Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Charcot-marie-tooth disease Peroneal muscle atrophy
38 genes
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36 of 38 corroborated by 2+ sources
DHTKD1(5), AARS1(7), VCP(5), SLC12A6(4), EGR2(8), KIF1B(6), MME(8), TRPV4(5), DYNC1H1(5), FIG4(7), MFN2(7), NEFL(7) +26 more
0.284 0.974 3.14e-80 2.48e-78 ✓ sig. Cluster 15 →
Heart valve disease Heart valve prolapse
29 genes
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27 of 29 corroborated by 2+ sources
NOTCH1(2), ACE(1), COL18A1(2), SPP1(2), CASP3(2), IL1B(2), PCDHA9(2), JAK2(2), CCL2(2), COL1A1(2), TIMP1(2), FGFR1(2) +17 more
0.690 1.000 2.62e-81 2.09e-79 ✓ sig. Cluster 370 →
Multiple sclerosis Rheumatoid arthritis
154 genes
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62 of 154 corroborated by 2+ sources
SH2B3(1), RBPJ(3), ABT1(1), ANKRD55(3), BTNL2(2), ELMO1(1), ETS1(1), FAM76B(1), GPC5(1), HLA-DQA1(2), HLA-DQB3(1), HLA-DRA(3) +142 more
0.142 0.267 1.07e-81 8.56e-80 ✓ sig. Cluster 28 →
Charcot-marie-tooth disease Dejerine-sottas disease
38 genes
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36 of 38 corroborated by 2+ sources
DHTKD1(5), AARS1(7), VCP(5), SLC12A6(4), EGR2(8), KIF1B(6), MME(8), TRPV4(5), DYNC1H1(5), FIG4(7), MFN2(7), NEFL(7) +26 more
0.286 1.000 8.10e-82 6.48e-80 ✓ sig. Cluster 15 →
Charcot-marie-tooth disease Hypertrophic neuropathy
38 genes
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36 of 38 corroborated by 2+ sources
DHTKD1(5), AARS1(7), VCP(5), SLC12A6(4), EGR2(8), KIF1B(6), MME(8), TRPV4(5), DYNC1H1(5), FIG4(7), MFN2(7), NEFL(7) +26 more
0.286 1.000 8.10e-82 6.48e-80 ✓ sig. Cluster 15 →
Charcot-marie-tooth disease Roussy-levy syndrome
38 genes
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36 of 38 corroborated by 2+ sources
DHTKD1(5), AARS1(7), VCP(5), SLC12A6(4), EGR2(8), KIF1B(6), MME(8), TRPV4(5), DYNC1H1(5), FIG4(7), MFN2(7), NEFL(7) +26 more
0.286 1.000 8.10e-82 6.48e-80 ✓ sig. Cluster 15 →
Diabetes mellitus type 2 Schizophrenia
882 genes
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346 of 882 corroborated by 2+ sources
SOX5(2), HMGA2(1), RAI1(2), HNF1B(6), KANSL1(1), NFIX(1), DPYD(3), HSPG2(2), RERE(1), ARVCF(2), COMT(3), HDAC4(2) +870 more
0.186 0.347 2.65e-82 2.15e-80 ✓ sig. Cluster 2 →
Attention deficit hyperactivity disorder Metabolic syndrome
299 genes
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12 of 299 corroborated by 2+ sources
SOX5(1), BPTF(1), RERE(1), COMT(3), JMJD1C(1), ZFPM2(1), ATP2A2(1), BMPR1B(1), GBE1(1), BRWD1(1), CACNA1D(1), ADARB1(1) +287 more
0.142 0.271 2.43e-82 1.97e-80 ✓ sig. Cluster 2 →
Genetic steroid-resistant nephrotic syndrome Idiopathic steroid-resistant nephrotic syndrome
28 genes
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22 of 28 corroborated by 2+ sources
WT1(2), NUP107(2), ACTN4(2), ARHGAP24(2), CD2AP(2), MYO1E(2), NUP160(2), NUP85(2), PAX2(2), PTPRO(1), TRPC6(2), PLCE1(1) +16 more
0.800 1.000 2.37e-82 1.93e-80 ✓ sig. Cluster 30 →
Hereditary steroid-resistant nephrotic syndrome Idiopathic steroid-resistant nephrotic syndrome
28 genes
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26 of 28 corroborated by 2+ sources
WT1(2), NUP107(2), ACTN4(2), ARHGAP24(2), CD2AP(2), MYO1E(2), NUP160(2), NUP85(2), PAX2(2), PTPRO(2), TRPC6(2), PLCE1(2) +16 more
0.800 1.000 2.37e-82 1.93e-80 ✓ sig. Cluster 30 →
Ankylosing spondylitis Celiac disease
78 genes
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21 of 78 corroborated by 2+ sources
SH2B3(1), ACE(2), ADGRL2(1), ANKRD55(1), ATXN2L(1), DAG1(1), ETS1(3), FUT2(1), HLA-DQA1(4), HLA-DRB1(2), IGF2(1), LRRK2(1) +66 more
0.182 0.404 1.27e-82 1.05e-80 ✓ sig. —
Coronary artery disease Hypertension
285 genes
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92 of 285 corroborated by 2+ sources
CYP17A1(1), CASZ1(1), PRDM16(3), MAP3K1(1), ZFPM2(1), APOA1(2), CELA2A(2), BMPR1B(1), SH2B3(3), TERT(3), ARHGAP31(2), TP53(2) +273 more
0.142 0.249 7.57e-83 6.25e-81 ✓ sig. Cluster 78 →
Hereditary hearing loss nonsyndromic genetic hearing loss
39 genes
