Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Metabolic syndrome Schizophrenia
466 genes
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162 of 466 corroborated by 2+ sources
SOX5(2), DPYD(3), HSPG2(2), RERE(1), COMT(3), ZFPM2(1), PDE4D(2), ATP2A2(2), BMPR1B(1), SH2B3(2), DOCK6(1), RBPJ(1) +454 more
0.138 0.358 1.27e-70 9.18e-69 ✓ sig. Cluster 2 →
Multiple sclerosis Systemic lupus erythematosus
142 genes
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45 of 142 corroborated by 2+ sources
RREB1(1), SH2B3(3), TERT(3), AFF1(1), ANKRD55(1), BTNL2(1), DOCK10(1), ETS1(4), FUT2(1), HLA-DQA1(3), HLA-DQB3(1), HLA-DRA(3) +130 more
0.130 0.247 1.27e-70 9.18e-69 ✓ sig. Cluster 28 →
Coronary artery disease Stroke
139 genes
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51 of 139 corroborated by 2+ sources
SOX5(1), CASZ1(2), PRDM16(3), APOA1(2), SH2B3(3), ANKRD26(1), ACE(2), ALDH1A2(1), ANKRD31(1), APOB(3), APOC1(1), BAZ1B(1) +127 more
0.105 0.430 3.71e-72 2.70e-70 ✓ sig. —
Limb girdle muscular dystrophy Muscular dystrophy
30 genes
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28 of 30 corroborated by 2+ sources
DAG1(2), GMPPB(3), PLEC(2), SGCA(5), HMGCR(4), CRPPA(3), TRAPPC11(6), ANO5(4), TNPO3(3), SGCD(6), LMNA(1), TTN(3) +18 more
0.500 0.789 3.59e-72 2.62e-70 ✓ sig. Cluster 14 →
Celiac disease Common variable immunodeficiency
47 genes
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5 of 47 corroborated by 2+ sources
ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), ICOS(4), IGF2(1), LRRK2(1), TENM3(1), TTC33(1), IL10(1), CRB1(1) +35 more
0.212 0.627 2.34e-72 1.72e-70 ✓ sig. Cluster 39 →
Non-melanoma skin carcinoma Skin cancer
47 genes
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TP53(1), ATP8B4(1), BNC2(1), CUX1(1), FADS2(1), FOXP1(1), HERC2(1), HLA-DQA1(1), HLA-DQB3(1), HLA-DRB1(1), ICOS(1), MYL10(1) +35 more
0.228 0.566 2.22e-72 1.63e-70 ✓ sig. Cluster 29 →
complex neurodevelopmental disorder Intellectual developmental disorder
79 genes
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79 of 79 corroborated by 2+ sources
CHD8(4), HNRNPU(2), CACNA1D(2), CHD2(2), CNTNAP2(2), CUL3(2), EPB41L1(4), GRIA1(6), GRIK2(6), GRIN2B(5), KCNQ2(2), KMT5B(5) +67 more
0.093 0.669 7.71e-73 5.69e-71 ✓ sig. Cluster 6 →
Autoimmune disease Common variable immunodeficiency
48 genes
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4 of 48 corroborated by 2+ sources
ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), ICOS(4), IGF2(1), IKZF1(4), LRRK2(1), TENM3(1), TTC33(1), IL10(1) +36 more
0.209 0.640 1.57e-73 1.17e-71 ✓ sig. Cluster 39 →
Celiac disease Juvenile idiopathic arthritis
69 genes
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13 of 69 corroborated by 2+ sources
RUNX1(1), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), HLA-DQA1(4), HLA-DRA(1), HLA-DRB1(3), IGF2(1), LRRK2(1) +57 more
0.176 0.358 9.42e-74 7.00e-72 ✓ sig. —
Attention deficit hyperactivity disorder Insomnia
258 genes
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12 of 258 corroborated by 2+ sources
SOX5(1), HMGA2(1), BPTF(1), JMJD1C(1), CACNA1D(1), ALMS1(1), ABCB9(1), ADARB1(1), AFF3(1), AKAP6(1), ARHGAP15(1), AS3MT(3) +246 more
0.134 0.239 5.86e-74 4.37e-72 ✓ sig. Cluster 2 →
Ischemic heart disease Myocardial infarction
84 genes
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59 of 84 corroborated by 2+ sources
PRDM16(2), APOA1(1), SH2B3(3), TP53(1), ABCG8(2), ACE(2), APOB(2), APOE(3), ICA1L(2), JCAD(2), KALRN(2), KCNE2(2) +72 more
0.126 0.494 2.96e-74 2.22e-72 ✓ sig. —
Atrial fibrillation Heart failure
150 genes
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49 of 150 corroborated by 2+ sources
YWHAE(1), CASZ1(3), ZFPM2(1), ATP2A2(3), ANKRD26(1), BRWD1(1), CACNA1D(1), ACE(2), AGT(3), AKAP6(3), ALDH1A2(1), ANKRD31(1) +138 more
0.127 0.319 2.29e-74 1.72e-72 ✓ sig. —
Diabetes mellitus type 1 Hypothyroidism
107 genes
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25 of 107 corroborated by 2+ sources
