Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

← Back to all clusters

Cluster 153

9 diseases · 18 shared-gene connections
9 Diseases
89 Unique genes
0.213 Avg. similarity score
Congestive ophthalmopathy Most-connected disease (6 links)
Log in to save this analysis

Save This Analysis

Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Congestive ophthalmopathy 6 6 13
Graves ophthalmopathy 6 6 18
Myopathic ophthalmopathy 6 6 13
Graft-versus-host disease 5 5 21
Granulomatosis with polyangiitis 4 4 14
T-cell leukemia-lymphoma 4 4 36
Anorexia 3 3 18
HELIOS deficiency 1 1 1
gray platelet syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
CTLA4 6 / 9 Congestive ophthalmopathy, Graft-versus-host disease, Granulomatosis with polyangiitis, Graves ophthalmopathy and 2 more
IL10 6 / 9 Congestive ophthalmopathy, Graft-versus-host disease, Granulomatosis with polyangiitis, Graves ophthalmopathy and 2 more
IL2 6 / 9 Anorexia, Congestive ophthalmopathy, Graft-versus-host disease, Graves ophthalmopathy and 2 more
IL1RN 5 / 9 Anorexia, Congestive ophthalmopathy, Graft-versus-host disease, Graves ophthalmopathy and 1 more
PTPN22 5 / 9 Congestive ophthalmopathy, Graft-versus-host disease, Granulomatosis with polyangiitis, Graves ophthalmopathy and 1 more
TNF 4 / 9 Anorexia, Congestive ophthalmopathy, Graves ophthalmopathy, Myopathic ophthalmopathy
CA1 3 / 9 Congestive ophthalmopathy, Graves ophthalmopathy, Myopathic ophthalmopathy
ICAM1 3 / 9 Congestive ophthalmopathy, Graves ophthalmopathy, Myopathic ophthalmopathy
IL23R 3 / 9 Congestive ophthalmopathy, Graves ophthalmopathy, Myopathic ophthalmopathy
IL3 3 / 9 Congestive ophthalmopathy, Graves ophthalmopathy, Myopathic ophthalmopathy
PTGS2 3 / 9 Congestive ophthalmopathy, Graves ophthalmopathy, Myopathic ophthalmopathy
SCD 3 / 9 Congestive ophthalmopathy, Graves ophthalmopathy, Myopathic ophthalmopathy
TSHR 3 / 9 Congestive ophthalmopathy, Graves ophthalmopathy, Myopathic ophthalmopathy
HLA-DPB1 2 / 9 Graft-versus-host disease, Granulomatosis with polyangiitis
IFNA2 2 / 9 Anorexia, T-cell leukemia-lymphoma
IFNG 2 / 9 Graft-versus-host disease, T-cell leukemia-lymphoma
IKZF2 2 / 9 HELIOS deficiency, T-cell leukemia-lymphoma
NBEAL2 2 / 9 Graves ophthalmopathy, gray platelet syndrome
TNFSF8 2 / 9 Graft-versus-host disease, T-cell leukemia-lymphoma
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Inflammatory bowel disease
IL1B, IL2, TNF, IL10, IL23R, IFNG, IL17A, HLA-DPB1, IL1A, NOD2, HLA-DPA1, STAT3
 KEGG 15 / 66 30.7× 6.44e-19 4.42e-16 ✓ sig.
Cytokine-cytokine receptor interaction
IFNA2, IL1B, IL1RN, IL2, TNF, TNFRSF10A, TNFRSF1A, IL10, IL23R, IL3, IFNG, IL17A
 KEGG 22 / 298 10.0× 2.01e-16 8.76e-14 ✓ sig.
Interleukin-10 signaling
IL1B, IL1RN, TNF, TNFRSF1A, ICAM1, IL10, PTGS2, IL10RB, IL1A, CCR5, STAT3
