Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Diabetes mellitus type 1 Rheumatoid arthritis
188 genes
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72 of 188 corroborated by 2+ sources
CAT(2), CP(2), SH2B3(3), BLTP1(1), AFF3(3), ANKRD55(3), BTNL2(2), CCRL2(1), DGKQ(1), EMSY(1), ERBB3(1), ETS1(2) +176 more
0.197 0.394 1.83e-136 3.04e-134 ✓ sig. Cluster 291 →
Testicular carcinoma Testicular germ cell tumor
53 genes
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6 of 53 corroborated by 2+ sources
HNF1B(1), DMRT1(1), GATA4(1), PIK3CD(1), TERT(1), ATF7IP(1), CENPE(1), GAB2(1), HEATR3(1), LIPG(1), MAD1L1(2), PDE8A(1) +41 more
0.779 0.883 8.06e-136 1.33e-133 ✓ sig. —
Cardiovascular disease Hypertension
220 genes
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46 of 220 corroborated by 2+ sources
CYP11B2(2), CASZ1(1), PRDM16(1), RERE(1), ZFPM2(1), POLR1A(1), PIK3R1(1), SH2B3(1), ADK(1), CACNA1D(1), ALG9(1), ACE(3) +208 more
0.162 0.509 5.38e-135 8.80e-133 ✓ sig. Cluster 2 →
Autoimmune disease Autoimmune thyroid disease
87 genes
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7 of 87 corroborated by 2+ sources
SH2B3(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), C12orf42(1), CAMK4(1), DAG1(1), ELMO1(1), ERBB3(1), FAM76B(1), FUT2(1), GIGYF1(1) +75 more
0.335 0.604 2.91e-133 4.71e-131 ✓ sig. Cluster 142 →
complex neurodevelopmental disorder Neurodevelopmental disorder
113 genes
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112 of 113 corroborated by 2+ sources
CHD8(3), GABRD(2), HNRNPU(4), CACNA1D(2), CHD2(4), CNTNAP2(2), CUL3(6), DLGAP2(2), EPB41L1(2), GIGYF1(4), GNB2(5), GRIA1(2) +101 more
0.120 0.958 8.38e-133 1.35e-130 ✓ sig. Cluster 5 →
Glaucoma Open angle glaucoma
118 genes
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25 of 118 corroborated by 2+ sources
PRDM16(1), LTBP3(1), CHEK2(1), RUNX1(1), ABCA1(1), ANKH(1), ANTXR1(1), APOE(2), BCAS3(1), BNC2(1), CADM2(1), CDKN2B(4) +106 more
0.243 0.504 1.41e-132 2.25e-130 ✓ sig. Cluster 235 →
Major depressive disorder Neurotic disorder
268 genes
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20 of 268 corroborated by 2+ sources
SOX5(1), CYP17A1(1), PAFAH1B1(1), KANSL1(1), RERE(1), PDE4D(2), ARHGAP15(1), ARHGEF10L(1), ARL17B(1), AS3MT(1), BNC2(1), CACNA1E(1) +256 more
0.126 0.616 3.73e-132 5.91e-130 ✓ sig. Cluster 2 →
Alzheimer disease Dementia
333 genes
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27 of 333 corroborated by 2+ sources
HNF1B(1), NFIX(1), ZFPM2(1), APP(7), PSEN1(6), PRRX1(1), AIPL1(1), TPCN2(1), ABCA1(2), ABCA7(4), ABI3(2), ACE(2) +321 more
0.134 0.564 8.54e-132 1.34e-129 ✓ sig. Cluster 2 →
Attention deficit hyperactivity disorder Bipolar disorder
350 genes
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85 of 350 corroborated by 2+ sources
SOX5(1), NFIX(2), NFIA(1), RERE(1), COMT(2), HDAC4(1), DHH(1), ZFPM2(1), ATP2A2(1), CDK10(1), CACNA1D(3), ALMS1(1) +338 more
0.177 0.317 1.74e-130 2.71e-128 ✓ sig. Cluster 2 →
Hepatocellular carcinoma Non-hodgkins lymphoma
110 genes
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6 of 110 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(2), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +98 more
0.163 0.815 1.94e-129 3.01e-127 ✓ sig. Cluster 56 →
Eczema Inflammatory skin disease
76 genes
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IFIH1(1), BLTP1(1), ANO3(1), CSMD1(1), EBF1(1), ELMO1(1), EMSY(1), MGMT(1), PTPRN2(1), RAP1GAP2(1), RASIP1(1), SMARCA4(1) +64 more
0.208 1.000 8.22e-128 1.26e-125 ✓ sig. Cluster 391 →
Cardiomyopathy Dilated cardiomyopathy
107 genes
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74 of 107 corroborated by 2+ sources
PRDM16(4), COMT(1), PSEN1(6), ABCC9(7), ACTN2(7), CTNNA3(1), DMD(6), DSG2(7), EYA4(5), FHOD3(4), JUP(1), KCNE2(1) +95 more
0.260 0.439 9.72e-128 1.48e-125 ✓ sig. Cluster 377 →
Hereditary spastic paraplegia Spastic paraplegia
67 genes
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58 of 67 corroborated by 2+ sources
