Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 9

35 diseases · 96 shared-gene connections
35 Diseases
395 Unique genes
0.128 Avg. similarity score
Wolff-parkinson-white syndrome Most-connected disease (15 links)
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Disease Searched: Sick sinus syndrome 2, autosomal dominant Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Wolff-parkinson-white syndrome 15 15 51
Catecholaminergic polymorphic ventricular tachycardia 13 13 23
Ventricular fibrillation 13 13 37
Left ventricular noncompaction cardiomyopathy 12 12 38
Arrhythmogenic right ventricular cardiomyopathy 11 11 54
Conduction disorder of the heart 11 11 24
Left ventricular disease 9 9 66
Short qt syndrome 8 8 11
Brugada syndrome 7 7 64
Cardiac arrest 7 7 28
Long qt syndrome 7 7 103
Sick sinus syndrome 7 7 18
Cardiac conduction disease 6 6 9
Hereditary bundle branch system defect 6 6 7
Dilated cardiomyopathy 1BB 5 5 1
Dilated cardiomyopathy 1JJ 5 5 1
Restrictive cardiomyopathy 5 5 23
Atrial flutter 4 4 81
Cardiac arrhythmia 4 4 99
Dilated cardiomyopathy 1W 4 4 1
Hereditary atrial fibrillation 4 4 24
Atrioventricular block 3 3 17
Cardiomyopathy, dilated, 2e 3 3 1
Concentric hypertrophic cardiomyopathy 3 3 3
Dilated cardiomyopathy 1Y 3 3 1
Paroxysmal atrial fibrillation 3 3 4
Sick sinus syndrome 2, autosomal dominant 3 3 1
Barth syndrome 2 2 1
Congenital short qt syndrome 2 2 5
Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 2 2 2 1
5-oxoprolinase deficiency 1 1 1
Congenital right-sided heart lesions 1 1 1
Dilated cardiomyopathy 1Z 1 1 1
Hypertrophy 1 1 51
Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
SCN5A 16 / 35 Arrhythmogenic right ventricular cardiomyopathy, Atrial flutter, Brugada syndrome, Cardiac arrest and 12 more
TTN 15 / 35 Arrhythmogenic right ventricular cardiomyopathy, Atrial flutter, Atrioventricular block, Brugada syndrome and 11 more
DSP 13 / 35 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Cardiac arrest, Cardiac arrhythmia and 9 more
MYH6 13 / 35 Arrhythmogenic right ventricular cardiomyopathy, Atrial flutter, Cardiac arrest, Cardiac arrhythmia and 9 more
TRPM4 12 / 35 Arrhythmogenic right ventricular cardiomyopathy, Atrioventricular block, Brugada syndrome, Cardiac arrest and 8 more
KCNH2 11 / 35 Atrial flutter, Brugada syndrome, Cardiac arrest, Cardiac arrhythmia and 7 more
RYR2 11 / 35 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Cardiac arrest, Cardiac arrhythmia and 7 more
CACNA1C 10 / 35 Brugada syndrome, Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Concentric hypertrophic cardiomyopathy and 6 more
ANK2 9 / 35 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Cardiac arrest, Cardiac arrhythmia and 5 more
HCN4 9 / 35 Arrhythmogenic right ventricular cardiomyopathy, Atrial flutter, Brugada syndrome, Cardiac arrest and 5 more
KCNJ2 9 / 35 Brugada syndrome, Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Congenital short qt syndrome and 5 more
KCNQ1 9 / 35 Brugada syndrome, Cardiac arrhythmia, Conduction disorder of the heart, Congenital short qt syndrome and 5 more
LMNA 9 / 35 Arrhythmogenic right ventricular cardiomyopathy, Atrioventricular block, Cardiac arrhythmia, Cardiac conduction disease and 5 more
MYBPC3 9 / 35 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Catecholaminergic polymorphic ventricular tachycardia, Concentric hypertrophic cardiomyopathy and 5 more
PKP2 9 / 35 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia and 5 more
DSG2 8 / 35 Arrhythmogenic right ventricular cardiomyopathy, Cardiac arrest, Catecholaminergic polymorphic ventricular tachycardia, Conduction disorder of the heart and 4 more
MYH7 8 / 35 Arrhythmogenic right ventricular cardiomyopathy, Cardiac arrhythmia, Conduction disorder of the heart, Left ventricular disease and 4 more
SCN1B 8 / 35 Brugada syndrome, Cardiac arrhythmia, Cardiac conduction disease, Conduction disorder of the heart and 4 more
