Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Idiopathic steroid-resistant nephrotic syndrome Nephrotic syndrome
23 genes
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21 of 23 corroborated by 2+ sources
WT1(5), NUP107(4), ACTN4(2), ARHGAP24(2), MYO1E(2), NUP160(5), NUP85(4), PAX2(2), PTPRO(4), TRPC6(2), PLCE1(6), MAGI2(4) +11 more
0.134 0.821 1.09e-41 4.76e-40 ✓ sig. Cluster 24 →
Atrial fibrillation Coronary artery disease
184 genes
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54 of 184 corroborated by 2+ sources
SOX5(3), CASZ1(3), JMJD1C(1), ZFPM2(1), ANKRD26(1), ACE(2), AGT(2), ALDH1A2(1), ANKRD31(1), APOB(3), APOC1(1), BAZ1B(1) +172 more
0.101 0.213 1.26e-41 5.50e-40 ✓ sig. Cluster 6 →
Distal spinal muscular atrophy Hereditary motor and sensory neuropathies
20 genes
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2 of 20 corroborated by 2+ sources
AARS1(1), SETX(1), TRPV4(3), DCTN1(1), DYNC1H1(1), NEFL(1), LITAF(1), SH3TC2(1), BSCL2(1), HSPB1(1), PLEKHG5(1), GARS1(1) +8 more
0.256 0.645 1.46e-41 6.38e-40 ✓ sig. Cluster 12 →
Cone-rod dystrophy Leber congenital amaurosis
25 genes
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16 of 25 corroborated by 2+ sources
ABCA4(7), CNGB3(1), PRPH2(4), AIPL1(6), ALMS1(1), PDE6B(1), RIMS1(3), USH2A(1), CRB1(6), CRX(8), GUCY2D(7), PROM1(6) +13 more
0.205 0.347 1.51e-41 6.55e-40 ✓ sig. Cluster 7 →
Congenital contractural arachnodactyly Thoracic aortic aneurysm and aortic dissection
18 genes
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18 of 18 corroborated by 2+ sources
SKI(2), FBN1(6), FBN2(8), PLOD1(2), SLC2A10(2), TGFB2(5), THSD4(3), BGN(5), SMAD3(6), COL3A1(2), EFEMP2(3), TGFBR1(6) +6 more
0.340 0.621 1.88e-41 8.16e-40 ✓ sig. Cluster 43 →
Graves ophthalmopathy Myopathic ophthalmopathy
13 genes
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3 of 13 corroborated by 2+ sources
SCD(2), ICAM1(1), IL10(1), IL2(1), TNF(1), PTGS2(2), IL3(1), CTLA4(1), IL23R(1), PTPN22(1), IL1RN(1), TSHR(2) +1 more
0.684 1.000 1.96e-41 8.47e-40 ✓ sig. Cluster 149 →
Congestive ophthalmopathy Graves ophthalmopathy
13 genes
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3 of 13 corroborated by 2+ sources
SCD(2), ICAM1(1), IL10(1), IL2(1), TNF(1), PTGS2(2), IL3(1), CTLA4(1), IL23R(1), PTPN22(1), IL1RN(1), TSHR(2) +1 more
0.684 1.000 1.96e-41 8.47e-40 ✓ sig. Cluster 149 →
Colobomatous microphthalmia Microphthalmia
15 genes
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15 of 15 corroborated by 2+ sources
TENM3(5), SHH(6), SOX2(4), STRA6(4), SIX6(4), OTX2(4), PORCN(3), RAX(4), VSX2(7), RBP4(6), MAB21L2(6), ALDH1A3(4) +3 more
0.385 1.000 3.14e-41 1.35e-39 ✓ sig. Cluster 54 →
Developmental coordination disorder Motor skills disorder
12 genes
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12 of 12 corroborated by 2+ sources
PTEN(2), DISC1(2), RPTOR(2), SQSTM1(2), SOD1(2), FGFR2(2), CNR1(2), SHANK1(2), CAMKMT(2), NDUFS4(2), OGG1(2), AKAP5(2)
0.857 1.000 3.52e-41 1.51e-39 ✓ sig. —
Congenital contractural arachnodactyly Marfan syndrome
18 genes
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6 of 18 corroborated by 2+ sources
FBN1(7), LTBP3(1), FBN2(7), SLC2A10(1), TGFB2(2), THSD4(1), BGN(1), SMAD3(1), COL3A1(2), TGFBR1(3), TGFBR2(3), LOX(1) +6 more
0.327 0.621 5.65e-41 2.43e-39 ✓ sig. Cluster 43 →
Jeune syndrome Short-rib thoracic dysplasia
17 genes
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17 of 17 corroborated by 2+ sources
NEK1(4), IFT80(6), CEP120(5), DYNC2H1(6), DYNC2I1(6), DYNC2I2(6), DYNC2LI1(5), DYNLT2B(4), IFT140(3), IFT172(5), IFT52(5), INTU(3) +5 more
0.347 0.739 5.94e-41 2.55e-39 ✓ sig. Cluster 17 →
Leber hereditary optic neuropathy Melas syndrome
15 genes
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13 of 15 corroborated by 2+ sources
IL1A(2), IL1B(2), ND1(2), ND2(2), SOD2(2), ATP6(2), ND6(2), COX3(2), ATP8(1), COX1(2), ND5(2), COX2(2) +3 more
0.469 0.833 6.19e-41 2.65e-39 ✓ sig. Cluster 27 →
Atrial fibrillation Cardioembolic stroke
54 genes
