Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
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Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Heart failure Stroke
87 genes
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26 of 87 corroborated by 2+ sources
CASZ1(2), SH2B3(2), ANKRD26(1), ACE(2), ALDH1A2(1), ANKRD31(1), APOB(1), APOC1(3), BAZ1B(1), BCL3(1), FADS1(1), FADS2(1) +75 more
0.123 0.269 2.62e-58 1.55e-56 ✓ sig. Cluster 6 →
Juvenile idiopathic arthritis Polyarticular juvenile idiopathic arthritis
32 genes
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8 of 32 corroborated by 2+ sources
RUNX1(1), ANKRD55(2), CLIC4(1), IL6R(1), JAZF1(1), UBE2L3(1), FAS(1), IL2(1), RUNX3(1), ATXN2(1), HLA-DQB1(2), IRF1(1) +20 more
0.120 1.000 5.86e-58 3.46e-56 ✓ sig. Cluster 316 →
Erythematosquamous dermatosis Seborrheic dermatitis
21 genes
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FOXP1(1), HERC2(1), KLK6(1), TAP2(1), RALY(1), IRF4(1), IL23R(1), IL2RA(1), TYK2(1), ZMIZ1(1), POLI(1), TYR(1) +9 more
0.538 0.955 1.70e-57 1.00e-55 ✓ sig. Cluster 162 →
Arrhythmogenic right ventricular cardiomyopathy Hypertrophic cardiomyopathy
38 genes
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31 of 38 corroborated by 2+ sources
ABCC9(1), ACTN2(3), CACNB2(1), DMD(1), DSG2(6), JUP(5), PKP2(7), PRKAG2(2), RBM20(3), TRPM4(1), DSP(5), MYH6(4) +26 more
0.140 0.731 2.07e-57 1.22e-55 ✓ sig. Cluster 3 →
Congenital hypoplasia of part of brain Microgyria
17 genes
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CASK(1), ARL3(1), TMEM216(1), TMEM237(1), SEPSECS(1), KIAA0586(1), KIAA0753(1), CHMP1A(1), IFT74(1), TUBB3(1), AMPD2(1), INPP5E(1) +5 more
0.944 1.000 2.33e-57 1.36e-55 ✓ sig. Cluster 109 →
Congenital brain malformation Congenital hypoplasia of part of brain
17 genes
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CASK(1), ARL3(1), TMEM216(1), TMEM237(1), SEPSECS(1), KIAA0586(1), KIAA0753(1), CHMP1A(1), IFT74(1), TUBB3(1), AMPD2(1), INPP5E(1) +5 more
0.944 1.000 2.33e-57 1.36e-55 ✓ sig. Cluster 109 →
Congenital brain malformation Microgyria
17 genes
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CASK(1), ARL3(1), TMEM216(1), TMEM237(1), SEPSECS(1), KIAA0586(1), KIAA0753(1), CHMP1A(1), IFT74(1), TUBB3(1), AMPD2(1), INPP5E(1) +5 more
0.944 1.000 2.33e-57 1.36e-55 ✓ sig. Cluster 109 →
Intellectual developmental disorder Intellectual disability
57 genes
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35 of 57 corroborated by 2+ sources
FOXG1(2), HDAC4(2), ANK3(5), AP4M1(3), CACNA1G(3), CRBN(5), GPT2(1), GRIN2B(4), HERC2(3), KCNN2(1), KDM5B(5), NOVA2(1) +45 more
0.069 0.750 2.57e-57 1.50e-55 ✓ sig. Cluster 5 →
Aneurysm Aortic aneurysm
24 genes
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5 of 24 corroborated by 2+ sources
FBN1(3), APOE(1), CSMD1(1), KCNH5(1), NCKAP5(1), LRP1(1), ZNF335(1), SMAD3(5), ADAMTS8(1), CAST(1), CDKN1A(1), CELSR2(1) +12 more
0.364 0.889 5.64e-57 3.27e-55 ✓ sig. Cluster 43 →
Crohn disease Eczema
105 genes
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15 of 105 corroborated by 2+ sources
CEBPA(1), IFIH1(1), BLTP1(1), ANKRD55(1), CCR7(3), CDC42SE2(1), CDH13(1), CSMD1(1), ELMO1(1), EMSY(1), ERBB3(1), ETS1(1) +93 more
0.110 0.288 2.04e-56 1.18e-54 ✓ sig. —
Cerebellar ataxia Spinocerebellar ataxia
38 genes
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32 of 38 corroborated by 2+ sources
WWOX(5), CACNA1A(6), CACNA1G(5), PEX6(2), PRDX3(4), SETX(6), ESR1(1), PDYN(6), ITPR1(7), SYT14(5), SYNE1(3), VPS13D(5) +26 more
0.210 0.365 2.79e-56 1.61e-54 ✓ sig. Cluster 77 →
Insomnia Neurotic disorder
139 genes
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SOX5(1), PAFAH1B1(1), SPI1(1), AGBL1(1), ARHGAP15(1), ARHGEF10L(1), AS3MT(1), B3GALT1(1), BNC2(1), CADM2(1), CAMTA1(1), CSMD1(1) +127 more
0.101 0.320 3.56e-56 2.05e-54 ✓ sig. Cluster 2 →
Microcephaly Primary microcephaly
28 genes
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27 of 28 corroborated by 2+ sources
LMNB1(5), CENPE(7), ZNF335(3), DPP6(2), CDK6(6), ASPM(7), CDK5RAP2(7), MCPH1(8), CIT(6), WDR62(8), CEP135(6), ANGPT2(1) +16 more
