Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 3

46 diseases · 124 shared-gene connections
46 Diseases
415 Unique genes
0.114 Avg. similarity score
Arrhythmogenic right ventricular cardiomyopathy Most-connected disease (17 links)
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Disease Searched: Left ventricular noncompaction cardiomyopathy Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Arrhythmogenic right ventricular cardiomyopathy 17 17 52
Wolff-parkinson-white syndrome 16 16 51
Conduction disorder of the heart 14 14 24
Left ventricular noncompaction cardiomyopathy 13 13 38
Ventricular fibrillation 11 11 36
Arrhythmogenic right ventricular dysplasia 10 10 14
Cardiac arrest 10 10 26
Catecholaminergic polymorphic ventricular tachycardia 10 10 20
Left ventricular disease 10 10 66
Brugada syndrome 9 9 63
Long qt syndrome 9 9 102
Cardiac conduction disease 8 8 9
Sick sinus syndrome 8 8 18
Hereditary bundle branch system defect 7 7 7
Restrictive cardiomyopathy 6 6 23
Atrioventricular block 5 5 17
Cardiac arrhythmia 5 5 98
Paroxysmal familial ventricular fibrillation 5 5 5
Polymorphic catecholaminergic ventricular tachycardia 5 5 15
dilated cardiomyopathy 1BB 5 5 1
dilated cardiomyopathy 1JJ 5 5 1
Atrial flutter 4 4 81
Hereditary atrial fibrillation 4 4 24
Myofibrillar myopathy 4 4 12
dilated cardiomyopathy 1CC 4 4 1
familial isolated arrhythmogenic right ventricular dysplasia 4 4 1
Atrial tachyarrhythmia, infra-hisian cardiac conduction disease 3 3 1
Bronchial disease 3 3 18
Cardiac and skeletal myopathy 3 3 1
cardiomyopathy, dilated, 2e 3 3 1
dilated cardiomyopathy 1HH 3 3 1
dilated cardiomyopathy 1I 3 3 1
dilated cardiomyopathy 1Y 3 3 1
intrinsic cardiomyopathy 3 3 1
sick sinus syndrome 2, autosomal dominant 3 3 1
Barth syndrome 2 2 1
lissencephaly 10 2 2 1
5-oxoprolinase deficiency 1 1 1
Cirrhosis 1 1 3
Congenital right-sided heart lesions 1 1 1
FNIP1-associated syndrome 1 1 1
Hypertrophy 1 1 49
Vici syndrome 1 1 1
dilated cardiomyopathy 1Z 1 1 1
hypokalemic alkalosis, familial, with specific renal tubulopathy 1 1 1
myofibrillar myopathy 8 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
SCN5A 18 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Atrial flutter, Brugada syndrome and 14 more
DSP 15 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Brugada syndrome, Cardiac arrest and 11 more
TTN 15 / 46 Arrhythmogenic right ventricular cardiomyopathy, Atrial flutter, Atrioventricular block, Brugada syndrome and 11 more
RYR2 14 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Brugada syndrome, Cardiac arrest and 10 more
MYH6 13 / 46 Arrhythmogenic right ventricular cardiomyopathy, Atrial flutter, Cardiac arrest, Cardiac arrhythmia and 9 more
PKP2 11 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Brugada syndrome, Cardiac arrhythmia and 7 more
TRPM4 11 / 46 Arrhythmogenic right ventricular cardiomyopathy, Atrioventricular block, Brugada syndrome, Cardiac arrest and 7 more
ANK2 10 / 46 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Cardiac arrest, Cardiac arrhythmia and 6 more
LMNA 10 / 46 Arrhythmogenic right ventricular cardiomyopathy, Atrioventricular block, Cardiac arrhythmia, Cardiac conduction disease and 6 more
DSG2 9 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Cardiac arrest, Catecholaminergic polymorphic ventricular tachycardia and 5 more
HCN4 9 / 46 Arrhythmogenic right ventricular cardiomyopathy, Atrial flutter, Brugada syndrome, Cardiac arrest and 5 more
MYH7 9 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Cardiac arrhythmia, Conduction disorder of the heart and 5 more
CACNA1C 8 / 46 Brugada syndrome, Cardiac arrhythmia, Conduction disorder of the heart, Long qt syndrome and 4 more
CASQ2 8 / 46 Atrial flutter, Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Conduction disorder of the heart and 4 more
JUP 8 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Conduction disorder of the heart, Left ventricular disease and 4 more
KCNH2 8 / 46 Atrial flutter, Brugada syndrome, Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia and 4 more
KCNJ2 8 / 46 Brugada syndrome, Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Hereditary atrial fibrillation and 4 more
