NCKAP5 (NCK associated protein 5)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 344148
• Gene name: NCK associated protein 5
• Gene symbol: NCKAP5
• Synonyms (NCBI Gene): ERIH1, ERIH2, NAP5
• Chromosome: 2
• Chromosome location: 2q21.2

miRNA Show/Hide all (128)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020258	hsa-miR-130b-3p	Sequencing	20371350
MIRT031217	hsa-miR-19b-3p	Sequencing	20371350
MIRT667261	hsa-miR-518e-3p	HITS-CLIP	23824327
MIRT655977	hsa-miR-4475	HITS-CLIP	23824327
MIRT655976	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT655975	hsa-miR-4267	HITS-CLIP	23824327
MIRT655974	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT655973	hsa-miR-6892-5p	HITS-CLIP	23824327
MIRT655972	hsa-miR-7977	HITS-CLIP	23824327
MIRT655977	hsa-miR-4475	HITS-CLIP	23824327
MIRT655976	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT655975	hsa-miR-4267	HITS-CLIP	23824327
MIRT655974	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT655973	hsa-miR-6892-5p	HITS-CLIP	23824327
MIRT655972	hsa-miR-7977	HITS-CLIP	23824327
MIRT667261	hsa-miR-518e-3p	HITS-CLIP	23824327
MIRT655977	hsa-miR-4475	HITS-CLIP	23824327
MIRT655976	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT655975	hsa-miR-4267	HITS-CLIP	23824327
MIRT655974	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT655973	hsa-miR-6892-5p	HITS-CLIP	23824327
MIRT655972	hsa-miR-7977	HITS-CLIP	23824327
MIRT655977	hsa-miR-4475	HITS-CLIP	23824327
MIRT655976	hsa-miR-5588-3p	HITS-CLIP	23824327
MIRT655975	hsa-miR-4267	HITS-CLIP	23824327
MIRT655974	hsa-miR-3925-3p	HITS-CLIP	23824327
MIRT655973	hsa-miR-6892-5p	HITS-CLIP	23824327
MIRT655972	hsa-miR-7977	HITS-CLIP	23824327
MIRT1176496	hsa-miR-132	CLIP-seq
MIRT1176497	hsa-miR-186	CLIP-seq
MIRT1176498	hsa-miR-212	CLIP-seq
MIRT1176499	hsa-miR-29a	CLIP-seq
MIRT1176500	hsa-miR-29b	CLIP-seq
MIRT1176501	hsa-miR-29c	CLIP-seq
MIRT1176502	hsa-miR-3609	CLIP-seq
MIRT1176503	hsa-miR-3674	CLIP-seq
MIRT1176504	hsa-miR-4775	CLIP-seq
MIRT1176505	hsa-miR-518a-5p	CLIP-seq
MIRT1176506	hsa-miR-527	CLIP-seq
MIRT1176507	hsa-miR-548ah	CLIP-seq
MIRT1176508	hsa-miR-548n	CLIP-seq
MIRT1176509	hsa-miR-548t	CLIP-seq
MIRT1176510	hsa-miR-590-3p	CLIP-seq
MIRT1176511	hsa-miR-767-5p	CLIP-seq
MIRT1176512	hsa-miR-1236	CLIP-seq
MIRT1176513	hsa-miR-3613-3p	CLIP-seq
MIRT1176514	hsa-miR-4282	CLIP-seq
MIRT1176515	hsa-miR-4753-3p	CLIP-seq
MIRT1176516	hsa-miR-4768-5p	CLIP-seq
MIRT1176517	hsa-miR-656	CLIP-seq
MIRT2051113	hsa-miR-142-5p	CLIP-seq
MIRT1176497	hsa-miR-186	CLIP-seq
MIRT2051114	hsa-miR-3133	CLIP-seq
MIRT2051115	hsa-miR-340	CLIP-seq
MIRT2051116	hsa-miR-34b	CLIP-seq
MIRT2051117	hsa-miR-4259	CLIP-seq
MIRT2051118	hsa-miR-4261	CLIP-seq
MIRT2051119	hsa-miR-4425	CLIP-seq
