLIP	27292025
MIRT493752	hsa-miR-5589-3p	PAR-CLIP	27292025
MIRT493750	hsa-miR-568	PAR-CLIP	27292025
MIRT567424	hsa-miR-576-3p	PAR-CLIP	27292025
MIRT493755	hsa-miR-656-3p	PAR-CLIP	27292025
MIRT567426	hsa-miR-6758-5p	PAR-CLIP	27292025
MIRT567427	hsa-miR-6816-3p	PAR-CLIP	27292025
MIRT567422	hsa-miR-6831-5p	PAR-CLIP	27292025
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	27292025
MIRT567425	hsa-miR-6856-5p	PAR-CLIP	27292025
MIRT502285	hsa-miR-7151-3p	PAR-CLIP	27292025
MIRT493751	hsa-miR-8074	PAR-CLIP	27292025
MIRT567428	hsa-miR-8080	PAR-CLIP	27292025
MIRT567421	hsa-miR-892c-5p	PAR-CLIP	27292025
MIRT027504	hsa-miR-98-5p	PAR-CLIP	27292025
MIRT493755	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT493754	hsa-miR-4513	PAR-CLIP	20371350
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	20371350
MIRT493750	hsa-miR-568	PAR-CLIP	20371350
MIRT493756	hsa-miR-183-5p	PAR-CLIP	20371350
MIRT567437	hsa-miR-4500	PAR-CLIP	20371350
MIRT027504	hsa-miR-98-5p	PAR-CLIP	20371350
MIRT567436	hsa-let-7a-5p	PAR-CLIP	20371350
MIRT567435	hsa-miR-4458	PAR-CLIP	20371350
MIRT567434	hsa-let-7i-5p	PAR-CLIP	20371350
MIRT567433	hsa-let-7g-5p	PAR-CLIP	20371350
MIRT051558	hsa-let-7e-5p	PAR-CLIP	20371350
MIRT567432	hsa-let-7b-5p	PAR-CLIP	20371350
MIRT567431	hsa-let-7c-5p	PAR-CLIP	20371350
MIRT567430	hsa-let-7d-5p	PAR-CLIP	20371350
MIRT567429	hsa-let-7f-5p	PAR-CLIP	20371350
MIRT567428	hsa-miR-8080	PAR-CLIP	20371350
MIRT567427	hsa-miR-6816-3p	PAR-CLIP	20371350
MIRT567426	hsa-miR-6758-5p	PAR-CLIP	20371350
MIRT567425	hsa-miR-6856-5p	PAR-CLIP	20371350
MIRT567424	hsa-miR-576-3p	PAR-CLIP	20371350
MIRT502289	hsa-miR-3169	PAR-CLIP	20371350
MIRT567423	hsa-miR-3927-3p	PAR-CLIP	20371350
MIRT567422	hsa-miR-6831-5p	PAR-CLIP	20371350
MIRT493755	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT567421	hsa-miR-892c-5p	PAR-CLIP	20371350
MIRT567420	hsa-miR-3919	PAR-CLIP	20371350
MIRT567419	hsa-miR-4756-3p	PAR-CLIP	20371350
MIRT493754	hsa-miR-4513	PAR-CLIP	20371350
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	20371350
MIRT493752	hsa-miR-5589-3p	PAR-CLIP	20371350
MIRT502288	hsa-miR-4740-5p	PAR-CLIP	20371350
MIRT502287	hsa-miR-3152-3p	PAR-CLIP	20371350
MIRT502286	hsa-miR-5095	PAR-CLIP	20371350
MIRT502285	hsa-miR-7151-3p	PAR-CLIP	20371350
MIRT493751	hsa-miR-8074	PAR-CLIP	20371350
