Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 36

17 diseases · 38 shared-gene connections
17 Diseases
281 Unique genes
0.109 Avg. similarity score
Thrombosis Most-connected disease (11 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Thrombosis 11 11 45
Venous thrombosis 11 11 22
Thrombophilia 8 8 32
Thromboembolism 7 7 12
Disseminated intravascular coagulation 6 6 9
Blood coagulation disorder 4 4 24
Hemorrhage 4 4 24
Ischemic stroke 4 4 51
Hemophilia a 3 3 16
Spontaneous coronary artery dissection 3 3 1
Thrombocytopenia 3 3 139
Thrombomodulin-related bleeding disorder 3 3 1
Cerebral hemorrhage 2 2 29
Fetal erythroblastosis 2 2 2
Hemorrhagic disease 2 2 21
MERTK-related retinopathy 2 2 1
hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
F2 9 / 17 Blood coagulation disorder, Disseminated intravascular coagulation, Hemophilia a, Hemorrhage and 5 more
PLAT 9 / 17 Cerebral hemorrhage, Hemophilia a, Hemorrhage, Ischemic stroke and 5 more
F7 8 / 17 Cerebral hemorrhage, Disseminated intravascular coagulation, Hemorrhage, Hemorrhagic disease and 4 more
PROC 7 / 17 Blood coagulation disorder, Disseminated intravascular coagulation, Ischemic stroke, Thromboembolism and 3 more
F5 6 / 17 Blood coagulation disorder, Ischemic stroke, Thromboembolism, Thrombophilia and 2 more
MTHFR 6 / 17 Blood coagulation disorder, Hemophilia a, Ischemic stroke, Thrombocytopenia and 2 more
PLAU 6 / 17 Cerebral hemorrhage, Hemorrhage, Ischemic stroke, Thromboembolism and 2 more
SERPINC1 6 / 17 Blood coagulation disorder, Cerebral hemorrhage, Disseminated intravascular coagulation, Thrombocytopenia and 2 more
THBD 6 / 17 Disseminated intravascular coagulation, Ischemic stroke, Thrombocytopenia, Thrombomodulin-related bleeding disorder and 2 more
PROS1 5 / 17 Ischemic stroke, Thrombocytopenia, Thromboembolism, Thrombophilia and 1 more
F13A1 4 / 17 Disseminated intravascular coagulation, Thrombocytopenia, Thrombophilia, Venous thrombosis
F3 4 / 17 Disseminated intravascular coagulation, Spontaneous coronary artery dissection, Thrombosis, Venous thrombosis
FCGR2A 4 / 17 Fetal erythroblastosis, Hemophilia a, Thrombocytopenia, Thrombosis
HMOX1 4 / 17 Blood coagulation disorder, Cerebral hemorrhage, Hemophilia a, Thrombosis
JAK2 4 / 17 Hemorrhagic disease, Thrombocytopenia, Thromboembolism, Venous thrombosis
TFPI 4 / 17 Disseminated intravascular coagulation, Hemophilia a, Thrombophilia, Venous thrombosis
EPO 3 / 17 Thrombocytopenia, Thrombosis, Venous thrombosis
F10 3 / 17 Blood coagulation disorder, Thrombocytopenia, Thrombosis
F8 3 / 17 Hemophilia a, Thrombophilia, Venous thrombosis
F9 3 / 17 Hemophilia a, Thrombophilia, Thrombosis
FGA 3 / 17 Thrombocytopenia, Thrombophilia, Thrombosis
FGG 3 / 17 Blood coagulation disorder, Thrombocytopenia, Thrombophilia
ITGB3 3 / 17 Cerebral hemorrhage, Hemorrhage, Thrombocytopenia
