Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 39

16 diseases · 30 shared-gene connections
16 Diseases
567 Unique genes
0.116 Avg. similarity score
Autoimmune thyroid disease Most-connected disease (9 links)
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Disease Searched: Hashimoto disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Autoimmune thyroid disease 9 9 144
Common variable immunodeficiency 7 7 75
Graves disease 6 6 99
Thyroid disease 6 6 53
Vitiligo 5 5 126
Autoimmune disease 4 4 202
Celiac disease 4 4 193
Hyperthyroidism 4 4 53
isolated sulfite oxidase deficiency 4 4 1
Hashimoto disease 3 3 27
Charcot-Marie-Tooth disease, demyelinating, type 1J 2 2 1
Primary angle-closure glaucoma 2 2 1
Autoinflammation with pulmonary and cutaneous vasculitis 1 1 1
immunodeficiency, common variable, 4 1 1 1
immunodeficiency, common variable, 6 1 1 1
immunodeficiency, common variable, 7 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
ICOS 9 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 5 more
IL2RA 9 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 5 more
BACH2 8 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Graves disease and 4 more
CTLA4 8 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Graves disease and 4 more
HLA-DQB1 8 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 4 more
LPP 8 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Graves disease and 4 more
HLA-DQA1 7 / 16 Autoimmune thyroid disease, Celiac disease, Graves disease, Hashimoto disease and 3 more
PHTF1 7 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more
PTPN22 7 / 16 Autoimmune disease, Autoimmune thyroid disease, Graves disease, Hashimoto disease and 3 more
RSBN1 7 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 3 more
STAT4 7 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Graves disease and 3 more
TG 7 / 16 Autoimmune disease, Autoimmune thyroid disease, Graves disease, Hashimoto disease and 3 more
FAM76B 6 / 16 Autoimmune disease, Autoimmune thyroid disease, Graves disease, Hashimoto disease and 2 more
HLA-DRB1 6 / 16 Autoimmune thyroid disease, Celiac disease, Graves disease, Hashimoto disease and 2 more
RNASET2 6 / 16 Autoimmune disease, Autoimmune thyroid disease, Graves disease, Hyperthyroidism and 2 more
SH2B3 6 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Hashimoto disease and 2 more
SUOX 6 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 2 more
VAV3 6 / 16 Autoimmune disease, Autoimmune thyroid disease, Graves disease, Hashimoto disease and 2 more
ARID5B 5 / 16 Autoimmune disease, Autoimmune thyroid disease, Graves disease, Thyroid disease and 1 more
ATXN2 5 / 16 Autoimmune thyroid disease, Celiac disease, Hashimoto disease, Thyroid disease and 1 more
C1QTNF6 5 / 16 Autoimmune disease, Autoimmune thyroid disease, Graves disease, Thyroid disease and 1 more
IL10 5 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
IL23R 5 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
MMEL1 5 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Graves disease and 1 more
ZMIZ1 5 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency and 1 more
ADCY7 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
ADGRL2 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
ANKRD55 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
ATG16L1 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
ATXN2L 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
BTNL2 4 / 16 Autoimmune thyroid disease, Celiac disease, Graves disease, Vitiligo
C1ORF141 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
CARD9 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
CRB1 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
CYTL1 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
DAG1 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
DCTD 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
ERAP2 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
FNBP1 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
FUT2 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
GPR35 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
GSDMB 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
IFNG 4 / 16 Autoimmune disease, Celiac disease, Graves disease, Vitiligo
IGF2 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
IL18RAP 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
IL6 4 / 16 Autoimmune disease, Celiac disease, Graves disease, Hashimoto disease
INS-IGF2 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
IRF1 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
IRF4 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Vitiligo
ITPR3 4 / 16 Celiac disease, Charcot-Marie-Tooth disease, demyelinating, type 1J, Graves disease, Vitiligo
JAK2 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
KEAP1 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
