Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 75

12 diseases · 29 shared-gene connections
12 Diseases
1,919 Unique genes
0.200 Avg. similarity score
Crohn disease Most-connected disease (9 links)
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Disease Searched: Ankylosing spondylitis Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Crohn disease 9 9 690
Inflammatory bowel disease 8 8 690
Ulcerative colitis 8 8 611
Ankylosing spondylitis 6 6 313
Psoriasis 6 6 731
Sclerosing cholangitis 6 6 230
Iga nephropathy 4 4 203
Benign flecked retina 3 3 1
Multiple sclerosis 3 3 576
neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 3 3 1
Autoinflammatory disease, systemic, with vasculitis 1 1 1
Ehrlich tumor carcinoma 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
ANKRD55 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
CD28 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
ETS1 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
HLA-B 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
HLA-DQA1 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
HLA-DQB1 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
HLA-DRB1 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
IKZF1 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
TAGAP 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
TTC33 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
ZMIZ1 8 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 4 more
ADCY3 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
ATXN2 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
BACH2 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
CARD9 7 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 3 more
CCDC88B 7 / 12 Crohn disease, Iga nephropathy, Inflammatory bowel disease, Multiple sclerosis and 3 more
CCL2 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
CCL20 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
CD226 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
CD40 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
CD6 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
CEP43 7 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 3 more
CXCR2 7 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 3 more
DNMT3A 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
FCGR2A 7 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 3 more
FUT2 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
IFNGR2 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
IL10 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
IL23R 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
IL2RA 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
INAVA 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
IRF1 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
IRF5 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
JAK2 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
JAZF1 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
KEAP1 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
LITAF 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
LTBR 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
NDFIP1 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
NFKB1 7 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Multiple sclerosis and 3 more
NOD2 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
OSMR 7 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 3 more
PLAU 7 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Inflammatory bowel disease and 3 more
PTPRK 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
PUS10 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
RMI2 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
RUNX3 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
SH2B3 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
SKAP2 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
SP140 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
SPMIP7 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
STAT3 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
THEMIS 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
TNFRSF14 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
TNFRSF1A 7 / 12 Ankylosing spondylitis, Crohn disease, Iga nephropathy, Multiple sclerosis and 3 more
TYK2 7 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Multiple sclerosis and 3 more
AQP12B 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
ASAP2 6 / 12 Ankylosing spondylitis, Crohn disease, Multiple sclerosis, Psoriasis and 2 more
ASCL2 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
ATG16L1 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
ATG5 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
BANK1 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
BSN 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
C17ORF67 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
C1ORF141 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
CCR6 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
CD244 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
CDKAL1 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
CFB 6 / 12 Crohn disease, Iga nephropathy, Inflammatory bowel disease, Psoriasis and 2 more
CLEC16A 6 / 12 Ankylosing spondylitis, Crohn disease, Multiple sclerosis, Psoriasis and 2 more
COMMD7 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
CORO1A 6 / 12 Ankylosing spondylitis, Crohn disease, Multiple sclerosis, Psoriasis and 2 more
CPEB4 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
CREM 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
CTLA4 6 / 12 Ankylosing spondylitis, Crohn disease, Multiple sclerosis, Psoriasis and 2 more
CXCR1 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
DAP 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
DENND1B 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
DLD 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
DNMT3B 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
EMSY 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
ERAP2 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
ERN1 6 / 12 Ankylosing spondylitis, Crohn disease, Multiple sclerosis, Psoriasis and 2 more
FAP 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
FAS 6 / 12 Ankylosing spondylitis, Crohn disease, Multiple sclerosis, Psoriasis and 2 more
FIBP 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
FNDC3A 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
GAL3ST2 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
GATD3 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
GCKR 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
GLYAT 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
GNA12 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
GPR35 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
HDAC7 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
HHEX 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
HIF3A 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
HLA-DQB3 6 / 12 Crohn disease, Iga nephropathy, Inflammatory bowel disease, Multiple sclerosis and 2 more
HLA-DRA 6 / 12 Iga nephropathy, Inflammatory bowel disease, Multiple sclerosis, Psoriasis and 2 more
HSPA6 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
IFIH1 6 / 12 Ankylosing spondylitis, Crohn disease, Inflammatory bowel disease, Psoriasis and 2 more
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Inflammatory bowel disease
HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IL12RB2, IL17A, IL18R1, IL18RAP, IL2, IL21
 KEGG 48 / 66 4.6× 1.23e-24 1.81e-21 ✓ sig.
Allograft rejection
CD28, CD40, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL12B, IL2, CD40LG, IFNG
 KEGG 35 / 39 5.6× 4.33e-24 6.16e-21 ✓ sig.
Th17 cell differentiation
AHR, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL17A, IL1R1, IL2, IL21, IL23R, IL27, IL2RA
 KEGG 58 / 109 3.3× 2.53e-19 1.66e-16 ✓ sig.
Type I diabetes mellitus
CD28, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL12B, IL2, IFNG, IL1B, TNF, HLA-DOB
 KEGG 34 / 44 4.8× 3.07e-19 1.99e-16 ✓ sig.
