Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Central nervous system cancer Glioma
643 genes
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8 of 643 corroborated by 2+ sources
AKR1C2(1), PAFAH1B1(1), HIRA(1), RREB1(1), HIBCH(1), ABCA4(1), ACTB(1), PIK3R1(1), RTEL1(2), TERT(2), DOCK6(1), ADNP(1) +631 more
0.833 0.980 < 1e-300 < 1e-300 ✓ sig. Cluster 291 →
Central nervous system cancer Glioblastoma
535 genes
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7 of 535 corroborated by 2+ sources
AKR1C2(1), PAFAH1B1(1), HIRA(1), RREB1(1), HIBCH(1), ABCA4(1), ACTB(1), PIK3R1(1), RTEL1(1), TERT(1), DOCK6(1), TP53(1) +523 more
0.734 0.881 < 1e-300 < 1e-300 ✓ sig. Cluster 291 →
Glioblastoma Glioma
543 genes
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13 of 543 corroborated by 2+ sources
AKR1C2(1), PAFAH1B1(1), NF1(1), HIRA(1), RREB1(1), HIBCH(1), ABCA4(1), ACTB(1), PIK3R1(1), RTEL1(2), TERT(2), DOCK6(1) +531 more
0.660 0.895 < 1e-300 < 1e-300 ✓ sig. Cluster 291 →
Crohn disease Inflammatory bowel disease
538 genes
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60 of 538 corroborated by 2+ sources
SOX5(1), WWOX(1), GLI3(1), ATP2A2(1), NOTCH2(1), PIK3R1(1), SH2B3(1), CEBPA(1), NOTCH1(1), RBPJ(1), IMPG2(1), PER3(1) +526 more
0.638 0.780 < 1e-300 < 1e-300 ✓ sig. Cluster 14 →
Crohn disease Ulcerative colitis
496 genes
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64 of 496 corroborated by 2+ sources
SOX5(1), WWOX(1), GLI3(1), ATP2A2(1), NOTCH2(1), SH2B3(1), CEBPA(1), NOTCH1(1), RBPJ(1), IMPG2(1), IFIH1(1), ALG11(1) +484 more
0.615 0.812 < 1e-300 < 1e-300 ✓ sig. Cluster 14 →
Cancer Ovarian serous carcinoma
196 genes
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ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +184 more
0.583 0.751 < 1e-300 < 1e-300 ✓ sig. Cluster 21 →
Inflammatory bowel disease Ulcerative colitis
453 genes
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57 of 453 corroborated by 2+ sources
SOX5(1), WWOX(1), GLI3(1), ATP2A2(1), NOTCH2(1), SH2B3(1), CEBPA(1), RTEL1(1), NOTCH1(1), RBPJ(1), IMPG2(1), IFIH1(1) +441 more
0.534 0.741 < 1e-300 < 1e-300 ✓ sig. Cluster 14 →
Ovarian cancer Ovarian serous carcinoma
244 genes
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USP7(1), ANKRD11(1), HNF1B(1), KANSL1(1), PRDM16(1), RREB1(1), MAP3K1(1), PDE4D(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1) +232 more
0.495 0.904 < 1e-300 < 1e-300 ✓ sig. Cluster 21 →
Lung cancer Squamous cell carcinoma
433 genes
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22 of 433 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), BPTF(1), RREB1(1), MAP3K1(1), COL2A1(1), TGM5(1), SH2B3(1), CHEK2(1), RTEL1(1), TERT(1) +421 more
0.430 0.667 < 1e-300 < 1e-300 ✓ sig. Cluster 21 →
Diabetes mellitus type 2 Metabolic syndrome
1222 genes
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84 of 1222 corroborated by 2+ sources
SOX5(1), ANKRD11(1), BPTF(1), DPYD(1), HSPG2(1), RERE(1), SKI(1), KIF15(1), COMT(1), JMJD1C(1), RREB1(1), SEC24C(1) +1210 more
0.386 0.938 < 1e-300 < 1e-300 ✓ sig. Cluster 2 →
Attention deficit hyperactivity disorder Substance abuse
445 genes
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16 of 445 corroborated by 2+ sources
SOX5(1), BPTF(1), NFIA(1), BNC1(1), ACTN2(1), GBE1(1), BRWD1(1), BLNK(1), TEAD1(1), CACNA1D(1), ALMS1(1), ADCYAP1R1(1) +433 more
0.378 0.862 < 1e-300 < 1e-300 ✓ sig. Cluster 2 →
Neurodevelopmental disorder Non-specific syndromic intellectual disability
333 genes
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332 of 333 corroborated by 2+ sources
CHD8(3), SUPT16H(4), CHRNA7(2), YWHAE(2), PSMD12(2), GABRD(3), SPEN(2), HNRNPU(4), JMJD1C(2), RREB1(2), VCP(2), CACNA1D(2) +321 more
0.342 0.905 < 1e-300 < 1e-300 ✓ sig. Cluster 6 →
Bipolar disorder Major depressive disorder
720 genes
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162 of 720 corroborated by 2+ sources