 Reactome 11 / 47 31.6× 2.74e-14 7.77e-12 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
IL1B, TNF, ICAM1, IL10, IL23R, PTGS2, IL17A, HGF, IL1A, STAT3, BIRC5, GATA3
 Reactome 14 / 108 17.5× 4.16e-14 1.12e-11 ✓ sig.
Leishmaniasis
IL1B, TNF, IL10, PTGS2, IFNG, FCGR3A, HLA-DPB1, IL1A, FCGR3B, HLA-DPA1, IL4, PRKCB
 KEGG 12 / 78 20.8× 3.72e-13 8.64e-11 ✓ sig.
Th17 cell differentiation
IL1B, IL2, IL23R, IFNG, IL17A, HLA-DPB1, HLA-DPA1, STAT3, FOXP3, GATA3, IL4, IRF4
 KEGG 13 / 109 16.1× 1.08e-12 2.36e-10 ✓ sig.
Autoimmune thyroid disease
IFNA2, IL2, CTLA4, IL10, TSHR, HLA-DPB1, HLA-DPA1, CD28, IFNA1, IL4
 KEGG 10 / 54 25.0× 5.45e-12 1.03e-9 ✓ sig.
Tuberculosis
IFNA2, IL1B, TNF, TNFRSF1A, IL10, IFNG, FCGR3A, HLA-DPB1, IL10RB, IL1A, NOD2, FCGR3B
 KEGG 14 / 181 10.4× 5.37e-11 8.20e-9 ✓ sig.
T cell receptor signaling pathway
IL2, TNF, CTLA4, IL10, IFNG, CARD11, CD28, FYN, ICOS, IL4, PLCG1, VAV1
 KEGG 12 / 122 13.3× 8.56e-11 1.25e-8 ✓ sig.
Natural killer cell mediated cytotoxicity
IFNA2, TNF, TNFRSF10A, ICAM1, IFNG, FCGR3A, FCGR3B, FYN, IFNA1, PLCG1, PRKCB, VAV1
 KEGG 12 / 133 12.2× 2.37e-10 3.13e-8 ✓ sig.
Allograft rejection
IL2, TNF, IL10, IFNG, HLA-DPB1, HLA-DPA1, CD28, IL4
 KEGG 8 / 39 27.7× 3.37e-10 4.31e-8 ✓ sig.
Type I diabetes mellitus
IL1B, IL2, TNF, IFNG, HLA-DPB1, IL1A, HLA-DPA1, CD28
 KEGG 8 / 44 24.5× 9.41e-10 1.06e-7 ✓ sig.
Graft-versus-host disease
IL1B, IL2, TNF, IFNG, HLA-DPB1, IL1A, HLA-DPA1, CD28
 KEGG 8 / 45 24.0× 1.14e-9 1.26e-7 ✓ sig.
Rheumatoid arthritis
IL1B, TNF, CTLA4, ICAM1, IFNG, IL17A, HLA-DPB1, IL1A, HLA-DPA1, CD28
 KEGG 10 / 95 14.2× 1.80e-9 1.87e-7 ✓ sig.
NF-kappa B signaling pathway
IL1B, TNF, TNFRSF1A, ICAM1, PTGS2, CARD11, CSNK2A1, CSNK2B, PLCG1, PRKCB
 KEGG 10 / 105 12.9× 4.84e-9 4.61e-7 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
immune response
CRHR1, IL1B, IL1RN, IL2, TNF, CTLA4, ICAM1, IL10, IL3, IFNG, IL17A, TNFSF8
 GO:0006955 32 / 543 12.4× 9.00e-27 3.35e-23 ✓ sig.
inflammatory response
CRH, IFNA2, IL1B, IL1RN, TAC1, TNF, TNFRSF1A, IL23R, IL17A, IL10RB, IL1A, CCR5
 GO:0006954 19 / 467 8.5× 5.67e-13 2.74e-10 ✓ sig.
positive regulation of transcription by RNA polymerase II
IL1B, IL2, TNF, TNFRSF1A, IL10, IFNG, IL17A, TNFSF8, HGF, IL1A, NOD2, GFI1B
 GO:0045944 25 / 1,208 4.3× 2.19e-10 5.78e-8 ✓ sig.
humoral immune response
IFNA2, TNF, IFNG, NOTCH1, CD28, GATA3, GPR183, IFNA1
 GO:0006959 8 / 58 29.0× 3.03e-10 7.74e-8 ✓ sig.
cell surface receptor signaling pathway
CRHR1, CRHR2, IFNA2, TNFRSF1A, TSHR, IFNG, FCGR3A, CCR5, FCGR3B, MS4A10, CCR4, CD28
 GO:0007166 14 / 373 7.9× 2.46e-9 4.96e-7 ✓ sig.
cell surface receptor signaling pathway via STAT
IFNA2, IL2, IL23R, IL3, IFNG, STAT3
 GO:0097696 6 / 28 45.0× 3.41e-9 6.63e-7 ✓ sig.
positive regulation of cell population proliferation