0.246 0.800 3.80e-56 2.18e-54 ✓ sig. Cluster 103 →
Congenital neurologic anomalies Intellectual developmental disorder
67 genes
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21 of 67 corroborated by 2+ sources
FOXG1(2), ANKRD11(1), WWOX(1), FGD1(1), ACTB(1), PTEN(2), ABCD1(1), ALDH18A1(1), ATRX(1), ANK3(5), AP4M1(2), ARSA(1) +55 more
0.078 0.583 8.02e-56 4.59e-54 ✓ sig. Cluster 5 →
Arrhythmogenic right ventricular cardiomyopathy Left ventricular noncompaction cardiomyopathy
25 genes
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12 of 25 corroborated by 2+ sources
ACTN2(1), CTNNA3(7), DMD(1), DSG2(6), JUP(5), PKP2(7), RBM20(1), DSP(4), MYH6(1), RYR2(3), SCN5A(3), LDB3(2) +13 more
0.379 0.658 8.23e-56 4.70e-54 ✓ sig. Cluster 3 →
Male infertility single gene azoospermia Spermatogenic failure
38 genes
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38 of 38 corroborated by 2+ sources
NR5A1(6), DMRT1(2), KLHL10(6), STAG3(5), XRCC2(6), SPAG17(6), C14orf39(5), RPL10L(5), MSH5(5), FANCM(5), TDRD9(5), DNHD1(5) +26 more
0.207 0.355 1.04e-55 5.93e-54 ✓ sig. Cluster 32 →
Diabetes mellitus Diabetic neuropathy
63 genes
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17 of 63 corroborated by 2+ sources
INS(2), CAT(2), NOTCH2(1), ANKH(1), ASIP(1), CDKAL1(2), HLA-DQA1(1), HMG20A(1), JAZF1(1), MACF1(1), MACIR(1), NRXN3(1) +51 more
0.135 0.269 4.83e-55 2.74e-53 ✓ sig. Cluster 155 →
Developmental and epileptic encephalopathy Epilepsy
57 genes
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54 of 57 corroborated by 2+ sources
FOXG1(3), UBE3A(2), GABRD(3), HNRNPU(4), WWOX(6), ATP1A2(6), ATP1A3(5), CELSR1(2), CHD2(5), CNTNAP2(3), CUX2(6), GABRA2(6) +45 more
0.144 0.259 4.92e-55 2.78e-53 ✓ sig. —
Cone-rod dystrophy Optic atrophy
38 genes
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18 of 38 corroborated by 2+ sources
ABCA4(7), CNGA3(3), CNGB3(1), PDE6C(1), PRPH2(4), CACNA1F(2), ALMS1(1), USH2A(1), CRB1(1), GUCY2D(5), PROM1(6), RPGRIP1(6) +26 more
0.174 0.514 9.09e-55 5.13e-53 ✓ sig. Cluster 7 →
Metabolic syndrome Obesity
268 genes
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73 of 268 corroborated by 2+ sources
SOX5(1), DPYD(3), RERE(1), COMT(2), INS(2), GNAT2(1), PDE4D(1), RBPJ(1), ABCA1(2), ABCG8(2), ADGRL2(1), AGAP1(1) +256 more
0.120 0.224 1.01e-54 5.67e-53 ✓ sig. Cluster 2 →
Short rib dysplasia-polydactyly syndrome Short-rib thoracic dysplasia
19 genes
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19 of 19 corroborated by 2+ sources
IFT81(5), NEK1(6), IFT43(3), IFT80(3), CEP120(4), DYNC2H1(5), DYNC2I1(7), DYNC2I2(7), DYNC2LI1(5), DYNLT2B(4), IFT140(4), IFT172(4) +7 more
0.655 0.826 1.27e-54 7.12e-53 ✓ sig. Cluster 17 →
Cardiovascular disease Myocardial infarction
103 genes
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32 of 103 corroborated by 2+ sources
PRDM16(1), ZFPM2(1), SH2B3(3), ABCG8(1), ACE(3), AGT(3), APOB(3), APOE(3), BCAS3(1), C1GALT1(1), CDH13(1), CSK(1) +91 more
0.113 0.238 2.87e-54 1.61e-52 ✓ sig. Cluster 6 →
Myositis Systemic sclerosis
33 genes
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7 of 33 corroborated by 2+ sources
DGKQ(1), HLA-DQA1(2), HLA-DRA(1), HLA-DRB1(2), TNIP1(2), NCF2(1), DRD4(1), HLA-DQB1(2), ATG5(1), IL12RB2(1), IRF5(2), PHTF1(1) +21 more
0.210 0.541 4.07e-54 2.27e-52 ✓ sig. Cluster 19 →
Jeune thoracic dystrophy Short-rib thoracic dysplasia
20 genes
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19 of 20 corroborated by 2+ sources
IFT81(5), NEK1(4), IFT43(3), IFT80(2), CEP120(3), DYNC2H1(2), DYNC2I1(4), DYNC2I2(5), DYNC2LI1(4), DYNLT2B(4), IFT140(3), IFT172(4) +8 more
0.541 0.870 4.44e-54 2.47e-52 ✓ sig. Cluster 17 →
Depression Mood disorder
66 genes
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9 of 66 corroborated by 2+ sources
COMT(1), DAO(1), DISC1(1), FOXP2(2), HTR1A(1), HTR3A(1), LSAMP(2), NTF3(1), NTRK2(1), NTRK3(1), PROK2(1), RELN(2) +54 more
0.129 0.237 1.74e-53 9.69e-52 ✓ sig. Cluster 2 →

Showing 25 of 20825 pairs, sorted by significance (ascending). Click a column header to sort.