Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
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Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Fatty liver, alcoholic Urban-schosser-spohr syndrome
1 gene
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SREBF1(1)
0.011 1.000 5.59e-3 6.78e-3 ✓ sig. —
Corticosteroid-binding globulin deficiency Fatty liver, alcoholic
1 gene
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1 of 1 corroborated by 2+ sources
SERPINA6(6)
0.011 1.000 5.59e-3 6.78e-3 ✓ sig. —
Fatty liver, alcoholic Oxysterol accumulation disorder
1 gene
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1 of 1 corroborated by 2+ sources
CYP7B1(2)
0.011 1.000 5.59e-3 6.78e-3 ✓ sig. —
Fatty liver, alcoholic Mucoepithelial dysplasia
1 gene
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1 of 1 corroborated by 2+ sources
SREBF1(2)
0.011 1.000 5.59e-3 6.78e-3 ✓ sig. —
Fatty liver, alcoholic mitochondrial trifunctional protein deficiency
1 gene
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1 of 1 corroborated by 2+ sources
HADHB(2)
0.011 1.000 5.59e-3 6.78e-3 ✓ sig. —
Fatty liver, alcoholic long chain 3-hydroxyacyl-coa dehydrogenase deficiency
1 gene
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1 of 1 corroborated by 2+ sources
HADHA(2)
0.011 1.000 5.59e-3 6.78e-3 ✓ sig. —
Cervical polyp Nonalcoholic fatty liver disease
2 genes
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IRAK1BP1(1), MEI4(1)
0.006 1.000 4.20e-4 9.33e-4 ✓ sig. —
Fatty liver Trifunctional protein deficiency
2 genes
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2 of 2 corroborated by 2+ sources
HADHA(2), HADHB(2)
0.021 0.667 1.08e-4 3.83e-4 ✓ sig. —
Fatty liver, alcoholic Trifunctional protein deficiency
2 genes
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1 of 2 corroborated by 2+ sources
HADHA(2), HADHB(1)
0.023 0.667 9.22e-5 3.28e-4 ✓ sig. —
Fatty liver, alcoholic Hepatomegaly
10 genes
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10 of 10 corroborated by 2+ sources
LDLR(2), LEP(2), NFE2L2(2), PPARA(2), AKT1(2), CYP1B1(2), MET(2), NR1H4(2), NR1I2(2), LEPR(2)
0.074 0.172 7.23e-13 8.82e-12 ✓ sig. —
Fatty liver, alcoholic Ventricular dysfunction
10 genes
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10 of 10 corroborated by 2+ sources
INS(2), NFE2L2(2), SOD2(2), TLR4(2), TNF(2), AKT1(2), SIRT1(2), ADRB2(2), LEPR(2), SIRT6(2)
0.081 0.217 5.96e-14 7.86e-13 ✓ sig. —
Fatty liver Hyperinsulinism
10 genes
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10 of 10 corroborated by 2+ sources
INS(2), MTTP(2), LEP(2), TNF(2), GPX1(2), CCL2(2), COL3A1(2), UCP2(3), LEPR(2), NEIL1(2)
0.079 0.238 4.93e-14 6.53e-13 ✓ sig. —
Fatty liver Hepatomegaly
11 genes
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10 of 11 corroborated by 2+ sources
LDLR(2), LEP(2), NFE2L2(2), PPARA(2), AKT1(2), IFNA2(1), CYP1B1(2), MET(2), NR1H4(2), NR1I2(2), LEPR(2)
0.078 0.190 3.83e-14 5.11e-13 ✓ sig. —
Fatty liver, alcoholic Hyperinsulinism
10 genes
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9 of 10 corroborated by 2+ sources
INS(2), MTTP(1), LEP(2), TNF(2), GPX1(2), CCL2(2), COL3A1(2), UCP2(2), LEPR(2), NEIL1(2)