CACNA2D1 7 / 35 Brugada syndrome, Cardiac arrest, Congenital short qt syndrome, Long qt syndrome and 3 more
CACNB2 7 / 35 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Cardiac arrest, Cardiac conduction disease and 3 more
CASQ2 7 / 35 Atrial flutter, Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Conduction disorder of the heart and 3 more
JUP 7 / 35 Arrhythmogenic right ventricular cardiomyopathy, Conduction disorder of the heart, Left ventricular disease, Left ventricular noncompaction cardiomyopathy and 3 more
SCN10A 7 / 35 Atrial flutter, Atrioventricular block, Brugada syndrome, Cardiac arrhythmia and 3 more
LAMA4 6 / 35 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Catecholaminergic polymorphic ventricular tachycardia, Dilated cardiomyopathy 1JJ and 2 more
NKX2-5 6 / 35 Atrial flutter, Atrioventricular block, Hereditary atrial fibrillation, Hereditary bundle branch system defect and 2 more
RBM20 6 / 35 Arrhythmogenic right ventricular cardiomyopathy, Conduction disorder of the heart, Left ventricular noncompaction cardiomyopathy, Long qt syndrome and 2 more
TBX5 6 / 35 Atrial flutter, Atrioventricular block, Brugada syndrome, Cardiac arrhythmia and 2 more
ABCC9 5 / 35 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Hereditary atrial fibrillation, Left ventricular disease and 1 more
ACTC1 5 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Restrictive cardiomyopathy and 1 more
AKAP9 5 / 35 Brugada syndrome, Cardiac arrest, Long qt syndrome, Ventricular fibrillation and 1 more
FLNC 5 / 35 Arrhythmogenic right ventricular cardiomyopathy, Cardiac arrhythmia, Conduction disorder of the heart, Restrictive cardiomyopathy and 1 more
KCNJ8 5 / 35 Brugada syndrome, Cardiac arrest, Cardiac arrhythmia, Long qt syndrome and 1 more
PITX2 5 / 35 Atrial flutter, Cardiac arrhythmia, Hereditary atrial fibrillation, Sick sinus syndrome and 1 more
SLC4A3 5 / 35 Cardiac arrest, Cardiac arrhythmia, Congenital short qt syndrome, Short qt syndrome and 1 more
SNTA1 5 / 35 Brugada syndrome, Long qt syndrome, Sick sinus syndrome, Ventricular fibrillation and 1 more
SYNE2 5 / 35 Atrial flutter, Cardiac arrhythmia, Left ventricular disease, Long qt syndrome and 1 more
TNNT2 5 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Restrictive cardiomyopathy and 1 more
VCL 5 / 35 Dilated cardiomyopathy 1W, Long qt syndrome, Short qt syndrome, Ventricular fibrillation and 1 more
ACTN2 4 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular noncompaction cardiomyopathy, Ventricular fibrillation, Wolff-parkinson-white syndrome
AGT 4 / 35 Cardiac arrhythmia, Hypertrophy, Left ventricular disease, Sick sinus syndrome
CEP85L 4 / 35 Arrhythmogenic right ventricular cardiomyopathy, Atrial flutter, Cardiac arrest, Cardiac arrhythmia
DMD 4 / 35 Arrhythmogenic right ventricular cardiomyopathy, Conduction disorder of the heart, Left ventricular noncompaction cardiomyopathy, Restrictive cardiomyopathy
DPP6 4 / 35 Cardiac arrest, Long qt syndrome, Ventricular fibrillation, Wolff-parkinson-white syndrome
DTNA 4 / 35 Cardiac arrhythmia, Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 2
JPH2 4 / 35 Cardiomyopathy, dilated, 2e, Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Ventricular fibrillation
KCNE2 4 / 35 Cardiac arrhythmia, Hereditary atrial fibrillation, Long qt syndrome, Ventricular fibrillation
KCNJ5 4 / 35 Atrial flutter, Hereditary atrial fibrillation, Long qt syndrome, Sick sinus syndrome
LDB3 4 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Long qt syndrome
NEXN 4 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Long qt syndrome
PRDM16 4 / 35 Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Restrictive cardiomyopathy, Wolff-parkinson-white syndrome
SCN3B 4 / 35 Brugada syndrome, Cardiac arrhythmia, Hereditary atrial fibrillation, Long qt syndrome
TNNI3 4 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular noncompaction cardiomyopathy, Long qt syndrome, Restrictive cardiomyopathy