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39 of 39 corroborated by 2+ sources
ESRRB(2), EYA4(2), MYO15A(2), OTOF(2), PCDH15(2), TMC1(2), HGF(2), RDX(2), GSDME(2), COL11A2(2), MYO6(2), CDH23(2) +27 more
0.415 0.780 1.46e-83 1.21e-81 ✓ sig. Cluster 26 →
Neural tube defect Neural tube defects, x-linked
31 genes
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29 of 31 corroborated by 2+ sources
SKI(2), INS(2), GLI3(2), CYP1A2(2), MTHFD1L(1), PAX3(2), ZIC5(2), MTHFR(2), PYY(2), CSF2(2), NPY1R(2), IFNG(2) +19 more
0.633 1.000 5.55e-84 4.62e-82 ✓ sig. —
Keratinocyte carcinoma Non-melanoma skin carcinoma
51 genes
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ANKRD11(1), TP53(1), BNC2(1), CUX1(1), EPB41L1(1), FOXP1(1), GPX4(1), HERC2(1), HLA-DQA1(1), HLA-DRB1(1), MYL10(1), RHOU(1) +39 more
0.260 0.662 5.19e-84 4.34e-82 ✓ sig. Cluster 29 →
Autoimmune thyroid disease Celiac disease
63 genes
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11 of 63 corroborated by 2+ sources
SH2B3(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), BTNL2(1), DAG1(1), ELMO1(1), FUT2(1), HLA-DQA1(4), HLA-DRA(2), HLA-DRB1(2), ICOS(2) +51 more
0.229 0.438 4.55e-84 3.82e-82 ✓ sig. Cluster 39 →
Celiac disease Systemic lupus erythematosus
99 genes
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22 of 99 corroborated by 2+ sources
SH2B3(3), ARHGAP31(1), BLTP1(1), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), BTNL2(1), CSK(3), DAG1(1), DDX6(1), ETS1(4) +87 more
0.132 0.513 1.80e-84 1.52e-82 ✓ sig. —
Hypogonadotropic hypogonadism Panhypopituitarism
34 genes
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30 of 34 corroborated by 2+ sources
FGF8(5), DUSP6(5), IL17RD(4), PROK2(6), TACR3(6), PROKR2(7), TCF12(4), GH1(1), CHD7(5), FGFR1(5), WDR11(5), SEMA3E(4) +22 more
0.596 0.791 1.02e-84 8.63e-83 ✓ sig. Cluster 54 →
Autoimmune disease Systemic lupus erythematosus
101 genes
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26 of 101 corroborated by 2+ sources
SH2B3(3), ARHGAP31(1), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), C12orf42(1), DAG1(1), FUT2(1), HLA-DQB3(1), ICOS(1), IGF2(1) +89 more
0.134 0.500 9.89e-85 8.40e-83 ✓ sig. —
Astrocytoma Central nervous system cancer
119 genes
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2 of 119 corroborated by 2+ sources
ADNP(1), HMCN1(1), TEAD1(1), AGBL1(1), ARHGEF28(1), C6orf118(1), CARD11(1), CTNNA3(1), DSCAM(1), EPHA4(1), FAM163A(1), G3BP1(2) +107 more
0.142 0.395 5.28e-85 4.50e-83 ✓ sig. Cluster 284 →
Basal cell carcinoma Skin neoplasms
74 genes
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12 of 74 corroborated by 2+ sources
TERT(2), TP53(3), TPCN2(1), ASIP(2), ATP8B4(1), BNC2(2), CUX1(1), EMSY(1), FADS2(1), FAM76B(1), FOXP1(1), GLI2(1) +62 more
0.185 0.510 2.18e-86 1.87e-84 ✓ sig. Cluster 29 →
Kallmann syndrome Pituitary dwarfism
33 genes
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21 of 33 corroborated by 2+ sources
FGF8(3), DUSP6(3), IL17RD(3), PROK2(4), TACR3(2), PROKR2(3), TCF12(2), GH1(2), CHD7(4), WDR11(3), SEMA3E(2), SPRY4(3) +21 more
0.673 0.868 5.61e-87 4.83e-85 ✓ sig. Cluster 54 →
Bipolar disorder Mood disorder
151 genes
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49 of 151 corroborated by 2+ sources
RERE(1), COMT(2), HDAC4(2), ATP2A2(2), CACNA1D(2), BLTP1(1), SERPINA1(2), ADCY8(2), ANK3(3), ARHGAP15(1), CACNA1E(1), DAO(1) +139 more
0.110 0.507 3.75e-87 3.24e-85 ✓ sig. Cluster 2 →
Bipolar disorder Tourette syndrome
141 genes
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33 of 141 corroborated by 2+ sources
SOX5(2), RERE(1), ATP2A2(1), AKAP6(1), ANK3(3), BANK1(1), BRAF(1), C8orf90(1), CACNB2(2), CSMD1(2), CTNND1(1), DCC(1) +129 more
0.105 0.547 3.40e-87 2.95e-85 ✓ sig. —
Cerebrovascular disorder Stroke
62 genes
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56 of 62 corroborated by 2+ sources
CASZ1(3), APOA1(2), SH2B3(3), FGA(3), ACE(2), HDAC9(3), ITGB3(2), MMP12(2), SMARCA4(1), SMOX(2), PLAU(2), F2(3) +50 more
0.179 0.738 1.23e-87 1.07e-85 ✓ sig. Cluster 307 →

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.