Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 57
15
Diseases
235
Unique genes
0.085
Avg. similarity score
Hereditary steroid-resistant nephrotic syndrome
Most-connected disease (12 links)
Disease
Searched: Keratolytic winter erythema
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Keratolytic winter erythema
Hereditary steroid-resistant nephrotic syndrome
Idiopathic steroid-resistant nephrotic syndrome
Nephrotic syndrome
Focal glomerulosclerosis
Focal segmental glomerulosclerosis
Nephrotic syndrome, type 12
Proteinuria
Charcot-Marie-Tooth disease dominant intermediate E
Congenital nephrotic syndrome
Nephrotic syndrome, type 13
Nephrotic syndrome, type 19
Nephrotic syndrome, type 20
Nephrotic syndrome, type 8
Nephrotic syndrome, type 3
Member diseases (most connected first ‐ the cluster's core)
| Disease ⇵ | Connections in cluster ⇵ | Significant partners ⇵ | Curated genes ⇵ |
|---|---|---|---|
| Hereditary steroid-resistant nephrotic syndrome | 12 | 12 | 35 |
| Idiopathic steroid-resistant nephrotic syndrome | 12 | 12 | 29 |
| Nephrotic syndrome | 10 | 10 | 169 |
| Focal glomerulosclerosis | 6 | 6 | 57 |
| Focal segmental glomerulosclerosis | 5 | 5 | 33 |
| Nephrotic syndrome, type 12 | 4 | 4 | 1 |
| Proteinuria | 4 | 4 | 47 |
| Charcot-Marie-Tooth disease dominant intermediate E | 3 | 3 | 1 |
| Congenital nephrotic syndrome | 3 | 3 | 1 |
| Nephrotic syndrome, type 13 | 3 | 3 | 1 |
| Nephrotic syndrome, type 19 | 3 | 3 | 1 |
| Nephrotic syndrome, type 20 | 3 | 3 | 1 |
| Nephrotic syndrome, type 8 | 3 | 3 | 1 |
| Nephrotic syndrome, type 3 | 2 | 2 | 1 |
| Keratolytic winter erythema | 1 | 1 | 1 |
Top shared genes (genes linked to 2+ member diseases)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| INF2 | 7 / 15 | Charcot-Marie-Tooth disease dominant intermediate E, Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome and 3 more |
| NPHS1 | 6 / 15 | Congenital nephrotic syndrome, Focal glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 2 more |
| TRPC6 | 6 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 2 more |
| ACTN4 | 5 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 1 more |
| ANLN | 5 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 1 more |
| ARHGAP24 | 5 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 1 more |
| MYO1E | 5 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 1 more |
| NUP93 | 5 / 15 | Focal glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome and 1 more |
| PAX2 | 5 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome and 1 more |
| PLCE1 | 5 / 15 | Focal glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome and 1 more |
| ARHGDIA | 4 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome, Nephrotic syndrome, type 8 |
| CD2AP | 4 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome |
| COL4A5 | 4 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Nephrotic syndrome, Proteinuria |
| COQ8B | 4 / 15 | Focal glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| CRB2 | 4 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome |
| NPHS2 | 4 / 15 | Focal glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| NUP107 | 4 / 15 | Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| NUP160 | 4 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome, Nephrotic syndrome, type 19 |
| NUP205 | 4 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome, Nephrotic syndrome, type 13 |
| PTPRO | 4 / 15 | Focal glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| TBC1D8B | 4 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome, Nephrotic syndrome, type 20 |
| WT1 | 4 / 15 | Focal glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| AGT | 3 / 15 | Focal glomerulosclerosis, Nephrotic syndrome, Proteinuria |
| APOL1 | 3 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome |
| COL4A3 | 3 / 15 | Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome, Proteinuria |
| EMP2 | 3 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| FAT1 | 3 / 15 | Focal segmental glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| LAMA5 | 3 / 15 | Focal glomerulosclerosis, Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| LMX1B | 3 / 15 | Focal segmental glomerulosclerosis, Nephrotic syndrome, Proteinuria |
| MAGI2 | 3 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| NUP133 | 3 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| NUP85 | 3 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| TGFB1 | 3 / 15 | Focal glomerulosclerosis, Nephrotic syndrome, Proteinuria |
| TRIM8 | 3 / 15 | Focal glomerulosclerosis, Focal segmental glomerulosclerosis, Nephrotic syndrome |
| ALB | 2 / 15 | Nephrotic syndrome, Proteinuria |
| ANKFY1 | 2 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome |
| AVIL | 2 / 15 | Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| AXDND1 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| CLCN5 | 2 / 15 | Nephrotic syndrome, Proteinuria |
