Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Dilated cardiomyopathy Hypertrophic cardiomyopathy
94 genes
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53 of 94 corroborated by 2+ sources
ABCC9(7), ACTN2(7), BRAF(1), CACNB2(1), DMD(6), DSG2(7), FERMT2(1), FHOD3(3), GNPNAT1(1), JUP(1), MYPN(7), PKP2(2) +82 more
0.216 0.367 3.68e-102 4.37e-100 ✓ sig. Cluster 377 →
Autoimmune disease Celiac disease
79 genes
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11 of 79 corroborated by 2+ sources
SH2B3(1), ARHGAP31(1), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), CTSH(1), DAG1(1), ELMO1(1), FUT2(1), ICOS(2), IGF2(1) +67 more
0.249 0.409 6.05e-102 7.15e-100 ✓ sig. Cluster 142 →
Arthrogryposis multiplex congenita Pena-shokeir syndrome
44 genes
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2 of 44 corroborated by 2+ sources
SCN4A(1), GBE1(1), BLTP1(1), ACTA1(1), NAGA(1), ASCC1(1), PRICKLE1(1), RAPSN(1), ROR2(1), SCN8A(1), SPAG16(1), DYNC1H1(1) +32 more
0.543 0.846 8.94e-102 1.05e-99 ✓ sig. —
Diabetes mellitus type 1 Systemic lupus erythematosus
159 genes
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46 of 159 corroborated by 2+ sources
RERE(1), GATA4(1), CAT(2), NOTCH2(1), SH2B3(3), IFIH1(3), BLTP1(1), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), BANK1(4) +147 more
0.163 0.333 9.62e-102 1.12e-99 ✓ sig. Cluster 291 →
Cardiovascular disease Coronary artery disease
190 genes
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57 of 190 corroborated by 2+ sources
CASZ1(1), PRDM16(3), ZFPM2(1), SH2B3(3), ABCG8(3), ACE(3), AGT(3), ALDH1A2(1), APOB(3), APOE(3), BCAS3(1), C1GALT1(1) +178 more
0.137 0.440 1.37e-101 1.59e-99 ✓ sig. Cluster 2 →
Age-related macular degeneration Atrophic macular degeneration
46 genes
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10 of 46 corroborated by 2+ sources
CFHR1(3), CFI(4), COL4A3(1), ABCA1(1), ALDH1A2(1), APOE(3), CNN2(1), EXOC3L2(1), LIPC(1), MARK4(1), PILRA(1), TRPM1(1) +34 more
0.489 0.821 2.54e-101 2.93e-99 ✓ sig. Cluster 189 →
Peripheral nervous system disease Peripheral neuropathy
52 genes
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52 of 52 corroborated by 2+ sources
DPYD(2), SLC12A6(2), GFAP(2), ABCA1(2), CACNA1H(2), ERCC1(2), MMP3(2), TCF4(2), GSTP1(2), ICAM1(2), IGF1(2), IGF1R(2) +40 more
0.268 0.981 2.70e-101 3.10e-99 ✓ sig. Cluster 238 →
Intellectual developmental disorder Non-specific syndromic intellectual disability
154 genes
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97 of 154 corroborated by 2+ sources
CHD8(3), CHRNA7(1), PSMD12(2), HNRNPU(1), JMJD1C(1), ACTL6A(2), VCP(1), CACNA1D(1), ACTL6B(2), ANK3(5), CAMK4(1), CAPZA2(1) +142 more
0.150 0.418 5.10e-101 5.83e-99 ✓ sig. Cluster 5 →
Bladder calculus Urolithiasis
40 genes
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KANSL1(1), ALPL(1), BCAS3(1), GIPR(1), PRKAG2(1), STC1(1), VEGFA(1), SLC30A10(1), HBB(1), PDILT(1), AP1S3(1), AHR(1) +28 more
0.571 1.000 6.46e-101 7.34e-99 ✓ sig. Cluster 179 →
Astrocytoma Glioma
138 genes
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4 of 138 corroborated by 2+ sources
NF1(1), ADNP(1), HMCN1(1), TEAD1(1), AGBL1(1), ARHGEF28(1), BRAF(1), C6orf118(1), CARD11(1), CTNNA3(1), DSCAM(1), EFL1(2) +126 more
0.150 0.458 8.08e-101 9.13e-99 ✓ sig. Cluster 290 →
Gastric cancer Hepatocellular carcinoma
115 genes
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14 of 115 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(2), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CDH13(2), CELF2(1) +103 more
0.153 0.528 9.93e-101 1.12e-98 ✓ sig. Cluster 56 →
Hereditary hearing loss Nonsyndromic hearing loss
47 genes
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47 of 47 corroborated by 2+ sources
ESRRB(3), EYA4(3), MYO15A(3), OTOF(2), PCDH15(3), TMC1(4), HGF(3), RDX(2), GSDME(3), DIAPH1(3), MYO1A(2), GJB6(4) +35 more
0.385 0.940 1.77e-100 1.98e-98 ✓ sig. Cluster 26 →
Growth hormone deficiency Kallmann syndrome
34 genes
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21 of 34 corroborated by 2+ sources