LPA 3 / 17 Thrombocytopenia, Thromboembolism, Venous thrombosis
MERTK 3 / 17 MERTK-related retinopathy, Thromboembolism, Thrombosis
P2RY12 3 / 17 Hemorrhage, Thrombocytopenia, Thrombosis
PLG 3 / 17 Thrombocytopenia, Thrombophilia, Venous thrombosis
TNF 3 / 17 Ischemic stroke, Thrombocytopenia, Thrombosis
VKORC1 3 / 17 Blood coagulation disorder, Hemorrhage, Thrombosis
VWF 3 / 17 Hemophilia a, Thrombocytopenia, Thrombosis
ABO 2 / 17 Blood coagulation disorder, Thrombophilia
ACE 2 / 17 Cerebral hemorrhage, Ischemic stroke
ACVRL1 2 / 17 Hemophilia a, Thrombocytopenia
ARHGEF3 2 / 17 Hemorrhagic disease, Thrombocytopenia
ATP1B1 2 / 17 Blood coagulation disorder, Thrombophilia
BAK1 2 / 17 Hemorrhagic disease, Thrombocytopenia
BDKRB2 2 / 17 Hemorrhage, Thrombosis
CDKN2A 2 / 17 Hemorrhagic disease, Thrombocytopenia
CSF2 2 / 17 Thrombocytopenia, Venous thrombosis
F11 2 / 17 Thrombocytopenia, Thrombophilia
FGB 2 / 17 Thrombocytopenia, Thrombophilia
GAS6 2 / 17 Thromboembolism, Thrombosis
GCSAML 2 / 17 Hemorrhagic disease, Thrombocytopenia
GGCX 2 / 17 Blood coagulation disorder, Thrombocytopenia
GP1BA 2 / 17 Thrombocytopenia, Thrombosis
GTF3C5 2 / 17 Hemorrhagic disease, Thrombocytopenia
HBS1L 2 / 17 Hemorrhagic disease, Thrombocytopenia
HLA-A 2 / 17 Ischemic stroke, Thrombocytopenia
HLA-DQA1 2 / 17 Hemophilia a, Thrombophilia
HRG 2 / 17 hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency, Thrombophilia
IL10 2 / 17 Hemophilia a, Thrombocytopenia
ITGA2B 2 / 17 Cerebral hemorrhage, Thrombocytopenia
JMJD1C 2 / 17 Hemorrhagic disease, Thrombocytopenia
KDR 2 / 17 Cerebral hemorrhage, Venous thrombosis
KLKB1 2 / 17 Thrombocytopenia, Thrombosis
MMP2 2 / 17 Cerebral hemorrhage, Ischemic stroke
MMP9 2 / 17 Cerebral hemorrhage, Ischemic stroke
NME7 2 / 17 Blood coagulation disorder, Thrombophilia
PF4 2 / 17 Thrombocytopenia, Thrombosis
PNPLA3 2 / 17 Hemorrhagic disease, Thrombocytopenia
PODXL 2 / 17 Hemorrhage, Thrombosis
POMC 2 / 17 Cerebral hemorrhage, Hemorrhage
SERPINA1 2 / 17 Hemorrhage, Hemorrhagic disease
SERPINA10 2 / 17 Thrombophilia, Venous thrombosis
SIRPA 2 / 17 Hemorrhagic disease, Thrombocytopenia
SLC19A2 2 / 17 Blood coagulation disorder, Thrombophilia
STXBP2 2 / 17 Hemorrhage, Thrombocytopenia
TBXAS1 2 / 17 Ischemic stroke, Thrombocytopenia
THADA 2 / 17 Hemorrhagic disease, Thrombocytopenia
THPO 2 / 17 Hemorrhagic disease, Thrombocytopenia
TPM4 2 / 17 Hemorrhagic disease, Thrombocytopenia
TUBB1 2 / 17 Hemorrhagic disease, Thrombocytopenia
VEGFA 2 / 17 Cerebral hemorrhage, Hemorrhage
ZNF474 2 / 17 Hemorrhagic disease, Thrombocytopenia
ZNF475 2 / 17 Hemorrhagic disease, Thrombocytopenia
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Complement and coagulation cascades
F2, F5, FGG, PROC, F10, SERPINC1, F7, PLAT, PLAU, PROS1, SERPING1, THBD
 KEGG 30 / 88 14.6× 2.24e-27 5.26e-24 ✓ sig.
