Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 14

23 diseases · 54 shared-gene connections
23 Diseases
3,075 Unique genes
0.149 Avg. similarity score
Crohn disease Most-connected disease (11 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Crohn disease 11 11 690
Inflammatory bowel disease 9 9 690
Psoriasis 9 9 731
Sclerosing cholangitis 9 9 230
Ulcerative colitis 9 9 611
Inflammatory skin disease 7 7 76
Ankylosing spondylitis 6 6 313
Eczema 6 6 365
Asthma 5 5 1,068
Psoriasis vulgaris 5 5 54
Respiratory system disease 5 5 241
Iga nephropathy 4 4 203
Obstructive pulmonary disease 4 4 559
Benign flecked retina 3 3 1
Multiple sclerosis 3 3 576
neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 3 3 1
Autonomic nervous system disease 2 2 2
Intellectual developmental disorder neuropsychiatric 2 2 1
Psoriatic arthritis 2 2 73
Autoinflammatory disease, systemic, with vasculitis 1 1 1
Ehrlich tumor carcinoma 1 1 1
intellectual developmental disorder 59 1 1 1
neurodevelopmental disorder with spasticity, seizures, and brain abnormalities 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
HLA-B 13 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 9 more
HLA-DQA1 13 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 9 more
RUNX3 13 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 9 more
ETS1 12 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 8 more
HLA-DQB1 12 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 8 more
IL2RA 12 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 8 more
TNFAIP3 12 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 8 more
BACH2 11 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 7 more
EMSY 11 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 7 more
HLA-DRB1 11 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 7 more
IKZF1 11 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 7 more
IL23R 11 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory bowel disease and 7 more
IRF1 11 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 7 more
FAP 10 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory bowel disease and 6 more
IFIH1 10 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory bowel disease and 6 more
IL18R1 10 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 6 more
NDFIP1 10 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 6 more
NOS2 10 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 6 more
PSMA6 10 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 6 more
SMAD3 10 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 6 more
STAT3 10 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 6 more
TAGAP 10 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Iga nephropathy and 6 more
TNIP1 10 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 6 more
TTC33 10 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Iga nephropathy and 6 more
UBAC2 10 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 6 more
ANKRD55 9 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Iga nephropathy and 5 more
CAMK2G 9 / 23 Asthma, Crohn disease, Inflammatory bowel disease, intellectual developmental disorder 59 and 5 more
CCL20 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 5 more
CD28 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Iga nephropathy and 5 more
CLEC16A 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 5 more
ELMO1 9 / 23 Autonomic nervous system disease, Crohn disease, Eczema, Inflammatory bowel disease and 5 more
HDAC7 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 5 more
IL2 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 5 more
JAK2 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 5 more
JAZF1 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 5 more
LTBR 9 / 23 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 5 more
MYRF 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 5 more
NFKB1 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Iga nephropathy and 5 more
NOD2 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 5 more
PRR5L 9 / 23 Asthma, Crohn disease, Eczema, Inflammatory bowel disease and 5 more
PTPN2 9 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory bowel disease and 5 more
PTPRK 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 5 more
RMI2 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 5 more
RORC 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 5 more
SPMIP7 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 5 more
THEMIS 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 5 more
TMEM258 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 5 more
TNFRSF14 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 5 more
TSPAN14 9 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 5 more
TYK2 9 / 23 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 5 more
ZMIZ1 9 / 23 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 5 more
ASAP2 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Multiple sclerosis and 4 more
