Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Hereditary spastic paraplegia Spastic paraplegia
67 genes
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58 of 67 corroborated by 2+ sources
NIPA1(4), ABCD1(1), ALDH18A1(4), SLC16A2(1), ALS2(2), AP4M1(2), ARSI(3), MTRFR(3), SETX(1), SPG11(4), USP8(3), UCHL1(5) +55 more
0.432 0.663 3.88e-125 5.85e-123 ✓ sig. Cluster 244 →
Cardiomyopathy Dilated cardiomyopathy
107 genes
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74 of 107 corroborated by 2+ sources
PRDM16(4), COMT(1), PSEN1(6), ABCC9(7), ACTN2(7), CTNNA3(1), DMD(6), DSG2(7), EYA4(5), FHOD3(4), JUP(1), KCNE2(1) +95 more
0.260 0.439 9.72e-128 1.48e-125 ✓ sig. Cluster 369 →
Eczema Inflammatory skin disease
76 genes
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IFIH1(1), BLTP1(1), ANO3(1), CSMD1(1), EBF1(1), ELMO1(1), EMSY(1), MGMT(1), PTPRN2(1), RAP1GAP2(1), RASIP1(1), SMARCA4(1) +64 more
0.208 1.000 8.22e-128 1.26e-125 ✓ sig. Cluster 252 →
Hepatocellular carcinoma Non-hodgkins lymphoma
110 genes
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6 of 110 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(2), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +98 more
0.163 0.815 1.94e-129 3.00e-127 ✓ sig. Cluster 67 →
Attention deficit hyperactivity disorder Bipolar disorder
350 genes
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85 of 350 corroborated by 2+ sources
SOX5(1), NFIX(2), NFIA(1), RERE(1), COMT(2), HDAC4(1), DHH(1), ZFPM2(1), ATP2A2(1), CDK10(1), CACNA1D(3), ALMS1(1) +338 more
0.177 0.317 1.74e-130 2.70e-128 ✓ sig. Cluster 2 →
Alzheimer disease Dementia
333 genes
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27 of 333 corroborated by 2+ sources
HNF1B(1), NFIX(1), ZFPM2(1), APP(7), PSEN1(6), PRRX1(1), AIPL1(1), TPCN2(1), ABCA1(2), ABCA7(4), ABI3(2), ACE(2) +321 more
0.134 0.564 8.54e-132 1.34e-129 ✓ sig. Cluster 2 →
Major depressive disorder Neurotic disorder
268 genes
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20 of 268 corroborated by 2+ sources
SOX5(1), CYP17A1(1), PAFAH1B1(1), KANSL1(1), RERE(1), PDE4D(2), ARHGAP15(1), ARHGEF10L(1), ARL17B(1), AS3MT(1), BNC2(1), CACNA1E(1) +256 more
0.126 0.616 3.73e-132 5.88e-130 ✓ sig. Cluster 2 →
Glaucoma Open angle glaucoma
118 genes
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25 of 118 corroborated by 2+ sources
PRDM16(1), LTBP3(1), CHEK2(1), RUNX1(1), ABCA1(1), ANKH(1), ANTXR1(1), APOE(2), BCAS3(1), BNC2(1), CADM2(1), CDKN2B(4) +106 more
0.243 0.504 1.41e-132 2.24e-130 ✓ sig. Cluster 240 →
complex neurodevelopmental disorder Neurodevelopmental disorder
113 genes
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112 of 113 corroborated by 2+ sources
CHD8(3), GABRD(2), HNRNPU(4), CACNA1D(2), CHD2(4), CNTNAP2(2), CUL3(6), DLGAP2(2), EPB41L1(2), GIGYF1(4), GNB2(5), GRIA1(2) +101 more
0.120 0.958 8.38e-133 1.34e-130 ✓ sig. Cluster 6 →
Autoimmune disease Autoimmune thyroid disease
87 genes
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7 of 87 corroborated by 2+ sources
SH2B3(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), C12orf42(1), CAMK4(1), DAG1(1), ELMO1(1), ERBB3(1), FAM76B(1), FUT2(1), GIGYF1(1) +75 more
0.335 0.604 2.91e-133 4.69e-131 ✓ sig. Cluster 39 →
Cardiovascular disease Hypertension
220 genes
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46 of 220 corroborated by 2+ sources
CYP11B2(2), CASZ1(1), PRDM16(1), RERE(1), ZFPM2(1), POLR1A(1), PIK3R1(1), SH2B3(1), ADK(1), CACNA1D(1), ALG9(1), ACE(3) +208 more
0.162 0.509 5.38e-135 8.75e-133 ✓ sig. Cluster 78 →
Testicular carcinoma Testicular germ cell tumor
53 genes
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6 of 53 corroborated by 2+ sources
HNF1B(1), DMRT1(1), GATA4(1), PIK3CD(1), TERT(1), ATF7IP(1), CENPE(1), GAB2(1), HEATR3(1), LIPG(1), MAD1L1(2), PDE8A(1) +41 more
0.779 0.883 8.06e-136 1.32e-133 ✓ sig. —
Diabetes mellitus type 1 Rheumatoid arthritis
188 genes
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72 of 188 corroborated by 2+ sources