Platelet degranulation
F5, FGG, ITGA2B, ITGB3, VEGFA, APP, PROS1, SERPING1, F13A1, F8, TGFB1, VWF
 Reactome 31 / 123 10.8× 9.35e-24 1.36e-20 ✓ sig.
Intrinsic Pathway of Fibrin Clot Formation
F2, PROC, F10, SERPINC1, PROS1, SERPING1, F8, F9, VWF, F11, GP1BA, GP1BB
 Reactome 16 / 23 29.7× 1.12e-21 1.17e-18 ✓ sig.
Platelet activation
ACTB, F2, FGG, GNAQ, ITGA2B, ITGB3, TBXAS1, FCGR2A, VWF, FERMT3, P2RY12, GNAS
 KEGG 29 / 126 9.8× 4.45e-21 4.31e-18 ✓ sig.
Common Pathway of Fibrin Clot Formation
F2, F5, FGG, PROC, F10, SERPINC1, PROS1, THBD, F13A1, F8, FGA, FGB
 Reactome 15 / 22 29.1× 3.50e-20 2.76e-17 ✓ sig.
Pathways in cancer
F2, GNAQ, HMOX1, BAX, BCL2, BCL2L1, CASP3, CASP8, COL4A1, COL4A2, ITGA2B, ITGAV
 KEGG 45 / 533 3.6× 4.19e-14 1.13e-11 ✓ sig.
Gamma-carboxylation of protein precursors
F2, PROC, F10, GGCX, F7, PROS1, F9, PROZ
 Reactome 8 / 9 38.0× 7.18e-13 1.61e-10 ✓ sig.
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
F2, PROC, F10, F7, PROS1, F9, PROZ, GAS6
 Reactome 8 / 9 38.0× 7.18e-13 1.61e-10 ✓ sig.
AGE-RAGE signaling pathway in diabetic complications
BAX, BCL2, CASP3, COL4A1, COL4A2, MMP2, VEGFA, THBD, TNF, F3, TGFB1, JAK2
 KEGG 19 / 101 8.0× 1.64e-12 3.45e-10 ✓ sig.
Removal of aminoterminal propeptides from gamma-carboxylated proteins
F2, PROC, F10, F7, PROS1, F9, PROZ, GAS6
 Reactome 8 / 10 34.2× 3.52e-12 6.87e-10 ✓ sig.
Integrin cell surface interactions
FGG, COL4A1, COL4A2, ITGA2B, ITGAV, ITGB3, KDR, SPP1, ITGA9, VWF, COL4A4, COL5A1
 Reactome 17 / 81 9.0× 3.90e-12 7.54e-10 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
HMOX1, BCL2, BCL2L1, MMP2, MMP3, MMP9, POMC, VEGFA, TNF, F13A1, IL10, TGFB1
 Reactome 19 / 108 7.5× 5.72e-12 1.08e-9 ✓ sig.
p130Cas linkage to MAPK signaling for integrins
FGG, ITGA2B, ITGB3, VWF, FGA, FGB, RAP1B, SRC, TLN1
 Reactome 9 / 15 25.6× 8.19e-12 1.50e-9 ✓ sig.
GRB2:SOS provides linkage to MAPK signaling for Integrins
FGG, ITGA2B, ITGB3, VWF, FGA, FGB, RAP1B, SRC, TLN1
 Reactome 9 / 15 25.6× 8.19e-12 1.50e-9 ✓ sig.