0.084 0.238 2.19e-14 2.99e-13 ✓ sig. —
Fatty liver Hyperglycemia
11 genes
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11 of 11 corroborated by 2+ sources
INS(2), LEP(2), NFE2L2(2), PON1(2), TF(2), SOD1(2), GPX1(2), CCL2(2), COL3A1(2), NUS1(2), LEPR(2)
0.081 0.212 1.05e-14 1.47e-13 ✓ sig. —
Fatty liver, alcoholic Hyperglycemia
11 genes
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9 of 11 corroborated by 2+ sources
INS(2), LEP(2), NFE2L2(2), PON1(1), TF(1), SOD1(2), GPX1(2), CCL2(2), COL3A1(2), NUS1(2), LEPR(2)
0.086 0.212 4.27e-15 6.12e-14 ✓ sig. —
Cardiomegaly Fatty liver
13 genes
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13 of 13 corroborated by 2+ sources
LEP(2), PPARA(2), SOD2(2), TNF(2), POMC(2), AKT1(2), CYP1B1(2), CYP2E1(2), HTR2B(2), PPARD(2), UCP2(2), CEBPB(2) +1 more
0.079 0.155 2.63e-15 3.82e-14 ✓ sig. —
Cardiomegaly Fatty liver, alcoholic
13 genes
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13 of 13 corroborated by 2+ sources
LEP(2), PPARA(2), SOD2(2), TNF(2), POMC(2), AKT1(2), CYP1B1(2), CYP2E1(2), HTR2B(2), PPARD(2), UCP2(2), CEBPB(2) +1 more
0.082 0.155 9.10e-16 1.37e-14 ✓ sig. —
Myocardial ischemia Nonalcoholic fatty liver disease
46 genes
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40 of 46 corroborated by 2+ sources
CDH2(3), SERPINA1(3), ACE(2), APOC1(1), APOE(2), BTNL2(2), JCAD(2), LDLR(3), MLXIPL(2), NYAP2(1), PTPRD(2), SCARB1(3) +34 more
0.069 0.146 3.73e-22 7.79e-21 ✓ sig. —
Kidney failure Nonalcoholic fatty liver disease
39 genes
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38 of 39 corroborated by 2+ sources
INS(2), CAT(2), SERPINA1(3), ACE(2), APOE(2), ATP5F1B(2), CYP1A2(3), MLXIPL(3), SCARB1(2), SREBF1(2), VEGFA(2), GSTP1(2) +27 more
0.074 0.155 2.61e-23 5.82e-22 ✓ sig. —
Fatty liver, alcoholic Nonalcoholic fatty liver disease
27 genes
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24 of 27 corroborated by 2+ sources
INS(2), MTTP(3), CAT(2), PTEN(2), APOE(2), FGF21(2), LDLR(2), SREBF1(2), F2(2), LEP(2), MTHFR(1), NFE2L2(2) +15 more
0.072 0.314 4.78e-25 1.17e-23 ✓ sig. —
Liver disease Nonalcoholic fatty liver disease
46 genes
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25 of 46 corroborated by 2+ sources
INS(2), MTTP(3), SERPINA1(3), APOC1(1), APOE(1), CYP1A2(2), HS3ST1(1), TRIB1(3), HFE(2), ALDH2(2), GSTP1(2), GSTT1(2) +34 more
0.107 0.293 1.37e-40 5.83e-39 ✓ sig. Cluster 226 →
Liver cirrhosis Nonalcoholic fatty liver disease
78 genes
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37 of 78 corroborated by 2+ sources
CAT(2), PTEN(2), CDH2(1), SERPINA1(3), ACE(2), APOC1(1), APOE(1), COMMD1(3), CYP1A2(2), FARP1(1), HLA-DQA1(2), HLA-DRB1(2) +66 more
0.155 0.295 9.78e-70 6.94e-68 ✓ sig. Cluster 226 →
Fatty liver Fatty liver, alcoholic
84 genes
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75 of 84 corroborated by 2+ sources
INS(2), MTTP(2), CAT(2), PTEN(2), SCD(1), APOB(2), APOE(2), ATP7B(2), CYCS(2), F2R(2), FGF21(2), GPX4(2) +72 more
0.875 0.977 2.61e-210 1.13e-207 ✓ sig. —

Showing 24 of 49 matching pairs, sorted by significance (descending). Click a column header to sort.