MYBPC3 8 / 46 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Catecholaminergic polymorphic ventricular tachycardia, Left ventricular disease and 4 more
SCN1B 8 / 46 Brugada syndrome, Cardiac arrhythmia, Cardiac conduction disease, Conduction disorder of the heart and 4 more
SCN10A 7 / 46 Atrial flutter, Atrioventricular block, Brugada syndrome, Cardiac arrhythmia and 3 more
CACNB2 6 / 46 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Cardiac arrest, Cardiac conduction disease and 2 more
FLNC 6 / 46 Arrhythmogenic right ventricular cardiomyopathy, Cardiac arrhythmia, Conduction disorder of the heart, Myofibrillar myopathy and 2 more
KCNQ1 6 / 46 Brugada syndrome, Cardiac arrhythmia, Conduction disorder of the heart, Hereditary atrial fibrillation and 2 more
LAMA4 6 / 46 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Catecholaminergic polymorphic ventricular tachycardia, dilated cardiomyopathy 1JJ and 2 more
LDB3 6 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Left ventricular disease, Left ventricular noncompaction cardiomyopathy and 2 more
NKX2-5 6 / 46 Atrial flutter, Atrioventricular block, Hereditary atrial fibrillation, Hereditary bundle branch system defect and 2 more
RBM20 6 / 46 Arrhythmogenic right ventricular cardiomyopathy, Conduction disorder of the heart, Left ventricular noncompaction cardiomyopathy, Long qt syndrome and 2 more
TBX5 6 / 46 Atrial flutter, Atrioventricular block, Brugada syndrome, Cardiac arrhythmia and 2 more
ABCC9 5 / 46 Arrhythmogenic right ventricular cardiomyopathy, Brugada syndrome, Hereditary atrial fibrillation, Left ventricular disease and 1 more
ACTC1 5 / 46 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Restrictive cardiomyopathy and 1 more
ACTN2 5 / 46 Arrhythmogenic right ventricular cardiomyopathy, Cardiac and skeletal myopathy, Left ventricular noncompaction cardiomyopathy, Ventricular fibrillation and 1 more
AKAP9 5 / 46 Brugada syndrome, Cardiac arrest, Long qt syndrome, Ventricular fibrillation and 1 more
BAG3 5 / 46 Arrhythmogenic right ventricular dysplasia, Atrioventricular block, dilated cardiomyopathy 1HH, Long qt syndrome and 1 more
CEP85L 5 / 46 Arrhythmogenic right ventricular cardiomyopathy, Atrial flutter, Cardiac arrest, Cardiac arrhythmia and 1 more
DES 5 / 46 Arrhythmogenic right ventricular cardiomyopathy, Atrioventricular block, dilated cardiomyopathy 1I, Myofibrillar myopathy and 1 more
DPP6 5 / 46 Cardiac arrest, Long qt syndrome, Paroxysmal familial ventricular fibrillation, Ventricular fibrillation and 1 more
DSC2 5 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, familial isolated arrhythmogenic right ventricular dysplasia, Left ventricular disease and 1 more
KCNJ8 5 / 46 Brugada syndrome, Cardiac arrest, Cardiac arrhythmia, Long qt syndrome and 1 more
NEXN 5 / 46 Arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy 1CC, Left ventricular disease, Left ventricular noncompaction cardiomyopathy and 1 more
PITX2 5 / 46 Atrial flutter, Cardiac arrhythmia, Hereditary atrial fibrillation, Sick sinus syndrome and 1 more
SNTA1 5 / 46 Brugada syndrome, Long qt syndrome, Sick sinus syndrome, Ventricular fibrillation and 1 more
SYNE2 5 / 46 Atrial flutter, Cardiac arrhythmia, Left ventricular disease, Long qt syndrome and 1 more
TNNT2 5 / 46 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Restrictive cardiomyopathy and 1 more
AGT 4 / 46 Cardiac arrhythmia, Hypertrophy, Left ventricular disease, Sick sinus syndrome
CACNA2D1 4 / 46 Brugada syndrome, Cardiac arrest, Long qt syndrome, Ventricular fibrillation
CALM1 4 / 46 Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Long qt syndrome, Polymorphic catecholaminergic ventricular tachycardia
CALM2 4 / 46 Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Long qt syndrome, Polymorphic catecholaminergic ventricular tachycardia
CALM3 4 / 46 Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Long qt syndrome, Polymorphic catecholaminergic ventricular tachycardia
CTNNA3 4 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Left ventricular noncompaction cardiomyopathy, Long qt syndrome