FGF8(3), DUSP6(3), IL17RD(3), PROK2(4), TACR3(2), PROKR2(3), TCF12(2), GH1(1), CHD7(4), FGFR1(4), WDR11(3), SEMA3E(2) +22 more
0.872 1.000 9.56e-100 1.05e-97 ✓ sig. Cluster 36 →
Kallmann syndrome Pituitary short stature
34 genes
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21 of 34 corroborated by 2+ sources
FGF8(3), DUSP6(3), IL17RD(3), PROK2(4), TACR3(2), PROKR2(3), TCF12(2), GH1(1), CHD7(4), FGFR1(4), WDR11(3), SEMA3E(2) +22 more
0.872 1.000 9.56e-100 1.05e-97 ✓ sig. Cluster 36 →
Kallmann syndrome Sheehan syndrome
34 genes
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21 of 34 corroborated by 2+ sources
FGF8(3), DUSP6(3), IL17RD(3), PROK2(4), TACR3(2), PROKR2(3), TCF12(2), GH1(1), CHD7(4), FGFR1(4), WDR11(3), SEMA3E(2) +22 more
0.872 1.000 9.56e-100 1.05e-97 ✓ sig. Cluster 36 →
Genetic steroid-resistant nephrotic syndrome Hereditary steroid-resistant nephrotic syndrome
33 genes
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33 of 33 corroborated by 2+ sources
WT1(2), NUP107(2), COL4A3(2), ACTN4(2), ARHGAP24(2), CD2AP(2), MYO1E(2), NUP160(2), NUP85(2), PAX2(2), PTPRO(2), TRPC6(2) +21 more
0.917 0.971 6.76e-99 7.41e-97 ✓ sig. Cluster 27 →
Leber congenital amaurosis Retinitis pigmentosa
64 genes
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60 of 64 corroborated by 2+ sources
ABCA4(6), CNGB3(2), PRPH2(7), AIPL1(6), ALMS1(2), ADAMTS18(2), LRAT(6), NBAS(2), NPHP4(2), PDE6B(6), RIMS1(2), TTC8(6) +52 more
0.175 0.889 5.55e-98 6.04e-96 ✓ sig. Cluster 6 →
Autism Obsessive-compulsive disorder
152 genes
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35 of 152 corroborated by 2+ sources
SOX5(3), RAI1(3), RERE(2), COMT(2), ATP2A2(1), AKAP6(1), ASAP1(1), BANK1(1), BRAF(1), C8orf90(1), CACNB2(2), COA8(1) +140 more
0.098 0.650 6.15e-98 6.67e-96 ✓ sig. —
Autoimmune disease Diabetes mellitus type 1
100 genes
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23 of 100 corroborated by 2+ sources
SH2B3(3), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), CAMK4(1), CTSH(3), DAG1(1), ERBB3(1), FAM76B(1), FUT2(1), HLA-DQB3(1) +88 more
0.172 0.495 6.96e-98 7.50e-96 ✓ sig. —
Adenoid cystic carcinoma Salivary gland neoplasms
43 genes
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JAG1(1), BCL11A(1), FAT1(1), MARCKS(1), MARK2(1), RBFOX2(1), SERPINF1(1), KRT5(1), ST3GAL4(1), GAS6(1), DAPK1(1), ITGB4(1) +31 more
0.422 0.977 9.30e-98 9.98e-96 ✓ sig. —
Nephrolithiasis Urolithiasis
51 genes
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4 of 51 corroborated by 2+ sources
KANSL1(1), HIBADH(1), ALPL(1), BCAS3(1), GIPR(1), NBPF3(1), PRKAG2(1), SHROOM3(1), SLC26A1(5), STC1(1), VEGFA(1), WDR72(1) +39 more
0.367 0.739 1.86e-97 1.98e-95 ✓ sig. Cluster 179 →
Psoriasis Systemic lupus erythematosus
186 genes
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50 of 186 corroborated by 2+ sources
RERE(1), CAT(2), SH2B3(3), TP63(1), IFIH1(3), BLTP1(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), BANK1(4), BTNL2(1), DAG1(1) +174 more
0.155 0.284 5.29e-97 5.61e-95 ✓ sig. —
Hereditary motor and sensory neuropathies Roussy-levy syndrome
38 genes
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4 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(1), KIF1B(1), MME(1), TRPV4(3), DYNC1H1(1), FIG4(1), MFN2(4), NEFL(1) +26 more
0.567 1.000 1.41e-96 1.47e-94 ✓ sig. Cluster 14 →
Hereditary motor and sensory neuropathies Hypertrophic neuropathy
38 genes
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6 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(2), KIF1B(1), MME(1), TRPV4(3), DYNC1H1(1), FIG4(1), MFN2(4), NEFL(1) +26 more
0.567 1.000 1.41e-96 1.47e-94 ✓ sig. Cluster 14 →
Dejerine-sottas disease Hereditary motor and sensory neuropathies
38 genes
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6 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(3), KIF1B(1), MME(1), TRPV4(3), DYNC1H1(1), FIG4(1), MFN2(4), NEFL(1) +26 more
0.567 1.000 1.41e-96 1.47e-94 ✓ sig. Cluster 14 →

Showing 25 of 20918 pairs, sorted by significance (ascending). Click a column header to sort.