Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 49

16 diseases · 31 shared-gene connections
16 Diseases
2,413 Unique genes
0.102 Avg. similarity score
Inflammatory skin disease Most-connected disease (7 links)
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Disease Searched: Pure spastic paraplegia Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Inflammatory skin disease 7 7 76
Respiratory system disease 7 7 241
Eczema 6 6 366
Psoriasis 6 6 731
Asthma 6 4 1,069
Sclerosing cholangitis 5 5 232
Obstructive pulmonary disease 4 4 559
Ankylosing spondylitis 3 3 313
Dental caries 3 3 231
Psoriasis vulgaris 3 3 54
Intellectual developmental disorder neuropsychiatric 2 2 1
Macrocephaly, dysmorphic facies, and psychomotor retardation 2 2 1
Psoriatic arthritis 2 2 73
Pure spastic paraplegia 2 2 1
Keratoderma, palmoplantar, nagashima type 2 1 1
Neurodevelopmental disorder with congenital malformations 2 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
HLA-B 9 / 16 Ankylosing spondylitis, Asthma, Dental caries, Eczema and 5 more
HLA-DQA1 9 / 16 Ankylosing spondylitis, Asthma, Dental caries, Eczema and 5 more
RUNX3 9 / 16 Ankylosing spondylitis, Asthma, Eczema, Obstructive pulmonary disease and 5 more
TNFAIP3 9 / 16 Ankylosing spondylitis, Asthma, Eczema, Inflammatory skin disease and 5 more
EMSY 8 / 16 Ankylosing spondylitis, Asthma, Eczema, Inflammatory skin disease and 4 more
HLA-DQB1 8 / 16 Ankylosing spondylitis, Asthma, Dental caries, Eczema and 4 more
IL2RA 8 / 16 Ankylosing spondylitis, Asthma, Eczema, Obstructive pulmonary disease and 4 more
NOS2 8 / 16 Ankylosing spondylitis, Asthma, Eczema, Inflammatory skin disease and 4 more
TNIP1 8 / 16 Ankylosing spondylitis, Asthma, Eczema, Inflammatory skin disease and 4 more
BACH2 7 / 16 Ankylosing spondylitis, Asthma, Eczema, Obstructive pulmonary disease and 3 more
ETS1 7 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 3 more
FAP 7 / 16 Ankylosing spondylitis, Eczema, Inflammatory skin disease, Psoriasis and 3 more
IFIH1 7 / 16 Ankylosing spondylitis, Eczema, Inflammatory skin disease, Psoriasis and 3 more
IL18R1 7 / 16 Ankylosing spondylitis, Asthma, Eczema, Obstructive pulmonary disease and 3 more
IL23R 7 / 16 Ankylosing spondylitis, Eczema, Inflammatory skin disease, Psoriasis and 3 more
IRF1 7 / 16 Ankylosing spondylitis, Asthma, Obstructive pulmonary disease, Psoriasis and 3 more
PSMA6 7 / 16 Ankylosing spondylitis, Asthma, Eczema, Inflammatory skin disease and 3 more
SMAD3 7 / 16 Ankylosing spondylitis, Asthma, Eczema, Obstructive pulmonary disease and 3 more
UBAC2 7 / 16 Ankylosing spondylitis, Asthma, Eczema, Obstructive pulmonary disease and 3 more
CLEC16A 6 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 2 more
ERAP1 6 / 16 Ankylosing spondylitis, Eczema, Inflammatory skin disease, Psoriasis and 2 more
GRHL3 6 / 16 Ankylosing spondylitis, Eczema, Inflammatory skin disease, Psoriasis and 2 more
HDAC7 6 / 16 Ankylosing spondylitis, Asthma, Obstructive pulmonary disease, Psoriasis and 2 more
HLA-DRB1 6 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 2 more
IFNLR1 6 / 16 Ankylosing spondylitis, Eczema, Inflammatory skin disease, Psoriasis and 2 more
IKZF1 6 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 2 more
IL2 6 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 2 more
IL6R 6 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 2 more
KCNH7 6 / 16 Ankylosing spondylitis, Eczema, Inflammatory skin disease, Psoriasis and 2 more
LCE3A 6 / 16 Ankylosing spondylitis, Eczema, Inflammatory skin disease, Psoriasis and 2 more
LCE3B 6 / 16 Ankylosing spondylitis, Eczema, Inflammatory skin disease, Psoriasis and 2 more
MYRF 6 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 2 more
NDFIP1 6 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 2 more