Hematopoietic cell lineage
ITGA2B, ITGB3, HLA-DRB1, TNF, HLA-DQA1, IL11, THPO, CSF2, CSF3, EPO, GP1BA, GP1BB
 KEGG 18 / 100 7.7× 1.40e-11 2.43e-9 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
blood coagulation
F2, F5, FGG, PROC, F10, GGCX, GNAQ, SERPINC1, VKORC1, F7, ITGB3, PLAT
 GO:0007596 51 / 106 32.0× 2.74e-65 1.79e-60 ✓ sig.
hemostasis
F2, F5, FGG, PROC, F10, SERPINC1, F7, PLAU, PROS1, SERPING1, THBD, F3
 GO:0007599 38 / 55 45.9× 2.24e-57 6.53e-53 ✓ sig.
fibrinolysis
F2, FGG, PLAT, PLAU, PROS1, SERPING1, FGA, FGB, GP1BA, KLKB1, PLG, F12
 GO:0042730 14 / 19 49.0× 2.38e-22 5.33e-19 ✓ sig.
platelet activation
F2, FGG, ITGB3, VWF, P2RY12, ACTN1, ADAMTS13, FGA, FGB, GP1BA, GP1BB, GP6
 GO:0030168 18 / 69 17.3× 7.76e-18 9.10e-15 ✓ sig.
platelet aggregation
ACTB, FGG, ITGB3, FERMT3, P2RY12, TUBB1, GNAS, ACTN1, FGA, FGB, FLNA, GATA1
 GO:0070527 16 / 49 21.7× 9.56e-18 1.12e-14 ✓ sig.
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F2, FLT1, KDR, VEGFA, APP, NTRK2, PARK7, PROS1, TNF, TGFB1, P2RY12, JAK2
 GO:0051897 27 / 217 8.3× 2.83e-17 3.04e-14 ✓ sig.
platelet formation
CASP3, TPM4, TUBB1, ACTN1, GATA1, MPIG6B, MPL, MYH9, NBEAL2, PTPN11, PTPRJ, WDR1
 GO:0030220 12 / 24 33.3× 2.43e-16 2.14e-13 ✓ sig.
megakaryocyte development
THPO, FLI1, FLNA, GP1BA, GP1BB, GP9, MPIG6B, PTPN11, VPS33B, MEIS1
 GO:0035855 10 / 23 28.9× 4.85e-13 2.37e-10 ✓ sig.
positive regulation of ERK1 and ERK2 cascade
FGG, ITGB3, KDR, VEGFA, APP, APOE, HLA-DRB1, NPY, TNF, TGFB1, THPO, EPO
 GO:0070374 20 / 201 6.6× 2.79e-11 9.11e-9 ✓ sig.
plasminogen activation
FGG, PLAT, PLAU, F11, FGA, FGB, KLKB1
 GO:0031639 7 / 12 38.8× 1.20e-10 3.38e-8 ✓ sig.
negative regulation of fibrinolysis
F2, PLAT, PLAU, THBD, PLG, HRG, SERPINE1
 GO:0051918 7 / 12 38.8× 1.20e-10 3.38e-8 ✓ sig.
positive regulation of platelet activation
JAK2, FLNA, GP1BA, GP1BB, GP9, PTPRJ, SELP
 GO:0010572 7 / 13 35.8× 2.56e-10 6.65e-8 ✓ sig.
blood coagulation, intrinsic pathway
F8, FLNA, GP1BA, GP1BB, GP9, F12
 GO:0007597 6 / 8 49.9× 2.99e-10 7.65e-8 ✓ sig.
angiogenesis
HMOX1, APOLD1, CASP8, COL4A1, COL4A2, FLT1, ITGA2B, ITGAV, ITGB3, KDR, MMP2, VEGFA
 GO:0001525 22 / 284 5.2× 3.73e-10 9.24e-8 ✓ sig.
blood coagulation, fibrin clot formation
FGG, ITGB3, F13A1, FGA, FGB, F13B
 GO:0072378 6 / 9 44.3× 8.87e-10 2.01e-7 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Hemorrhagic disease Thrombocytopenia 0.118 17 3.71e-32 1.29e-30 ✓ sig.
Thrombophilia Venous thrombosis 0.222 10 1.99e-22 4.46e-21 ✓ sig.
Thromboembolism Venous thrombosis 0.296 8 2.02e-21 4.30e-20 ✓ sig.
Disseminated intravascular coagulation Venous thrombosis 0.280 7 1.51e-19 2.95e-18 ✓ sig.