CRH, IL1B, IL2, NPY, IL23R, IL3, TSHR, IFNG, NOD2, PRTN3, NOTCH1, STAT3
 GO:0008284 16 / 532 6.3× 3.86e-9 7.41e-7 ✓ sig.
positive regulation of T cell proliferation
IL1B, IL2, IL23R, HLA-DPB1, HLA-DPA1, CD28, IL4
 GO:0042102 7 / 67 21.9× 3.02e-8 4.41e-6 ✓ sig.
positive regulation of ERK1 and ERK2 cascade
GCG, IL1B, NPY, TNF, ICAM1, PTPN22, NOD2, NOTCH1, CCR7, GPR183
 GO:0070374 10 / 201 10.4× 4.03e-8 5.64e-6 ✓ sig.
negative regulation of inflammatory response
IL2, TNFRSF1A, IL10, HGF, PTPN2, STAT3, FOXP3, GATA3, IL4
 GO:0050728 9 / 152 12.4× 4.49e-8 6.18e-6 ✓ sig.
positive regulation of interleukin-10 production
HGF, NOD2, STAT3, CD28, IL4, IRF4
 GO:0032733 6 / 43 29.3× 5.21e-8 7.02e-6 ✓ sig.
response to lipopolysaccharide
IL1B, TAC1, TNF, IL10, IL23R, PTPN22, NOTCH1, CCR7, FOXP3
 GO:0032496 9 / 161 11.7× 7.37e-8 9.33e-6 ✓ sig.
positive regulation of type II interferon production
IL1B, IL2, TNF, IL23R, PTPN22, HLA-DPB1, HLA-DPA1
 GO:0032729 7 / 77 19.1× 8.03e-8 1.00e-5 ✓ sig.
signal transduction
CCK, CRH, CRHR1, CRHR2, GIP, HTR4, IL1B, IL1RN, TNFRSF10A, TNFRSF1A, TSHR, TNFRSF8
 GO:0007165 29 / 2,125 2.9× 8.14e-8 1.01e-5 ✓ sig.
T cell receptor signaling pathway
CTLA4, PTPN22, HLA-DPB1, CD28, FOXP3, FYN, GATA3, PLCG1
 GO:0050852 8 / 121 13.9× 1.12e-7 1.32e-5 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Congestive ophthalmopathy Myopathic ophthalmopathy 0.929 13 2.29e-45 1.15e-43 ✓ sig.
Graves ophthalmopathy Myopathic ophthalmopathy 0.684 13 1.96e-41 8.96e-40 ✓ sig.
Congestive ophthalmopathy Graves ophthalmopathy 0.684 13 1.96e-41 8.96e-40 ✓ sig.
Congestive ophthalmopathy Graft-versus-host disease 0.167 5 3.61e-12 4.35e-11 ✓ sig.
Graft-versus-host disease Myopathic ophthalmopathy 0.167 5 3.61e-12 4.35e-11 ✓ sig.
Graft-versus-host disease Graves ophthalmopathy 0.143 5 2.39e-11 2.68e-10 ✓ sig.
Graft-versus-host disease T-cell leukemia-lymphoma 0.094 5 1.04e-9 9.92e-9 ✓ sig.
Graft-versus-host disease Granulomatosis with polyangiitis 0.125 4 2.54e-9 2.32e-8 ✓ sig.
Congestive ophthalmopathy Granulomatosis with polyangiitis 0.120 3 1.70e-7 1.21e-6 ✓ sig.
Granulomatosis with polyangiitis Myopathic ophthalmopathy 0.120 3 1.70e-7 1.21e-6 ✓ sig.
Anorexia Myopathic ophthalmopathy 0.103 3 3.81e-7 2.53e-6 ✓ sig.
Anorexia Congestive ophthalmopathy 0.103 3 3.81e-7 2.53e-6 ✓ sig.
Granulomatosis with polyangiitis Graves ophthalmopathy 0.100 3 4.84e-7 3.19e-6 ✓ sig.
Anorexia Graves ophthalmopathy 0.088 3 1.08e-6 6.68e-6 ✓ sig.
Congestive ophthalmopathy T-cell leukemia-lymphoma 0.064 3 3.30e-6 1.87e-5 ✓ sig.
Myopathic ophthalmopathy T-cell leukemia-lymphoma 0.064 3 3.30e-6 1.87e-5 ✓ sig.
Graves ophthalmopathy gray platelet syndrome 0.053 1 1.17e-3 1.88e-3 ✓ sig.
HELIOS deficiency T-cell leukemia-lymphoma 0.027 1 2.34e-3 3.23e-3 ✓ sig.