MIRT2051120	hsa-miR-4436a	CLIP-seq
MIRT2051121	hsa-miR-4496	CLIP-seq
MIRT2051122	hsa-miR-450b-3p	CLIP-seq
MIRT2051123	hsa-miR-4719	CLIP-seq
MIRT2051124	hsa-miR-4729	CLIP-seq
MIRT2051125	hsa-miR-487a	CLIP-seq
MIRT2051126	hsa-miR-513b	CLIP-seq
MIRT2051127	hsa-miR-548ae	CLIP-seq
MIRT2051128	hsa-miR-548aj	CLIP-seq
MIRT2051129	hsa-miR-548am	CLIP-seq
MIRT2051130	hsa-miR-548x	CLIP-seq
MIRT2051131	hsa-miR-579	CLIP-seq
MIRT2051132	hsa-miR-769-3p	CLIP-seq
MIRT2051133	hsa-miR-888	CLIP-seq
MIRT2578707	hsa-miR-1270	CLIP-seq
MIRT2578708	hsa-miR-1273f	CLIP-seq
MIRT2051113	hsa-miR-142-5p	CLIP-seq
MIRT2578709	hsa-miR-143	CLIP-seq
MIRT1176497	hsa-miR-186	CLIP-seq
MIRT2578710	hsa-miR-216b	CLIP-seq
MIRT2578711	hsa-miR-3117-5p	CLIP-seq
MIRT2578712	hsa-miR-3128	CLIP-seq
MIRT2051114	hsa-miR-3133	CLIP-seq
MIRT2578713	hsa-miR-3140-5p	CLIP-seq
MIRT2578714	hsa-miR-3150b-3p	CLIP-seq
MIRT2578715	hsa-miR-3200-5p	CLIP-seq
MIRT2578716	hsa-miR-326	CLIP-seq
MIRT2578717	hsa-miR-330-5p	CLIP-seq
MIRT2051115	hsa-miR-340	CLIP-seq
MIRT2051116	hsa-miR-34b	CLIP-seq
MIRT2578718	hsa-miR-3618	CLIP-seq
MIRT2578719	hsa-miR-3622a-3p	CLIP-seq
MIRT2578720	hsa-miR-3622b-3p	CLIP-seq
MIRT2578721	hsa-miR-3646	CLIP-seq
MIRT2578722	hsa-miR-3662	CLIP-seq
MIRT2578723	hsa-miR-3691-3p	CLIP-seq
MIRT2578724	hsa-miR-382	CLIP-seq
MIRT2578725	hsa-miR-3914	CLIP-seq
MIRT2578726	hsa-miR-3928	CLIP-seq
MIRT2578727	hsa-miR-4461	CLIP-seq
MIRT2578728	hsa-miR-4534	CLIP-seq
MIRT2578729	hsa-miR-4650-5p	CLIP-seq
MIRT2578730	hsa-miR-4683	CLIP-seq
MIRT2578731	hsa-miR-4689	CLIP-seq
MIRT2578732	hsa-miR-4704-5p	CLIP-seq
MIRT2578733	hsa-miR-4708-5p	CLIP-seq
MIRT2578734	hsa-miR-4720-5p	CLIP-seq
MIRT2578735	hsa-miR-4766-5p	CLIP-seq
MIRT2578736	hsa-miR-4770	CLIP-seq
MIRT2578737	hsa-miR-4784	CLIP-seq
MIRT2578738	hsa-miR-4799-3p	CLIP-seq
MIRT2051125	hsa-miR-487a	CLIP-seq
MIRT2578739	hsa-miR-556-3p	CLIP-seq
MIRT2578740	hsa-miR-587	CLIP-seq
MIRT2578741	hsa-miR-620	CLIP-seq
MIRT2578742	hsa-miR-758	CLIP-seq
MIRT2051133	hsa-miR-888	CLIP-seq
MIRT2578743	hsa-miR-891a	CLIP-seq
MIRT2578744	hsa-miR-934	CLIP-seq
MIRT2578710	hsa-miR-216b	CLIP-seq
MIRT2578711	hsa-miR-3117-5p	CLIP-seq
MIRT2578712	hsa-miR-3128	CLIP-seq
MIRT2578713	hsa-miR-3140-5p	CLIP-seq
MIRT2578716	hsa-miR-326	CLIP-seq
MIRT2578717	hsa-miR-330-5p	CLIP-seq
MIRT2578719	hsa-miR-3622a-3p	CLIP-seq
MIRT2578720	hsa-miR-3622b-3p	CLIP-seq
MIRT2578734	hsa-miR-4720-5p	CLIP-seq
MIRT2578738	hsa-miR-4799-3p	CLIP-seq
MIRT2578739	hsa-miR-556-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001578	Process	Microtubule bundle formation	IBA
GO:0005515	Function	Protein binding	IPI	17474147, 33961781
GO:0007019	Process	Microtubule depolymerization	IBA
GO:0035371	Component	Microtubule plus-end	IBA