RERE(1), SH2B3(3), IFIH1(1), BTNL2(1), CAMK4(1), ERBB3(1), ETS1(2), FADS1(1), FADS2(1), FAM76B(1), GLIS3(3), HLA-C(1) +95 more
0.144 0.286 1.44e-74 1.09e-72 ✓ sig. Cluster 28 →
Bladder calculus Nephrolithiasis
36 genes
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3 of 36 corroborated by 2+ sources
KANSL1(1), ALPL(1), BCAS3(1), GIPR(1), PRKAG2(1), STC1(1), VEGFA(1), SLC30A10(1), PDILT(1), AP1S3(1), TFAP2B(1), ABCG2(1) +24 more
0.290 0.923 3.37e-75 2.55e-73 ✓ sig. Cluster 178 →
Insomnia Major depressive disorder
360 genes
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56 of 360 corroborated by 2+ sources
SOX5(1), PAFAH1B1(1), BPTF(1), WWOX(1), PER2(2), BLTP1(1), ADARB1(1), ADCK1(1), AKAP6(1), APOE(1), ARHGAP15(1), ARHGEF10L(1) +348 more
0.134 0.334 1.38e-75 1.05e-73 ✓ sig. Cluster 2 →
Autoimmune disease Hypothyroidism
79 genes
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7 of 79 corroborated by 2+ sources
SH2B3(1), C12orf42(1), CAMK4(1), ELMO1(1), ERBB3(1), FAM76B(1), GIGYF1(1), HLA-DQB3(1), ICOS(1), ITGB3(1), MACIR(1), MB21D2(1) +67 more
0.159 0.391 1.31e-75 9.96e-74 ✓ sig. —
Leigh syndrome Mitochondrial complex deficiency
48 genes
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45 of 48 corroborated by 2+ sources
NDUFA10(6), NDUFA12(5), NDUFA9(5), NDUFAF2(5), NDUFAF6(6), ND2(1), NDUFS3(6), NDUFS2(6), TTC19(7), LRPPRC(5), NDUFA2(6), TIMMDC1(5) +36 more
0.268 0.449 3.86e-76 2.95e-74 ✓ sig. Cluster 50 →
Congenital myasthenic syndrome Myasthenic syndrome
28 genes
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28 of 28 corroborated by 2+ sources
CHD8(2), SCN4A(5), ALG2(7), AGRN(6), CHRNE(6), COLQ(4), GFPT1(7), GMPPB(5), PLEC(2), RAPSN(5), RPH3A(2), CHAT(6) +16 more
0.667 0.966 2.85e-77 2.19e-75 ✓ sig. Cluster 34 →
Autism Intellectual developmental disorder
261 genes
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185 of 261 corroborated by 2+ sources
SOX5(3), CHD8(3), FOXG1(2), UBE3A(2), CHRNA7(2), SIN3A(2), ANKRD11(2), RAI1(2), NF1(2), KANSL1(3), NFIX(2), JMJD1C(3) +249 more
0.130 0.323 7.32e-78 5.64e-76 ✓ sig. —
Diabetes mellitus Diabetic eye disease
46 genes
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5 of 46 corroborated by 2+ sources
RREB1(1), APOE(2), AUTS2(1), CDKAL1(2), HLA-DQB3(1), HMG20A(1), JAZF1(1), KLHL42(1), MACF1(1), MACIR(1), NRXN3(1), NYAP2(1) +34 more
0.154 0.958 3.32e-78 2.57e-76 ✓ sig. Cluster 73 →
Keratinocyte carcinoma Skin neoplasms
47 genes
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3 of 47 corroborated by 2+ sources
TERT(1), TP53(2), BNC2(1), CUX1(1), FOXP1(1), HERC2(1), HLA-DQA1(1), HLA-DRB1(1), MYL10(1), RHOU(1), SMC2(1), TRPS1(1) +35 more
0.267 0.610 2.48e-78 1.93e-76 ✓ sig. Cluster 29 →
Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy
47 genes
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36 of 47 corroborated by 2+ sources
ABCC9(7), ACTN2(7), CDH2(5), CACNB2(1), CTNNA3(7), DMD(6), DSG2(8), JUP(5), PKP2(7), PLEC(1), PRKAG2(1), RBM20(8) +35 more
0.168 0.904 1.89e-78 1.47e-76 ✓ sig. —
Autoimmune thyroid disease Common variable immunodeficiency
47 genes
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2 of 47 corroborated by 2+ sources
ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), FUT2(1), ICOS(4), IGF2(1), LRRK2(1), TENM3(1), TTC33(1), IL10(1), MBL2(1) +35 more
0.272 0.627 2.53e-79 1.98e-77 ✓ sig. Cluster 39 →
Coronary artery disease Diabetes mellitus type 2
498 genes
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116 of 498 corroborated by 2+ sources
WT1(1), SOX5(1), CYP17A1(1), RAI1(1), DPYD(1), CASZ1(1), SKI(1), ARVCF(1), JMJD1C(1), COLEC11(1), MAP3K1(1), ZFPM2(1) +486 more
0.134 0.436 7.27e-80 5.71e-78 ✓ sig. —
Intellectual developmental disorder Nonsyndromic intellectual disability
90 genes
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88 of 90 corroborated by 2+ sources
CDH15(7), CLIP1(4), CRADD(6), CRBN(6), CUX1(3), DEAF1(4), EPB41L1(4), FMN2(6), GABBR1(2), GRIA1(6), GRIK2(6), GRIN2B(5) +78 more
0.105 0.638 3.83e-80 3.02e-78 ✓ sig. Cluster 6 →

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.