ATG5 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
ATXN2 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
CCDC88B 8 / 23 Crohn disease, Iga nephropathy, Inflammatory bowel disease, Multiple sclerosis and 4 more
CCL2 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
CD40 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
DNMT3A 8 / 23 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 4 more
ERAP1 8 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory skin disease and 4 more
GRHL3 8 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory skin disease and 4 more
GSDMB 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
HLA-DOB 8 / 23 Asthma, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 4 more
IFNLR1 8 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory skin disease and 4 more
IL10 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
IL1R1 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 4 more
IL21 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 4 more
IL4R 8 / 23 Asthma, Crohn disease, Eczema, Inflammatory bowel disease and 4 more
IL6R 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 4 more
IL7R 8 / 23 Ankylosing spondylitis, Asthma, Eczema, Iga nephropathy and 4 more
ITGAL 8 / 23 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Obstructive pulmonary disease and 4 more
KIF3B 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
LCE3A 8 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory skin disease and 4 more
LCE3B 8 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory skin disease and 4 more
LITAF 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
PDE4A 8 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory bowel disease and 4 more
PLAU 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Iga nephropathy and 4 more
PLCL1 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
POFUT1 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
PTCD2 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
PUS10 8 / 23 Ankylosing spondylitis, Crohn disease, Eczema, Inflammatory bowel disease and 4 more
RORA 8 / 23 Asthma, Crohn disease, Eczema, Iga nephropathy and 4 more
RPS26 8 / 23 Asthma, Crohn disease, Eczema, Inflammatory bowel disease and 4 more
SBNO2 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Inflammatory bowel disease and 4 more
SETD1A 8 / 23 Ankylosing spondylitis, Crohn disease, Multiple sclerosis, Obstructive pulmonary disease and 4 more
SLC9A4 8 / 23 Ankylosing spondylitis, Asthma, Crohn disease, Eczema and 4 more
STAT4 8 / 23 Asthma, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
TAP2 8 / 23 Ankylosing spondylitis, Asthma, Iga nephropathy, Inflammatory bowel disease and 4 more
TRAF3IP2 8 / 23 Crohn disease, Eczema, Inflammatory bowel disease, Inflammatory skin disease and 4 more
TSBP1 8 / 23 Asthma, Crohn disease, Eczema, Inflammatory bowel disease and 4 more
ZBTB38 8 / 23 Asthma, Crohn disease, Eczema, Inflammatory bowel disease and 4 more
ADCY3 7 / 23 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
BLTP1 7 / 23 Asthma, Crohn disease, Eczema, Inflammatory bowel disease and 3 more
BSN 7 / 23 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Obstructive pulmonary disease and 3 more
C1ORF141 7 / 23 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 3 more
CARD9 7 / 23 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 3 more
CD226 7 / 23 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
CD6 7 / 23 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
CDKAL1 7 / 23 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 3 more
CEBPA 7 / 23 Asthma, Crohn disease, Eczema, Inflammatory bowel disease and 3 more
CEP43 7 / 23 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 3 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Inflammatory bowel disease
HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IL12RB2, IL17A, IL18R1, IL18RAP, IL2, IL21
 KEGG 58 / 66 3.4× 1.88e-26 4.08e-23 ✓ sig.
Allograft rejection
CD28, CD40, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL12B, IL2, CD40LG, IFNG
 KEGG 36 / 39 3.6× 1.67e-18 1.08e-15 ✓ sig.
Th17 cell differentiation
AHR, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL17A, IL1R1, IL2, IL21, IL23R, IL27, IL2RA
 KEGG 68 / 109 2.4× 4.84e-16 1.99e-13 ✓ sig.
Cytokine-cytokine receptor interaction
CCL2, CCL20, CCL21, CCR6, CD40, CSF2RB, CXCR1, CXCR2, FAS, IFNGR2, IFNLR1, IL10
 KEGG 138 / 298 1.8× 4.56e-15 1.55e-12 ✓ sig.
Type I diabetes mellitus
CD28, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL12B, IL2, IFNG, HLA-C, LTA, TNF
 KEGG 36 / 44 3.2× 7.87e-15 2.54e-12 ✓ sig.
Th1 and Th2 cell differentiation
HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL12B, IL12RB2, IL2, IL2RA, JAK2, MAPK3, NFATC1, NFKB1
 KEGG 57 / 93 2.4× 3.41e-13 7.95e-11 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
CCL2, IL10, IL12B, IL17A, IL23R, IL6, IL6R, JAK2, NOS2, RORC, STAT3, TNFRSF1B
 Reactome 63 / 108 2.3× 4.90e-13 1.12e-10 ✓ sig.