Other IDs

• MIM: 608789
• HGNC: 29847
• e!Ensembl: ENSG00000176771

Protein

• UniProt ID: O14513
• Protein name: Nck-associated protein 5 (NAP-5) (Peripheral clock protein)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15246	NCKAP5	1468 → 1776	Nck-associated protein 5, Peripheral clock protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in fetal and adult brain, leukocytes and fetal fibroblasts.
• Sequence:

  MEGKRQLEKRDFGKRLSLDSSLVEYMDSNKYIEHLLTQLEEQHRSLWREKLAVARLQREV
  AQRTSEGAMHEKLIHELEEERHLRLQSEKRLQEVTLESERNRIQMRSLQQQFSRMEETVR
  NLLQSQGSPEQKKEETVNIMVYQEKLSEEERKHKEALEDLHMVVDEDSRSESSSTDEGKE
  KTKLLLERLKALEAENSALALENENQREQYERCLDEVANQVVQALLTQKDLREECVKLKT
  RVFDLEQQNRTLSILFQQRVRPTSDLLLQKLHSRLLDLSSGDLLSEVERNRSLTQSRTDA
  EVHEHQLNTKSALKCPGLGAVIPGHLCPRNSYSSSSELSLSSTCSEYSSGSSYTWHDGKN
  LRKRQSSQNWDKRLSIDSSLPSGFASPTNELPPTRIKESHILEGLRKLQKRKVLLEPPSV
  ITKWGYKDCMNSNEGIYSPGIKSSSLKEYPPCKTADLGSPCKEPHKTFVYDLDSHVDADD
  DPSTLALLQAVPNQSCRPHGSKLTHSVSDSLFGWETNRKHFLEGTSSVYPKERPEKLTSC
  ASSCPLEMKLCPSVQTPQVQRERGPQGQGHGRMALNLQLSDTDDNETFDELHIESSDEKS
  PSDVSLAADTDKSVENLDVLVGFGKSLCGSPEEEEKQVPIPSETRPKTFSFIKQQRVVKR
  TSSEECVTVIFDAEDGEPIEFSSHQTGVVTVTRNEISINSTPAGPKAEHTELLPQGIACL
  QPRAAARDYTFFKRSEEDTEKNIPKDNVDNVPRVSTESFSSRTVTQNPQQQKLVKPTHNI
  SCQSNSRSSAPMGIYQKQNLTKIPPRGKSSPQKSKLMEPEATTLLPSSGLVTLEKSPALA
  PGKLSRFMKTESSGPLFELRSDPHIPKHSAQLPHSSRMPSRRDWVQCPKSQTPGSRSRPA
  IESSDSGEPPTRDEHCGSGPEAGVKSPSPPPPPGRSVSLLARPSYDYSPAPSSTKSETRV
  PSETARTPFKSPLLKGISAPVISSNPATTEVQRKKPSVAFKKPIFTHPMPSPEAVIQTRC
  PAHAPSSSFTVMALGPPKVSPKRGVPKTSPRQTLGTPQRDIGLQTPRISPSTHEPLEMTS
  SKSVSPGRKGQLNDSASTPPKPSFLGVNESPSSQVSSSSSSSSPAKSHNSPHGCQSAHEK
  GLKTRLPVGLKVLMKSPQLLRKSSTVPGKHEKDSLNEASKSSVAVNKSKPEDSKNPASME
  ITAGERNVTLPDSQAQGSLADGLPLETALQEPLESSIPGSDGRDGVDNRSMRRSLSSSKP
  HLKPALGMNGAKARSHSFSTHSGDKPSTPPIEGSGKVRTQIITNTAERGNSLTRQNSSTE
  SSPNKAPSAPMLESLPSVGRPSGHPSSGKGSLGSSGSFSSQHGSPSKLPLRIPPKSEGLL
  IPPGKEDQQAFTQGECPSANVAVLGEPGSDRRSCPPTPTDCPEALQSPGRTQHPSTFETS
  STSKLETSGRHPDASATATDAVSSEAPLSPTIEEKVMLCIQENVEKGQVQTKPTSVEAKQ
  KPGPSFASWFGFRKSRLPALSSRKMDISKTKVEKKDAKVLGFGNRQLKSERKKEKKKPEL
  QCETENELIKDTKSADNPDGGLQSKNNRRTPQDIYNQLKIEPRNRHSPVACSTKDTFMTE
  LLNRVDKKAAPQTESGSSNASCRNVLKGSSQGSCLIGSSISTQGNHKKNMKIKADMEVPK
  DSLVKEANENLQEDEDDAVADSVFQSHIIESNCQMRTLDSGIGTFPLPDSGNRSTGRYLC
  QPDSPEDAEPLLPLQSALSAVSSMRAQTLEREVPSSTDGQRPADSAIVHSTSDPIMTARG
  MRPLQSRLPKPASSGKVSSQKQNEAEPRPQTCSSFGYAEDPMASQPLPDWGSEVAATGTQ
  DKAPRMCTYSASGGSNSDSDLDYGDNGFGAGRGQLVKALKSAAPEIETT

• Sequence length: 1909

