Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Deafness Hearing loss
132 genes
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124 of 132 corroborated by 2+ sources
EDNRB(1), CACNA1D(2), CEACAM16(5), CLIC5(3), COL11A1(4), ESRRB(4), EYA4(4), GIPC3(4), GRAP(5), LMX1A(5), MYO15A(4), NARS2(5) +120 more
0.308 0.767 1.31e-183 3.80e-181 ✓ sig. Cluster 31 →
Ovarian cancer Ovarian epithelial cancer
115 genes
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HNF1B(1), GLI3(1), TERT(1), AMPD1(1), POU2AF1(1), ADARB2(1), BCL11A(1), BNC2(1), CARD11(1), CDCP1(1), CTNND1(1), DMD(1) +103 more
0.246 1.000 6.45e-182 1.85e-179 ✓ sig. Cluster 21 →
Biliary tract cancer Estrogen-receptor negative breast cancer
108 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +96 more
0.352 0.915 1.02e-181 2.88e-179 ✓ sig. —
Lung cancer Ovarian cancer
217 genes
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5 of 217 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), PDE4D(1), SH2B3(1), CHEK2(2), RTEL1(1), TERT(1), TP53(1), ADARB2(1) +205 more
0.241 0.466 4.86e-181 1.36e-178 ✓ sig. Cluster 21 →
Anorexia nervosa Obsessive-compulsive disorder
129 genes
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1 of 129 corroborated by 2+ sources
SOX5(1), RERE(1), ATP2A2(1), ABT1(1), AKAP6(2), BANK1(1), BRAF(1), C8orf90(1), CACNB2(1), CSMD1(1), CTNND1(1), DCC(1) +117 more
0.361 0.551 1.68e-180 4.63e-178 ✓ sig. Cluster 75 →
Estrogen-receptor negative breast cancer Non-hodgkins lymphoma
113 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +101 more
0.354 0.837 2.60e-180 7.07e-178 ✓ sig. —
Skin cancer Skin neoplasms
83 genes
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3 of 83 corroborated by 2+ sources
TERT(1), TP53(2), TPCN2(1), ATP8B4(1), BNC2(1), CTNNA2(1), CUX1(1), EMSY(1), FADS1(1), FADS2(1), FAM76B(1), FOXP1(1) +71 more
0.565 0.988 7.36e-180 1.98e-177 ✓ sig. Cluster 16 →
Non-hodgkins lymphoma Pancreatic cancer
108 genes
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3 of 108 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +96 more
0.387 0.800 2.52e-177 6.70e-175 ✓ sig. Cluster 72 →
Obsessive-compulsive disorder Tourette syndrome
128 genes
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1 of 128 corroborated by 2+ sources
SOX5(2), RERE(1), ATP2A2(1), AKAP6(1), BANK1(1), BRAF(1), C8orf90(1), CACNB2(1), CAMTA1(1), CSMD1(1), CTNND1(1), CYLC2(1) +116 more
0.351 0.547 3.14e-176 8.24e-174 ✓ sig. Cluster 75 →
Cholecystolithiasis Gallstones
92 genes
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5 of 92 corroborated by 2+ sources
HNF1B(1), JMJD1C(1), GATA4(1), ADAR(1), SERPINA1(1), ABCG8(3), ANO1(1), APOE(1), CPS1(1), FADS1(1), FADS2(1), FARP2(1) +80 more
0.526 0.742 2.74e-175 7.09e-173 ✓ sig. Cluster 239 →
Isolated sensorineural deafness nonsyndromic genetic hearing loss
78 genes
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78 of 78 corroborated by 2+ sources
CEACAM16(2), ESRRB(2), EYA4(2), GIPC3(2), GRAP(2), MYO15A(2), NARS2(2), OTOF(2), OTOGL(2), PCDH15(2), MCM2(2), OTOG(2) +66 more
0.629 0.951 8.37e-174 2.14e-171 ✓ sig. Cluster 31 →
Cervical cancer Esophageal cancer
109 genes
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1 of 109 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +97 more
0.395 0.694 3.37e-173 8.54e-171 ✓ sig. Cluster 72 →
Ovarian cancer Squamous cell carcinoma
226 genes
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15 of 226 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), GLI3(1), SH2B3(1), CHEK2(2), RTEL1(1), TERT(1), TP53(2), TPCN2(1) +214 more