CAT(2), CP(2), SH2B3(3), BLTP1(1), AFF3(3), ANKRD55(3), BTNL2(2), CCRL2(1), DGKQ(1), EMSY(1), ERBB3(1), ETS1(2) +176 more
0.197 0.394 1.83e-136 3.03e-134 ✓ sig. Cluster 28 →
Hearing loss Nonsyndromic hearing loss
97 genes
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95 of 97 corroborated by 2+ sources
CEACAM16(3), CLIC5(4), COL11A1(4), ESRRB(3), EYA4(4), GIPC3(3), LMX1A(6), MYO15A(4), OTOF(2), OTOGL(2), PCDH15(5), THOC1(3) +85 more
0.237 0.822 1.09e-138 1.82e-136 ✓ sig. Cluster 26 →
Dermatologic disorder Skin disease
68 genes
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66 of 68 corroborated by 2+ sources
PTEN(2), SCD(1), CCRL2(2), ERCC2(2), INPP5A(3), PDE4B(2), GSTO1(2), HSPA1B(2), IL10(1), IL1A(2), IL1B(2), MTHFR(2) +56 more
0.382 1.000 5.03e-139 8.44e-137 ✓ sig. Cluster 29 →
Rheumatoid arthritis Systemic lupus erythematosus
216 genes
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84 of 216 corroborated by 2+ sources
CAT(2), SH2B3(3), TP63(1), TPCN2(1), BLTP1(1), AFF3(3), ANKRD55(3), BTNL2(2), DDX6(3), DGKQ(1), ESR2(1), ETS1(4) +204 more
0.196 0.330 1.66e-139 2.82e-137 ✓ sig. Cluster 28 →
Colorectal cancer Lung cancer
254 genes
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10 of 254 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), CHEK2(2), RTEL1(1), TERT(1), ADAR(1), TP53(3), ADCY8(1) +242 more
0.185 0.391 3.99e-141 6.80e-139 ✓ sig. Cluster 20 →
Ankylosing spondylitis Autoimmune disease
112 genes
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52 of 112 corroborated by 2+ sources
SH2B3(1), ADGRL2(1), AICDA(2), ANKRD55(1), ATXN2L(1), C1S(2), CRYBB2(2), DAG1(1), FUT2(1), IGF2(1), IKZF1(3), LRRK2(1) +100 more
0.277 0.554 2.10e-141 3.61e-139 ✓ sig. —
Intellectual developmental disorder, x-linked X-linked intellectual disability
63 genes
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62 of 63 corroborated by 2+ sources
SOX3(6), FGD1(2), ATRX(1), DMD(3), FRMPD4(6), SLC9A7(5), GDI1(7), GRIA3(5), OPHN1(7), CASK(6), MECP2(7), MED12(4) +51 more
0.624 0.851 2.95e-142 5.12e-140 ✓ sig. Cluster 115 →
Bone fragility with contractures, arterial rupture, and deafness Osteoporosis-pseudoglioma syndrome
49 genes
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2 of 49 corroborated by 2+ sources
ALPL(1), BMP1(1), CCDC134(1), GORAB(1), NBAS(1), SERPINF1(1), TENT5A(1), XYLT1(1), AMBN(1), SEC16B(1), COL1A1(1), SLC10A7(1) +37 more
0.980 1.000 4.28e-143 7.49e-141 ✓ sig. Cluster 68 →
Non-neoplastic peripheral nervous system disease Peripheral nervous system disease
52 genes
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52 of 52 corroborated by 2+ sources
DPYD(2), SLC12A6(2), GFAP(2), ABCA1(2), CACNA1H(2), ERCC1(2), MMP3(2), TCF4(2), GSTP1(2), ICAM1(2), IGF1(2), IGF1R(2) +40 more
0.929 0.981 1.19e-145 2.10e-143 ✓ sig. Cluster 243 →
Biliary tract cancer Hepatocellular carcinoma
111 genes
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8 of 111 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(2), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +99 more
0.169 0.941 6.28e-147 1.12e-144 ✓ sig. Cluster 67 →
Global developmental delay Intellectual developmental disorder
191 genes
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64 of 191 corroborated by 2+ sources
FOXG1(2), UBE3A(1), ANKRD11(1), KANSL1(2), BPTF(1), NFIX(1), SHANK3(2), WWOX(1), PTEN(2), ACTL6A(1), ADNP(1), VCP(1) +179 more
0.193 0.516 1.60e-148 2.87e-146 ✓ sig. Cluster 6 →
Asthma Respiratory system disease
174 genes
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22 of 174 corroborated by 2+ sources
RERE(1), CEBPA(1), RTEL1(1), RUNX1(1), ARHGAP15(1), BCL3(1), CARD11(2), CCR7(1), DOCK3(1), EMSY(1), ETS1(1), FADS1(1) +162 more
0.153 0.722 1.46e-149 2.64e-147 ✓ sig. Cluster 252 →
Breast cancer Lung cancer
272 genes
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12 of 272 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(2), PDE4D(1), SH2B3(1), CHEK2(1), RTEL1(1), TERT(1), TP53(4), TP63(1) +260 more
0.189 0.419 1.84e-150 3.35e-148 ✓ sig. Cluster 20 →

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.