H2BC8 (H2B clustered histone 8)

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Gene Gene information from NCBI Gene database.
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Entrez ID 8339
Gene name H2B clustered histone 8
Gene symbol H2BC8
Synonyms (NCBI Gene)
H2B.1AH2B/aH2BC10H2BC4H2BC6H2BC7H2BFAHIST1H2BGdJ221C16.8
Chromosome 6
Chromosome location 6p22.2
Summary Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core hi
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
23 Show/Hide all (23)
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GO ID Ontology Definition Evidence Reference
GO:0000786 Component Nucleosome IEA
GO:0000786 Component Nucleosome NAS 422550, 9119399
GO:0002227 Process Innate immune response in mucosa IDA 12860195
GO:0003677 Function DNA binding IEA
GO:0003677 Function DNA binding NAS 422550, 9119399
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
602798 4746 ENSG00000273802
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
Neutrophil extracellular trap formation Recognition and association of DNA glycosylase with site containing an affected purine
Alcoholism Cleavage of the damaged purine
Viral carcinogenesis Packaging Of Telomere Ends
Systemic lupus erythematosus Formation of the beta-catenin:TCF transactivating complex
  PRC2 methylates histones and DNA
  Condensation of Prophase Chromosomes
  Oxidative Stress Induced Senescence
  Senescence-Associated Secretory Phenotype (SASP)
  DNA Damage/Telomere Stress Induced Senescence
  HDACs deacetylate histones
  HATs acetylate histones
  SIRT1 negatively regulates rRNA expression
  NoRC negatively regulates rRNA expression
  B-WICH complex positively regulates rRNA expression
  Transcriptional regulation by small RNAs
  Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  Ub-specific processing proteases
  Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  Nonhomologous End-Joining (NHEJ)
  Processing of DNA double-strand break ends
  Deposition of new CENPA-containing nucleosomes at the centromere
  G2/M DNA damage checkpoint
  RNA Polymerase I Promoter Opening
  RNA Polymerase I Promoter Escape
  E3 ubiquitin ligases ubiquitinate target proteins
  RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  Estrogen-dependent gene expression
  HCMV Early Events
  HCMV Late Events
  Amyloid fiber formation
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (7)
Phenotype Name Clinical Significance Source Reference Evidence Score
ARTHRITIS, JUVENILE — CTD 19565504
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
JUVENILE CHRONIC POLYARTHRITIS — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MONOARTICULAR JUVENILE RHEUMATOID ARTHRITIS — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PAUCIARTICULAR JUVENILE RHEUMATOID ARTHRITIS — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS — CTD 19208208
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
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H2AC8 3 shared diseasesJuvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis 28 shared pathwaysNeutrophil extracellular trap formation, Alcoholism, Systemic lupus erythematosus, Ub-specific processing proteases, Condensation of Prophase Chromosomes, Deposition of new CENPA-containing nucleosomes at the centromere, HCMV Late Events, Oxidative Stress Induced Senescence, Amyloid fiber formation, DNA Damage/Telomere Stress Induced Senescence, HCMV Early Events, Senescence-Associated Secretory Phenotype (SASP) +16 more 3 shared evidence sourcesCTD (Juvenile arthritis), Disgenet (Juvenile idiopathic arthritis), Disgenet (Oligoarticular juvenile idiopathic arthritis) Related via 28 shared pathways including Neutrophil extracellular trap formation, Alcoholism — evidence mostly Disgenet. ACP3 3 shared diseasesJuvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis 3 shared evidence sourcesCTD (Juvenile arthritis), Disgenet (Juvenile idiopathic arthritis), Disgenet (Oligoarticular juvenile idiopathic arthritis) Related via 3 shared diseases including Juvenile arthritis, Juvenile idiopathic arthritis — evidence mostly Disgenet. ACRBP 3 shared diseasesJuvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis 3 shared evidence sourcesCTD (Juvenile arthritis), Disgenet (Juvenile idiopathic arthritis), Disgenet (Oligoarticular juvenile idiopathic arthritis) Related via 3 shared diseases including Juvenile arthritis, Juvenile idiopathic arthritis — evidence mostly Disgenet. ANKRD9 3 shared diseasesJuvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis 3 shared evidence sourcesCTD (Juvenile arthritis), Disgenet (Juvenile idiopathic arthritis), Disgenet (Oligoarticular juvenile idiopathic arthritis) Related via 3 shared diseases including Juvenile arthritis, Juvenile idiopathic arthritis — evidence mostly Disgenet. AVL9 3 shared diseasesJuvenile arthritis, Juvenile idiopathic arthritis, Oligoarticular juvenile idiopathic arthritis 3 shared evidence sourcesCTD (Juvenile arthritis), Disgenet (Juvenile idiopathic arthritis), Disgenet (Oligoarticular juvenile idiopathic arthritis) Related via 3 shared diseases including Juvenile arthritis, Juvenile idiopathic arthritis — evidence mostly Disgenet.
Insomnia Linked via 2 of 5 related genesH2AC8, AVL9 Alzheimer disease Linked via 1 of 5 related genesAVL9