LRRK2 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
LURAP1L 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
NKD1 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
NKX2-3 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
NPIPB6 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
PDE4A 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
PDE8B 4 / 16 Autoimmune thyroid disease, Hashimoto disease, Hyperthyroidism, Thyroid disease
PSMB9 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Vitiligo
PTPN2 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Vitiligo
RHOH 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Graves disease, Vitiligo
SBK1 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
SLC25A28 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
SLC9A4 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
SMAD3 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
SPATA13 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Primary angle-closure glaucoma, Thyroid disease
STMN3 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
TENM3 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
TNFSF15 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
TPO 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Graves disease, Thyroid disease
TSBP1 4 / 16 Autoimmune disease, Celiac disease, Graves disease, Hyperthyroidism
TTC33 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
UBASH3A 4 / 16 Autoimmune disease, Celiac disease, Graves disease, Vitiligo
ZPBP2 4 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease, Common variable immunodeficiency
CCR6 3 / 16 Graves disease, Thyroid disease, Vitiligo
CD40LG 3 / 16 Autoimmune disease, Common variable immunodeficiency, Graves disease
CD69 3 / 16 Autoimmune thyroid disease, Hashimoto disease, Thyroid disease
CLNK 3 / 16 Autoimmune thyroid disease, Thyroid disease, Vitiligo
ELMO1 3 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease
FASLG 3 / 16 Autoimmune disease, Celiac disease, Vitiligo
HLA-B 3 / 16 Autoimmune disease, Celiac disease, Graves disease
HLA-DPA1 3 / 16 Autoimmune disease, Celiac disease, Graves disease
HLA-DRA 3 / 16 Autoimmune thyroid disease, Celiac disease, Hyperthyroidism
IFIH1 3 / 16 Autoimmune thyroid disease, Graves disease, Vitiligo
MBL2 3 / 16 Autoimmune thyroid disease, Common variable immunodeficiency, Vitiligo
NEK6 3 / 16 Autoimmune disease, Thyroid disease, Vitiligo
NFIA 3 / 16 Celiac disease, Hyperthyroidism, Thyroid disease
PDE10A 3 / 16 Autoimmune thyroid disease, Hyperthyroidism, Thyroid disease
PRICKLE1 3 / 16 Autoimmune thyroid disease, Graves disease, Hashimoto disease
PRSS36 3 / 16 Autoimmune thyroid disease, Graves disease, Hashimoto disease
RAB5C 3 / 16 Autoimmune disease, Autoimmune thyroid disease, Vitiligo
RASGRP1 3 / 16 Autoimmune disease, Autoimmune thyroid disease, Hyperthyroidism
SAMD5 3 / 16 Autoimmune disease, Autoimmune thyroid disease, Thyroid disease
SASH1 3 / 16 Autoimmune disease, Autoimmune thyroid disease, Thyroid disease
SLC25A27 3 / 16 Autoimmune thyroid disease, Graves disease, Hashimoto disease
SOD2 3 / 16 Autoimmune disease, Hyperthyroidism, Vitiligo
TNF 3 / 16 Graves disease, Hyperthyroidism, Vitiligo
TNFRSF14 3 / 16 Autoimmune disease, Autoimmune thyroid disease, Celiac disease
TSHR 3 / 16 Autoimmune thyroid disease, Graves disease, Hyperthyroidism
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Inflammatory bowel disease
GATA3, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL10, IL18RAP, IL23R, SMAD3, STAT4, STAT3, IFNG
 KEGG 38 / 66 12.2× 1.22e-33 4.11e-30 ✓ sig.
Allograft rejection
CD28, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL10, CD40LG, FAS, IFNG, IL4
 KEGG 28 / 39 15.2× 4.02e-29 1.02e-25 ✓ sig.
Autoimmune thyroid disease
CD28, CTLA4, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL10, TG, TPO, CD40LG
 KEGG 31 / 54 12.2× 1.39e-27 2.97e-24 ✓ sig.
Intestinal immune network for IgA production
CD28, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, ICOS, IL10, AICDA, CD40LG, IL4, IL6, CD86
 KEGG 30 / 50 12.7× 1.53e-27 3.22e-24 ✓ sig.
Th17 cell differentiation
GATA3, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL23R, IL2RA, IRF4, JAK1, JAK2, SMAD3, TYK2
 KEGG 40 / 109 7.8× 1.19e-25 2.11e-22 ✓ sig.
Type I diabetes mellitus
CD28, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, FAS, IFNG, CD86, HLA-DQA1, HLA-DRA
 KEGG 27 / 44 13.0× 2.80e-25 4.72e-22 ✓ sig.
Graft-versus-host disease
CD28, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, FAS, IFNG, IL6, CD86, HLA-DQA1
 KEGG 27 / 45 12.7× 6.70e-25 1.09e-21 ✓ sig.
Rheumatoid arthritis
CD28, CTLA4, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IFNG, IL17A, IL6, TGFB2, CD86, HLA-DQA1
 KEGG 35 / 95 7.8× 1.19e-22 1.42e-19 ✓ sig.
Cytokine-cytokine receptor interaction
CCL21, CXCR5, FASLG, IL10, IL18RAP, IL23R, IL2RA, TNFRSF11B, TNFRSF14, TNFSF15, CD40LG, CXCR3
 KEGG 59 / 298 4.2× 1.46e-21 1.37e-18 ✓ sig.