0.219 0.485 2.16e-172 5.42e-170 ✓ sig. Cluster 21 →
Endometrial cancer Gastric cancer
110 genes
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1 of 110 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +98 more
0.389 0.632 2.57e-170 6.37e-168 ✓ sig. Cluster 72 →
Esophageal cancer Pancreatic cancer
110 genes
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3 of 110 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +98 more
0.368 0.701 2.80e-169 6.86e-167 ✓ sig. Cluster 72 →
Coronary artery disease Myocardial ischemia
235 genes
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124 of 235 corroborated by 2+ sources
PRDM16(3), APOA1(2), ACAT2(1), SH2B3(3), TERT(3), ARHGAP31(1), AMPD1(1), TP53(1), AHSG(1), SERPINA1(1), ABCA1(2), ABCG8(3) +223 more
0.181 0.601 5.77e-168 1.40e-165 ✓ sig. —
Colorectal cancer Ovarian cancer
240 genes
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13 of 240 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), CHEK2(2), RTEL1(1), TERT(1), TP53(3), POU2AF1(1), TPCN2(1) +228 more
0.200 0.515 1.54e-167 3.70e-165 ✓ sig. Cluster 21 →
Ovarian cancer Prostate cancer
238 genes
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18 of 238 corroborated by 2+ sources
ANKRD11(1), HNF1B(2), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), CHEK2(6), RTEL1(1), TERT(1), TP53(1), TPCN2(1), ADARB2(1) +226 more
0.200 0.511 1.53e-166 3.64e-164 ✓ sig. Cluster 21 →
Cervical cancer Endometrial cancer
109 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +97 more
0.372 0.626 2.44e-165 5.72e-163 ✓ sig. Cluster 72 →
Major depressive disorder Mood disorder
241 genes
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62 of 241 corroborated by 2+ sources
PAFAH1B1(1), KANSL1(1), RERE(1), COMT(1), HDAC4(2), ATP2A2(2), BLTP1(1), SERPINA1(2), ADCY8(2), ANK3(2), ARFGAP2(1), ARHGAP15(1) +229 more
0.119 0.809 2.23e-163 5.18e-161 ✓ sig. Cluster 2 →
Anorexia nervosa Tourette syndrome
124 genes
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4 of 124 corroborated by 2+ sources
SOX5(2), RERE(1), ATP2A2(1), AKAP6(2), BANK1(1), BRAF(1), C8orf90(1), CACNB2(1), CSMD1(1), CTNND1(1), DCC(1), DGKI(1) +112 more
0.321 0.494 1.56e-162 3.59e-160 ✓ sig. Cluster 75 →
Inflammatory bowel disease Sclerosing cholangitis
158 genes
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15 of 158 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ANKRD55(1), BANK1(1), BSN(1), CDKAL1(1), EMSY(1), ETS1(1), FIBP(1), FOXP1(1), FUT2(1) +146 more
0.207 0.687 3.30e-162 7.50e-160 ✓ sig. Cluster 14 →
Mitochondrial complex deficiency Mitochondrial disease
97 genes
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84 of 97 corroborated by 2+ sources
COA8(5), COX5A(5), NDUFA10(6), NDUFA12(4), NDUFA9(4), NDUFAF2(5), NDUFAF6(6), SDHB(6), UQCRFS1(6), UQCRH(5), ATP5F1A(5), ND1(1) +85 more
0.366 0.815 1.09e-161 2.46e-159 ✓ sig. Cluster 62 →
Attention deficit hyperactivity disorder Schizophrenia
553 genes
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175 of 553 corroborated by 2+ sources
SOX5(2), HMGA2(1), RAI1(2), NFIX(1), RERE(1), COMT(3), HDAC4(2), ZFPM2(1), ATP2A2(2), BMPR1B(1), TEAD1(1), CDK10(1) +541 more
0.179 0.500 2.31e-161 5.14e-159 ✓ sig. Cluster 2 →
Endometrial cancer Pancreatic cancer
110 genes
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3 of 110 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +98 more
0.348 0.632 2.67e-161 5.89e-159 ✓ sig. Cluster 72 →

Showing 25 of 22038 pairs, sorted by significance (ascending). Click a column header to sort.