Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 219

7 diseases · 12 shared-gene connections
7 Diseases
337 Unique genes
0.076 Avg. similarity score
Lymphocytic leukemia Most-connected disease (5 links)
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Disease Searched: Multiple myeloma Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Lymphocytic leukemia 5 5 115
Lymphoid leukemia 5 5 28
Hodgkin lymphoma 4 4 111
Hepatic veno occlusive disease with immunodeficiency 3 3 2
Lymphocytic b-cell leukemia 3 3 34
Multiple myeloma 3 3 143
Dentici novelli neurodevelopmental syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
SP140 6 / 7 Hepatic veno occlusive disease with immunodeficiency, Hodgkin lymphoma, Lymphocytic b-cell leukemia, Lymphocytic leukemia and 2 more
ACOXL 5 / 7 Hodgkin lymphoma, Lymphocytic b-cell leukemia, Lymphocytic leukemia, Lymphoid leukemia and 1 more
BMF 5 / 7 Hodgkin lymphoma, Lymphocytic b-cell leukemia, Lymphocytic leukemia, Lymphoid leukemia and 1 more
IRF4 5 / 7 Hodgkin lymphoma, Lymphocytic b-cell leukemia, Lymphocytic leukemia, Lymphoid leukemia and 1 more
BCL2 4 / 7 Hodgkin lymphoma, Lymphocytic b-cell leukemia, Lymphocytic leukemia, Multiple myeloma
EXOC2 4 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
GRAMD1B 4 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
HLA-DQB1 4 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
IRF8 4 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
QPCT 4 / 7 Hodgkin lymphoma, Lymphocytic b-cell leukemia, Lymphocytic leukemia, Multiple myeloma
ACTRT3 3 / 7 Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
BAK1 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
BCL2L11 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
CIB3 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
DTNB 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
ELL2 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
EOMES 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
FABP3 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
HLA-DQA1 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
HLA-DRB1 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
LPP 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
MNS1 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
MYNN 3 / 7 Lymphocytic leukemia, Lymphoid leukemia, Multiple myeloma
NCAPH2 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
NCK1 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
PHLPP1 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
SERINC2 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
ULK4 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
ZNF280D 3 / 7 Hodgkin lymphoma, Lymphocytic leukemia, Multiple myeloma
C11ORF21 2 / 7 Lymphocytic b-cell leukemia, Lymphocytic leukemia
CCSER1 2 / 7 Hodgkin lymphoma, Multiple myeloma
CD86 2 / 7 Hodgkin lymphoma, Multiple myeloma
DMRTA1 2 / 7 Lymphocytic leukemia, Lymphoid leukemia
FARP2 2 / 7 Lymphocytic b-cell leukemia, Lymphocytic leukemia
FAS 2 / 7 Lymphocytic leukemia, Lymphoid leukemia
GIPC2 2 / 7 Hodgkin lymphoma, Multiple myeloma
GRIP1 2 / 7 Lymphoid leukemia, Multiple myeloma
HBS1L 2 / 7 Hodgkin lymphoma, Multiple myeloma
IL6 2 / 7 Lymphocytic b-cell leukemia, Multiple myeloma
LEF1 2 / 7 Lymphocytic b-cell leukemia, Lymphocytic leukemia
LRRC34 2 / 7 Lymphocytic leukemia, Multiple myeloma
MEGF11 2 / 7 Hodgkin lymphoma, Lymphoid leukemia
PALD1 2 / 7 Lymphocytic leukemia, Lymphoid leukemia
PRKD2 2 / 7 Lymphocytic b-cell leukemia, Lymphocytic leukemia
PTPRK 2 / 7 Hodgkin lymphoma, Lymphocytic leukemia
SP110 2 / 7 Hepatic veno occlusive disease with immunodeficiency, Lymphocytic leukemia
SP140L 2 / 7 Lymphoid leukemia, Multiple myeloma
TERT 2 / 7 Lymphocytic leukemia, Lymphoid leukemia
THEMIS 2 / 7 Hodgkin lymphoma, Lymphocytic leukemia
TNFSF8 2 / 7 Lymphocytic b-cell leukemia, Multiple myeloma
TP53 2 / 7 Lymphocytic b-cell leukemia, Lymphoid leukemia
TSBP1 2 / 7 Hodgkin lymphoma, Lymphocytic leukemia
ZNF526 2 / 7 Dentici novelli neurodevelopmental syndrome, Hodgkin lymphoma
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Interleukin-4 and Interleukin-13 signaling
BCL2, IRF4, OPRM1, RHOU, GATA3, IL13, IL6, PTGS2, TP53, BCL2L1, CCL2, CCND1
 Reactome 15 / 108 4.9× 3.18e-7 1.81e-5 ✓ sig.
