Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 320

6 diseases · 10 shared-gene connections
6 Diseases
271 Unique genes
0.218 Avg. similarity score
Oligoarticular juvenile idiopathic arthritis Most-connected disease (5 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Oligoarticular juvenile idiopathic arthritis 5 5 170
Juvenile idiopathic arthritis 4 4 266
Juvenile arthritis 3 3 130
Polyarticular juvenile idiopathic arthritis 3 3 32
cardiomyopathy, dilated, 2k 3 3 1
COG6-congenital disorder of glycosylation 2 2 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
COG6 4 / 6 COG6-congenital disorder of glycosylation, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
MYZAP 4 / 6 cardiomyopathy, dilated, 2k, Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ACP3 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ACRBP 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ADCY7 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ALOX12 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ANKRD55 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
ANKRD9 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
AQP9 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
AREG 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ASAP1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ATXN2 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
AVL9 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
B4GALT5 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
BEND2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
BLTP3B 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
BTG1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
BTG3 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
C8B 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
C9ORF72 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CALD1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CAMSAP1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CCR3 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
CD14 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CD247 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
CD83 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CD8B 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CLIC4 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
CLU 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CMTM2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CREM 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CTLA4 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CTTN 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CXCL1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CXCR2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
CXCR4 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
DAPK1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
DDIT3 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
DUSP1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
DUSP2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
DUSP4 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
DYSF 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
EGF 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
EGR1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ELF2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ETNK1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ETV6 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
FAM20A 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
FAS 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
FAXDC2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
FCGR1A 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
FCHSD2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
FOS 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
FOSB 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
FOSL2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
FOXP1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
GADD45A 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
GMPR 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
GNG11 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
GP1BB 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
H2AC8 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
H2BC8 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
HBEGF 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
HERPUD2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
HLA-DQB1 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
HSPA6 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
IGF1R 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
IL1RN 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
IL2 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
IL21 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
IL2RA 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
IL2RB 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
IL6R 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
IRF1 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
ITGA2B 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
ITGB5 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
JAZF1 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
JUN 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
KAT6B 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
KCNJ15 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
KLF4 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
KRAS 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
LACC1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
LILRA5 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
LNPEP 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
LPP 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
LTBR 3 / 6 Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis, Polyarticular juvenile idiopathic arthritis
MAD1L1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
MAFF 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
MAML2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
MAP2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
MAPK1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
MEX3C 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
MS4A4A 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
MSN 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
MTSS1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
NDEL1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
NR4A2 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
NR4A3 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
NRG1 3 / 6 Juvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Th17 cell differentiation
FOS, JUN, MAPK1, SMAD3, STAT3, HLA-DQA1, HLA-DQB1, HLA-DRB1, CD247, IL2, IL21, IL23R
 KEGG 21 / 109 8.5× 3.14e-14 8.84e-12 ✓ sig.
Inflammatory bowel disease
JUN, SMAD3, STAT3, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL1A, IL10, IL18RAP, IL2, IL21, IL23R
 KEGG 16 / 66 10.7× 9.04e-13 1.99e-10 ✓ sig.
Th1 and Th2 cell differentiation
FOS, JUN, MAML2, MAPK1, HLA-DQA1, HLA-DQB1, HLA-DRB1, CD247, IL2, IL2RA, JAK2, RUNX3
 KEGG 17 / 93 8.1× 2.29e-11 3.79e-9 ✓ sig.
Toxoplasmosis
HSPA6, MAPK1, STAT3, CCR5, CIITA, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, JAK2, LAMA2, LAMB4
 KEGG 15 / 112 5.9× 3.01e-8 2.30e-6 ✓ sig.
Viral protein interaction with cytokine and cytokine receptor
CXCL1, CXCR2, CXCR4, TNFRSF10C, CCR5, CCR3, IL10, IL18RAP, IL2, IL2RA, IL2RB, IL6R
 KEGG 14 / 100 6.2× 4.95e-8 3.53e-6 ✓ sig.