Th1 and Th2 cell differentiation
GATA3, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL2RA, JAK1, JAK2, STAT4, TYK2, ZAP70, IFNG
 KEGG 31 / 93 7.1× 1.01e-18 6.32e-16 ✓ sig.
Herpes simplex virus 1 infection
CARD9, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, ITGB3, JAK1, JAK2, TAP1, TICAM1
 KEGG 42 / 182 4.9× 3.43e-18 2.00e-15 ✓ sig.
Asthma
HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL10, CD40LG, IL4, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DPB1
 KEGG 19 / 32 12.6× 9.35e-18 4.88e-15 ✓ sig.
Hematopoietic cell lineage
FLT3, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL2RA, ITGB3, IL4, IL6, HLA-DQA1, IL7R, HLA-DRA
 KEGG 31 / 100 6.6× 1.10e-17 5.66e-15 ✓ sig.
Toxoplasmosis
HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL10, JAK1, JAK2, SOCS1, TYK2, STAT3, CD40LG, IFNG
 KEGG 32 / 112 6.1× 4.79e-17 2.20e-14 ✓ sig.
Leishmaniasis
HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL10, JAK1, JAK2, IFNG, IL4, TGFB2, HLA-DQA1, HLA-DRA
 KEGG 27 / 78 7.3× 6.03e-17 2.73e-14 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
CBLB, CCL21, CD28, CTLA4, CTSH, CXCR5, FASLG, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1
 GO:0006955 95 / 543 5.8× 1.80e-45 2.66e-41 ✓ sig.
immune system process
CAMK4, CARD9, CD28, CTLA4, ERAP2, GATA3, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL18RAP
 GO:0002376 102 / 943 3.6× 4.71e-30 2.38e-26 ✓ sig.
inflammatory response
CAMK4, CCL21, GATA3, IL18RAP, IL23R, IL2RA, IRF5, MACIR, TICAM1, TNFAIP3, TNIP1, STAT3
 GO:0006954 60 / 467 4.2× 1.72e-21 3.34e-18 ✓ sig.
positive regulation of T cell proliferation
CCDC88B, CD28, HLA-DMB, HLA-DPA1, IL23R, IL2RA, JAK2, TYK2, CD274, CD40LG, IL4, IL6
 GO:0042102 23 / 67 11.3× 1.20e-18 1.51e-15 ✓ sig.
peptide antigen assembly with MHC class II protein complex
HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, B2M, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DPB1, HLA-DQB2, HLA-DRB3
 GO:0002503 13 / 16 26.8× 8.32e-18 9.39e-15 ✓ sig.
positive regulation of T cell activation
CCDC88B, CD28, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, B2M, HLA-DQA1, HLA-DRA, HLA-DRB1, CCR2, HLA-DOB
 GO:0050870 19 / 45 13.9× 1.25e-17 1.40e-14 ✓ sig.
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DPB1, HLA-DQB2, HLA-DRB3, HLA-DRB5
 GO:0002504 12 / 15 26.4× 2.27e-16 2.05e-13 ✓ sig.
positive regulation of canonical NF-kappaB signal transduction
CARD9, CCL21, FASLG, LURAP1L, NEK6, TICAM1, TNFSF15, ADIPOQ, STAT3, CD40LG, TNFRSF1A, CX3CR1
 GO:0043123 36 / 232 5.1× 6.60e-16 5.41e-13 ✓ sig.
positive regulation of tumor necrosis factor production
CARD9, JAK2, LRRK2, TICAM1, STAT3, FCGR2B, IFNG, IL17A, IL6, PF4, IFIH1, TLR3
 GO:0032760 25 / 113 7.3× 4.28e-15 3.03e-12 ✓ sig.
cellular response to lipopolysaccharide
IL10, JAK2, TICAM1, TNFAIP3, TNIP1, CD274, AICDA, B2M, IL6, PF4, CD86, CX3CR1
 GO:0071222 31 / 187 5.5× 1.11e-14 7.28e-12 ✓ sig.
antigen processing and presentation
CTSH, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, RAB5B, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DPB1
 GO:0019882 17 / 48 11.7× 2.19e-14 1.36e-11 ✓ sig.
cytokine-mediated signaling pathway
FLT3, IL23R, IRF5, JAK1, JAK2, SOCS1, SOCS4, STAT4, TYK2, STAT3, HCK, IL6
 GO:0019221 27 / 145 6.1× 3.14e-14 1.90e-11 ✓ sig.