Kaposi sarcoma-associated herpesvirus infection
BAK1, CASP8, FAS, LEF1, MAP1LC3B2, MAP2K2, CD86, ITPR2, MAPK3, MICA, IL6, PLCG2
 KEGG 20 / 196 3.6× 6.18e-7 3.20e-5 ✓ sig.
Human T-cell leukemia virus 1 infection
BUB1B, ETS1, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, MAP2K2, SMAD3, TERT, HLA-DRA, MAPK3, TCF3
 KEGG 21 / 224 3.3× 1.31e-6 6.15e-5 ✓ sig.
Apoptosis
BAK1, BCL2, BCL2L11, CASP10, CASP8, CFLAR, FAS, MAP2K2, ITPR2, MAPK3, ATM, PMAIP1
 KEGG 16 / 137 4.2× 1.41e-6 6.58e-5 ✓ sig.
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
BCL2, BCL2L11, BMF, PMAIP1, BCL2L1
 Reactome 5 / 9 19.8× 1.94e-6 8.65e-5 ✓ sig.
EGFR tyrosine kinase inhibitor resistance
BCL2, BCL2L11, MAP2K2, RPS6KB1, MAPK3, PDGFD, IL6, PLCG2, BCL2L1, FGFR3, HGF, PDGFB
 KEGG 12 / 80 5.3× 2.13e-6 9.37e-5 ✓ sig.
Graft-versus-host disease
FAS, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, CD86, HLA-DRA, IL6, HLA-A
 KEGG 9 / 45 7.1× 3.52e-6 1.45e-4 ✓ sig.
Hepatocellular carcinoma
BAK1, LEF1, MAP2K2, RPS6KB1, SMAD3, TERT, LRP5, MAPK3, PLCG2, TP53, BCL2L1, CCND1
 KEGG 17 / 170 3.6× 5.72e-6 2.16e-4 ✓ sig.
Pathways in cancer
BAK1, BCL2, BCL2L11, CAMK2D, CASP8, ETS1, FAS, LEF1, MAP2K2, RPS6KB1, SMAD3, TERT
 KEGG 34 / 533 2.3× 6.48e-6 2.39e-4 ✓ sig.
Platinum drug resistance
BAK1, BCL2, CASP8, FAS, MAPK3, ATM, PMAIP1, TP53, BCL2L1, CDKN2A, GSTT1
 KEGG 11 / 75 5.2× 7.10e-6 2.58e-4 ✓ sig.
Intestinal immune network for IgA production
HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, CD86, HLA-DRA, IL6, ITGA4, TNFRSF13B
 KEGG 9 / 50 6.4× 8.80e-6 3.09e-4 ✓ sig.
Allograft rejection
FAS, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, CD86, HLA-DRA, HLA-A
 KEGG 8 / 39 7.3× 1.02e-5 3.47e-4 ✓ sig.
Bladder cancer
MAP2K2, MAPK3, RPS6KA5, TP53, CCND1, CDKN2A, DAPK1, FGFR3
 KEGG 8 / 41 7.0× 1.50e-5 4.79e-4 ✓ sig.
Autoimmune thyroid disease
FAS, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, CD86, HLA-DRA, HLA-A, IFNA2
 KEGG 9 / 54 5.9× 1.69e-5 5.29e-4 ✓ sig.
Viral myocarditis
CASP8, HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, CD86, HLA-DRA, CCND1, EIF4G1, HLA-A
 KEGG 10 / 70 5.1× 2.35e-5 6.98e-4 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
response to gamma radiation
BAK1, BCL2, GATA3, POLB, TP53, BRCA2, LIG4, PARP1, SOD2
 GO:0010332 9 / 27 18.5× 6.39e-10 1.46e-7 ✓ sig.
release of cytochrome c from mitochondria
BAK1, BCL2, SMAD3, PMAIP1, TP53, BCL2L1, MCL1, SOD2
 GO:0001836 8 / 23 19.3× 3.99e-9 7.45e-7 ✓ sig.
apoptotic process
APP, BAK1, BCL2, BCL2L11, BMF, BUB1B, CASP10, CASP8, CFLAR, CLPTM1L, CSRNP1, FAS
 GO:0006915 38 / 747 2.8× 8.73e-9 1.48e-6 ✓ sig.
positive regulation of transcription by RNA polymerase II
APP, ASCL2, CSRNP1, DRD2, EOMES, ETS1, FLI1, IRF4, IRF8, LEF1, NCK1, PRKD2
 GO:0045944 49 / 1,208 2.2× 8.04e-8 1.01e-5 ✓ sig.