TPM1 4 / 35 Arrhythmogenic right ventricular cardiomyopathy, Dilated cardiomyopathy 1Y, Left ventricular disease, Left ventricular noncompaction cardiomyopathy
ACE 3 / 35 Cardiac arrhythmia, Hypertrophy, Left ventricular disease
ACTA1 3 / 35 Hypertrophy, Left ventricular disease, Restrictive cardiomyopathy
BAG3 3 / 35 Arrhythmogenic right ventricular cardiomyopathy, Atrioventricular block, Long qt syndrome
CALM1 3 / 35 Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Long qt syndrome
CALM2 3 / 35 Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Long qt syndrome
CALM3 3 / 35 Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Long qt syndrome
COL5A1 3 / 35 Brugada syndrome, Cardiac arrhythmia, Wolff-parkinson-white syndrome
CTNNA3 3 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular noncompaction cardiomyopathy, Long qt syndrome
DES 3 / 35 Arrhythmogenic right ventricular cardiomyopathy, Atrioventricular block, Restrictive cardiomyopathy
DSC2 3 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular disease, Long qt syndrome
EDN1 3 / 35 Cardiac arrhythmia, Hypertrophy, Left ventricular disease
GJA5 3 / 35 Atrial flutter, Hereditary atrial fibrillation, Wolff-parkinson-white syndrome
GPD1L 3 / 35 Brugada syndrome, Long qt syndrome, Wolff-parkinson-white syndrome
KCNA5 3 / 35 Atrioventricular block, Cardiac arrhythmia, Hereditary atrial fibrillation
KCNE1 3 / 35 Arrhythmogenic right ventricular cardiomyopathy, Hereditary atrial fibrillation, Long qt syndrome
KCNE3 3 / 35 Brugada syndrome, Long qt syndrome, Ventricular fibrillation
MYL3 3 / 35 Arrhythmogenic right ventricular cardiomyopathy, Long qt syndrome, Restrictive cardiomyopathy
MYPN 3 / 35 Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Restrictive cardiomyopathy
NEBL 3 / 35 Cardiac arrest, Cardiac arrhythmia, Wolff-parkinson-white syndrome
NPPA 3 / 35 Hereditary atrial fibrillation, Hypertrophy, Left ventricular disease
PLN 3 / 35 Arrhythmogenic right ventricular cardiomyopathy, Cardiac arrest, Cardiac arrhythmia
PRKAG2 3 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular disease, Wolff-parkinson-white syndrome
SCN4B 3 / 35 Catecholaminergic polymorphic ventricular tachycardia, Hereditary atrial fibrillation, Long qt syndrome
SIRT6 3 / 35 Hypertrophy, Left ventricular disease, Long qt syndrome
SLMAP 3 / 35 Brugada syndrome, Cardiac arrest, Long qt syndrome
TAFAZZIN 3 / 35 Barth syndrome, Left ventricular disease, Left ventricular noncompaction cardiomyopathy
TBX20 3 / 35 Brugada syndrome, Left ventricular disease, Wolff-parkinson-white syndrome
TGFB3 3 / 35 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Long qt syndrome
TMEM43 3 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular noncompaction cardiomyopathy, Long qt syndrome
TRDN 3 / 35 Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Long qt syndrome
ZFHX3 3 / 35 Atrial flutter, Cardiac arrhythmia, Sick sinus syndrome
ADRB3 2 / 35 Hypertrophy, Left ventricular disease
AGTR2 2 / 35 Hypertrophy, Left ventricular disease
AHR 2 / 35 Hypertrophy, Left ventricular disease
AKAP6 2 / 35 Atrial flutter, Cardiac arrhythmia
ANKRD1 2 / 35 Brugada syndrome, Left ventricular disease
AOPEP 2 / 35 Atrial flutter, Cardiac arrhythmia
ASAH1 2 / 35 Atrial flutter, Cardiac arrhythmia
C2ORF49 2 / 35 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular noncompaction cardiomyopathy
CACNA1C-IT2 2 / 35 Brugada syndrome, Long qt syndrome
CACNA1D 2 / 35 Long qt syndrome, Sick sinus syndrome
CAND2 2 / 35 Atrial flutter, Cardiac arrhythmia
CAV1 2 / 35 Atrial flutter, Cardiac arrhythmia
CAV3 2 / 35 Brugada syndrome, Long qt syndrome
CCDC141 2 / 35 Atrioventricular block, Sick sinus syndrome
CDKN1A 2 / 35 Atrial flutter, Hypertrophy
CEP68 2 / 35 Atrial flutter, Cardiac arrhythmia
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Cytoskeleton in muscle cells
FLNC, LMNA, PKP2, DES, DSC2, DSG2, DSP, JUP, LDB3, MYBPC3, MYH7, MYL3
 KEGG 51 / 232 6.7× 3.58e-28 8.37e-25 ✓ sig.
