FGF21 (fibroblast growth factor 21)

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Gene Gene information from NCBI Gene database.
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Entrez ID 26291
Gene name Fibroblast growth factor 21
Gene symbol FGF21
Synonyms (NCBI Gene)
-
Chromosome 19
Chromosome location 19q13.33
Summary Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that funct
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT731299 hsa-miR-149-5p Western blot 27061435
MIRT731299 hsa-miR-149-5p Western blot 27061435
MIRT755574 hsa-miR-143-3p Luciferase reporter assay 36602629
MIRT995644 hsa-miR-1276 CLIP-seq
MIRT995645 hsa-miR-4311 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
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Transcription factor Regulation Reference
ATF4 Activation 22233381
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005104 Function Fibroblast growth factor receptor binding IBA
GO:0005104 Function Fibroblast growth factor receptor binding IEA
GO:0005515 Function Protein binding IPI 18829467, 19059246, 19117008, 32296183, 32814053
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS 10858549
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
609436 3678 ENSG00000105550
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NSA1
Protein name Fibroblast growth factor 21 (FGF-21)
Protein function Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Regulates systemic glucose homeostasis and insulin
PDB 5VAQ , 6M6E , 6M6F
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00167 FGF 45 → 155 Fibroblast growth factor Domain
Sequence 
MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAH
LEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEA
CSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPALPEPPGI
LAPQPPDVGSSDPLSMVGPSQGRSPSYAS
Sequence length 209
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
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KEGG Pathway Reactome Pathway
MAPK signaling pathway Cellular hexose transport
Ras signaling pathway  
Rap1 signaling pathway  
Calcium signaling pathway  
PI3K-Akt signaling pathway  
Thermogenesis  
Regulation of actin cytoskeleton  
Pathways in cancer  
Melanoma  
Breast cancer  
Gastric cancer  
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (16)
Phenotype Name Clinical Significance Source Reference Evidence Score
ALZHEIMER DISEASE — GWAS catalog 39998322
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Congenital fibrosis of extraocular muscles Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CONGENITAL FIBROSIS OF THE EXTRAOCULAR MUSCLES — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, INSULIN-DEPENDENT — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIABETES MELLITUS, NON-INSULIN-DEPENDENT — Disgenet —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (249)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acromegaly Acromegaly BEFREE 28931175, 29754168
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 31175853
★★★★★
★☆☆☆☆
Found in Text Mining only
Adrenal Gland Pheochromocytoma Adrenal Gland Pheochromocytoma BEFREE 24369918, 30959789
★★★★★
★☆☆☆☆
Found in Text Mining only
Age related macular degeneration Age-related macular degeneration BEFREE 28199833
★★★★★
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 33131010 Inhibit
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Alzheimer Disease Alzheimer disease Pubtator 33946944 Associate
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis BEFREE 31476622
★★★★★
★☆☆☆☆
Found in Text Mining only
Angina Unstable Angina pectoris Pubtator 30185439 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only
Angina, Unstable Intermediate coronary syndrome BEFREE 30185439
★★★★★
★☆☆☆☆
Found in Text Mining only
Anorexia Nervosa Anorexia LHGDN 18559909
★★★★★
★☆☆☆☆
Found in Text Mining only
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CA3 2 shared diseasesFatty liver, Fatty liver, alcoholic 4 shared evidence sourcesDisgenet (Obesity), Disgenet (Fatty liver), Disgenet (Fatty liver, alcoholic), CTD (Obesity) Related via 2 shared diseases including Fatty liver, Fatty liver, alcoholic — evidence mostly Disgenet. DHRS7 2 shared diseasesFatty liver, Fatty liver, alcoholic 3 shared evidence sourcesDisgenet (Fatty liver), CTD (Fatty liver), Disgenet (Fatty liver, alcoholic) Related via 2 shared diseases including Fatty liver, Fatty liver, alcoholic — evidence mostly Disgenet. HAS3 2 shared diseasesFatty liver, Fatty liver, alcoholic 3 shared evidence sourcesDisgenet (Fatty liver), CTD (Fatty liver), Disgenet (Fatty liver, alcoholic) Related via 2 shared diseases including Fatty liver, Fatty liver, alcoholic — evidence mostly Disgenet. PLIN2 2 shared diseasesFatty liver, Fatty liver, alcoholic 3 shared evidence sourcesDisgenet (Fatty liver), CTD (Fatty liver), Disgenet (Fatty liver, alcoholic) Related via 2 shared diseases including Fatty liver, Fatty liver, alcoholic — evidence mostly Disgenet. GPT 2 shared diseasesFatty liver, Fatty liver, alcoholic 5 shared evidence sourcesDisgenet (Fatty liver), CTD (Fatty liver), Disgenet (Fatty liver, alcoholic), CTD (Nonalcoholic fatty liver disease), Disgenet (Nonalcoholic fatty liver disease) Related via 2 shared diseases including Fatty liver, Fatty liver, alcoholic — evidence mostly Disgenet.
Atrial fibrillation Linked via 1 of 5 related genesHAS3 Attention deficit hyperactivity disorder Linked via 1 of 5 related genesHAS3 Stomach neoplasms Linked via 1 of 5 related genesPLIN2 Liver disease Linked via 1 of 5 related genesGPT