NIPA1(4), ABCD1(1), ALDH18A1(4), SLC16A2(1), ALS2(2), AP4M1(2), ARSI(3), MTRFR(3), SETX(1), SPG11(4), USP8(3), UCHL1(5) +55 more
0.432 0.663 3.88e-125 5.88e-123 ✓ sig. Cluster 239 →
Charcot-marie-tooth disease Hereditary motor and sensory neuropathies
60 genes
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51 of 60 corroborated by 2+ sources
DHTKD1(5), AARS1(7), VCP(5), SLC12A6(4), EGR2(8), KIF1B(6), MME(8), RAB7A(7), SETX(2), TRPV4(6), PLD3(1), DCTN1(2) +48 more
0.432 0.909 1.02e-123 1.54e-121 ✓ sig. Cluster 14 →
Psoriasis Rheumatoid arthritis
212 genes
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69 of 212 corroborated by 2+ sources
CAT(2), CP(2), SH2B3(1), RUNX1(3), TP63(1), BLTP1(1), ABT1(1), ANKRD55(3), BSN(1), BTNL2(2), ELMO1(1), EMSY(1) +200 more
0.179 0.320 1.52e-123 2.27e-121 ✓ sig. —
Basal cell carcinoma Keratinocyte carcinoma
74 genes
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9 of 74 corroborated by 2+ sources
ANKRD11(1), COLEC10(1), PIK3R1(1), TERT(2), TP53(3), BNC2(2), CTSH(1), CUX1(1), EPB41L1(1), EXO1(1), FOXP1(1), GPX4(1) +62 more
0.224 0.961 1.71e-123 2.53e-121 ✓ sig. Cluster 25 →
Cardiomyopathy Hypertrophic cardiomyopathy
101 genes
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65 of 101 corroborated by 2+ sources
INS(2), ABCC9(1), ACTN2(3), TP53(2), AGT(2), DMD(2), DSG2(1), FHOD3(5), JUP(1), KAT8(2), MYOZ2(6), MYPN(2) +89 more
0.253 0.414 2.63e-120 3.88e-118 ✓ sig. Cluster 377 →
Degenerative disorder Neurodegenerative disorder
40 genes
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38 of 40 corroborated by 2+ sources
APP(2), PSEN1(2), SERPINA1(2), MAPT(2), EPO(2), GSTO1(2), HMOX1(2), NGFR(2), SNCA(2), SOD2(2), IL6(2), NGF(2) +28 more
0.952 1.000 1.12e-118 1.63e-116 ✓ sig. —
Autism Major depressive disorder
507 genes
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241 of 507 corroborated by 2+ sources
SOX5(3), KANSL1(1), PRKCZ(2), RERE(2), COMT(2), HDAC4(2), MCCC2(2), SOX9(2), WWOX(2), ZFPM2(1), CAT(3), ATP2A2(2) +495 more
0.174 0.347 7.08e-118 1.03e-115 ✓ sig. Cluster 2 →
Autism Bipolar disorder
388 genes
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181 of 388 corroborated by 2+ sources
SOX5(3), CHRNA7(2), ANKRD11(3), AKR1C4(2), NFIX(2), NFIA(1), PRKCZ(2), RERE(2), COMT(2), HDAC4(1), WWOX(2), ZFPM2(1) +376 more
0.169 0.318 1.31e-117 1.89e-115 ✓ sig. Cluster 2 →
Cardiac embolism Cardioembolic stroke
50 genes
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PRRX1(1), C16orf95(1), DOCK10(1), EPHA4(1), GLIS3(1), GORAB(1), HNF4G(1), HTR1E(1), KCNN3(1), RBFOX1(1), RBMS3(1), RGS4(1) +38 more
0.490 1.000 2.79e-116 3.99e-114 ✓ sig. —
Dejerine-sottas disease Hypertrophic neuropathy
38 genes
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4 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(4), KIF1B(1), MME(1), TRPV4(1), DYNC1H1(1), FIG4(1), MFN2(1), NEFL(1) +26 more
0.974 1.000 4.12e-115 5.78e-113 ✓ sig. Cluster 14 →
Dejerine-sottas disease Roussy-levy syndrome
38 genes
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4 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(3), KIF1B(1), MME(1), TRPV4(1), DYNC1H1(1), FIG4(1), MFN2(1), NEFL(1) +26 more
0.974 1.000 4.12e-115 5.78e-113 ✓ sig. Cluster 14 →
Hypertrophic neuropathy Roussy-levy syndrome
38 genes
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4 of 38 corroborated by 2+ sources
DHTKD1(1), AARS1(1), VCP(1), SLC12A6(1), EGR2(2), KIF1B(1), MME(1), TRPV4(1), DYNC1H1(1), FIG4(1), MFN2(1), NEFL(1) +26 more
0.974 1.000 4.12e-115 5.78e-113 ✓ sig. Cluster 14 →
Esophageal cancer Hepatocellular carcinoma
109 genes
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7 of 109 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(2), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +97 more
0.156 0.694 1.45e-114 2.02e-112 ✓ sig. Cluster 56 →

Showing 25 of 20918 pairs, sorted by significance (ascending). Click a column header to sort.