Adrenergic signaling in cardiomyocytes
AGT, CACNA1C, CALM1, CALM2, CALM3, KCNQ1, PLN, PPP1R1A, RYR2, SCN5A, MYH7, MYL3
 KEGG 37 / 154 7.3× 4.42e-22 4.32e-19 ✓ sig.
Hypertrophic cardiomyopathy
ACE, AGT, CACNA1C, EDN1, LMNA, RYR2, DES, MYBPC3, MYH7, MYL3, TGFB3, TTN
 KEGG 29 / 99 8.9× 3.84e-20 2.69e-17 ✓ sig.
Dilated cardiomyopathy
AGT, CACNA1C, LMNA, PLN, RYR2, DES, MYBPC3, MYH7, MYL3, TGFB3, TTN, ACTC1
 KEGG 27 / 105 7.8× 3.17e-17 1.38e-14 ✓ sig.
Oxytocin signaling pathway
CACNA1C, CALM1, CALM2, CALM3, KCNJ2, PTGS2, RYR2, CACNB2, RYR1, PRKAG2, CDKN1A, KCNJ5
 KEGG 30 / 154 5.9× 2.04e-15 6.32e-13 ✓ sig.
Striated Muscle Contraction
DES, MYBPC3, MYL3, TTN, ACTC1, ACTN2, DMD, MYH6, MYL2, TNNC1, TNNI3, TNNT2
 Reactome 16 / 36 13.5× 5.56e-15 1.57e-12 ✓ sig.
Phase 0 - rapid depolarisation
CACNA1C, CALM1, CALM2, CALM3, SCN5A, CACNB2, SCN10A, CACNA2D1, CAMK2D, RANGRF, SCN1B, SCN2B
 Reactome 17 / 44 11.7× 1.33e-14 3.51e-12 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy
CACNA1C, GJA1, LMNA, PKP2, RYR2, CDH2, CTNNA3, DES, DSC2, DSG2, DSP, JUP
 KEGG 22 / 86 7.8× 3.27e-14 8.20e-12 ✓ sig.
Cardiac muscle contraction
CACNA1C, CASQ2, RYR2, TRDN, MYH7, MYL3, ACTC1, CACNB2, MYH6, MYL2, TNNC1, TNNI3
 KEGG 21 / 87 7.3× 4.40e-13 8.50e-11 ✓ sig.
cGMP-PKG signaling pathway
CACNA1C, CALM1, CALM2, CALM3, KNG1, PLN, MYH7, MYH6, GNAI2, GATA4, KCNJ8, INS
 KEGG 28 / 166 5.1× 7.79e-13 1.42e-10 ✓ sig.
Proteoglycans in cancer
ANK2, CAV1, CDKN1A, PTK2, WNT8A, CAMK2D, CAV3, PRKCA, SOS1, TNF, CAV2, RAF1
 KEGG 30 / 204 4.5× 4.54e-12 6.86e-10 ✓ sig.
Renin secretion
ACE, AGT, CACNA1C, CALM1, CALM2, CALM3, EDN1, KCNJ2, GNAI2, CACNA1D, ITPR3, NPPA
 KEGG 17 / 69 7.5× 5.45e-11 6.44e-9 ✓ sig.