Interleukin-6 signaling
STAT3, JAK2, IL6R, STAT1, TYK2, IL6
 Reactome 6 / 11 24.2× 5.25e-8 3.73e-6 ✓ sig.
Leishmaniasis
FCGR1A, FOS, JUN, MAPK1, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL1A, IL10, JAK2, STAT1, HLA-DRA
 KEGG 12 / 78 6.8× 1.58e-7 9.72e-6 ✓ sig.
Hematopoietic cell lineage
CD14, CD8B, FCGR1A, GP1BB, ITGA2B, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL1A, IL2RA, IL6R, IL6
 KEGG 13 / 100 5.8× 3.64e-7 2.04e-5 ✓ sig.
Interleukin-23 signaling
STAT3, IL23R, JAK2, STAT4, TYK2
 Reactome 5 / 9 24.6× 6.60e-7 3.40e-5 ✓ sig.
MAPK1 (ERK2) activation
MAPK1, JAK2, IL6R, TYK2, IL6
 Reactome 5 / 9 24.6× 6.60e-7 3.40e-5 ✓ sig.
Pathways in cancer
ADCY7, CXCR4, DAPK1, EGF, FOS, GADD45A, GNG11, IGF1R, ITGA2B, JUN, KRAS, MAPK1
 KEGG 31 / 533 2.6× 1.23e-6 5.87e-5 ✓ sig.
JAK-STAT signaling pathway
EGF, OSM, STAT3, IL10, IL2, IL21, IL23R, IL2RA, JAK2, STAT4, PTPN2, IL2RB
 KEGG 16 / 168 4.2× 1.24e-6 5.89e-5 ✓ sig.
Intestinal immune network for IgA production
CXCR4, HLA-DQA1, HLA-DQB1, HLA-DRB1, IL10, IL2, LTBR, IL6, HLA-DRA
 KEGG 9 / 50 8.0× 1.48e-6 6.85e-5 ✓ sig.
Translocation of ZAP-70 to Immunological synapse
HLA-DQA1, HLA-DQB1, HLA-DRB1, PTPN22, CD247, HLA-DRA
 Reactome 6 / 19 14.0× 2.65e-6 1.12e-4 ✓ sig.
Cytokine-cytokine receptor interaction
CXCL1, CXCR2, CXCR4, IL1RN, OSM, TNFRSF10C, CCR5, IL1A, CCR3, FAS, IL10, IL18RAP
 KEGG 21 / 298 3.1× 3.91e-6 1.56e-4 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
C8B, CD8B, CTLA4, CXCL1, CXCR2, CXCR4, FCGR1A, IGF1R, IL1RN, OSM, SMAD3, STAT3
 GO:0006955 36 / 543 4.6× 2.46e-14 1.49e-11 ✓ sig.
positive regulation of interleukin-17 production
OSM, CARD9, IL2, IL21, IL23R, JAK2, TYK2, IL6
 GO:0032740 8 / 27 20.4× 3.09e-9 6.06e-7 ✓ sig.
positive regulation of transcription by RNA polymerase II
CREM, DDIT3, EGR1, ETV6, FOS, FOSB, FOSL2, JUN, KAT6B, KLF4, MAFF, MAML2
 GO:0045944 44 / 1,208 2.5× 1.39e-8 2.28e-6 ✓ sig.
inflammatory response
CD14, CXCL1, CXCR2, CXCR4, FOS, FOSL2, IL1RN, OLR1, SLC11A1, STAB1, STAT3, THBS1
 GO:0006954 25 / 467 3.7× 2.19e-8 3.38e-6 ✓ sig.
positive regulation of tumor necrosis factor production
CD14, CLU, FCGR1A, LILRA5, STAT3, THBS1, IL1A, CARD9, JAK2, LRRK2, IL6, MIF
 GO:0032760 12 / 113 7.3× 9.14e-8 1.12e-5 ✓ sig.