MIRT493750	hsa-miR-568	PAR-CLIP	20371350
MIRT567418	hsa-miR-4477b	PAR-CLIP	20371350
MIRT493749	hsa-miR-3149	PAR-CLIP	20371350
MIRT493756	hsa-miR-183-5p	PAR-CLIP	21572407
MIRT502289	hsa-miR-3169	PAR-CLIP	21572407
MIRT493755	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT493754	hsa-miR-4513	PAR-CLIP	21572407
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	21572407
MIRT493752	hsa-miR-5589-3p	PAR-CLIP	21572407
MIRT502288	hsa-miR-4740-5p	PAR-CLIP	21572407
MIRT502287	hsa-miR-3152-3p	PAR-CLIP	21572407
MIRT502286	hsa-miR-5095	PAR-CLIP	21572407
MIRT502285	hsa-miR-7151-3p	PAR-CLIP	21572407
MIRT493751	hsa-miR-8074	PAR-CLIP	21572407
MIRT493750	hsa-miR-568	PAR-CLIP	21572407
MIRT493749	hsa-miR-3149	PAR-CLIP	21572407
MIRT493756	hsa-miR-183-5p	PAR-CLIP	24398324
MIRT502289	hsa-miR-3169	PAR-CLIP	24398324
MIRT493755	hsa-miR-656-3p	PAR-CLIP	24398324
MIRT493754	hsa-miR-4513	PAR-CLIP	24398324
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	24398324
MIRT493752	hsa-miR-5589-3p	PAR-CLIP	24398324
MIRT502288	hsa-miR-4740-5p	PAR-CLIP	24398324
MIRT502287	hsa-miR-3152-3p	PAR-CLIP	24398324
MIRT502286	hsa-miR-5095	PAR-CLIP	24398324
MIRT502285	hsa-miR-7151-3p	PAR-CLIP	24398324
MIRT493751	hsa-miR-8074	PAR-CLIP	24398324
MIRT493750	hsa-miR-568	PAR-CLIP	24398324
MIRT493749	hsa-miR-3149	PAR-CLIP	24398324
MIRT493756	hsa-miR-183-5p	PAR-CLIP	23592263
MIRT493755	hsa-miR-656-3p	PAR-CLIP	23592263
MIRT493754	hsa-miR-4513	PAR-CLIP	23592263
MIRT493753	hsa-miR-6855-3p	PAR-CLIP	23592263
MIRT493752	hsa-miR-5589-3p	PAR-CLIP	23592263
MIRT493751	hsa-miR-8074	PAR-CLIP	23592263
MIRT493750	hsa-miR-568	PAR-CLIP	23592263
MIRT493749	hsa-miR-3149	PAR-CLIP	23592263
MIRT567432	hsa-let-7b-5p	Luciferase reporter assayWestern blottingqRT-PCRFlow cytometry	36643646
MIRT1024517	hsa-let-7a	CLIP-seq
MIRT1024518	hsa-let-7b	CLIP-seq
MIRT1024519	hsa-let-7c	CLIP-seq
MIRT1024520	hsa-let-7d	CLIP-seq
MIRT1024521	hsa-let-7e	CLIP-seq
MIRT1024522	hsa-let-7f	CLIP-seq
MIRT1024523	hsa-let-7g	CLIP-seq
MIRT1024524	hsa-let-7i	CLIP-seq
MIRT1024525	hsa-miR-105	CLIP-seq
MIRT1024526	hsa-miR-1243	CLIP-seq
MIRT1024527	hsa-miR-183	CLIP-seq
MIRT1024528	hsa-miR-199a-5p	CLIP-seq
MIRT1024529	hsa-miR-199b-5p	CLIP-seq
MIRT1024530	hsa-miR-297	CLIP-seq
MIRT1024531	hsa-miR-3121-3p	CLIP-seq
