Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
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Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Ankylosing spondylitis Inflammatory bowel disease
171 genes
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26 of 171 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ANKRD55(1), ATXN2L(1), BANK1(1), BSN(1), CDKAL1(1), EMSY(1), ETS1(1), FIBP(1), FUT2(1) +159 more
0.205 0.546 8.80e-151 1.62e-148 ✓ sig. Cluster 28 →
Cervical cancer Gastric cancer
110 genes
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1 of 110 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), ATXN7L1(1), BAD(1), BNC2(1), CELF2(1) +98 more
0.327 0.505 5.68e-152 1.06e-149 ✓ sig. Cluster 67 →
Gastric cancer Pancreatic cancer
113 genes
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5 of 113 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(4), ARHGEF10L(1), ASB3(1), ASIP(1), BAD(1), BNC2(1), CELF2(1) +101 more
0.317 0.518 4.90e-152 9.18e-150 ✓ sig. Cluster 67 →
Attention deficit hyperactivity disorder Major depressive disorder
474 genes
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83 of 474 corroborated by 2+ sources
SOX5(1), BPTF(1), RERE(1), COMT(2), HDAC4(2), MCM9(1), ZFPM2(1), ATP2A2(2), CDK10(1), ADAMTS2(1), ADARB1(1), ADCYAP1R1(1) +462 more
0.183 0.429 3.77e-152 7.13e-150 ✓ sig. Cluster 2 →
nonsyndromic genetic hearing loss Nonsyndromic hearing loss
72 genes
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72 of 72 corroborated by 2+ sources
CEACAM16(4), ESRRB(4), EYA4(4), GIPC3(3), MYO15A(4), OTOF(2), OTOGL(2), PCDH15(4), MCM2(4), OTOG(4), TMC1(5), HGF(4) +60 more
0.558 0.878 6.64e-153 1.27e-150 ✓ sig. Cluster 26 →
Breast cancer Prostate cancer
329 genes
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31 of 329 corroborated by 2+ sources
ANKRD11(1), HNF1B(2), KANSL1(1), RREB1(1), TBX1(1), MAP3K1(2), SH2B3(1), CHEK2(5), RTEL1(1), TERT(1), TP53(4), TPCN2(1) +317 more
0.194 0.342 6.00e-153 1.16e-150 ✓ sig. Cluster 20 →
Non-organic psychosis Psychotic disorders
69 genes
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TBX1(1), ANK3(1), CD34(1), GCH1(1), NPAS3(1), PCNT(1), PDE10A(1), SOBP(1), TCF4(1), WWC1(1), GSTP1(1), LEP(1) +57 more
0.548 1.000 3.58e-155 6.97e-153 ✓ sig. —
Anorexia nervosa Attention deficit hyperactivity disorder
183 genes
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3 of 183 corroborated by 2+ sources
SOX5(1), HMGA2(1), RERE(1), ATP2A2(1), ALMS1(1), AKAP6(2), BANK1(1), BCL11A(1), BRAF(1), BSN(1), C8orf90(1), CACNB2(1) +171 more
0.156 0.729 5.68e-156 1.12e-153 ✓ sig. —
Hearing loss Isolated sensorineural deafness
105 genes
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88 of 105 corroborated by 2+ sources
CEACAM16(3), CLIC5(2), COL11A1(3), ESRRB(2), EYA4(2), GIPC3(2), GRAP(4), LMX1A(4), MYO15A(2), NARS2(4), OTOF(2), OTOGL(2) +93 more
0.261 0.882 1.18e-157 2.34e-155 ✓ sig. Cluster 26 →
Deafness nonsyndromic genetic hearing loss
79 genes
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79 of 79 corroborated by 2+ sources
CEACAM16(4), ESRRB(4), EYA4(4), GIPC3(4), GRAP(3), MYO15A(4), NARS2(3), OTOF(4), OTOGL(4), PCDH15(4), MCM2(4), OTOG(4) +67 more
0.449 0.963 3.04e-159 6.08e-157 ✓ sig. Cluster 26 →
Autism Schizophrenia
652 genes
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347 of 652 corroborated by 2+ sources
SOX5(3), CHRNA7(2), RAI1(3), KANSL1(1), NFIX(1), DPYD(3), RERE(2), COMT(3), SHANK3(4), HDAC4(2), SRD5A2(1), WWOX(2) +640 more
0.194 0.446 2.32e-159 4.68e-157 ✓ sig. Cluster 2 →
Inflammatory bowel disease Psoriasis
248 genes
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39 of 248 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(3), BLTP1(1), ABT1(1), ANKRD55(1), ATXN2L(1), BANK1(2), BSN(1), BTNL2(1), CDKAL1(1), ELL(1) +236 more