positive regulation of miRNA transcription
EGR1, FOS, JUN, KLF4, SMAD3, STAT3, IL10, SMAD1, IL6
 GO:1902895 9 / 56 11.1× 1.04e-7 1.25e-5 ✓ sig.
interleukin-23-mediated signaling pathway
STAT3, IL23R, JAK2, TYK2
 GO:0038155 4 / 6 46.0× 6.34e-7 5.71e-5 ✓ sig.
type II interferon-mediated signaling pathway
CIITA, IRF1, JAK2, STAT1, TYK2
 GO:0060333 5 / 15 23.0× 1.65e-6 1.24e-4 ✓ sig.
cell surface receptor signaling pathway via STAT
STAT3, IL2, IL23R, IL6R, STAT1, IL6
 GO:0097696 6 / 28 14.8× 2.54e-6 1.74e-4 ✓ sig.
positive regulation of T cell proliferation
IL2, IL21, IL23R, IL2RA, JAK2, VTCN1, TYK2, IL6
 GO:0042102 8 / 67 8.2× 5.49e-6 3.24e-4 ✓ sig.
cell surface receptor signaling pathway via JAK-STAT
STAT3, IL23R, JAK2, STAT4, IL6R, STAT1, TYK2, IL6
 GO:0007259 8 / 67 8.2× 5.49e-6 3.24e-4 ✓ sig.
signal transduction
CD83, CMTM2, CREM, CTTN, CXCL1, CXCR2, CXCR4, DAPK1, DUSP1, DUSP2, DUSP4, FCGR1A
 GO:0007165 56 / 2,125 1.8× 6.28e-6 3.60e-4 ✓ sig.
response to cAMP
AREG, DUSP1, FOS, FOSB, PER1, STAT1
 GO:0051591 6 / 34 12.2× 8.42e-6 4.56e-4 ✓ sig.
cytokine-mediated signaling pathway
KRAS, LILRA5, STAT3, IL1A, IL23R, JAK2, STAT4, IL2RB, IL6R, TYK2, IL6
 GO:0019221 11 / 145 5.2× 8.87e-6 4.76e-4 ✓ sig.
positive regulation of smooth muscle cell proliferation
FOXP1, HBEGF, NR4A3, THBS1, IL6R, STAT1, IL6
 GO:0048661 7 / 52 9.3× 9.56e-6 5.04e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Juvenile idiopathic arthritis Oligoarticular juvenile idiopathic arthritis 0.625 168 1.53e-322 2.25e-319 ✓ sig.
Juvenile arthritis Oligoarticular juvenile idiopathic arthritis 0.720 126 1.23e-268 1.23e-265 ✓ sig.
Juvenile arthritis Juvenile idiopathic arthritis 0.470 127 1.22e-234 7.44e-232 ✓ sig.
Oligoarticular juvenile idiopathic arthritis Polyarticular juvenile idiopathic arthritis 0.187 32 1.09e-64 7.62e-63 ✓ sig.
Juvenile idiopathic arthritis Polyarticular juvenile idiopathic arthritis 0.120 32 5.86e-58 3.67e-56 ✓ sig.
COG6-congenital disorder of glycosylation Polyarticular juvenile idiopathic arthritis 0.030 1 2.08e-3 2.95e-3 ✓ sig.
cardiomyopathy, dilated, 2k Juvenile arthritis 0.008 1 8.44e-3 9.77e-3 ✓ sig.
cardiomyopathy, dilated, 2k Oligoarticular juvenile idiopathic arthritis 0.006 1 1.10e-2 1.24e-2 ✓ sig.
COG6-congenital disorder of glycosylation Oligoarticular juvenile idiopathic arthritis 0.006 1 1.10e-2 1.24e-2 ✓ sig.
cardiomyopathy, dilated, 2k Juvenile idiopathic arthritis 0.004 1 1.73e-2 1.90e-2 ✓ sig.