Leishmaniasis
FCGR2A, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IRAK1, JAK2, MAPK3, NFKB1, NOS2
 KEGG 50 / 78 2.5× 8.13e-13 1.81e-10 ✓ sig.
Interleukin-10 signaling
CCL2, CCL20, IL10, IL12B, IL1R1, IL1R2, IL6, STAT3, TNFRSF1A, TNFRSF1B, TYK2, TIMP1
 Reactome 35 / 47 2.9× 2.95e-12 5.85e-10 ✓ sig.
Graft-versus-host disease
CD28, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL2, IL6, IFNG, HLA-C, TNF, CD80
 KEGG 34 / 45 3.0× 3.01e-12 5.94e-10 ✓ sig.
Asthma
CD40, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, CD40LG, IL4, IL13, TNF, CCL11, FCER1G, HLA-DMB
 KEGG 27 / 32 3.3× 4.79e-12 9.09e-10 ✓ sig.
Intestinal immune network for IgA production
CD28, CD40, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL15RA, IL2, IL6, LTBR, AICDA, CD40LG
 KEGG 36 / 50 2.8× 7.63e-12 1.40e-9 ✓ sig.
Viral protein interaction with cytokine and cytokine receptor
CCL2, CCL20, CCL21, CCR6, CXCR1, CXCR2, IL10, IL18R1, IL18RAP, IL19, IL2, IL2RA
 KEGG 56 / 100 2.2× 8.94e-11 1.30e-8 ✓ sig.
Tuberculosis
CARD9, CORO1A, FCGR2A, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IL6, IRAK1, JAK2
 KEGG 86 / 181 1.9× 1.33e-10 1.87e-8 ✓ sig.
Autoimmune thyroid disease
CD28, CD40, CTLA4, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL2, CD40LG, IL4
 KEGG 35 / 54 2.5× 1.44e-9 1.53e-7 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
inflammatory response
CCL2, CCL20, CCL21, CD40, CXCR2, IL17A, IL18R1, IL18RAP, IL1R1, IL23R, IL27, IL2RA
 GO:0006954 185 / 467 2.4× 7.62e-34 5.33e-30 ✓ sig.
immune response
CCL2, CCL20, CCL21, CCR6, CD244, CD28, CTLA4, CXCR1, CXCR2, ETS1, FAS, HLA-B
 GO:0006955 197 / 543 2.2× 6.03e-30 3.15e-26 ✓ sig.
response to lipopolysaccharide
CD6, CSF2RB, CYP1A1, IL10, IL12RB2, IL23R, IRAK1, LITAF, MAPK3, NOS2, NOTCH1, PTPN22
 GO:0032496 76 / 161 2.9× 7.17e-20 1.15e-16 ✓ sig.
positive regulation of transcription by RNA polymerase II
ACTR2, AHR, ASCL2, CD28, CD40, CREM, CYTL1, EOMES, ETS1, GRHL3, HHEX, IGF2
 GO:0045944 319 / 1,208 1.6× 7.49e-20 1.19e-16 ✓ sig.
cytokine-mediated signaling pathway
CCL2, CSF2RB, IFNGR2, IFNLR1, IL12RB2, IL1R1, IL1R2, IL23R, IL6, IL6R, IL7R, IRAK1
 GO:0019221 69 / 145 2.9× 2.09e-18 2.65e-15 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
CCL2, CD40, CSF2RB, IL12B, IL15RA, IL23R, IL6, IL6R, JAK2, STAT3, TNFRSF1A, TYK2
 GO:0007259 40 / 67 3.6× 1.40e-15 1.06e-12 ✓ sig.
positive regulation of type II interferon production
CD226, CD244, IL12B, IL12RB2, IL18R1, IL1R1, IL2, IL21, IL23R, IL27, JAK2, PTPN22
 GO:0032729 43 / 77 3.4× 3.56e-15 2.55e-12 ✓ sig.
positive regulation of canonical NF-kappaB signal transduction
CARD9, CCL21, CD40, HLA-DRB1, IL1R1, INAVA, IRAK1, LITAF, LTBR, LURAP1L, NDFIP1, NOD2
 GO:0043123 87 / 232 2.3× 7.11e-15 4.70e-12 ✓ sig.