PTPN2 6 / 16 Ankylosing spondylitis, Eczema, Inflammatory skin disease, Psoriasis and 2 more
RORC 6 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 2 more
STAT3 6 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 2 more
TMEM258 6 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 2 more
TSPAN14 6 / 16 Ankylosing spondylitis, Asthma, Obstructive pulmonary disease, Psoriasis and 2 more
ADAM19 5 / 16 Asthma, Eczema, Inflammatory skin disease, Obstructive pulmonary disease and 1 more
ASAP2 5 / 16 Ankylosing spondylitis, Asthma, Obstructive pulmonary disease, Psoriasis and 1 more
ATG5 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
CCL20 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
CORO1A 5 / 16 Ankylosing spondylitis, Dental caries, Obstructive pulmonary disease, Psoriasis and 1 more
CSMD1 5 / 16 Asthma, Eczema, Inflammatory skin disease, Obstructive pulmonary disease and 1 more
GSDMB 5 / 16 Ankylosing spondylitis, Asthma, Obstructive pulmonary disease, Psoriasis and 1 more
HLA-DOB 5 / 16 Asthma, Obstructive pulmonary disease, Psoriasis, Psoriatic arthritis and 1 more
HLA-DRB5 5 / 16 Asthma, Dental caries, Eczema, Obstructive pulmonary disease and 1 more
IL13 5 / 16 Asthma, Eczema, Psoriasis, Psoriasis vulgaris and 1 more
IL1R1 5 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 1 more
IL21 5 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 1 more
IL7R 5 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 1 more
ITGAL 5 / 16 Ankylosing spondylitis, Obstructive pulmonary disease, Psoriasis, Respiratory system disease and 1 more
JAK2 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
JAZF1 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
KIF3B 5 / 16 Ankylosing spondylitis, Asthma, Obstructive pulmonary disease, Psoriasis and 1 more
KPNA3 5 / 16 Eczema, Inflammatory skin disease, Obstructive pulmonary disease, Psoriasis and 1 more
LTBR 5 / 16 Ankylosing spondylitis, Obstructive pulmonary disease, Psoriasis, Respiratory system disease and 1 more
MAPK3 5 / 16 Ankylosing spondylitis, Dental caries, Obstructive pulmonary disease, Psoriasis and 1 more
MICA 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Psoriatic arthritis and 1 more
NFKB1 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
NOD2 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
PLCL1 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
PLXNC1 5 / 16 Asthma, Eczema, Obstructive pulmonary disease, Psoriasis and 1 more
POFUT1 5 / 16 Ankylosing spondylitis, Asthma, Obstructive pulmonary disease, Psoriasis and 1 more
POLI 5 / 16 Asthma, Eczema, Inflammatory skin disease, Psoriasis and 1 more
PRKCQ 5 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 1 more
PRR5L 5 / 16 Asthma, Eczema, Inflammatory skin disease, Psoriasis and 1 more
PTCD2 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
PTPRK 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
RERE 5 / 16 Asthma, Eczema, Obstructive pulmonary disease, Psoriasis and 1 more
RMI2 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Psoriasis vulgaris and 1 more
RPS26 5 / 16 Asthma, Eczema, Inflammatory skin disease, Obstructive pulmonary disease and 1 more
SBNO2 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
SETD1A 5 / 16 Ankylosing spondylitis, Obstructive pulmonary disease, Psoriasis, Psoriasis vulgaris and 1 more
SLC9A4 5 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 1 more
SOCS3 5 / 16 Asthma, Eczema, Inflammatory skin disease, Psoriasis and 1 more
SPMIP7 5 / 16 Ankylosing spondylitis, Asthma, Eczema, Psoriasis and 1 more
STAT2 5 / 16 Eczema, Inflammatory skin disease, Psoriasis, Psoriasis vulgaris and 1 more
TAGAP 5 / 16 Ankylosing spondylitis, Eczema, Psoriasis, Psoriasis vulgaris and 1 more