Phase 2 - plateau phase
CACNA1C, KCNQ1, CACNB2, KCNE1, AKAP9, CACNA2D1, KCNE3, KCNE5, KCNE2, CACNA1D, CACNA1S
 Reactome 11 / 25 13.4× 1.25e-10 1.34e-8 ✓ sig.
Glioma
CALM1, CALM2, CALM3, CDK6, CDKN1A, CAMK2D, PRKCA, SOS1, RAF1, BRAF, CCND1, MAPK1
 KEGG 17 / 76 6.8× 2.83e-10 2.81e-8 ✓ sig.
Cellular senescence
CALM1, CALM2, CALM3, TGFB3, CDK6, CDKN1A, GATA4, RAF1, CACNA1D, CCND1, ITPR3, MAPK1
 KEGG 24 / 157 4.6× 2.94e-10 2.90e-8 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
regulation of heart rate by cardiac conduction
ACE, CACNA1C, KCNH2, KCNJ2, KCNQ1, PKP2, SCN5A, CTNNA3, DSC2, DSG2, DSP, JUP
 GO:0086091 34 / 43 37.4× 1.28e-49 2.77e-45 ✓ sig.
cardiac muscle contraction
CASQ2, KCNH2, KCNQ1, RYR2, SCN5A, MYBPC3, MYH7, MYL3, TTN, ACTC1, DMD, MYH6
 GO:0060048 31 / 43 34.1× 4.46e-43 5.79e-39 ✓ sig.
ventricular cardiac muscle cell action potential
KCNH2, KCNQ1, PKP2, RYR2, SCN5A, ANK2, KCNE1, GJA5, CAV3, GPD1L, KCNE3, KCNE5
 GO:0086005 15 / 17 41.7× 7.55e-24 2.03e-20 ✓ sig.
regulation of heart rate
CALM1, CALM2, CALM3, CASQ2, KCNQ1, RYR2, SCN5A, MYH7, ANK2, DMD, HCN4, MYH6
 GO:0002027 20 / 39 24.3× 9.38e-24 2.45e-20 ✓ sig.
regulation of ventricular cardiac muscle cell membrane repolarization
KCNH2, KCNQ1, SCN5A, ANK2, KCNE1, GJA5, AKAP9, CACNA2D1, CAV3, KCNE3, KCNE5, SCN1B
 GO:0060307 16 / 21 36.0× 2.17e-23 5.49e-20 ✓ sig.
membrane repolarization during ventricular cardiac muscle cell action potential
KCNH2, KCNQ1, KCNE1, KCNJ5, DLG1, KCND3, KCNE3, KCNE5, KCNJ8, SCN2B, KCNE2, KCNJ3
 GO:0098915 12 / 13 43.7× 8.60e-20 1.36e-16 ✓ sig.
heart development
CACNA1C, EDN1, GJA1, KCNQ1, PKP2, LDB3, TGFB3, ABCC9, MYL2, TNNI3, PRKAR1A, CDKN1A
 GO:0007507 37 / 273 6.4× 1.71e-19 2.65e-16 ✓ sig.
sarcomere organization
FLNC, LDB3, MYBPC3, TTN, ACTN2, MYH6, MYOM1, TNNT2, TPM1, PLEC, PRKAR1A, OBSCN
 GO:0045214 18 / 43 19.8× 1.81e-19 2.78e-16 ✓ sig.
regulation of ventricular cardiac muscle cell action potential
CACNA1C, PKP2, RYR2, CTNNA3, DSC2, DSG2, DSP, JUP, TRPM4, CAV1, DLG1
 GO:0098911 11 / 11 47.3× 3.28e-19 4.84e-16 ✓ sig.
regulation of cardiac muscle contraction
CALM1, CALM2, CALM3, RYR2, SCN5A, ANK2, HCN4, TNNI3K, GJA5, NKX2-5, SCN10A, CAV3
 GO:0055117 14 / 24 27.6× 4.58e-18 5.58e-15 ✓ sig.