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35 of 54 corroborated by 2+ sources
PRRX1(3), ESR2(3), GORAB(1), KCNN2(3), KCNN3(3), NCOR2(1), RBM20(3), TBX5(3), TNFSF12-TNFSF13(1), TRIM36(1), VRTN(1), IGF1R(3) +42 more
0.059 0.535 6.90e-41 2.94e-39 ✓ sig. —
Congenital impairment of spermatozoa motility Spermatogenic failure
20 genes
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20 of 20 corroborated by 2+ sources
CATSPER1(5), SPAG17(4), SPEF2(4), ACTL9(4), ARMC2(5), CFAP43(5), TTC29(4), SLC26A8(4), DRC1(4), DNAH1(5), AK7(5), DNAH17(4) +8 more
0.169 0.870 7.34e-41 3.13e-39 ✓ sig. Cluster 32 →
Cancer Stroke
56 genes
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2 of 56 corroborated by 2+ sources
SH2B3(2), ANKRD26(1), ALDH1A2(1), ANKRD31(1), APOB(1), APOC1(1), BAZ1B(1), BCL3(1), CCDC91(1), FADS1(1), FADS2(1), LIPC(1) +44 more
0.106 0.215 1.07e-40 4.55e-39 ✓ sig. —
Liver disease Nonalcoholic fatty liver disease
46 genes
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25 of 46 corroborated by 2+ sources
INS(2), MTTP(3), SERPINA1(3), APOC1(1), APOE(1), CYP1A2(2), HS3ST1(1), TRIB1(3), HFE(2), ALDH2(2), GSTP1(2), GSTT1(2) +34 more
0.107 0.293 1.37e-40 5.83e-39 ✓ sig. Cluster 285 →
Jeune syndrome Short rib dysplasia-polydactyly syndrome
17 genes
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16 of 17 corroborated by 2+ sources
NEK1(3), IFT80(5), CEP120(3), DYNC2H1(6), DYNC2I1(4), DYNC2I2(4), DYNC2LI1(4), DYNLT2B(2), IFT140(3), IFT172(3), IFT52(2), INTU(1) +5 more
0.340 0.708 2.03e-40 8.61e-39 ✓ sig. Cluster 17 →
Kidney failure Myocardial ischemia
59 genes
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42 of 59 corroborated by 2+ sources
TP53(1), GATM(3), AHSG(1), SERPINA1(2), ABCA1(2), ACE(2), AGT(2), APOE(2), EPHX2(2), MLXIPL(2), MMP3(1), SCARB1(3) +47 more
0.101 0.235 2.17e-40 9.17e-39 ✓ sig. Cluster 6 →
Astrocytoma Glioblastoma
76 genes
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3 of 76 corroborated by 2+ sources
NF1(1), NOTCH2(1), NOTCH1(1), HMCN1(1), TEAD1(1), AGBL1(1), ARHGEF28(1), C6orf118(1), CTNNA3(1), DSCAM(1), FAM163A(1), G3BP1(2) +64 more
0.091 0.252 2.46e-40 1.04e-38 ✓ sig. Cluster 289 →
Diabetes mellitus type 2 Gout
324 genes
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55 of 324 corroborated by 2+ sources
SIN3A(1), SKI(1), JMJD1C(1), RREB1(1), INS(3), GNAT2(1), ATP2A2(3), NOTCH2(3), PIK3R1(3), TPCN2(1), SERPINF2(1), ABCA1(2) +312 more
0.091 0.396 3.56e-40 1.50e-38 ✓ sig. Cluster 2 →
Bardet-biedl syndrome Ciliopathy
23 genes
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23 of 23 corroborated by 2+ sources
WDPCP(8), RPGRIP1L(3), TMEM67(4), IFT172(6), WDR19(2), SCLT1(3), BBS7(5), SDCCAG8(7), IFT74(7), ARL6(7), BBS2(7), CFAP418(7) +11 more
0.213 0.390 4.40e-40 1.85e-38 ✓ sig. Cluster 8 →
Congenital neutropenia Severe congenital neutropenia
14 genes
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14 of 14 corroborated by 2+ sources
CLPB(5), CSF3R(6), VPS45(6), GFI1(6), ELANE(6), SRP19(2), SRP54(5), TCIRG1(3), SEC61A1(3), G6PC3(7), JAGN1(6), HAX1(3) +2 more
0.538 0.824 4.52e-40 1.89e-38 ✓ sig. Cluster 197 →
Lung neoplasms Prostatic neoplasms
71 genes
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HNF1B(1), PTEN(1), CHEK2(1), TERT(1), TP53(1), ACE(1), BRAF(1), CDH13(1), EGFR(1), ERBB3(1), ROBO1(1), MPO(1) +59 more
0.088 0.280 5.91e-40 2.47e-38 ✓ sig. Cluster 21 →
Generalized epilepsy Partial epilepsy
21 genes
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1 of 21 corroborated by 2+ sources
CUX2(1), GABRA2(1), GRM3(1), OGA(1), PCDH7(1), RPH3A(1), TRIM36(1), ALDH2(1), VRK2(1), GBF1(1), SCN1A(3), TNKS(1) +9 more
0.236 0.477 6.88e-40 2.87e-38 ✓ sig. —
Neurotic disorder Post-traumatic stress disorder
56 genes
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SOX5(1), KANSL1(1), ARHGAP15(1), CACNA1E(1), CSMD1(1), CTTNBP2(1), DCC(1), FOXP2(1), GABBR1(1), GRM8(1), LINC02210-CRHR1(1), LINGO1(1) +44 more
0.096 0.276 6.95e-40 2.90e-38 ✓ sig. Cluster 2 →

Showing 25 of 20825 pairs, sorted by significance (ascending). Click a column header to sort.