Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Non-neoplastic peripheral nervous system disease Peripheral neuropathy
54 genes
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DPYD(1), SLC12A6(1), GFAP(1), ABCA1(1), CACNA1H(1), ERCC1(1), MMP3(1), TCF4(1), GSTP1(1), GSTT1(1), ICAM1(1), IGF1(1) +42 more
0.280 1.000 4.24e-107 5.42e-105 ✓ sig. Cluster 243 →
Leigh syndrome Mitochondrial disease
72 genes
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67 of 72 corroborated by 2+ sources
HIBCH(3), TRMU(3), IARS2(4), MTRFR(3), NARS2(3), NDUFA10(5), NDUFA12(2), NDUFA9(3), NDUFAF2(4), NDUFAF6(4), ND2(1), NDUFS3(4) +60 more
0.259 0.673 1.62e-107 2.08e-105 ✓ sig. Cluster 50 →
Cleft lip Complete unilateral cleft lip
36 genes
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25 of 36 corroborated by 2+ sources
FGF8(2), ABCA4(2), FGFR3(2), KIF7(1), TP63(2), FGF10(2), IRF6(2), SPRY2(2), TCN2(2), NOS3(2), MTHFR(2), BMP4(1) +24 more
0.947 1.000 2.56e-108 3.31e-106 ✓ sig. Cluster 63 →
Cognition disorder Delirium, dementia, and cognitive disorders
44 genes
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44 of 44 corroborated by 2+ sources
COMT(2), APP(2), PSEN1(2), AGT(2), APOE(3), IGF2(2), LAMB2(2), MAPT(2), SETD7(2), BCHE(2), CDK5R1(2), CRH(2) +32 more
0.657 0.815 2.12e-108 2.75e-106 ✓ sig. Cluster 351 →
Aortic stenosis Aortic valve disease
49 genes
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HMGA2(1), ACAN(1), ALPL(1), PRRX1(1), ALDH1A2(1), ARHGAP24(1), ASCC2(1), FADS1(1), FADS2(1), FLNB(1), HCN1(1), LDLR(1) +37 more
0.527 0.817 5.20e-109 6.80e-107 ✓ sig. —
Autoimmune thyroid disease Hypothyroidism
89 genes
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9 of 89 corroborated by 2+ sources
RERE(1), SH2B3(1), IFIH1(1), BTNL2(1), C12orf42(1), CAMK4(1), ELMO1(1), ERBB3(1), FAM76B(1), GIGYF1(1), HLA-DQA1(2), HLA-DRA(2) +77 more
0.207 0.618 2.72e-109 3.58e-107 ✓ sig. —
Bipolar depression Bipolar disorder
102 genes
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72 of 102 corroborated by 2+ sources
COMT(2), INS(2), PER3(1), CACNA1D(2), SERPINA1(2), ATP1A3(1), ANK3(3), BRD1(1), DISC1(1), FADS2(3), FSTL5(3), GCH1(1) +90 more
0.083 0.971 1.32e-109 1.75e-107 ✓ sig. Cluster 2 →
Endometrial cancer Hepatocellular carcinoma
111 genes
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8 of 111 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(2), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +99 more
0.156 0.638 2.99e-110 3.98e-108 ✓ sig. Cluster 67 →
Attention deficit hyperactivity disorder Obsessive-compulsive disorder
148 genes
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6 of 148 corroborated by 2+ sources
SOX5(1), RAI1(1), RERE(1), COMT(2), ATP2A2(1), AKAP6(1), BANK1(1), BRAF(1), C6orf118(1), C8orf90(1), CACNA2D3(1), CACNB2(1) +136 more
0.124 0.632 4.51e-111 6.06e-109 ✓ sig. —
Diabetes mellitus type 1 Psoriasis
176 genes
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54 of 176 corroborated by 2+ sources
BPTF(1), RERE(1), COLEC10(1), CAT(2), CP(2), SH2B3(3), IFIH1(3), BLTP1(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), BANK1(2) +164 more
0.170 0.369 4.02e-113 5.44e-111 ✓ sig. Cluster 28 →
Dejerine-sottas disease Peroneal muscle atrophy
38 genes
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4 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(3), KIF1B(1), MME(1), TRPV4(1), DYNC1H1(1), FIG4(1), MFN2(1), NEFL(1) +26 more
0.950 1.000 1.61e-113 2.18e-111 ✓ sig. Cluster 15 →
Hypertrophic neuropathy Peroneal muscle atrophy
38 genes
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4 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(2), KIF1B(1), MME(1), TRPV4(1), DYNC1H1(1), FIG4(1), MFN2(1), NEFL(1) +26 more
0.950 1.000 1.61e-113 2.18e-111 ✓ sig. Cluster 15 →
Peroneal muscle atrophy Roussy-levy syndrome
38 genes
