Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
complex neurodevelopmental disorder Non-specific syndromic intellectual disability
105 genes
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105 of 105 corroborated by 2+ sources
CHD8(2), GABRD(2), HNRNPU(2), CACNA1D(2), CHD2(2), CNTNAP2(2), CUL3(3), DLGAP2(2), EPB41L1(2), GIGYF1(2), GNB2(3), GRIA1(2) +93 more
0.275 0.890 2.96e-161 6.13e-159 ✓ sig. Cluster 5 →
Inflammatory bowel disease Psoriasis
248 genes
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39 of 248 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(3), BLTP1(1), ABT1(1), ANKRD55(1), ATXN2L(1), BANK1(2), BSN(1), BTNL2(1), CDKAL1(1), ELL(1) +236 more
0.211 0.359 7.22e-161 1.48e-158 ✓ sig. Cluster 74 →
Autism Schizophrenia
652 genes
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347 of 652 corroborated by 2+ sources
SOX5(3), CHRNA7(2), RAI1(3), KANSL1(1), NFIX(1), DPYD(3), RERE(2), COMT(3), SHANK3(4), HDAC4(2), SRD5A2(1), WWOX(2) +640 more
0.194 0.446 2.32e-159 4.71e-157 ✓ sig. Cluster 2 →
Deafness nonsyndromic genetic hearing loss
79 genes
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79 of 79 corroborated by 2+ sources
CEACAM16(4), ESRRB(4), EYA4(4), GIPC3(4), GRAP(3), MYO15A(4), NARS2(3), OTOF(4), OTOGL(4), PCDH15(4), MCM2(4), OTOG(4) +67 more
0.449 0.963 3.04e-159 6.11e-157 ✓ sig. Cluster 26 →
Hearing loss Isolated sensorineural deafness
105 genes
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88 of 105 corroborated by 2+ sources
CEACAM16(3), CLIC5(2), COL11A1(3), ESRRB(2), EYA4(2), GIPC3(2), GRAP(4), LMX1A(4), MYO15A(2), NARS2(4), OTOF(2), OTOGL(2) +93 more
0.261 0.882 1.18e-157 2.35e-155 ✓ sig. Cluster 26 →
Anorexia nervosa Attention deficit hyperactivity disorder
183 genes
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3 of 183 corroborated by 2+ sources
SOX5(1), HMGA2(1), RERE(1), ATP2A2(1), ALMS1(1), AKAP6(2), BANK1(1), BCL11A(1), BRAF(1), BSN(1), C8orf90(1), CACNB2(1) +171 more
0.156 0.729 5.68e-156 1.12e-153 ✓ sig. —
Non-organic psychosis Psychotic disorders
69 genes
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TBX1(1), ANK3(1), CD34(1), GCH1(1), NPAS3(1), PCNT(1), PDE10A(1), SOBP(1), TCF4(1), WWC1(1), GSTP1(1), LEP(1) +57 more
0.548 1.000 3.58e-155 7.00e-153 ✓ sig. —
Breast cancer Prostate cancer
330 genes
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31 of 330 corroborated by 2+ sources
ANKRD11(1), HNF1B(2), KANSL1(1), RREB1(1), TBX1(1), MAP3K1(2), SH2B3(1), CHEK2(5), RTEL1(1), TERT(1), TP53(4), TPCN2(1) +318 more
0.194 0.343 1.23e-153 2.39e-151 ✓ sig. Cluster 17 →
nonsyndromic genetic hearing loss Nonsyndromic hearing loss
72 genes
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72 of 72 corroborated by 2+ sources
CEACAM16(4), ESRRB(4), EYA4(4), GIPC3(3), MYO15A(4), OTOF(2), OTOGL(2), PCDH15(4), MCM2(4), OTOG(4), TMC1(5), HGF(4) +60 more
0.558 0.878 6.64e-153 1.27e-150 ✓ sig. Cluster 26 →
Attention deficit hyperactivity disorder Major depressive disorder
474 genes
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83 of 474 corroborated by 2+ sources
SOX5(1), BPTF(1), RERE(1), COMT(2), HDAC4(2), MCM9(1), ZFPM2(1), ATP2A2(2), CDK10(1), ADAMTS2(1), ADARB1(1), ADCYAP1R1(1) +462 more
0.183 0.429 3.77e-152 7.17e-150 ✓ sig. Cluster 2 →
Cervical cancer Gastric cancer
110 genes
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1 of 110 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), ATXN7L1(1), BAD(1), BNC2(1), CELF2(1) +98 more
0.327 0.505 5.68e-152 1.07e-149 ✓ sig. Cluster 56 →
Gastric cancer Pancreatic cancer
113 genes
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5 of 113 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(4), ARHGEF10L(1), ASB3(1), ASIP(1), BAD(1), BNC2(1), CELF2(1) +101 more
0.317 0.518 8.85e-152 1.65e-149 ✓ sig. Cluster 56 →
Breast cancer Lung cancer
273 genes
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12 of 273 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(2), PDE4D(1), SH2B3(1), CHEK2(1), RTEL1(1), TERT(1), TP53(4), TP63(1) +261 more