TAP2 5 / 16 Ankylosing spondylitis, Asthma, Dental caries, Psoriasis and 1 more
THEMIS 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
TNFRSF14 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
TRAF3IP2 5 / 16 Eczema, Inflammatory skin disease, Psoriasis, Psoriasis vulgaris and 1 more
TTC33 5 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Respiratory system disease and 1 more
TYK2 5 / 16 Ankylosing spondylitis, Psoriasis, Psoriasis vulgaris, Psoriatic arthritis and 1 more
ACO1 4 / 16 Asthma, Eczema, Inflammatory skin disease, Psoriasis
ADCY3 4 / 16 Ankylosing spondylitis, Dental caries, Psoriasis, Sclerosing cholangitis
AHR 4 / 16 Ankylosing spondylitis, Psoriasis, Respiratory system disease, Sclerosing cholangitis
ANKRD55 4 / 16 Ankylosing spondylitis, Eczema, Psoriasis, Sclerosing cholangitis
AP5B1 4 / 16 Asthma, Eczema, Psoriasis, Respiratory system disease
ATXN2 4 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Sclerosing cholangitis
BLTP1 4 / 16 Asthma, Eczema, Inflammatory skin disease, Psoriasis
BSN 4 / 16 Ankylosing spondylitis, Obstructive pulmonary disease, Psoriasis, Sclerosing cholangitis
C1ORF141 4 / 16 Ankylosing spondylitis, Psoriasis, Psoriatic arthritis, Sclerosing cholangitis
CAMK2G 4 / 16 Asthma, Obstructive pulmonary disease, Psoriasis, Psoriasis vulgaris
CAPSL 4 / 16 Ankylosing spondylitis, Asthma, Eczema, Respiratory system disease
CCL2 4 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Sclerosing cholangitis
CD28 4 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Sclerosing cholangitis
CD40 4 / 16 Ankylosing spondylitis, Asthma, Psoriasis, Sclerosing cholangitis
CDKAL1 4 / 16 Ankylosing spondylitis, Psoriasis, Psoriasis vulgaris, Sclerosing cholangitis
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Inflammatory bowel disease
HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IL12RB2, IL17A, IL18R1, IL18RAP, IL2, IL21
 KEGG 56 / 66 4.2× 1.36e-29 4.15e-26 ✓ sig.
Allograft rejection
CD28, CD40, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL12B, IL2, CD40LG, IFNG
 KEGG 34 / 39 4.3× 3.28e-19 2.18e-16 ✓ sig.
Type I diabetes mellitus
CD28, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL12B, IL2, IFNG, HLA-C, LTA, TNF
 KEGG 34 / 44 3.8× 4.85e-16 1.82e-13 ✓ sig.
Th17 cell differentiation
AHR, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL17A, IL1R1, IL2, IL21, IL23R, IL27, IL2RA
 KEGG 60 / 109 2.7× 6.27e-16 2.27e-13 ✓ sig.
Asthma
CD40, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, CD40LG, IL4, IL13, TNF, CCL11, FCER1G, HLA-DMB
 KEGG 27 / 32 4.2× 9.38e-15 2.68e-12 ✓ sig.
Graft-versus-host disease
CD28, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL2, IL6, IFNG, HLA-C, TNF, CD80
 KEGG 32 / 45 3.5× 1.91e-13 4.19e-11 ✓ sig.
Cytokine-cytokine receptor interaction
CCL2, CCL20, CCL21, CCR6, CD40, CSF2RB, CXCR1, CXCR2, FAS, IFNGR2, IFNLR1, IL10
 KEGG 111 / 298 1.9× 3.02e-12 5.15e-10 ✓ sig.
Autoimmune thyroid disease
CD28, CD40, CTLA4, FAS, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL2, CD40LG, IL4
 KEGG 34 / 54 3.1× 7.39e-12 1.16e-9 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
CCL2, IL10, IL12B, IL17A, IL23R, IL6, IL6R, JAK2, NOS2, RORC, STAT3, TNFRSF1B
 Reactome 52 / 108 2.4× 4.95e-11 6.33e-9 ✓ sig.
Intestinal immune network for IgA production
CD28, CD40, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL15RA, IL2, IL6, LTBR, AICDA, CD40LG
 KEGG 31 / 50 3.1× 1.11e-10 1.28e-8 ✓ sig.
Leishmaniasis
FCGR2A, HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL10, IL12B, IRAK1, JAK2, MAPK3, NFKB1, NOS2
 KEGG 41 / 78 2.6× 1.76e-10 1.93e-8 ✓ sig.
Th1 and Th2 cell differentiation
HLA-DQA1, HLA-DQB1, HLA-DRB1, IFNGR2, IL12B, IL12RB2, IL2, IL2RA, JAK2, MAPK3, NFATC1, NFKB1
 KEGG 46 / 93 2.5× 2.05e-10 2.21e-8 ✓ sig.