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (28)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	25649651, 39998322	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANEURYSM	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AORTIC ANEURYSM	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	32439431	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	18821565	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	20889312	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BLADDER EXSTROPHY	—	GWAS catalog	25763902	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTROPHIC CARDIOMYOPATHY	—	GWAS catalog	33495597	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALE INFERTILITY	—	GWAS catalog	40229599	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL OR BEHAVIOURAL DISORDER	—	GWAS catalog	20889312	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	39349817	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	19010793, 23412934	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN FAILURE, PREMATURE	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PELVIC ORGAN PROLAPSE	—	GWAS catalog	37040585	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	38538606	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	38538606	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	20889312	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SELECTIVE IGA DEFICIENCY DISEASE	—	GWAS catalog	27723758	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYMPTOMS OF DEPRESSION	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	39349817	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UPPER AERODIGESTIVE TRACT NEOPLASM	—	GWAS catalog	33667223	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VITREOUS BODY DISEASE	—	GWAS catalog	37601966	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (9)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Bipolar Disorder	Bipolar disorder	Pubtator	19488044, 32066727	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Depressive Disorder	Major depressive disorder	Pubtator	22628180	Associate	★☆☆☆☆ Found in Text Mining only
Hypersomnia	Hypersomnia	GWASCAT_DG	23646285		★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	GWASCAT_DG	20889312		★☆☆☆☆ Found in Text Mining only
Mental disorders	Mental Disorders	GWASDB_DG	20889312		★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	GWASDB_DG	20889312		★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	GWASCAT_DG	20889312		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	32066727	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Stomach Neoplasms	Stomach neoplasms	Pubtator	36484990	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