Blood coagulation disorder Thrombophilia 0.188 9 2.69e-19 5.18e-18 ✓ sig.
Thromboembolism Thrombosis 0.160 8 1.35e-18 2.53e-17 ✓ sig.
Thrombocytopenia Thrombosis 0.082 14 1.61e-18 3.00e-17 ✓ sig.
Thrombosis Venous thrombosis 0.133 8 8.55e-16 1.36e-14 ✓ sig.
Hemophilia a Thrombophilia 0.167 7 9.35e-16 1.48e-14 ✓ sig.
Thrombocytopenia Venous thrombosis 0.066 10 1.53e-15 2.39e-14 ✓ sig.
Ischemic stroke Thromboembolism 0.123 7 2.23e-15 3.43e-14 ✓ sig.
Thrombophilia Thrombosis 0.114 8 2.75e-14 3.95e-13 ✓ sig.
Hemorrhage Thrombosis 0.111 7 3.72e-13 4.94e-12 ✓ sig.
Blood coagulation disorder Thrombosis 0.111 7 3.72e-13 4.94e-12 ✓ sig.
Ischemic stroke Venous thrombosis 0.104 7 4.68e-13 6.17e-12 ✓ sig.
Ischemic stroke Thrombosis 0.090 8 1.60e-12 2.02e-11 ✓ sig.
Cerebral hemorrhage Hemorrhage 0.125 6 3.38e-12 4.08e-11 ✓ sig.
Disseminated intravascular coagulation Thrombophilia 0.135 5 3.50e-12 4.22e-11 ✓ sig.
Ischemic stroke Thrombophilia 0.091 7 9.00e-12 1.05e-10 ✓ sig.
Hemophilia a Venous thrombosis 0.147 5 1.58e-11 1.81e-10 ✓ sig.
Blood coagulation disorder Venous thrombosis 0.119 5 1.53e-10 1.58e-9 ✓ sig.
Cerebral hemorrhage Venous thrombosis 0.106 5 4.24e-10 4.22e-9 ✓ sig.
Hemorrhage Thromboembolism 0.121 4 2.23e-9 2.05e-8 ✓ sig.
Disseminated intravascular coagulation Thromboembolism 0.158 3 3.03e-8 2.42e-7 ✓ sig.
Hemorrhage Venous thrombosis 0.093 4 3.26e-8 2.59e-7 ✓ sig.
Blood coagulation disorder Disseminated intravascular coagulation 0.097 3 2.78e-7 1.91e-6 ✓ sig.
Hemorrhagic disease Thromboembolism 0.063 2 1.16e-4 3.90e-4 ✓ sig.
Disseminated intravascular coagulation Spontaneous coronary artery dissection 0.100 1 5.84e-4 1.14e-3 ✓ sig.
Disseminated intravascular coagulation Thrombomodulin-related bleeding disorder 0.100 1 5.84e-4 1.14e-3 ✓ sig.
MERTK-related retinopathy Thromboembolism 0.077 1 7.79e-4 1.39e-3 ✓ sig.
Spontaneous coronary artery dissection Venous thrombosis 0.043 1 1.43e-3 2.21e-3 ✓ sig.
Fetal erythroblastosis Hemophilia a 0.056 1 2.08e-3 2.95e-3 ✓ sig.
hereditary thrombophilia due to congenital histidine-rich (poly-L) glycoprotein deficiency Thrombophilia 0.030 1 2.08e-3 2.95e-3 ✓ sig.
Thrombomodulin-related bleeding disorder Thrombophilia 0.030 1 2.08e-3 2.95e-3 ✓ sig.
MERTK-related retinopathy Thrombosis 0.022 1 2.92e-3 3.87e-3 ✓ sig.
Spontaneous coronary artery dissection Thrombosis 0.022 1 2.92e-3 3.87e-3 ✓ sig.
Thrombomodulin-related bleeding disorder Thrombosis 0.022 1 2.92e-3 3.87e-3 ✓ sig.
Fetal erythroblastosis Thrombosis 0.021 1 5.84e-3 7.05e-3 ✓ sig.