Interleukin-10 signaling
CCL2, CCL20, IL10, IL12B, IL1R1, IL1R2, IL6, STAT3, TNFRSF1A, TNFRSF1B, TYK2, TIMP1
 Reactome 29 / 47 3.1× 5.27e-10 5.24e-8 ✓ sig.
Rheumatoid arthritis
CCL2, CCL20, CD28, CTLA4, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL17A, IL6, ITGAL, TLR4, IFNG
 KEGG 44 / 95 2.3× 6.88e-9 5.29e-7 ✓ sig.
Human T-cell leukemia virus 1 infection
ADCY3, ADCY7, CD40, ETS1, HLA-B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL15RA, IL1R1, IL1R2, IL2
 KEGG 81 / 224 1.8× 1.29e-8 9.30e-7 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
inflammatory response
CCL2, CCL20, CCL21, CD40, CXCR2, IL17A, IL18R1, IL18RAP, IL1R1, IL23R, IL27, IL2RA
 GO:0006954 141 / 467 2.3× 2.46e-23 6.24e-20 ✓ sig.
immune response
CCL2, CCL20, CCL21, CCR6, CD244, CD28, CTLA4, CXCR1, CXCR2, ETS1, FAS, HLA-B
 GO:0006955 149 / 543 2.1× 3.80e-20 6.16e-17 ✓ sig.
positive regulation of transcription by RNA polymerase II
ACTR2, AHR, ASCL2, CD28, CD40, CREM, CYTL1, EOMES, ETS1, GRHL3, HHEX, IGF2
 GO:0045944 249 / 1,208 1.6× 6.65e-15 4.69e-12 ✓ sig.
cytokine-mediated signaling pathway
CCL2, CSF2RB, IFNGR2, IFNLR1, IL12RB2, IL1R1, IL1R2, IL23R, IL6, IL6R, IL7R, IRAK1
 GO:0019221 54 / 145 2.9× 8.61e-14 5.04e-11 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
CCL2, CD40, CSF2RB, IL12B, IL15RA, IL23R, IL6, IL6R, JAK2, STAT3, TNFRSF1A, TYK2
 GO:0007259 34 / 67 3.9× 8.83e-14 5.14e-11 ✓ sig.
positive regulation of type II interferon production
CD226, CD244, IL12B, IL12RB2, IL18R1, IL1R1, IL2, IL21, IL23R, IL27, JAK2, PTPN22
 GO:0032729 36 / 77 3.6× 4.07e-13 2.06e-10 ✓ sig.
peptide antigen assembly with MHC class II protein complex
HLA-DQA1, HLA-DQB1, HLA-DRB1, B2M, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-DQB2, HLA-DRA
 GO:0002503 15 / 16 7.3× 6.27e-13 3.06e-10 ✓ sig.
positive regulation of T cell proliferation
CD28, CD6, CORO1A, IL12B, IL2, IL21, IL23R, IL2RA, IL6, JAK2, NR5A2, TYK2
 GO:0042102 32 / 67 3.7× 3.95e-12 1.65e-9 ✓ sig.
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
HLA-DQA1, HLA-DQB1, HLA-DRB1, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA2, HLA-DQB2, HLA-DRA, HLA-DRB3
 GO:0002504 14 / 15 7.2× 4.58e-12 1.88e-9 ✓ sig.
positive regulation of T cell activation
CCL2, CD28, CORO1A, HLA-DQA1, HLA-DQB1, HLA-DRB1, NR5A2, PRKCQ, B2M, CCR2, ADA, CARD11
 GO:0050870 25 / 45 4.3× 1.23e-11 4.65e-9 ✓ sig.
positive regulation of DNA-templated transcription
AHR, EOMES, ETS1, GRHL3, HHEX, HLA-DRB1, IL10, IL6, IRF1, KDM5A, KPNB1, MYRF
 GO:0045893 166 / 778 1.7× 1.75e-11 6.31e-9 ✓ sig.
positive regulation of interleukin-17 production
CARD9, IL12B, IL2, IL21, IL23R, IL6, JAK2, NOD2, PRKCQ, TYK2, IL15, IL18
 GO:0032740 18 / 27 5.2× 1.38e-10 4.07e-8 ✓ sig.
positive regulation of inflammatory response
ETS1, IL12B, IL2, IL21, MEFV, NFKB1, PTGER4, STAT3, TLR4, TNFRSF1A, TNIP1, IFNG
 GO:0050729 43 / 122 2.7× 2.23e-10 6.28e-8 ✓ sig.
