Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Semilobar holoprosencephaly Syntelencephaly
15 genes
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15 of 15 corroborated by 2+ sources
FGF8(2), CDON(2), GLI2(2), SHH(2), PTCH1(2), SIX3(2), GAS1(2), ZIC2(2), DLL1(2), STIL(2), DISP1(2), CRIPTO(2) +3 more
0.789 1.000 1.66e-48 8.35e-47 ✓ sig. Cluster 96 →
Semilobar holoprosencephaly Septopreoptic holoprosencephaly
15 genes
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15 of 15 corroborated by 2+ sources
FGF8(2), CDON(2), GLI2(2), SHH(2), PTCH1(2), SIX3(2), GAS1(2), ZIC2(2), DLL1(2), STIL(2), DISP1(2), CRIPTO(2) +3 more
0.789 1.000 1.66e-48 8.35e-47 ✓ sig. Cluster 96 →
Atherosclerosis Myocardial ischemia
50 genes
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39 of 50 corroborated by 2+ sources
APOA1(2), ABCA1(2), AGT(2), APOB(2), APOC1(1), APOE(3), HDAC9(3), LDLR(3), SERPINE1(2), SMARCA4(1), TCF7L2(3), VEGFA(2) +38 more
0.108 0.420 1.65e-48 8.34e-47 ✓ sig. —
Melanoma Non-melanoma skin carcinoma
59 genes
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10 of 59 corroborated by 2+ sources
ANKRD11(1), TP53(2), ASIP(2), BNC2(1), CDH15(1), EPB41L1(1), FOXP1(1), HERC2(1), HLA-DQA1(1), HLA-DRB1(1), ICOS(1), RHOU(1) +47 more
0.108 0.349 9.69e-49 4.92e-47 ✓ sig. Cluster 29 →
Microphthalmia Microphthalmos
21 genes
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21 of 21 corroborated by 2+ sources
RARB(7), TENM3(4), SHH(5), PRSS56(3), PAX6(2), SOX2(3), STRA6(3), OTX2(3), PORCN(2), RAX(3), VAX1(4), VSX2(6) +9 more
0.389 0.583 9.45e-49 4.81e-47 ✓ sig. Cluster 56 →
Hydranencephaly Macrogyria
18 genes
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1 of 18 corroborated by 2+ sources
CASK(1), ARL3(1), NDE1(3), TMEM216(1), TMEM237(1), SEPSECS(1), KIAA0586(1), KIAA0753(1), CHMP1A(1), IFT74(1), TUBB3(1), AMPD2(1) +6 more
0.529 0.818 6.89e-49 3.52e-47 ✓ sig. Cluster 110 →
Metabolic syndrome Substance abuse
157 genes
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8 of 157 corroborated by 2+ sources
SOX5(1), BPTF(1), GBE1(1), BRWD1(1), CACNA1D(1), ADGRL2(1), AFF3(1), AHCYL1(1), AKAP6(1), ALCAM(1), ARHGAP15(1), AUTS2(1) +145 more
0.094 0.304 5.38e-49 2.75e-47 ✓ sig. Cluster 2 →
Biliary cirrhosis Liver cirrhosis
46 genes
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43 of 46 corroborated by 2+ sources
HLA-DQA1(1), NOS3(2), NFE2L2(2), RELA(2), HLA-DQB1(2), VDR(1), ALB(2), HIF1A(2), ATG5(3), TGFB1(2), HLA-DPB1(1), CLEC16A(3) +34 more
0.133 0.359 4.56e-49 2.34e-47 ✓ sig. —
Focal glomerulosclerosis Nephrotic syndrome
32 genes
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14 of 32 corroborated by 2+ sources
WT1(4), COL4A5(1), COL4A4(1), ACTN4(1), AGT(2), ARHGAP24(1), LAMB2(3), MYO1E(1), PAX2(1), PTPRO(4), SERPINE1(2), TRPC6(1) +20 more
0.167 0.561 3.76e-49 1.93e-47 ✓ sig. Cluster 30 →
Hyperlipidemia Hyperlipoproteinemia
28 genes
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24 of 28 corroborated by 2+ sources
ABCA1(3), ABCG8(2), APOB(3), APOC2(2), APOE(6), LDLR(3), LIPC(6), NOS3(2), ADRB3(2), GCG(2), HMGCR(2), HSPA1B(1) +16 more
0.182 0.700 2.52e-49 1.30e-47 ✓ sig. —
Basal cell carcinoma Melanoma
77 genes
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21 of 77 corroborated by 2+ sources
ANKRD11(1), RAI1(2), TERT(5), TP53(3), TPCN2(1), ASIP(2), BNC2(2), EPB41L1(1), FOXP1(1), HERC2(1), HLA-DQA1(1), HLA-DRB1(1) +65 more
0.112 0.235 2.38e-49 1.23e-47 ✓ sig. Cluster 29 →
Calcinosis Heart valve prolapse
21 genes
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21 of 21 corroborated by 2+ sources
NOTCH1(2), COL18A1(2), SPP1(2), CASP3(2), IL1B(2), JAK2(2), CCL2(2), COL1A1(2), TIMP1(2), FCGR1A(2), IL18(2), LCN2(2) +9 more
0.382 0.724 1.76e-49 9.13e-48 ✓ sig. Cluster 370 →
Macrogyria Microgyria
17 genes