Leishmaniasis
FCGR2A, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IRAK1, JAK2, MAPK3, NFKB1, NOS2
 KEGG 46 / 78 3.7× 5.57e-18 3.02e-15 ✓ sig.
Graft-versus-host disease
CD28, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL2, IL6, IFNG, IL1B, TNF, HLA-DOB
 KEGG 33 / 45 4.6× 1.62e-17 8.11e-15 ✓ sig.
Th1 and Th2 cell differentiation
HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL12B, IL12RB2, IL2, IL2RA, JAK2, MAPK3, NFATC1, NFKB1
 KEGG 50 / 93 3.4× 4.31e-17 1.95e-14 ✓ sig.
Cytokine-cytokine receptor interaction
CCL2, CCL20, CCL21, CCR6, CD40, CSF2RB, CXCR1, CXCR2, FAS, IFNGR2, IFNLR1, IL10
 KEGG 105 / 298 2.2× 1.47e-16 5.97e-14 ✓ sig.
Tuberculosis
CARD9, CORO1A, FCGR2A, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IL6, IRAK1, JAK2
 KEGG 75 / 181 2.6× 1.59e-16 6.36e-14 ✓ sig.
Intestinal immune network for IgA production
CD28, CD40, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL15RA, IL2, IL6, LTBR, AICDA, CD40LG
 KEGG 34 / 50 4.3× 2.25e-16 8.80e-14 ✓ sig.
Toxoplasmosis
CD40, HLA-DQA1, HLA-DQB1, HLA-DRB1, HSPA6, IFNGR2, IL10, IL12B, IRAK1, IRGM, JAK2, MAPK3
 KEGG 53 / 112 3.0× 6.07e-15 1.81e-12 ✓ sig.
Autoimmune thyroid disease
CD28, CD40, CTLA4, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL2, CD40LG, IL4
 KEGG 34 / 54 3.9× 7.58e-15 2.22e-12 ✓ sig.
Herpes simplex virus 1 infection
CARD9, CCL2, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFIH1, IFNGR2, IL12B, IL6, IRAK1
 KEGG 72 / 182 2.5× 1.16e-14 3.25e-12 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
CCL2, IL10, IL12B, IL17A, IL23R, IL6, IL6R, JAK2, NOS2, RORC, STAT3, TNFRSF1B
 Reactome 50 / 108 2.9× 1.05e-13 2.44e-11 ✓ sig.
Interleukin-10 signaling
CCL2, CCL20, IL10, IL12B, IL1R1, IL1R2, IL6, STAT3, TNFRSF1A, TNFRSF1B, TYK2, TIMP1
 Reactome 30 / 47 4.0× 1.74e-13 3.90e-11 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
CCL2, CCL20, CCL21, CCR6, CD244, CD28, CTLA4, CXCR1, CXCR2, ETS1, FAS, HLA-B
 GO:0006955 164 / 543 2.9× 4.76e-39 4.41e-35 ✓ sig.
inflammatory response
CCL2, CCL20, CCL21, CD40, CXCR2, IL17A, IL18R1, IL18RAP, IL1R1, IL23R, IL27, IL2RA
 GO:0006954 136 / 467 2.8× 1.19e-30 7.02e-27 ✓ sig.
response to lipopolysaccharide
CD6, CSF2RB, CYP1A1, IL10, IL12RB2, IL23R, IRAK1, LITAF, MAPK3, NOS2, NOTCH1, PTPN22
 GO:0032496 61 / 161 3.7× 1.10e-20 1.95e-17 ✓ sig.
cellular response to lipopolysaccharide
CCL2, CD40, IL10, IL12B, IL6, IRAK1, IRGM, JAK2, LITAF, NFKB1, NOD2, NOS2
 GO:0071222 62 / 187 3.2× 1.25e-17 1.37e-14 ✓ sig.
cytokine-mediated signaling pathway
CCL2, CSF2RB, IFNGR2, IFNLR1, IL12RB2, IL1R1, IL1R2, IL23R, IL6, IL6R, IL7R, IRAK1
 GO:0019221 53 / 145 3.6× 2.36e-17 2.45e-14 ✓ sig.
positive regulation of transcription by RNA polymerase II
ACTR2, AHR, ASCL2, CD28, CD40, CREM, CYTL1, EOMES, ETS1, GRHL3, HHEX, IGF2
 GO:0045944 213 / 1,208 1.7× 5.17e-16 4.35e-13 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
CCL2, CD40, CSF2RB, IL12B, IL15RA, IL23R, IL6, IL6R, JAK2, STAT3, TNFRSF1A, TYK2
 GO:0007259 33 / 67 4.8× 7.98e-16 6.35e-13 ✓ sig.
positive regulation of type II interferon production
CD226, CD244, IL12B, IL12RB2, IL18R1, IL1R1, IL2, IL21, IL23R, IL27, JAK2, PTPN22
 GO:0032729 35 / 77 4.4× 2.50e-15 1.82e-12 ✓ sig.