cellular response to lipopolysaccharide
CCL2, CD40, IL10, IL12B, IL6, IRAK1, IRGM, JAK2, LITAF, NFKB1, NOD2, NOS2
 GO:0071222 72 / 187 2.3× 3.26e-13 1.65e-10 ✓ sig.
response to hypoxia
ASCL2, CYP1A1, HIF3A, MTHFR, NOS2, PLAU, SMAD3, STAT3, CRYAA, EGR1, SOD2, TGFB2
 GO:0001666 68 / 176 2.3× 1.22e-12 5.50e-10 ✓ sig.
positive regulation of cytokine production
CARD9, CD28, IL10, IL21, JAK2, PTGER4, IFNG, TNF, AGER, BATF, CD14, GATA3
 GO:0001819 41 / 81 3.1× 1.25e-12 5.66e-10 ✓ sig.
positive regulation of ERK1 and ERK2 cascade
ACTA2, CARD9, CCL21, HLA-DRB1, MAPK3, NOD2, NOTCH1, PDE8A, PDGFB, PTPN22, TLR4, BMP4
 GO:0070374 74 / 201 2.2× 2.11e-12 9.00e-10 ✓ sig.
positive regulation of T cell activation
CCL2, CD28, CORO1A, HLA-DQA1, HLA-DQB1, HLA-DRB1, NR5A2, PRKCQ, B2M, CCR2, ADA, CARD11
 GO:0050870 28 / 45 3.8× 6.16e-12 2.37e-9 ✓ sig.
positive regulation of DNA-templated transcription
AHR, EOMES, ETS1, GRHL3, HHEX, HLA-DRB1, IL10, IL6, IRF1, KDM5A, KPNB1, MYRF
 GO:0045893 200 / 778 1.6× 1.33e-11 4.75e-9 ✓ sig.
positive regulation of interleukin-6 production
CARD9, IFIH1, IL17A, IL6, IL6R, INAVA, NOD2, NOS2, STAT3, TLR4, IFNG, TNF
 GO:0032755 46 / 103 2.7× 1.56e-11 5.49e-9 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Crohn disease Inflammatory bowel disease 0.638 538 < 1e-300 < 1e-300 ✓ sig.
Crohn disease Ulcerative colitis 0.615 496 < 1e-300 < 1e-300 ✓ sig.
Inflammatory bowel disease Ulcerative colitis 0.534 453 < 1e-300 < 1e-300 ✓ sig.
Ankylosing spondylitis Sclerosing cholangitis 0.559 195 2.96e-323 4.67e-320 ✓ sig.
Ankylosing spondylitis Ulcerative colitis 0.327 228 1.73e-263 1.59e-260 ✓ sig.
Psoriasis Sclerosing cholangitis 0.272 206 1.03e-254 8.38e-252 ✓ sig.
Sclerosing cholangitis Ulcerative colitis 0.307 198 1.60e-254 1.26e-251 ✓ sig.
Ankylosing spondylitis Psoriasis 0.285 232 1.06e-249 8.09e-247 ✓ sig.
Ankylosing spondylitis Crohn disease 0.294 228 7.26e-249 5.34e-246 ✓ sig.
Crohn disease Sclerosing cholangitis 0.277 200 1.10e-246 7.55e-244 ✓ sig.
Crohn disease Psoriasis 0.255 289 7.25e-214 3.47e-211 ✓ sig.
Psoriasis Ulcerative colitis 0.253 271 2.80e-207 1.19e-204 ✓ sig.
Inflammatory bowel disease Sclerosing cholangitis 0.207 158 3.30e-162 7.50e-160 ✓ sig.
Inflammatory bowel disease Psoriasis 0.211 248 7.22e-161 1.56e-158 ✓ sig.
Ankylosing spondylitis Inflammatory bowel disease 0.205 171 8.80e-151 1.70e-148 ✓ sig.
Asthma Respiratory system disease 0.153 174 1.46e-149 2.80e-147 ✓ sig.
Eczema Inflammatory skin disease 0.208 76 8.22e-128 1.33e-125 ✓ sig.