MIRT1024532	hsa-miR-3163	CLIP-seq
MIRT1024533	hsa-miR-3173-3p	CLIP-seq
MIRT1024534	hsa-miR-3611	CLIP-seq
MIRT1024535	hsa-miR-3647-3p	CLIP-seq
MIRT1024536	hsa-miR-3671	CLIP-seq
MIRT1024537	hsa-miR-3927	CLIP-seq
MIRT1024538	hsa-miR-410	CLIP-seq
MIRT1024539	hsa-miR-4275	CLIP-seq
MIRT1024540	hsa-miR-433	CLIP-seq
MIRT1024541	hsa-miR-4420	CLIP-seq
MIRT1024542	hsa-miR-4428	CLIP-seq
MIRT1024543	hsa-miR-4438	CLIP-seq
MIRT1024544	hsa-miR-4635	CLIP-seq
MIRT1024545	hsa-miR-4728-3p	CLIP-seq
MIRT1024546	hsa-miR-4760-3p	CLIP-seq
MIRT1024547	hsa-miR-607	CLIP-seq
MIRT1024548	hsa-miR-656	CLIP-seq
MIRT1024549	hsa-miR-98	CLIP-seq
MIRT1024517	hsa-let-7a	CLIP-seq
MIRT1024518	hsa-let-7b	CLIP-seq
MIRT1024519	hsa-let-7c	CLIP-seq
MIRT1024520	hsa-let-7d	CLIP-seq
MIRT1024521	hsa-let-7e	CLIP-seq
MIRT1024522	hsa-let-7f	CLIP-seq
MIRT1024523	hsa-let-7g	CLIP-seq
MIRT1024524	hsa-let-7i	CLIP-seq
MIRT1024527	hsa-miR-183	CLIP-seq
MIRT1024535	hsa-miR-3647-3p	CLIP-seq
MIRT1024537	hsa-miR-3927	CLIP-seq
MIRT1024548	hsa-miR-656	CLIP-seq
MIRT1024549	hsa-miR-98	CLIP-seq
MIRT1024527	hsa-miR-183	CLIP-seq
MIRT1024548	hsa-miR-656	CLIP-seq
MIRT1024517	hsa-let-7a	CLIP-seq
MIRT1024518	hsa-let-7b	CLIP-seq
MIRT1024519	hsa-let-7c	CLIP-seq
MIRT1024520	hsa-let-7d	CLIP-seq
MIRT1024521	hsa-let-7e	CLIP-seq
MIRT1024522	hsa-let-7f	CLIP-seq
MIRT1024523	hsa-let-7g	CLIP-seq
MIRT1024524	hsa-let-7i	CLIP-seq
MIRT1024525	hsa-miR-105	CLIP-seq
MIRT1024527	hsa-miR-183	CLIP-seq
MIRT1024528	hsa-miR-199a-5p	CLIP-seq
MIRT1024529	hsa-miR-199b-5p	CLIP-seq
MIRT1024530	hsa-miR-297	CLIP-seq
MIRT1024535	hsa-miR-3647-3p	CLIP-seq
MIRT1024536	hsa-miR-3671	CLIP-seq
MIRT1024537	hsa-miR-3927	CLIP-seq
MIRT1024538	hsa-miR-410	CLIP-seq
MIRT1024541	hsa-miR-4420	CLIP-seq
MIRT1024543	hsa-miR-4438	CLIP-seq
MIRT1024544	hsa-miR-4635	CLIP-seq
MIRT1024545	hsa-miR-4728-3p	CLIP-seq
MIRT1024547	hsa-miR-607	CLIP-seq
MIRT1024548	hsa-miR-656	CLIP-seq
MIRT1024549	hsa-miR-98	CLIP-seq
MIRT1024517	hsa-let-7a	CLIP-seq
MIRT1024518	hsa-let-7b	CLIP-seq
MIRT1024519	hsa-let-7c	CLIP-seq
MIRT1024520	hsa-let-7d	CLIP-seq
MIRT1024521	hsa-let-7e	CLIP-seq
MIRT1024522	hsa-let-7f	CLIP-seq
MIRT1024523	hsa-let-7g	CLIP-seq
MIRT1024524	hsa-let-7i	CLIP-seq
MIRT1024525	hsa-miR-105	CLIP-seq
MIRT1024527	hsa-miR-183	CLIP-seq
MIRT1024528	hsa-miR-199a-5p	CLIP-seq