peptide antigen assembly with MHC class II protein complex
HLA-DQA1, HLA-DQB1, HLA-DRB1, B2M, HLA-DOB, HLA-DQB2, HLA-DPA1, HLA-DRA, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DQA2
 GO:0002503 15 / 16 9.1× 2.05e-14 1.28e-11 ✓ sig.
positive regulation of T cell proliferation
CD28, CD6, CORO1A, IL12B, IL2, IL21, IL23R, IL2RA, IL6, JAK2, NR5A2, TYK2
 GO:0042102 31 / 67 4.5× 5.34e-14 3.12e-11 ✓ sig.
positive regulation of T cell activation
CCL2, CD28, CORO1A, HLA-DQA1, HLA-DQB1, HLA-DRB1, NR5A2, PRKCQ, B2M, CCDC88B, CD3E, HLA-DOB
 GO:0050870 25 / 45 5.4× 6.88e-14 3.91e-11 ✓ sig.
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DOB, HLA-DQB2, HLA-DPA1, HLA-DRA, HLA-DMA, HLA-DMB, HLA-DOA, HLA-DQA2, HLA-DRB5
 GO:0002504 14 / 15 9.1× 1.89e-13 9.82e-11 ✓ sig.
positive regulation of canonical NF-kappaB signal transduction
CARD9, CCL21, CD40, HLA-DRB1, IL1R1, INAVA, IRAK1, LITAF, LTBR, LURAP1L, NDFIP1, NOD2
 GO:0043123 63 / 232 2.6× 2.66e-13 1.35e-10 ✓ sig.
antigen processing and presentation
HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DOB, HLA-DQB2, HFE, HLA-DPA1, HLA-DRA, PSMB8, HLA-C, HLA-DMA
 GO:0019882 25 / 48 5.1× 4.94e-13 2.37e-10 ✓ sig.
B cell differentiation
HHEX, IL10, NKX2-3, PTPN2, AICDA, CD40LG, IL4, BCL6, VCAM1, FOSL2, IKZF3, ITGA4
 GO:0030183 32 / 80 3.9× 2.88e-12 1.19e-9 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Crohn disease Inflammatory bowel disease 0.638 538 < 1e-300 < 1e-300 ✓ sig.
Crohn disease Ulcerative colitis 0.615 496 < 1e-300 < 1e-300 ✓ sig.
Inflammatory bowel disease Ulcerative colitis 0.534 453 < 1e-300 < 1e-300 ✓ sig.
Ankylosing spondylitis Sclerosing cholangitis 0.559 195 2.96e-323 4.41e-320 ✓ sig.
Ankylosing spondylitis Ulcerative colitis 0.327 228 1.73e-263 1.50e-260 ✓ sig.
Psoriasis Sclerosing cholangitis 0.272 206 1.03e-254 7.92e-252 ✓ sig.
Sclerosing cholangitis Ulcerative colitis 0.307 198 1.60e-254 1.19e-251 ✓ sig.
Ankylosing spondylitis Psoriasis 0.285 232 1.06e-249 7.64e-247 ✓ sig.
Ankylosing spondylitis Crohn disease 0.294 228 7.26e-249 5.04e-246 ✓ sig.
Crohn disease Sclerosing cholangitis 0.277 200 1.10e-246 7.14e-244 ✓ sig.
Crohn disease Psoriasis 0.255 289 7.25e-214 3.28e-211 ✓ sig.
Psoriasis Ulcerative colitis 0.253 271 2.80e-207 1.12e-204 ✓ sig.
Inflammatory bowel disease Sclerosing cholangitis 0.207 158 3.30e-162 7.09e-160 ✓ sig.
Inflammatory bowel disease Psoriasis 0.211 248 7.22e-161 1.47e-158 ✓ sig.
Ankylosing spondylitis Inflammatory bowel disease 0.205 171 8.80e-151 1.62e-148 ✓ sig.
Crohn disease Multiple sclerosis 0.124 140 1.59e-65 1.07e-63 ✓ sig.
Multiple sclerosis Ulcerative colitis 0.125 132 4.72e-65 3.16e-63 ✓ sig.
Inflammatory bowel disease Multiple sclerosis 0.119 135 5.64e-61 3.49e-59 ✓ sig.
Iga nephropathy Ulcerative colitis 0.058 45 1.51e-21 3.07e-20 ✓ sig.
Iga nephropathy Sclerosing cholangitis 0.056 23 3.98e-14 5.31e-13 ✓ sig.
Ankylosing spondylitis Iga nephropathy 0.053 26 6.60e-14 8.67e-13 ✓ sig.
Autoinflammatory disease, systemic, with vasculitis Iga nephropathy 0.005 1 1.32e-2 1.47e-2 ✓ sig.
neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties Ulcerative colitis 0.002 1 3.97e-2 4.15e-2 ✓ sig.
Crohn disease neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Inflammatory bowel disease neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Crohn disease Ehrlich tumor carcinoma 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Benign flecked retina Crohn disease 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Benign flecked retina Inflammatory bowel disease 0.001 1 4.48e-2 4.66e-2 ✓ sig.
Benign flecked retina Psoriasis 0.001 1 4.75e-2 4.92e-2 ✓ sig.