SOX5(1), HNF1B(1), PRKCZ(1), RERE(1), KIF15(1), COMT(2), SEC24C(1), HDAC4(2), WWOX(1), ZFPM2(1), APP(1), SMARCAD1(1) +708 more
0.293 0.590 < 1e-300 < 1e-300 ✓ sig. Cluster 2 →
Ankylosing spondylitis Sclerosing cholangitis
195 genes
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19 of 195 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ANKRD55(1), BANK1(1), BSN(1), CDKAL1(1), EMSY(1), ERN1(1), ETS1(1), FAM177A1(1), FIBP(1) +183 more
0.559 0.848 2.96e-323 4.67e-320 ✓ sig. Cluster 14 →
Juvenile idiopathic arthritis Oligoarticular juvenile idiopathic arthritis
168 genes
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16 of 168 corroborated by 2+ sources
RERE(1), GP1BB(1), WWOX(2), SLC26A2(1), ETV6(1), RUNX1(1), ANKRD55(2), ASAP1(1), AVL9(1), CAMSAP1(1), CLIC4(1), CLU(1) +156 more
0.625 0.988 1.53e-322 2.25e-319 ✓ sig. Cluster 320 →
Breast cancer Estrogen-receptor negative breast cancer
282 genes
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5 of 282 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(2), ZFPM2(1), SH2B3(1), RTEL1(1), TERT(1), TP53(4), ARHGEF10L(1), ARL17B(1) +270 more
0.261 0.953 3.16e-321 4.36e-318 ✓ sig. Cluster 21 →
Cancer Estrogen-receptor negative breast cancer
197 genes
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ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +185 more
0.546 0.755 8.86e-315 1.15e-311 ✓ sig. Cluster 21 →
Bipolar disorder Schizophrenia
751 genes
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232 of 751 corroborated by 2+ sources
SOX5(2), CHRNA7(1), YWHAE(2), HNF1B(1), NFIX(2), RERE(1), COMT(3), HDAC4(2), WWOX(2), ZFPM2(1), SMARCAD1(1), COL2A1(1) +739 more
0.249 0.616 1.24e-309 1.51e-306 ✓ sig. Cluster 2 →
Estrogen-receptor negative breast cancer Ovarian serous carcinoma
196 genes
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ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +184 more
0.528 0.726 6.32e-307 7.33e-304 ✓ sig. Cluster 21 →
Biliary cholangitis Biliary cirrhosis
128 genes
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16 of 128 corroborated by 2+ sources
SH2B3(1), POU2AF1(3), DDX6(1), DEAF1(1), DGKQ(1), ELMO1(1), ETS1(1), HLA-DQA1(1), HLA-DRA(1), ITGB8(1), MACIR(1), RARB(1) +116 more
0.865 1.000 2.44e-297 2.68e-294 ✓ sig. Cluster 288 →
Ischemic heart disease Myocardial ischemia
170 genes
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44 of 170 corroborated by 2+ sources
PRDM16(1), APOA1(1), ACAT2(1), SH2B3(2), TERT(1), ARHGAP31(1), AMPD1(1), TP53(1), AHSG(1), ABCA1(1), ABCG8(2), ACE(1) +158 more
0.434 1.000 1.83e-290 1.92e-287 ✓ sig. Cluster 73 →
Juvenile arthritis Oligoarticular juvenile idiopathic arthritis
126 genes
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126 of 126 corroborated by 2+ sources
RERE(2), GP1BB(2), WWOX(2), ETV6(2), ASAP1(2), AVL9(2), CAMSAP1(2), CLU(2), FOXP1(2), GMPR(2), HBEGF(2), HSPA6(2) +114 more
0.720 0.969 1.23e-268 1.23e-265 ✓ sig. Cluster 320 →
Congestive heart failure Heart failure
173 genes
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137 of 173 corroborated by 2+ sources
INS(2), HMGCS2(2), EDNRB(2), CAT(2), ACACA(2), ATP2A2(2), AMPD1(1), TP53(1), SCD(1), GATM(2), ATP1A3(2), ACE(2) +161 more
0.363 0.966 1.01e-267 9.71e-265 ✓ sig. Cluster 34 →
Ankylosing spondylitis Ulcerative colitis
228 genes
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41 of 228 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), BANK1(1), BSN(1), CDKAL1(1), DAG1(1), EMSY(1), ERN1(1) +216 more
0.327 0.728 1.73e-263 1.59e-260 ✓ sig. Cluster 14 →
Estrogen-receptor negative breast cancer Ovarian cancer
207 genes
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ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +195 more
0.372 0.699 1.23e-261 1.09e-258 ✓ sig. Cluster 21 →

Showing 25 of 22038 pairs, sorted by significance (ascending). Click a column header to sort.