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CASK(1), ARL3(1), TMEM216(1), TMEM237(1), SEPSECS(1), KIAA0586(1), KIAA0753(1), CHMP1A(1), IFT74(1), TUBB3(1), AMPD2(1), INPP5E(1) +5 more
0.567 1.000 1.21e-49 6.29e-48 ✓ sig. Cluster 110 →
Congenital brain malformation Macrogyria
17 genes
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CASK(1), ARL3(1), TMEM216(1), TMEM237(1), SEPSECS(1), KIAA0586(1), KIAA0753(1), CHMP1A(1), IFT74(1), TUBB3(1), AMPD2(1), INPP5E(1) +5 more
0.567 1.000 1.21e-49 6.29e-48 ✓ sig. Cluster 110 →
Congenital hypoplasia of part of brain Macrogyria
17 genes
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CASK(1), ARL3(1), TMEM216(1), TMEM237(1), SEPSECS(1), KIAA0586(1), KIAA0753(1), CHMP1A(1), IFT74(1), TUBB3(1), AMPD2(1), INPP5E(1) +5 more
0.567 1.000 1.21e-49 6.29e-48 ✓ sig. Cluster 110 →
Cardiovascular disease Myocardial ischemia
83 genes
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59 of 83 corroborated by 2+ sources
PRDM16(2), SH2B3(2), ABCG8(2), ACE(3), AGT(3), APOB(3), APOE(3), CDH13(1), DDAH1(1), HDAC9(1), KCNE2(2), LDLR(2) +71 more
0.112 0.212 1.05e-49 5.48e-48 ✓ sig. —
Atrial flutter Cardioembolic stroke
32 genes
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PRRX1(1), ESR2(1), GORAB(1), KCNN3(1), TBX5(1), TNFSF12-TNFSF13(1), CAV1(1), KCNJ5(1), AOPEP(1), FAM13B(1), FGF5(1), LRMDA(1) +20 more
0.212 0.395 1.67e-50 8.74e-49 ✓ sig. —
Autism Neurodevelopmental disorder
241 genes
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206 of 241 corroborated by 2+ sources
CHD8(4), FOXG1(2), UBE3A(2), CHRNA7(3), SIN3A(2), ANKRD11(2), RAI1(2), NFIX(2), NFIA(2), RERE(6), SPEN(2), JMJD1C(3) +229 more
0.112 0.257 1.06e-50 5.59e-49 ✓ sig. —
Hereditary steroid-resistant nephrotic syndrome Nephrotic syndrome
28 genes
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28 of 28 corroborated by 2+ sources
WT1(5), NUP107(5), COL4A3(2), ACTN4(2), ARHGAP24(2), MYO1E(2), NUP160(6), NUP85(4), PAX2(2), PTPRO(5), TRPC6(2), PLCE1(7) +16 more
0.162 0.824 9.60e-51 5.06e-49 ✓ sig. Cluster 30 →
Attention deficit hyperactivity disorder Neurotic disorder
134 genes
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10 of 134 corroborated by 2+ sources
SOX5(1), RERE(1), GBE1(1), ARHGAP15(1), AS3MT(3), BNC2(1), CADM2(1), CAMTA1(1), CELF2(1), CELF4(1), CSMD1(1), CTNNA3(1) +122 more
0.095 0.308 9.15e-51 4.83e-49 ✓ sig. Cluster 2 →
Insomnia Substance abuse
145 genes
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7 of 145 corroborated by 2+ sources
SOX5(1), BPTF(1), PER2(2), CACNA1D(1), ALMS1(1), AFF3(1), AKAP6(1), ARHGAP15(1), AUTS2(1), BNC2(1), CADM2(1), CAMTA1(1) +133 more
0.100 0.281 8.92e-51 4.73e-49 ✓ sig. Cluster 2 →
Cone dystrophy Cone-rod dystrophy
25 genes
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17 of 25 corroborated by 2+ sources
ABCA4(7), CNGA3(3), CNGB3(3), PDE6C(7), PRPH2(4), CACNA1F(2), PDE6B(1), USH2A(1), CRB1(1), GUCY2D(5), RPGRIP1(6), NMNAT1(2) +13 more
0.284 0.658 5.94e-51 3.15e-49 ✓ sig. Cluster 7 →
Atrial flutter Cardiac arrhythmia
32 genes
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5 of 32 corroborated by 2+ sources
PRRX1(1), AKAP6(1), ESR2(3), GORAB(1), KCNN3(1), MAPT(1), TBX5(1), CAV1(1), AOPEP(1), FAM13B(1), FGF5(1), LRMDA(1) +20 more
0.216 0.395 5.29e-51 2.82e-49 ✓ sig. Cluster 4 →
Alzheimer disease Schizophrenia
624 genes
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235 of 624 corroborated by 2+ sources
HMGA2(1), CHRNA7(1), HNF1B(1), KANSL1(1), NFIX(1), HSPG2(2), RERE(1), ARVCF(2), WWOX(2), ZFPM2(1), NCSTN(1), PDE4D(2) +612 more
0.151 0.281 4.24e-51 2.26e-49 ✓ sig. Cluster 2 →
Cone-rod dystrophy Macular dystrophy
26 genes
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15 of 26 corroborated by 2+ sources
ABCA4(7), ATF6(3), CNGA3(3), CNGB3(1), IMPG1(3), IMPG2(2), PRPH2(5), CACNA1F(2), PDE6B(1), USH2A(1), CRB1(1), CRX(8) +14 more
0.280 0.591 3.55e-51 1.90e-49 ✓ sig. Cluster 7 →

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.