positive regulation of apoptotic process
APP, BAK1, BCL2, BCL2L11, BMF, CASP8, FAS, IRF8, SPDEF, EPHA7, LPAR1, ATM
 GO:0043065 22 / 326 3.7× 1.28e-7 1.51e-5 ✓ sig.
intrinsic apoptotic signaling pathway in response to DNA damage
BAK1, BCL2, BCL2L11, ATM, POLB, BCL2L1, BRCA2, MCL1, SOD2
 GO:0008630 9 / 54 9.2× 4.72e-7 4.51e-5 ✓ sig.
regulation of T-helper cell differentiation
HLA-DRB1, IRF4, GATA3, HLA-DRA
 GO:0045622 4 / 5 44.4× 5.12e-7 4.84e-5 ✓ sig.
positive regulation of DNA-templated transcription
CXXC1, EOMES, ETS1, FLI1, HLA-DRB1, IRF4, IRF8, LEF1, MAP2K2, RFX7, RREB1, SMAD3
 GO:0045893 35 / 778 2.5× 6.69e-7 6.02e-5 ✓ sig.
reactive oxygen species metabolic process
BCL2, IL19, P2RX7, PMAIP1, TP53, BNIP3, PDGFB, PREX1
 GO:0072593 8 / 45 9.9× 1.24e-6 9.97e-5 ✓ sig.
positive regulation of T cell activation
HLA-DOB, HLA-DQA1, HLA-DQB1, HLA-DRB1, CORO1A, HLA-DRA, TNFSF11, CCL2
 GO:0050870 8 / 45 9.9× 1.24e-6 9.97e-5 ✓ sig.
regulation of mitochondrial membrane permeability
BAK1, BCL2, PMAIP1, BCL2L1, BNIP3
 GO:0046902 5 / 12 23.1× 1.32e-6 1.05e-4 ✓ sig.
positive regulation of neuron apoptotic process
APP, BCL2L11, CASP10, CASP8, CFLAR, EPHA7, ATM, TP53, MCL1
 GO:0043525 9 / 65 7.7× 2.38e-6 1.69e-4 ✓ sig.
positive regulation of ERK1 and ERK2 cascade
ACTA2, APP, CFLAR, DRD2, HLA-DRB1, OPRM1, PRKD2, MAPK3, PDGFD, PTPN22, SERPINF2, TNFRSF11A
 GO:0070374 15 / 201 4.1× 3.90e-6 2.51e-4 ✓ sig.
regulation of apoptotic process
BAK1, BCL2, BCL2L11, CASP10, CASP8, CFLAR, ETS1, FAS, PHLPP1, ZBTB7A, LRP5, ATM
 GO:0042981 17 / 254 3.7× 3.92e-6 2.52e-4 ✓ sig.
positive regulation of release of cytochrome c from mitochondria
BAK1, BCL2L11, BMF, PMAIP1, TP53, BNIP3
 GO:0090200 6 / 25 13.3× 4.36e-6 2.74e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Hodgkin lymphoma Lymphocytic leukemia 0.152 30 1.88e-39 7.77e-38 ✓ sig.
Hodgkin lymphoma Multiple myeloma 0.138 31 5.27e-38 2.10e-36 ✓ sig.
Lymphocytic leukemia Multiple myeloma 0.131 30 9.00e-36 3.36e-34 ✓ sig.
Lymphocytic leukemia Lymphoid leukemia 0.108 14 2.73e-23 6.09e-22 ✓ sig.
Lymphoid leukemia Multiple myeloma 0.075 12 6.90e-18 1.18e-16 ✓ sig.
Lymphocytic b-cell leukemia Lymphocytic leukemia 0.071 10 4.09e-14 5.47e-13 ✓ sig.
Hodgkin lymphoma Lymphoid leukemia 0.069 9 2.33e-13 2.98e-12 ✓ sig.
Lymphocytic b-cell leukemia Lymphoid leukemia 0.086 5 3.66e-9 3.14e-8 ✓ sig.
Hepatic veno occlusive disease with immunodeficiency Lymphocytic leukemia 0.017 2 5.53e-5 2.32e-4 ✓ sig.
Hepatic veno occlusive disease with immunodeficiency Lymphoid leukemia 0.033 1 3.63e-3 4.67e-3 ✓ sig.
Hepatic veno occlusive disease with immunodeficiency Lymphocytic b-cell leukemia 0.028 1 4.41e-3 5.53e-3 ✓ sig.
Dentici novelli neurodevelopmental syndrome Hodgkin lymphoma 0.009 1 7.21e-3 8.52e-3 ✓ sig.