| COL4A1 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| COL4A4 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| COQ2 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| CTSB | 2 / 15 | Keratolytic winter erythema, Proteinuria |
| CUBN | 2 / 15 | Focal glomerulosclerosis, Proteinuria |
| DAAM2 | 2 / 15 | Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| EDN1 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| FN1 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| GAPVD1 | 2 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome |
| HAVCR1 | 2 / 15 | Focal glomerulosclerosis, Proteinuria |
| HLA-DQA1 | 2 / 15 | Nephrotic syndrome, Proteinuria |
| HLA-DRB1 | 2 / 15 | Nephrotic syndrome, Proteinuria |
| IL1RN | 2 / 15 | Nephrotic syndrome, Proteinuria |
| ITGB4 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| KANK2 | 2 / 15 | Hereditary steroid-resistant nephrotic syndrome, Nephrotic syndrome |
| KIRREL2 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| LAMB2 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| MPV17 | 2 / 15 | Focal glomerulosclerosis, Proteinuria |
| MUC16 | 2 / 15 | Nephrotic syndrome, Proteinuria |
| MYH9 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| NCK1 | 2 / 15 | Nephrotic syndrome, Proteinuria |
| NCK2 | 2 / 15 | Nephrotic syndrome, Proteinuria |
| NOC3L | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| NUP37 | 2 / 15 | Hereditary steroid-resistant nephrotic syndrome, Idiopathic steroid-resistant nephrotic syndrome |
| PDSS2 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| RCAN1 | 2 / 15 | Focal segmental glomerulosclerosis, Nephrotic syndrome |
| REN | 2 / 15 | Nephrotic syndrome, Proteinuria |
| SERPINE1 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| SGPL1 | 2 / 15 | Focal segmental glomerulosclerosis, Nephrotic syndrome |
| SMARCAL1 | 2 / 15 | Focal glomerulosclerosis, Nephrotic syndrome |
| SOD1 | 2 / 15 | Nephrotic syndrome, Proteinuria |
| SPP1 | 2 / 15 | Focal glomerulosclerosis, Proteinuria |
| SYNPO | 2 / 15 | Focal segmental glomerulosclerosis, Nephrotic syndrome |
| TTC21B | 2 / 15 | Focal segmental glomerulosclerosis, Nephrotic syndrome |
| XPO5 | 2 / 15 | Idiopathic steroid-resistant nephrotic syndrome, Nephrotic syndrome |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| AGE-RAGE signaling pathway in diabetic complications | KEGG | 18 / 101 | 9.1× | 8.14e-13 | 1.60e-10 ✓ sig. |
| Amoebiasis | KEGG | 16 / 103 | 7.9× | 1.37e-10 | 1.55e-8 ✓ sig. |
| Laminin interactions | Reactome | 9 / 28 | 16.4× | 1.80e-9 | 1.58e-7 ✓ sig. |
| Focal adhesion | KEGG | 20 / 203 | 5.0× | 2.79e-9 | 2.36e-7 ✓ sig. |
| Extracellular matrix organization | Reactome | 7 / 15 | 23.8× | 5.66e-9 | 4.45e-7 ✓ sig. |
| Type I diabetes mellitus | KEGG | 10 / 44 | 11.6× | 9.41e-9 | 7.00e-7 ✓ sig. |
| Nephrin family interactions | Reactome | 6 / 10 | 30.7× | 1.04e-8 | 7.64e-7 ✓ sig. |
| Non-integrin membrane-ECM interactions | Reactome | 8 / 24 | 17.0× | 1.07e-8 | 7.88e-7 ✓ sig. |
| Graft-versus-host disease | KEGG | 10 / 45 | 11.4× | 1.19e-8 | 8.63e-7 ✓ sig. |
| ECM-receptor interaction | KEGG | 13 / 89 | 7.5× | 1.67e-8 | 1.17e-6 ✓ sig. |
| Allograft rejection | KEGG | 9 / 39 | 11.8× | 4.59e-8 | 2.82e-6 ✓ sig. |
| Postmitotic nuclear pore complex (NPC) reformation | Reactome | 7 / 22 | 16.3× | 1.33e-7 | 7.21e-6 ✓ sig. |
| Interleukin-4 and Interleukin-13 signaling | Reactome | 13 / 108 | 6.2× | 1.76e-7 | 9.15e-6 ✓ sig. |
| Anchoring fibril formation | Reactome | 6 / 15 | 20.4× | 2.27e-7 | 1.15e-5 ✓ sig. |
| Rheumatoid arthritis | KEGG | 12 / 95 | 6.5× | 3.10e-7 | 1.51e-5 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| regulation of blood pressure | GO:0008217 | 12 / 83 | 11.5× | 5.21e-10 | 1.33e-7 ✓ sig. |
| glomerular basement membrane development | GO:0032836 | 6 / 10 | 47.7× | 7.47e-10 | 1.81e-7 ✓ sig. |
| kidney development | GO:0001822 | 13 / 146 | 7.1× | 4.09e-8 | 5.98e-6 ✓ sig. |
| nephron development | GO:0072006 | 5 / 11 | 36.1× | 1.31e-7 | 1.59e-5 ✓ sig. |
| positive regulation of T cell proliferation | GO:0042102 | 9 / 67 | 10.7× | 1.53e-7 | 1.82e-5 ✓ sig. |
| podocyte differentiation | GO:0072112 | 5 / 12 | 33.1× | 2.22e-7 | 2.47e-5 ✓ sig. |
| collagen-activated tyrosine kinase receptor signaling pathway | GO:0038063 | 5 / 12 | 33.1× | 2.22e-7 | 2.47e-5 ✓ sig. |
| glomerulus development | GO:0032835 | 5 / 13 | 30.6× | 3.57e-7 | 3.67e-5 ✓ sig. |
| cell-cell adhesion | GO:0098609 | 14 / 218 | 5.1× | 7.13e-7 | 6.53e-5 ✓ sig. |
| positive regulation of nitric oxide biosynthetic process | GO:0045429 | 7 / 42 | 13.3× | 8.44e-7 | 7.46e-5 ✓ sig. |
| positive regulation of cell population proliferation | GO:0008284 | 22 / 532 | 3.3× | 1.08e-6 | 9.19e-5 ✓ sig. |
| cell adhesion | GO:0007155 | 25 / 665 | 3.0× | 1.11e-6 | 9.38e-5 ✓ sig. |
| peptide antigen assembly with MHC class II protein complex | GO:0002503 | 5 / 16 | 24.8× | 1.18e-6 | 9.81e-5 ✓ sig. |
| symbiont entry into host cell | GO:0046718 | 10 / 112 | 7.1× | 1.51e-6 | 1.21e-4 ✓ sig. |
| cell migration | GO:0016477 | 16 / 303 | 4.2× | 1.55e-6 | 1.24e-4 ✓ sig. |