Inflammatory skin disease Psoriasis 0.104 76 5.45e-103 6.86e-101 ✓ sig.
Eczema Psoriasis 0.150 143 3.37e-95 3.55e-93 ✓ sig.
Asthma Eczema 0.130 165 6.56e-95 6.82e-93 ✓ sig.
Asthma Psoriasis 0.123 197 3.43e-67 2.52e-65 ✓ sig.
Crohn disease Multiple sclerosis 0.124 140 1.59e-65 1.14e-63 ✓ sig.
Multiple sclerosis Ulcerative colitis 0.125 132 4.72e-65 3.34e-63 ✓ sig.
Asthma Crohn disease 0.117 184 9.50e-62 6.29e-60 ✓ sig.
Eczema Respiratory system disease 0.137 73 4.23e-61 2.78e-59 ✓ sig.
Inflammatory bowel disease Multiple sclerosis 0.119 135 5.64e-61 3.69e-59 ✓ sig.
Crohn disease Eczema 0.110 105 2.04e-56 1.25e-54 ✓ sig.
Respiratory system disease Ulcerative colitis 0.092 72 1.77e-43 8.44e-42 ✓ sig.
Psoriasis vulgaris Sclerosing cholangitis 0.113 29 2.25e-39 9.77e-38 ✓ sig.
Inflammatory skin disease Psoriasis vulgaris 0.202 22 4.37e-38 1.83e-36 ✓ sig.
Asthma Obstructive pulmonary disease 0.083 125 4.22e-33 1.52e-31 ✓ sig.
Respiratory system disease Sclerosing cholangitis 0.098 42 6.49e-33 2.33e-31 ✓ sig.
Obstructive pulmonary disease Respiratory system disease 0.068 51 4.47e-25 1.16e-23 ✓ sig.
Psoriasis vulgaris Psoriatic arthritis 0.133 15 2.23e-23 5.26e-22 ✓ sig.
Inflammatory bowel disease Obstructive pulmonary disease 0.072 84 3.87e-23 9.05e-22 ✓ sig.
Iga nephropathy Ulcerative colitis 0.058 45 1.51e-21 3.25e-20 ✓ sig.
Iga nephropathy Sclerosing cholangitis 0.056 23 3.98e-14 5.62e-13 ✓ sig.
Ankylosing spondylitis Iga nephropathy 0.053 26 6.60e-14 9.17e-13 ✓ sig.
Inflammatory skin disease Sclerosing cholangitis 0.051 15 3.30e-13 4.41e-12 ✓ sig.
Inflammatory skin disease Psoriatic arthritis 0.064 9 8.04e-11 8.56e-10 ✓ sig.
intellectual developmental disorder 59 Psoriasis vulgaris 0.018 1 3.51e-3 4.51e-3 ✓ sig.
Inflammatory skin disease Intellectual developmental disorder neuropsychiatric 0.013 1 4.94e-3 6.05e-3 ✓ sig.
Autonomic nervous system disease Psoriasis vulgaris 0.018 1 7.00e-3 8.29e-3 ✓ sig.
Autonomic nervous system disease Inflammatory skin disease 0.013 1 9.85e-3 1.12e-2 ✓ sig.
Autoinflammatory disease, systemic, with vasculitis Iga nephropathy 0.005 1 1.32e-2 1.47e-2 ✓ sig.
Eczema Intellectual developmental disorder neuropsychiatric 0.003 1 2.37e-2 2.56e-2 ✓ sig.
neurodevelopmental disorder with spasticity, seizures, and brain abnormalities Obstructive pulmonary disease 0.002 1 3.63e-2 3.83e-2 ✓ sig.
neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties Ulcerative colitis 0.002 1 3.97e-2 4.15e-2 ✓ sig.
Inflammatory bowel disease neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Benign flecked retina Inflammatory bowel disease 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Benign flecked retina Crohn disease 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Crohn disease neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Crohn disease Ehrlich tumor carcinoma 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Benign flecked retina Psoriasis 0.001 1 4.75e-2 4.93e-2 ✓ sig.