GDF7 3 shared diseasesAneurysm, Aortic aneurysm, Pelvic organ prolapse 3 shared evidence sourcesGWAS catalog (Aneurysm), GWAS catalog (Aortic aneurysm), GWAS catalog (Pelvic organ prolapse) Related via 3 shared diseases including Aneurysm, Aortic aneurysm — evidence mostly GWAS catalog. CHST1 2 shared diseasesHypertrophic cardiomyopathy, Pelvic organ prolapse 2 shared evidence sourcesGWAS catalog (Hypertrophic cardiomyopathy), GWAS catalog (Pelvic organ prolapse) Related via 2 shared diseases including Hypertrophic cardiomyopathy, Pelvic organ prolapse — evidence mostly GWAS catalog. HEATR1 2 shared diseasesHypertrophic cardiomyopathy, Upper aerodigestive tract neoplasm 2 shared evidence sourcesGWAS catalog (Hypertrophic cardiomyopathy), GWAS catalog (Upper aerodigestive tract neoplasm) Related via 2 shared diseases including Hypertrophic cardiomyopathy, Upper aerodigestive tract neoplasm — evidence mostly GWAS catalog. WDR59 2 shared diseasesPelvic organ prolapse, Upper aerodigestive tract neoplasm 2 shared evidence sourcesGWAS catalog (Pelvic organ prolapse), GWAS catalog (Upper aerodigestive tract neoplasm) Related via 2 shared diseases including Pelvic organ prolapse, Upper aerodigestive tract neoplasm — evidence mostly GWAS catalog. STRN 2 shared diseasesHypertrophic cardiomyopathy, Upper aerodigestive tract neoplasm 2 shared evidence sourcesGWAS catalog (Hypertrophic cardiomyopathy), GWAS catalog (Upper aerodigestive tract neoplasm) Related via 2 shared diseases including Hypertrophic cardiomyopathy, Upper aerodigestive tract neoplasm — evidence mostly GWAS catalog.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
GDF7	3	["Aneurysm","Aortic aneurysm","Pelvic organ prolapse"]	0	[]	3	["GWAS catalog (Aneurysm)","GWAS catalog (Aortic aneurysm)","GWAS catalog (Pelvic organ prolapse)"]
CHST1	2	["Hypertrophic cardiomyopathy","Pelvic organ prolapse"]	0	[]	2	["GWAS catalog (Hypertrophic cardiomyopathy)","GWAS catalog (Pelvic organ prolapse)"]
HEATR1	2	["Hypertrophic cardiomyopathy","Upper aerodigestive tract neoplasm"]	0	[]	2	["GWAS catalog (Hypertrophic cardiomyopathy)","GWAS catalog (Upper aerodigestive tract neoplasm)"]
WDR59	2	["Pelvic organ prolapse","Upper aerodigestive tract neoplasm"]	0	[]	2	["GWAS catalog (Pelvic organ prolapse)","GWAS catalog (Upper aerodigestive tract neoplasm)"]
STRN	2	["Hypertrophic cardiomyopathy","Upper aerodigestive tract neoplasm"]	0	[]	2	["GWAS catalog (Hypertrophic cardiomyopathy)","GWAS catalog (Upper aerodigestive tract neoplasm)"]

Diseases Linked via Similar Genes

Obesity Linked via 2 of 5 related genesCHST1, WDR59 Barrett esophagus Linked via 1 of 5 related genesGDF7 Diverticular disease Linked via 1 of 5 related genesGDF7 Esophageal adenocarcinoma Linked via 1 of 5 related genesGDF7 Hemorrhoid Linked via 1 of 5 related genesGDF7

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Obesity	2	["CHST1","WDR59"]
Barrett esophagus	1	["GDF7"]
Diverticular disease	1	["GDF7"]
Esophageal adenocarcinoma	1	["GDF7"]
Hemorrhoid	1	["GDF7"]