cardiac muscle cell action potential involved in contraction
CACNA1C, KCNJ2, PKP2, SCN5A, KCNE1, SCN10A, CACNA2D1, SCN1B, SCN2B, SCN3B, KCNE2, CACNA1D
 GO:0086002 14 / 24 27.6× 4.58e-18 5.58e-15 ✓ sig.
muscle contraction
CACNA1C, TRDN, DES, MYH7, MYL3, TTN, DMD, HCN4, MYH6, RYR1, KCND3, SLMAP
 GO:0006936 21 / 85 11.7× 4.98e-17 5.16e-14 ✓ sig.
striated muscle contraction
CASQ2, RYR2, MYH7, TTN, MYH6, RYR1, TNNI3, TNNT2, DTNA, GAA, MYLK2, CACNA1S
 GO:0006941 12 / 24 23.7× 1.45e-14 9.83e-12 ✓ sig.
cardiac muscle cell development
TTN, ACTN2, MYH6, PLEC, LRRC10, NKX2-5, CAV3, MYO18B, MTOR, MYH11, ALPK3, TCAP
 GO:0055013 12 / 25 22.7× 2.74e-14 1.75e-11 ✓ sig.
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
CACNA1C, CALM1, CALM2, CALM3, CASQ2, PLN, RYR2, TRDN, ANK2, DMD, CAMK2D, HRC
 GO:0010881 12 / 25 22.7× 2.74e-14 1.75e-11 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Hypertrophy Left ventricular disease 0.341 30 3.28e-61 9.97e-60 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Left ventricular noncompaction cardiomyopathy 0.368 25 2.50e-55 7.13e-54 ✓ sig.
Atrial flutter Cardiac arrhythmia 0.215 32 6.48e-51 1.76e-49 ✓ sig.
Long qt syndrome Ventricular fibrillation 0.217 25 2.10e-47 5.47e-46 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Long qt syndrome 0.208 27 5.04e-46 1.29e-44 ✓ sig.
Brugada syndrome Long qt syndrome 0.201 28 1.35e-45 3.42e-44 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Long qt syndrome 0.189 20 5.66e-42 1.36e-40 ✓ sig.
Long qt syndrome Wolff-parkinson-white syndrome 0.176 23 7.99e-38 1.81e-36 ✓ sig.
Cardiac arrhythmia Long qt syndrome 0.148 26 2.19e-35 4.77e-34 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Wolff-parkinson-white syndrome 0.218 19 2.51e-35 5.47e-34 ✓ sig.
Brugada syndrome Ventricular fibrillation 0.214 18 1.48e-34 3.19e-33 ✓ sig.
Left ventricular disease Left ventricular noncompaction cardiomyopathy 0.207 18 5.33e-34 1.14e-32 ✓ sig.
Cardiac arrest Ventricular fibrillation 0.294 15 6.41e-34 1.36e-32 ✓ sig.
Brugada syndrome Wolff-parkinson-white syndrome 0.196 19 1.17e-33 2.47e-32 ✓ sig.
Conduction disorder of the heart Wolff-parkinson-white syndrome 0.246 15 7.60e-33 1.59e-31 ✓ sig.
Ventricular fibrillation Wolff-parkinson-white syndrome 0.219 16 1.70e-31 3.44e-30 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Conduction disorder of the heart 0.215 14 1.19e-29 2.33e-28 ✓ sig.
Conduction disorder of the heart Ventricular fibrillation 0.265 13 1.86e-29 3.59e-28 ✓ sig.
Left ventricular noncompaction cardiomyopathy Wolff-parkinson-white syndrome 0.200 15 8.73e-29 1.67e-27 ✓ sig.
Cardiac arrhythmia Catecholaminergic polymorphic ventricular tachycardia 0.139 15 1.89e-28 3.57e-27 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Left ventricular disease 0.163 17 2.24e-28 4.25e-27 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Wolff-parkinson-white syndrome 0.210 13 1.13e-27 2.10e-26 ✓ sig.
Cardiac arrhythmia Wolff-parkinson-white syndrome 0.135 18 1.46e-27 2.71e-26 ✓ sig.
Left ventricular disease Wolff-parkinson-white syndrome 0.157 16 1.06e-26 1.92e-25 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Conduction disorder of the heart 0.297 11 1.09e-26 1.96e-25 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Restrictive cardiomyopathy 0.182 12 1.14e-24 1.93e-23 ✓ sig.
