Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Basal cell carcinoma Skin cancer
62 genes
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8 of 62 corroborated by 2+ sources
TERT(2), TP53(3), TPCN2(1), ATP8B4(1), BNC2(2), CUX1(1), EMSY(1), FADS2(1), FAM76B(1), FOXP1(1), HERC2(1), HLA-DQA1(1) +50 more
0.178 0.747 7.59e-88 6.64e-86 ✓ sig. Cluster 29 →
Diabetic angiopathies Diabetic peripheral angiopathy
28 genes
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16 of 28 corroborated by 2+ sources
ASS1(2), ADCY8(2), GCH1(1), HLA-DRB1(1), SERPINE1(1), SERPINF1(2), VEGFA(1), NOS3(2), AGER(2), CASP3(2), EPO(1), HMOX1(2) +16 more
0.966 1.000 1.76e-88 1.55e-86 ✓ sig. Cluster 368 →
Hypopituitarism Panhypopituitarism
35 genes
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1 of 35 corroborated by 2+ sources
FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(1), CHD7(1), FGFR1(1), WDR11(1), SEMA3E(1) +23 more
0.636 0.814 5.67e-89 5.00e-87 ✓ sig. Cluster 54 →
Hypopituitarism Kallmann syndrome
34 genes
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21 of 34 corroborated by 2+ sources
FGF8(3), DUSP6(3), IL17RD(3), PROK2(4), TACR3(2), PROKR2(3), TCF12(2), GH1(1), CHD7(4), FGFR1(4), WDR11(3), SEMA3E(2) +22 more
0.667 0.895 3.71e-89 3.28e-87 ✓ sig. Cluster 54 →
Chronic obstructive pulmonary disease Obstructive airway disease
40 genes
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39 of 40 corroborated by 2+ sources
TP53(2), SERPINA1(2), CYP1A2(2), TRPV4(2), NOS3(2), HMOX1(2), ICAM1(2), TLR4(1), TNF(2), IL6(2), EPHX1(2), DSP(2) +28 more
0.388 0.952 3.20e-89 2.84e-87 ✓ sig. Cluster 119 →
Stevens-johnson syndrome Toxic epidermal necrolysis
37 genes
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3 of 37 corroborated by 2+ sources
LTBP3(1), HLA-C(2), IKZF1(3), SMC2(1), SPMIP7(1), UBE2K(1), UMAD1(1), ZBTB20(1), TAP2(1), POU5F1(1), ZNF423(1), HLA-B(3) +25 more
0.468 1.000 4.09e-90 3.66e-88 ✓ sig. —
Congenital cartilage disorder Osteochondrodysplasias
30 genes
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16 of 30 corroborated by 2+ sources
HSPG2(2), SLC26A2(1), COL2A1(2), BMPR1B(1), COL11A1(2), DYM(1), FLNB(1), TRPS1(1), TRPV4(2), VEGFA(2), BCL2(2), FLNA(2) +18 more
0.882 1.000 3.54e-90 3.17e-88 ✓ sig. Cluster 345 →
Keratinocyte carcinoma Skin cancer
46 genes
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TERT(1), TP53(1), BNC2(1), CUX1(1), FOXP1(1), HERC2(1), HLA-DQA1(1), HLA-DRB1(1), MYL10(1), RHOU(1), SMC2(1), TRPS1(1) +34 more
0.400 0.597 2.18e-90 1.96e-88 ✓ sig. Cluster 29 →
Hereditary hearing loss Isolated sensorineural deafness
44 genes
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44 of 44 corroborated by 2+ sources
ESRRB(2), EYA4(2), MYO15A(2), OTOF(2), PCDH15(2), TMC1(2), HGF(2), RDX(2), GSDME(2), GJB6(2), SLC26A4(2), COL11A2(2) +32 more
0.349 0.880 2.08e-90 1.88e-88 ✓ sig. Cluster 26 →
Panhypopituitarism Pituitary dwarfism
35 genes
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2 of 35 corroborated by 2+ sources
FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(2), CHD7(1), WDR11(1), SEMA3E(1), SPRY4(1) +23 more
0.673 0.814 6.18e-91 5.61e-89 ✓ sig. Cluster 54 →
Pituitary dwarfism Pituitary short stature
33 genes
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1 of 33 corroborated by 2+ sources
FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(2), CHD7(1), WDR11(1), SEMA3E(1), SPRY4(1) +21 more
0.733 0.971 3.81e-91 3.48e-89 ✓ sig. Cluster 54 →
Pituitary dwarfism Sheehan syndrome
33 genes
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1 of 33 corroborated by 2+ sources
FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(2), CHD7(1), WDR11(1), SEMA3E(1), SPRY4(1) +21 more
0.733 0.971 3.81e-91 3.48e-89 ✓ sig. Cluster 54 →
Growth hormone deficiency Pituitary dwarfism
33 genes
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1 of 33 corroborated by 2+ sources
FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(2), CHD7(1), WDR11(1), SEMA3E(1), SPRY4(1) +21 more
0.733 0.971 3.81e-91 3.48e-89 ✓ sig. Cluster 54 →
Deafness Hereditary hearing loss
47 genes
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47 of 47 corroborated by 2+ sources
ESRRB(4), EYA4(4), MYO15A(4), OTOF(4), PCDH15(4), TMC1(4), HGF(4), RDX(4), GSDME(4), DIAPH1(4), MYO1A(3), GJB6(5) +35 more
0.267 0.940 3.60e-91 3.33e-89 ✓ sig. Cluster 26 →
Basal cell carcinoma Non-melanoma skin carcinoma
81 genes
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11 of 81 corroborated by 2+ sources
ANKRD11(1), TP53(3), ASIP(2), ATP8B4(1), BNC2(2), CUX1(1), EPB41L1(1), FADS2(1), FARP1(2), FOXP1(1), GABBR1(1), GPX4(1) +69 more
0.195 0.479 7.31e-92 6.79e-90 ✓ sig. Cluster 29 →
Celiac disease Diabetes mellitus type 1
95 genes
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33 of 95 corroborated by 2+ sources
SH2B3(3), BLTP1(1), ACE(2), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), BTNL2(1), CTSH(3), DAG1(1), ETS1(3), FUT2(1) +83 more
0.165 0.492 1.56e-92 1.45e-90 ✓ sig. —
Hypogonadotropic hypogonadism Kallmann syndrome
35 genes
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30 of 35 corroborated by 2+ sources
FGF8(6), DUSP6(6), IL17RD(5), PROK2(8), TACR3(7), PROKR2(8), PNPLA6(1), TCF12(4), GH1(1), CHD7(6), FGFR1(6), WDR11(6) +23 more
0.686 0.921 1.30e-92 1.22e-90 ✓ sig. Cluster 54 →
Kidney disease Kidney failure
101 genes
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43 of 101 corroborated by 2+ sources
INS(2), A4GALT(1), CST3(3), GATM(3), COL4A3(1), COL4A4(1), ACE(2), AGT(2), CHRM3(1), CLU(2), COL6A3(2), CPS1(1) +89 more
0.175 0.402 6.97e-93 6.57e-91 ✓ sig. Cluster 139 →
Clear cell renal cell carcinoma Kidney cancer
43 genes
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TERT(1), CDKAL1(1), COL25A1(1), FANCD2(1), MAD1L1(1), SCARB1(1), TLN2(1), INSR(1), AKT1(1), AP3D1(1), MYEOV(1), SSPN(1) +31 more
0.457 0.782 4.35e-93 4.12e-91 ✓ sig. —
Amyotrophic lateral sclerosis Motor neuron disease
61 genes
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55 of 61 corroborated by 2+ sources
CST3(2), GFAP(2), ALS2(7), BCL2L1(2), CLU(2), LAT(2), LDLR(2), OPTN(7), SETX(6), TIAM1(3), CTSD(2), PON1(4) +49 more
0.178 0.859 2.75e-93 2.62e-91 ✓ sig. Cluster 15 →
Growth hormone deficiency Hypogonadotropic hypogonadism
34 genes
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30 of 34 corroborated by 2+ sources
FGF8(5), DUSP6(5), IL17RD(4), PROK2(6), TACR3(6), PROKR2(7), TCF12(4), GH1(1), CHD7(5), FGFR1(5), WDR11(5), SEMA3E(4) +22 more
0.708 1.000 1.82e-93 1.74e-91 ✓ sig. Cluster 54 →
Hypogonadotropic hypogonadism Pituitary short stature
34 genes
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30 of 34 corroborated by 2+ sources
FGF8(5), DUSP6(5), IL17RD(4), PROK2(6), TACR3(6), PROKR2(7), TCF12(4), GH1(1), CHD7(5), FGFR1(5), WDR11(5), SEMA3E(4) +22 more
0.708 1.000 1.82e-93 1.74e-91 ✓ sig. Cluster 54 →
Hypogonadotropic hypogonadism Sheehan syndrome
34 genes
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30 of 34 corroborated by 2+ sources
FGF8(5), DUSP6(5), IL17RD(4), PROK2(6), TACR3(6), PROKR2(7), TCF12(4), GH1(1), CHD7(5), FGFR1(5), WDR11(5), SEMA3E(4) +22 more
0.708 1.000 1.82e-93 1.74e-91 ✓ sig. Cluster 54 →
Alzheimer disease Gastroesophageal reflux disease
189 genes
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12 of 189 corroborated by 2+ sources
WT1(2), APP(6), ABAT(3), ABCG8(1), ABI3(2), ACE(2), ADAMTS18(1), ADARB1(1), ADGRB3(1), ADGRL2(1), AFF3(1), AKAP6(1) +177 more
0.082 0.677 1.57e-93 1.52e-91 ✓ sig. Cluster 2 →
Bipolar disorder Obsessive-compulsive disorder
140 genes
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30 of 140 corroborated by 2+ sources
SOX5(1), RERE(1), COMT(2), ATP2A2(1), AKAP6(1), BANK1(1), BRAF(1), C6orf118(1), C8orf90(1), CACNA2D3(1), CACNB2(2), COA8(1) +128 more
0.106 0.598 5.29e-94 5.14e-92 ✓ sig. —

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.