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2 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(1), KIF1B(1), MME(1), TRPV4(1), DYNC1H1(1), FIG4(1), MFN2(1), NEFL(1) +26 more
0.950 1.000 1.61e-113 2.18e-111 ✓ sig. Cluster 15 →
Esophageal cancer Hepatocellular carcinoma
109 genes
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7 of 109 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(2), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +97 more
0.156 0.694 1.45e-114 2.01e-112 ✓ sig. Cluster 67 →
Hypertrophic neuropathy Roussy-levy syndrome
38 genes
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4 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(2), KIF1B(1), MME(1), TRPV4(1), DYNC1H1(1), FIG4(1), MFN2(1), NEFL(1) +26 more
0.974 1.000 4.12e-115 5.75e-113 ✓ sig. Cluster 15 →
Dejerine-sottas disease Hypertrophic neuropathy
38 genes
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4 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(4), KIF1B(1), MME(1), TRPV4(1), DYNC1H1(1), FIG4(1), MFN2(1), NEFL(1) +26 more
0.974 1.000 4.12e-115 5.75e-113 ✓ sig. Cluster 15 →
Dejerine-sottas disease Roussy-levy syndrome
38 genes
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4 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(3), KIF1B(1), MME(1), TRPV4(1), DYNC1H1(1), FIG4(1), MFN2(1), NEFL(1) +26 more
0.974 1.000 4.12e-115 5.75e-113 ✓ sig. Cluster 15 →
Cardiac embolism Cardioembolic stroke
50 genes
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PRRX1(1), C16orf95(1), DOCK10(1), EPHA4(1), GLIS3(1), GORAB(1), HNF4G(1), HTR1E(1), KCNN3(1), RBFOX1(1), RBMS3(1), RGS4(1) +38 more
0.490 1.000 2.79e-116 3.97e-114 ✓ sig. —
Autism Bipolar disorder
388 genes
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181 of 388 corroborated by 2+ sources
SOX5(3), CHRNA7(2), ANKRD11(3), AKR1C4(2), NFIX(2), NFIA(1), PRKCZ(2), RERE(2), COMT(2), HDAC4(1), WWOX(2), ZFPM2(1) +376 more
0.169 0.318 1.31e-117 1.88e-115 ✓ sig. Cluster 2 →
Autism Major depressive disorder
507 genes
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241 of 507 corroborated by 2+ sources
SOX5(3), KANSL1(1), PRKCZ(2), RERE(2), COMT(2), HDAC4(2), MCCC2(2), SOX9(2), WWOX(2), ZFPM2(1), CAT(3), ATP2A2(2) +495 more
0.174 0.347 7.08e-118 1.02e-115 ✓ sig. Cluster 2 →
Degenerative disorder Neurodegenerative disorder
40 genes
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38 of 40 corroborated by 2+ sources
APP(2), PSEN1(2), SERPINA1(2), MAPT(2), EPO(2), GSTO1(2), HMOX1(2), NGFR(2), SNCA(2), SOD2(2), IL6(2), NGF(2) +28 more
0.952 1.000 1.12e-118 1.63e-116 ✓ sig. —
Cardiomyopathy Hypertrophic cardiomyopathy
101 genes
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65 of 101 corroborated by 2+ sources
INS(2), ABCC9(1), ACTN2(3), TP53(2), AGT(2), DMD(2), DSG2(1), FHOD3(5), JUP(1), KAT8(2), MYOZ2(6), MYPN(2) +89 more
0.253 0.414 2.63e-120 3.86e-118 ✓ sig. Cluster 369 →
Basal cell carcinoma Keratinocyte carcinoma
74 genes
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9 of 74 corroborated by 2+ sources
ANKRD11(1), COLEC10(1), PIK3R1(1), TERT(2), TP53(3), BNC2(2), CTSH(1), CUX1(1), EPB41L1(1), EXO1(1), FOXP1(1), GPX4(1) +62 more
0.224 0.961 1.71e-123 2.52e-121 ✓ sig. Cluster 29 →
Psoriasis Rheumatoid arthritis
212 genes
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69 of 212 corroborated by 2+ sources
CAT(2), CP(2), SH2B3(1), RUNX1(3), TP63(1), BLTP1(1), ABT1(1), ANKRD55(3), BSN(1), BTNL2(2), ELMO1(1), EMSY(1) +200 more
0.179 0.320 1.52e-123 2.26e-121 ✓ sig. Cluster 28 →
Charcot-marie-tooth disease Hereditary motor and sensory neuropathies
60 genes
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51 of 60 corroborated by 2+ sources
DHTKD1(5), AARS1(7), VCP(5), SLC12A6(4), EGR2(8), KIF1B(6), MME(8), RAB7A(7), SETX(2), TRPV4(6), PLD3(1), DCTN1(2) +48 more
0.432 0.909 1.02e-123 1.53e-121 ✓ sig. Cluster 15 →

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.