cell surface receptor signaling pathway
ADGRL2, CBLB, CD28, FLT3, IL2RA, LRRK2, TICAM1, TNFRSF14, TNFSF15, CD274, CD40LG, CXCR3
 GO:0007166 43 / 373 3.8× 5.40e-14 3.11e-11 ✓ sig.
adaptive immune response
CAMK4, CARD9, CTLA4, CTSH, ERAP2, HLA-B, HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, IL18RAP, JAK2
 GO:0002250 51 / 507 3.3× 5.47e-14 3.14e-11 ✓ sig.
antigen processing and presentation of exogenous peptide antigen via MHC class II
HLA-DMB, HLA-DOA, HLA-DPA1, HLA-DQB1, B2M, FCGR2B, HLA-DQA1, HLA-DRA, HLA-DRB1, HLA-DOB, HLA-DPB1, HLA-DQB2
 GO:0019886 14 / 31 14.9× 7.89e-14 4.40e-11 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Autoimmune disease Autoimmune thyroid disease 0.335 87 2.91e-133 4.69e-131 ✓ sig.
Autoimmune disease Celiac disease 0.249 79 6.05e-102 7.11e-100 ✓ sig.
Autoimmune thyroid disease Celiac disease 0.229 63 4.55e-84 3.82e-82 ✓ sig.
Autoimmune thyroid disease Common variable immunodeficiency 0.272 47 2.53e-79 1.98e-77 ✓ sig.
Autoimmune disease Common variable immunodeficiency 0.209 48 1.57e-73 1.17e-71 ✓ sig.
Celiac disease Common variable immunodeficiency 0.212 47 2.34e-72 1.72e-70 ✓ sig.
Autoimmune thyroid disease Thyroid disease 0.172 29 4.67e-46 2.25e-44 ✓ sig.
Graves disease Hashimoto disease 0.187 20 1.61e-39 6.65e-38 ✓ sig.
Autoimmune thyroid disease Vitiligo 0.139 33 2.60e-39 1.06e-37 ✓ sig.
Hyperthyroidism Thyroid disease 0.216 19 4.45e-35 1.61e-33 ✓ sig.
Autoimmune thyroid disease Graves disease 0.124 27 1.02e-32 3.41e-31 ✓ sig.
Hashimoto disease Thyroid disease 0.227 15 2.15e-31 6.86e-30 ✓ sig.
Graves disease Thyroid disease 0.150 20 3.24e-31 1.03e-29 ✓ sig.
Graves disease Vitiligo 0.124 25 6.00e-31 1.88e-29 ✓ sig.
Thyroid disease Vitiligo 0.132 21 6.63e-31 2.07e-29 ✓ sig.
Autoimmune thyroid disease Hyperthyroidism 0.112 20 1.04e-27 2.92e-26 ✓ sig.
Graves disease Hyperthyroidism 0.125 17 3.47e-25 8.56e-24 ✓ sig.
Hashimoto disease Hyperthyroidism 0.157 11 3.32e-21 6.65e-20 ✓ sig.
Primary angle-closure glaucoma Thyroid disease 0.019 1 3.44e-3 4.45e-3 ✓ sig.
Common variable immunodeficiency immunodeficiency, common variable, 4 0.013 1 4.87e-3 5.99e-3 ✓ sig.
Common variable immunodeficiency immunodeficiency, common variable, 6 0.013 1 4.87e-3 5.99e-3 ✓ sig.
Common variable immunodeficiency immunodeficiency, common variable, 7 0.013 1 4.87e-3 5.99e-3 ✓ sig.
Common variable immunodeficiency isolated sulfite oxidase deficiency 0.013 1 4.87e-3 5.99e-3 ✓ sig.
Charcot-Marie-Tooth disease, demyelinating, type 1J Graves disease 0.010 1 6.43e-3 7.68e-3 ✓ sig.
isolated sulfite oxidase deficiency Vitiligo 0.008 1 8.18e-3 9.49e-3 ✓ sig.
Charcot-Marie-Tooth disease, demyelinating, type 1J Vitiligo 0.008 1 8.18e-3 9.49e-3 ✓ sig.
Autoimmune thyroid disease isolated sulfite oxidase deficiency 0.007 1 9.35e-3 1.07e-2 ✓ sig.
Autoimmune thyroid disease Primary angle-closure glaucoma 0.007 1 9.35e-3 1.07e-2 ✓ sig.
Celiac disease isolated sulfite oxidase deficiency 0.005 1 1.25e-2 1.40e-2 ✓ sig.
Autoimmune disease Autoinflammation with pulmonary and cutaneous vasculitis 0.005 1 1.31e-2 1.46e-2 ✓ sig.