0.189 0.421 1.88e-151 3.49e-149 ✓ sig. Cluster 17 →
Ankylosing spondylitis Inflammatory bowel disease
171 genes
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26 of 171 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ANKRD55(1), ATXN2L(1), BANK1(1), BSN(1), CDKAL1(1), EMSY(1), ETS1(1), FIBP(1), FUT2(1) +159 more
0.205 0.546 8.80e-151 1.61e-148 ✓ sig. Cluster 74 →
Asthma Respiratory system disease
174 genes
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22 of 174 corroborated by 2+ sources
RERE(1), CEBPA(1), RTEL1(1), RUNX1(1), ARHGAP15(1), BCL3(1), CARD11(2), CCR7(1), DOCK3(1), EMSY(1), ETS1(1), FADS1(1) +162 more
0.153 0.722 1.46e-149 2.66e-147 ✓ sig. Cluster 391 →
Global developmental delay Intellectual developmental disorder
191 genes
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64 of 191 corroborated by 2+ sources
FOXG1(2), UBE3A(1), ANKRD11(1), KANSL1(2), BPTF(1), NFIX(1), SHANK3(2), WWOX(1), PTEN(2), ACTL6A(1), ADNP(1), VCP(1) +179 more
0.193 0.516 1.60e-148 2.88e-146 ✓ sig. Cluster 5 →
Biliary tract cancer Hepatocellular carcinoma
111 genes
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8 of 111 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(2), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +99 more
0.169 0.941 6.28e-147 1.12e-144 ✓ sig. Cluster 56 →
Non-neoplastic peripheral nervous system disease Peripheral nervous system disease
52 genes
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52 of 52 corroborated by 2+ sources
DPYD(2), SLC12A6(2), GFAP(2), ABCA1(2), CACNA1H(2), ERCC1(2), MMP3(2), TCF4(2), GSTP1(2), ICAM1(2), IGF1(2), IGF1R(2) +40 more
0.929 0.981 1.19e-145 2.11e-143 ✓ sig. Cluster 238 →
Bone fragility with contractures, arterial rupture, and deafness Osteoporosis-pseudoglioma syndrome
49 genes
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2 of 49 corroborated by 2+ sources
ALPL(1), BMP1(1), CCDC134(1), GORAB(1), NBAS(1), SERPINF1(1), TENT5A(1), XYLT1(1), AMBN(1), SEC16B(1), COL1A1(1), SLC10A7(1) +37 more
0.980 1.000 4.28e-143 7.53e-141 ✓ sig. Cluster 117 →
Intellectual developmental disorder, x-linked X-linked intellectual disability
63 genes
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62 of 63 corroborated by 2+ sources
SOX3(6), FGD1(2), ATRX(1), DMD(3), FRMPD4(6), SLC9A7(5), GDI1(7), GRIA3(5), OPHN1(7), CASK(6), MECP2(7), MED12(4) +51 more
0.624 0.851 2.95e-142 5.15e-140 ✓ sig. Cluster 119 →
Ankylosing spondylitis Autoimmune disease
112 genes
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52 of 112 corroborated by 2+ sources
SH2B3(1), ADGRL2(1), AICDA(2), ANKRD55(1), ATXN2L(1), C1S(2), CRYBB2(2), DAG1(1), FUT2(1), IGF2(1), IKZF1(3), LRRK2(1) +100 more
0.277 0.554 2.10e-141 3.63e-139 ✓ sig. —
Colorectal cancer Lung cancer
254 genes
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10 of 254 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), CHEK2(2), RTEL1(1), TERT(1), ADAR(1), TP53(3), ADCY8(1) +242 more
0.185 0.391 3.99e-141 6.84e-139 ✓ sig. Cluster 17 →
Rheumatoid arthritis Systemic lupus erythematosus
216 genes
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84 of 216 corroborated by 2+ sources
CAT(2), SH2B3(3), TP63(1), TPCN2(1), BLTP1(1), AFF3(3), ANKRD55(3), BTNL2(2), DDX6(3), DGKQ(1), ESR2(1), ETS1(4) +204 more
0.196 0.330 1.66e-139 2.83e-137 ✓ sig. Cluster 291 →
Dermatologic disorder Skin disease
68 genes
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66 of 68 corroborated by 2+ sources
PTEN(2), SCD(1), CCRL2(2), ERCC2(2), INPP5A(3), PDE4B(2), GSTO1(2), HSPA1B(2), IL10(1), IL1A(2), IL1B(2), MTHFR(2) +56 more
0.382 1.000 5.03e-139 8.49e-137 ✓ sig. Cluster 25 →
Hearing loss Nonsyndromic hearing loss
97 genes
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95 of 97 corroborated by 2+ sources
CEACAM16(3), CLIC5(4), COL11A1(4), ESRRB(3), EYA4(4), GIPC3(3), LMX1A(6), MYO15A(4), OTOF(2), OTOGL(2), PCDH15(5), THOC1(3) +85 more
0.237 0.822 1.09e-138 1.83e-136 ✓ sig. Cluster 26 →

Showing 25 of 20918 pairs, sorted by significance (ascending). Click a column header to sort.