antigen processing and presentation of exogenous peptide antigen via MHC class II
HLA-DQA1, HLA-DQB1, HLA-DRB1, B2M, FCGR2B, FCER1G, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1, HLA-DQA2
 GO:0019886 19 / 31 4.7× 3.60e-10 9.58e-8 ✓ sig.
response to lipopolysaccharide
CD6, CSF2RB, CYP1A1, IL10, IL12RB2, IL23R, IRAK1, LITAF, MAPK3, NOS2, NOTCH1, PTPN22
 GO:0032496 51 / 161 2.5× 4.10e-10 1.08e-7 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Ankylosing spondylitis Sclerosing cholangitis 0.557 195 5.93e-323 5.72e-321 ✓ sig.
Psoriasis Sclerosing cholangitis 0.272 206 1.98e-254 1.66e-252 ✓ sig.
Ankylosing spondylitis Psoriasis 0.286 232 1.90e-250 1.57e-248 ✓ sig.
Asthma Respiratory system disease 0.153 174 6.41e-150 3.61e-148 ✓ sig.
Eczema Inflammatory skin disease 0.207 76 6.66e-128 3.39e-126 ✓ sig.
Inflammatory skin disease Psoriasis 0.104 76 3.13e-103 1.34e-101 ✓ sig.
Eczema Psoriasis 0.150 143 1.98e-95 7.94e-94 ✓ sig.
Asthma Eczema 0.130 165 5.37e-95 2.14e-93 ✓ sig.
Asthma Psoriasis 0.124 198 2.03e-68 6.59e-67 ✓ sig.
Eczema Respiratory system disease 0.136 73 3.48e-61 1.06e-59 ✓ sig.
Psoriasis vulgaris Sclerosing cholangitis 0.113 29 2.18e-39 5.07e-38 ✓ sig.
Inflammatory skin disease Psoriasis vulgaris 0.202 22 3.84e-38 8.76e-37 ✓ sig.
Asthma Obstructive pulmonary disease 0.083 125 2.65e-33 5.58e-32 ✓ sig.
Respiratory system disease Sclerosing cholangitis 0.097 42 6.22e-33 1.30e-31 ✓ sig.
Ankylosing spondylitis Respiratory system disease 0.088 45 1.19e-30 2.36e-29 ✓ sig.
Obstructive pulmonary disease Respiratory system disease 0.068 51 3.44e-25 5.92e-24 ✓ sig.
Psoriasis vulgaris Psoriatic arthritis 0.133 15 2.04e-23 3.32e-22 ✓ sig.
Inflammatory skin disease Sclerosing cholangitis 0.051 15 3.23e-13 3.59e-12 ✓ sig.
Dental caries Psoriasis 0.042 39 3.14e-12 3.26e-11 ✓ sig.
Inflammatory skin disease Psoriatic arthritis 0.064 9 7.64e-11 7.22e-10 ✓ sig.
Dental caries Obstructive pulmonary disease 0.041 31 2.73e-10 2.47e-9 ✓ sig.
Inflammatory skin disease Intellectual developmental disorder neuropsychiatric 0.013 1 4.91e-3 5.89e-3 ✓ sig.
Inflammatory skin disease Pure spastic paraplegia 0.013 1 4.91e-3 5.89e-3 ✓ sig.
Dental caries Macrocephaly, dysmorphic facies, and psychomotor retardation 0.004 1 1.49e-2 1.63e-2 ✓ sig.
Keratoderma, palmoplantar, nagashima type Respiratory system disease 0.004 1 1.56e-2 1.70e-2 ✓ sig.
Neurodevelopmental disorder with congenital malformations Respiratory system disease 0.004 1 1.56e-2 1.70e-2 ✓ sig.
Eczema Intellectual developmental disorder neuropsychiatric 0.003 1 2.36e-2 2.52e-2 ✓ sig.
Eczema Pure spastic paraplegia 0.003 1 2.36e-2 2.52e-2 ✓ sig.
Macrocephaly, dysmorphic facies, and psychomotor retardation Obstructive pulmonary disease 0.002 1 3.61e-2 3.78e-2 ✓ sig.
Asthma Keratoderma, palmoplantar, nagashima type 0.001 1 6.90e-2 7.03e-2
Asthma Neurodevelopmental disorder with congenital malformations 0.001 1 6.90e-2 7.03e-2