MIRT1024529	hsa-miR-199b-5p	CLIP-seq
MIRT1024531	hsa-miR-3121-3p	CLIP-seq
MIRT1024532	hsa-miR-3163	CLIP-seq
MIRT1024534	hsa-miR-3611	CLIP-seq
MIRT1024535	hsa-miR-3647-3p	CLIP-seq
MIRT1024536	hsa-miR-3671	CLIP-seq
MIRT1024537	hsa-miR-3927	CLIP-seq
MIRT1024538	hsa-miR-410	CLIP-seq
MIRT1024539	hsa-miR-4275	CLIP-seq
MIRT1024543	hsa-miR-4438	CLIP-seq
MIRT1024544	hsa-miR-4635	CLIP-seq
MIRT1024545	hsa-miR-4728-3p	CLIP-seq
MIRT1024547	hsa-miR-607	CLIP-seq
MIRT1024548	hsa-miR-656	CLIP-seq
MIRT1024549	hsa-miR-98	CLIP-seq
MIRT1024525	hsa-miR-105	CLIP-seq
MIRT1024536	hsa-miR-3671	CLIP-seq
MIRT1024543	hsa-miR-4438	CLIP-seq
MIRT1024544	hsa-miR-4635	CLIP-seq
MIRT1024547	hsa-miR-607	CLIP-seq
MIRT1024525	hsa-miR-105	CLIP-seq
MIRT1024527	hsa-miR-183	CLIP-seq
MIRT1024536	hsa-miR-3671	CLIP-seq
MIRT1024543	hsa-miR-4438	CLIP-seq
MIRT1024544	hsa-miR-4635	CLIP-seq
MIRT1024547	hsa-miR-607	CLIP-seq
MIRT1024548	hsa-miR-656	CLIP-seq
MIRT1024548	hsa-miR-656	CLIP-seq
MIRT1024525	hsa-miR-105	CLIP-seq
MIRT1024526	hsa-miR-1243	CLIP-seq
MIRT2540537	hsa-miR-140-5p	CLIP-seq
MIRT1024527	hsa-miR-183	CLIP-seq
MIRT2540538	hsa-miR-3122	CLIP-seq
MIRT2540539	hsa-miR-3153	CLIP-seq
MIRT1024533	hsa-miR-3173-3p	CLIP-seq
MIRT1024536	hsa-miR-3671	CLIP-seq
MIRT2540540	hsa-miR-3913-5p	CLIP-seq
MIRT1024541	hsa-miR-4420	CLIP-seq
MIRT1024542	hsa-miR-4428	CLIP-seq
MIRT1024543	hsa-miR-4438	CLIP-seq
MIRT1024544	hsa-miR-4635	CLIP-seq
MIRT2540541	hsa-miR-4668-5p	CLIP-seq
MIRT2540542	hsa-miR-488	CLIP-seq
MIRT2540543	hsa-miR-579	CLIP-seq
MIRT1024547	hsa-miR-607	CLIP-seq
MIRT1024548	hsa-miR-656	CLIP-seq
MIRT2540544	hsa-miR-664	CLIP-seq
MIRT1024525	hsa-miR-105	CLIP-seq
MIRT1024526	hsa-miR-1243	CLIP-seq
MIRT2540537	hsa-miR-140-5p	CLIP-seq
MIRT1024527	hsa-miR-183	CLIP-seq
MIRT2540538	hsa-miR-3122	CLIP-seq
MIRT2540539	hsa-miR-3153	CLIP-seq
MIRT1024533	hsa-miR-3173-3p	CLIP-seq
MIRT1024536	hsa-miR-3671	CLIP-seq
MIRT2540540	hsa-miR-3913-5p	CLIP-seq
MIRT1024541	hsa-miR-4420	CLIP-seq
MIRT1024542	hsa-miR-4428	CLIP-seq
MIRT1024543	hsa-miR-4438	CLIP-seq
MIRT1024544	hsa-miR-4635	CLIP-seq
MIRT2540541	hsa-miR-4668-5p	CLIP-seq
MIRT2540542	hsa-miR-488	CLIP-seq
MIRT2540543	hsa-miR-579	CLIP-seq
MIRT1024547	hsa-miR-607	CLIP-seq
MIRT1024548	hsa-miR-656	CLIP-seq
MIRT2540544	hsa-miR-664	CLIP-seq