0.211 0.359 7.22e-161 1.47e-158 ✓ sig. Cluster 28 →
complex neurodevelopmental disorder Non-specific syndromic intellectual disability
105 genes
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105 of 105 corroborated by 2+ sources
CHD8(2), GABRD(2), HNRNPU(2), CACNA1D(2), CHD2(2), CNTNAP2(2), CUL3(3), DLGAP2(2), EPB41L1(2), GIGYF1(2), GNB2(3), GRIA1(2) +93 more
0.275 0.890 2.96e-161 6.10e-159 ✓ sig. Cluster 6 →
Attention deficit hyperactivity disorder Schizophrenia
553 genes
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175 of 553 corroborated by 2+ sources
SOX5(2), HMGA2(1), RAI1(2), NFIX(1), RERE(1), COMT(3), HDAC4(2), ZFPM2(1), ATP2A2(2), BMPR1B(1), TEAD1(1), CDK10(1) +541 more
0.179 0.500 2.31e-161 4.80e-159 ✓ sig. Cluster 2 →
Endometrial cancer Pancreatic cancer
110 genes
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3 of 110 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +98 more
0.349 0.632 1.51e-161 3.17e-159 ✓ sig. Cluster 67 →
Mitochondrial complex deficiency Mitochondrial disease
97 genes
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84 of 97 corroborated by 2+ sources
COA8(5), COX5A(5), NDUFA10(6), NDUFA12(4), NDUFA9(4), NDUFAF2(5), NDUFAF6(6), SDHB(6), UQCRFS1(6), UQCRH(5), ATP5F1A(5), ND1(1) +85 more
0.366 0.815 1.09e-161 2.32e-159 ✓ sig. Cluster 50 →
Inflammatory bowel disease Sclerosing cholangitis
158 genes
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15 of 158 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ANKRD55(1), BANK1(1), BSN(1), CDKAL1(1), EMSY(1), ETS1(1), FIBP(1), FOXP1(1), FUT2(1) +146 more
0.207 0.687 3.30e-162 7.09e-160 ✓ sig. Cluster 28 →
Anorexia nervosa Tourette syndrome
124 genes
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4 of 124 corroborated by 2+ sources
SOX5(2), RERE(1), ATP2A2(1), AKAP6(2), BANK1(1), BRAF(1), C8orf90(1), CACNB2(1), CSMD1(1), CTNND1(1), DCC(1), DGKI(1) +112 more
0.321 0.494 1.56e-162 3.39e-160 ✓ sig. Cluster 69 →
Major depressive disorder Mood disorder
241 genes
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62 of 241 corroborated by 2+ sources
PAFAH1B1(1), KANSL1(1), RERE(1), COMT(1), HDAC4(2), ATP2A2(2), BLTP1(1), SERPINA1(2), ADCY8(2), ANK3(2), ARFGAP2(1), ARHGAP15(1) +229 more
0.119 0.809 2.23e-163 4.89e-161 ✓ sig. Cluster 2 →
Cervical cancer Endometrial cancer
109 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +97 more
0.372 0.626 2.44e-165 5.40e-163 ✓ sig. Cluster 67 →
Ovarian cancer Prostate cancer
237 genes
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18 of 237 corroborated by 2+ sources
ANKRD11(1), HNF1B(2), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), CHEK2(6), RTEL1(1), TERT(1), TP53(1), TPCN2(1), ADARB2(1) +225 more
0.199 0.509 2.39e-165 5.36e-163 ✓ sig. Cluster 20 →
Colorectal cancer Ovarian cancer
240 genes
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13 of 240 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), CHEK2(2), RTEL1(1), TERT(1), TP53(3), POU2AF1(1), TPCN2(1) +228 more
0.200 0.515 1.54e-167 3.49e-165 ✓ sig. Cluster 20 →
Coronary artery disease Myocardial ischemia
235 genes
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124 of 235 corroborated by 2+ sources
PRDM16(3), APOA1(2), ACAT2(1), SH2B3(3), TERT(3), ARHGAP31(1), AMPD1(1), TP53(1), AHSG(1), SERPINA1(1), ABCA1(2), ABCG8(3) +223 more
0.181 0.601 5.77e-168 1.32e-165 ✓ sig. —
Esophageal cancer Pancreatic cancer
110 genes
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3 of 110 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +98 more
0.369 0.701 1.58e-169 3.65e-167 ✓ sig. Cluster 67 →
Endometrial cancer Gastric cancer
110 genes
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1 of 110 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +98 more
0.389 0.632 2.57e-170 6.01e-168 ✓ sig. Cluster 67 →

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.