Conduction disorder of the heart Left ventricular noncompaction cardiomyopathy 0.212 11 9.58e-24 1.58e-22 ✓ sig.
Brugada syndrome Catecholaminergic polymorphic ventricular tachycardia 0.158 12 1.08e-23 1.78e-22 ✓ sig.
Brugada syndrome Conduction disorder of the heart 0.156 12 2.16e-23 3.51e-22 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Cardiac arrest 0.169 12 2.53e-23 4.10e-22 ✓ sig.
Short qt syndrome Ventricular fibrillation 0.225 9 4.84e-23 7.77e-22 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Ventricular fibrillation 0.196 10 1.79e-21 2.74e-20 ✓ sig.
Left ventricular noncompaction cardiomyopathy Restrictive cardiomyopathy 0.192 10 2.43e-21 3.71e-20 ✓ sig.
Left ventricular disease Restrictive cardiomyopathy 0.139 11 4.55e-21 6.89e-20 ✓ sig.
Restrictive cardiomyopathy Wolff-parkinson-white syndrome 0.136 9 1.70e-17 2.28e-16 ✓ sig.
Cardiac arrest Conduction disorder of the heart 0.178 8 2.74e-17 3.63e-16 ✓ sig.
Congenital short qt syndrome Short qt syndrome 0.417 5 6.22e-17 8.15e-16 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Cardiac conduction disease 0.123 7 1.50e-16 1.93e-15 ✓ sig.
Brugada syndrome Hereditary atrial fibrillation 0.113 9 2.43e-16 3.12e-15 ✓ sig.
Conduction disorder of the heart Restrictive cardiomyopathy 0.171 7 1.97e-15 2.43e-14 ✓ sig.
Cardiac arrest Catecholaminergic polymorphic ventricular tachycardia 0.156 7 6.72e-15 8.08e-14 ✓ sig.
Cardiac arrest Short qt syndrome 0.176 6 9.03e-15 1.08e-13 ✓ sig.
Atrial flutter Sick sinus syndrome 0.087 8 1.65e-14 1.94e-13 ✓ sig.
Sick sinus syndrome Wolff-parkinson-white syndrome 0.111 7 8.46e-14 9.61e-13 ✓ sig.
Conduction disorder of the heart Hereditary bundle branch system defect 0.185 5 1.20e-13 1.35e-12 ✓ sig.
Hereditary bundle branch system defect Ventricular fibrillation 0.125 5 1.23e-12 1.32e-11 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Short qt syndrome 0.167 5 2.08e-12 2.18e-11 ✓ sig.
Hereditary atrial fibrillation Ventricular fibrillation 0.107 6 1.58e-11 1.59e-10 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Hereditary bundle branch system defect 0.148 4 1.29e-10 1.20e-9 ✓ sig.
Atrial flutter Wolff-parkinson-white syndrome 0.064 8 2.09e-10 1.90e-9 ✓ sig.
Cardiac conduction disease Conduction disorder of the heart 0.133 4 5.56e-10 4.91e-9 ✓ sig.
Atrioventricular block Sick sinus syndrome 0.125 4 3.01e-9 2.51e-8 ✓ sig.
Cardiac conduction disease Hereditary bundle branch system defect 0.214 3 4.74e-9 3.89e-8 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Sick sinus syndrome 0.105 4 1.12e-8 8.76e-8 ✓ sig.
Hereditary atrial fibrillation Sick sinus syndrome 0.103 4 1.34e-8 1.04e-7 ✓ sig.
Cardiac conduction disease Short qt syndrome 0.167 3 2.23e-8 1.72e-7 ✓ sig.
Cardiac conduction disease Sick sinus syndrome 0.120 3 1.10e-7 7.69e-7 ✓ sig.
Hereditary atrial fibrillation Hereditary bundle branch system defect 0.103 3 1.14e-7 7.94e-7 ✓ sig.
Congenital short qt syndrome Paroxysmal atrial fibrillation 0.250 2 5.00e-7 3.18e-6 ✓ sig.
Paroxysmal atrial fibrillation Short qt syndrome 0.143 2 2.75e-6 1.58e-5 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Concentric hypertrophic cardiomyopathy 0.080 2 6.32e-6 3.48e-5 ✓ sig.