18 Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003924	Function	GTPase activity	NAS	10819326
GO:0005515	Function	Protein binding	IPI	25416956, 33961781, 35271311
GO:0005834	Component	Heterotrimeric G-protein complex	IBA
GO:0005834	Component	Heterotrimeric G-protein complex	IEA
GO:0005834	Component	Heterotrimeric G-protein complex	NAS	9790912
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007165	Process	Signal transduction	NAS	9790912
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	NAS	20277477
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0030165	Function	PDZ domain binding	IDA	23209302
GO:0031681	Function	G-protein beta-subunit binding	IBA
GO:0031681	Function	G-protein beta-subunit binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337

MIM	HGNC	e!Ensembl
600874	4408	ENSG00000174021

P63218

Protein name

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5

Protein function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G prote

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00631	G-gamma	4 → 68	GGL domain	Domain

Sequence

MSGSSSVAAMKKVVQQLRLEAGLNRVKVSQAAADLKQFCLQNAQHDPLLTGVSSSTNPFR
PQKVCSFL

Sequence length

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ras signaling pathway	Activation of G protein gated Potassium channels
Chemokine signaling pathway	Glucagon signaling in metabolic regulation
Hormone signaling	G-protein activation
PI3K-Akt signaling pathway	Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Apelin signaling pathway	ADP signalling through P2Y purinoceptor 12
Circadian entrainment	G beta:gamma signalling through PI3Kgamma
Retrograde endocannabinoid signaling	Prostacyclin signalling through prostacyclin receptor
Glutamatergic synapse	Adrenaline,noradrenaline inhibits insulin secretion
Cholinergic synapse	Ca2+ pathway
Serotonergic synapse	G alpha (q) signalling events
GABAergic synapse	G alpha (12/13) signalling events
Dopaminergic synapse	G beta:gamma signalling through PLC beta
Relaxin signaling pathway	G alpha (s) signalling events
Morphine addiction	ADP signalling through P2Y purinoceptor 1
Alcoholism	G alpha (i) signalling events
Human cytomegalovirus infection	G alpha (z) signalling events
Kaposi sarcoma-associated herpesvirus infection	Glucagon-type ligand receptors
Human immunodeficiency virus 1 infection	Thromboxane signalling through TP receptor
Pathways in cancer	Vasopressin regulates renal water homeostasis via Aquaporins
	Thrombin signalling through proteinase activated receptors (PARs)
	Presynaptic function of Kainate receptors
	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
	G beta:gamma signalling through BTK
	G beta:gamma signalling through CDC42
	Extra-nuclear estrogen signaling
	ADORA2B mediated anti-inflammatory cytokines production
	Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
PROSTATIC NEOPLASMS	—	CTD	17013881	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (9)
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35686033	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Heart Defects	Congenital heart defects	BEFREE	24599258		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial neoplasm	Pubtator	22706224	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Essential Hypertension	Hypertension	BEFREE	26574874		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	33000557	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	33000557	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	Pubtator	33883344	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	17013881		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	17013881		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
GNB2	[]	44	["Ras signaling pathway","Chemokine signaling pathway","Hormone signaling","Apelin signaling pathway","Circadian entrainment","Retrograde endocannabinoid signaling","Glutamatergic synapse","Cholinergic synapse","Serotonergic synapse","GABAergic synapse","Dopaminergic synapse","Relaxin signaling pathway"]	[]
GNG3	[]	44	["Ras signaling pathway","Chemokine signaling pathway","Hormone signaling","Apelin signaling pathway","Circadian entrainment","Retrograde endocannabinoid signaling","Glutamatergic synapse","Cholinergic synapse","Serotonergic synapse","GABAergic synapse","Dopaminergic synapse","Relaxin signaling pathway"]	[]
GNG4	[]	44	["Ras signaling pathway","Chemokine signaling pathway","Hormone signaling","Apelin signaling pathway","Circadian entrainment","Retrograde endocannabinoid signaling","Glutamatergic synapse","Cholinergic synapse","Serotonergic synapse","GABAergic synapse","Dopaminergic synapse","Relaxin signaling pathway"]	[]
GNG7	[]	44	["Ras signaling pathway","Chemokine signaling pathway","Hormone signaling","Apelin signaling pathway","Circadian entrainment","Retrograde endocannabinoid signaling","Glutamatergic synapse","Cholinergic synapse","Serotonergic synapse","GABAergic synapse","Dopaminergic synapse","Relaxin signaling pathway"]	[]
GNG10	[]	44	["Ras signaling pathway","Chemokine signaling pathway","Hormone signaling","Apelin signaling pathway","Circadian entrainment","Retrograde endocannabinoid signaling","Glutamatergic synapse","Cholinergic synapse","Serotonergic synapse","GABAergic synapse","Dopaminergic synapse","Relaxin signaling pathway"]	[]

GNG5 (G protein subunit gamma 5)

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