Atrioventricular block Hereditary bundle branch system defect 0.087 2 2.37e-5 1.24e-4 ✓ sig.
Atrioventricular block Cardiac conduction disease 0.080 2 4.06e-5 1.98e-4 ✓ sig.
Dilated cardiomyopathy 1W Short qt syndrome 0.083 1 7.10e-4 1.17e-3 ✓ sig.
Concentric hypertrophic cardiomyopathy Paroxysmal atrial fibrillation 0.143 1 7.75e-4 1.25e-3 ✓ sig.
Sick sinus syndrome Sick sinus syndrome 2, autosomal dominant 0.053 1 1.16e-3 1.73e-3 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Dilated cardiomyopathy 1JJ 0.042 1 1.49e-3 2.12e-3 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Dilated cardiomyopathy 1BB 0.042 1 1.49e-3 2.12e-3 ✓ sig.
Conduction disorder of the heart Dilated cardiomyopathy 1BB 0.040 1 1.55e-3 2.19e-3 ✓ sig.
Cardiac arrest Sick sinus syndrome 2, autosomal dominant 0.034 1 1.81e-3 2.49e-3 ✓ sig.
Cardiac arrest Dilated cardiomyopathy 1BB 0.034 1 1.81e-3 2.49e-3 ✓ sig.
Concentric hypertrophic cardiomyopathy Short qt syndrome 0.071 1 2.13e-3 2.85e-3 ✓ sig.
Dilated cardiomyopathy 1W Ventricular fibrillation 0.026 1 2.39e-3 3.12e-3 ✓ sig.
Dilated cardiomyopathy 1BB Ventricular fibrillation 0.026 1 2.39e-3 3.12e-3 ✓ sig.
Congenital right-sided heart lesions Ventricular fibrillation 0.026 1 2.39e-3 3.12e-3 ✓ sig.
Cardiomyopathy, dilated, 2e Ventricular fibrillation 0.026 1 2.39e-3 3.12e-3 ✓ sig.
Left ventricular noncompaction cardiomyopathy Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 2 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Barth syndrome Left ventricular noncompaction cardiomyopathy 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Cardiomyopathy, dilated, 2e Left ventricular noncompaction cardiomyopathy 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Dilated cardiomyopathy 1Y Left ventricular noncompaction cardiomyopathy 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Dilated cardiomyopathy 1JJ Left ventricular noncompaction cardiomyopathy 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Dilated cardiomyopathy 1BB Left ventricular noncompaction cardiomyopathy 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Left ventricular noncompaction cardiomyopathy Sick sinus syndrome 2, autosomal dominant 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypotonia, ataxia, developmental delay, and tooth enamel defect syndrome Wolff-parkinson-white syndrome 0.019 1 3.29e-3 4.15e-3 ✓ sig.
Dilated cardiomyopathy 1W Wolff-parkinson-white syndrome 0.019 1 3.29e-3 4.15e-3 ✓ sig.
Dilated cardiomyopathy 1JJ Wolff-parkinson-white syndrome 0.019 1 3.29e-3 4.15e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy 1JJ 0.018 1 3.49e-3 4.34e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy 1Z 0.018 1 3.49e-3 4.34e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy 1Y 0.018 1 3.49e-3 4.34e-3 ✓ sig.
Brugada syndrome Dilated cardiomyopathy 1JJ 0.015 1 4.13e-3 5.06e-3 ✓ sig.
Left ventricular disease Myopathy with myalgia, increased serum creatine kinase, and with or without episodic rhabdomyolysis 2 0.015 1 4.26e-3 5.20e-3 ✓ sig.
Dilated cardiomyopathy 1Y Left ventricular disease 0.015 1 4.26e-3 5.20e-3 ✓ sig.
Barth syndrome Left ventricular disease 0.015 1 4.26e-3 5.20e-3 ✓ sig.
Cardiomyopathy, dilated, 2e Left ventricular disease 0.015 1 4.26e-3 5.20e-3 ✓ sig.
5-oxoprolinase deficiency Atrial flutter 0.012 1 5.23e-3 6.23e-3 ✓ sig.
Dilated cardiomyopathy 1W Long qt syndrome 0.010 1 6.59e-3 7.69e-3 ✓ sig.