DMD 4 / 46 Arrhythmogenic right ventricular cardiomyopathy, Conduction disorder of the heart, Left ventricular noncompaction cardiomyopathy, Restrictive cardiomyopathy
JPH2 4 / 46 cardiomyopathy, dilated, 2e, Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Ventricular fibrillation
KCNE2 4 / 46 Cardiac arrhythmia, Hereditary atrial fibrillation, Long qt syndrome, Ventricular fibrillation
KCNJ5 4 / 46 Atrial flutter, Hereditary atrial fibrillation, Long qt syndrome, Sick sinus syndrome
PLN 4 / 46 Arrhythmogenic right ventricular cardiomyopathy, Cardiac arrest, Cardiac arrhythmia, intrinsic cardiomyopathy
PRDM16 4 / 46 Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Restrictive cardiomyopathy, Wolff-parkinson-white syndrome
SCN3B 4 / 46 Brugada syndrome, Cardiac arrhythmia, Hereditary atrial fibrillation, Long qt syndrome
TGFB3 4 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Brugada syndrome, Long qt syndrome
TMEM43 4 / 46 Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular dysplasia, Left ventricular noncompaction cardiomyopathy, Long qt syndrome
TNNI3 4 / 46 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular noncompaction cardiomyopathy, Long qt syndrome, Restrictive cardiomyopathy
TNNI3K 4 / 46 Arrhythmogenic right ventricular cardiomyopathy, Atrial tachyarrhythmia, infra-hisian cardiac conduction disease, Bronchial disease, Cardiac conduction disease
TPM1 4 / 46 Arrhythmogenic right ventricular cardiomyopathy, dilated cardiomyopathy 1Y, Left ventricular disease, Left ventricular noncompaction cardiomyopathy
TRDN 4 / 46 Cardiac arrhythmia, Catecholaminergic polymorphic ventricular tachycardia, Long qt syndrome, Polymorphic catecholaminergic ventricular tachycardia
ZFHX3 4 / 46 Atrial flutter, Bronchial disease, Cardiac arrhythmia, Sick sinus syndrome
ACE 3 / 46 Cardiac arrhythmia, Hypertrophy, Left ventricular disease
ACTA1 3 / 46 Hypertrophy, Left ventricular disease, Restrictive cardiomyopathy
COL5A1 3 / 46 Brugada syndrome, Cardiac arrhythmia, Wolff-parkinson-white syndrome
DTNA 3 / 46 Cardiac arrhythmia, Left ventricular disease, Left ventricular noncompaction cardiomyopathy
EDN1 3 / 46 Cardiac arrhythmia, Hypertrophy, Left ventricular disease
FPGT-TNNI3K 3 / 46 Arrhythmogenic right ventricular cardiomyopathy, Bronchial disease, Cardiac conduction disease
GJA5 3 / 46 Atrial flutter, Hereditary atrial fibrillation, Wolff-parkinson-white syndrome
GPD1L 3 / 46 Brugada syndrome, Long qt syndrome, Wolff-parkinson-white syndrome
KCNA5 3 / 46 Atrioventricular block, Cardiac arrhythmia, Hereditary atrial fibrillation
KCNE1 3 / 46 Arrhythmogenic right ventricular cardiomyopathy, Hereditary atrial fibrillation, Long qt syndrome
KCNE3 3 / 46 Brugada syndrome, Long qt syndrome, Ventricular fibrillation
MYL3 3 / 46 Arrhythmogenic right ventricular cardiomyopathy, Long qt syndrome, Restrictive cardiomyopathy
MYPN 3 / 46 Left ventricular disease, Left ventricular noncompaction cardiomyopathy, Restrictive cardiomyopathy
NEBL 3 / 46 Cardiac arrest, Cardiac arrhythmia, Wolff-parkinson-white syndrome
NPPA 3 / 46 Hereditary atrial fibrillation, Hypertrophy, Left ventricular disease
PRKAG2 3 / 46 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular disease, Wolff-parkinson-white syndrome
SCN4B 3 / 46 Catecholaminergic polymorphic ventricular tachycardia, Hereditary atrial fibrillation, Long qt syndrome
SIRT6 3 / 46 Hypertrophy, Left ventricular disease, Long qt syndrome
SLMAP 3 / 46 Brugada syndrome, Cardiac arrest, Long qt syndrome
TAFAZZIN 3 / 46 Barth syndrome, Left ventricular disease, Left ventricular noncompaction cardiomyopathy
TBX20 3 / 46 Brugada syndrome, Left ventricular disease, Wolff-parkinson-white syndrome
TECRL 3 / 46 Catecholaminergic polymorphic ventricular tachycardia, Long qt syndrome, Polymorphic catecholaminergic ventricular tachycardia
VCL 3 / 46 Long qt syndrome, Ventricular fibrillation, Wolff-parkinson-white syndrome
ADRB3 2 / 46 Hypertrophy, Left ventricular disease
AGTR2 2 / 46 Hypertrophy, Left ventricular disease
AHR 2 / 46 Hypertrophy, Left ventricular disease
AKAP6 2 / 46 Atrial flutter, Cardiac arrhythmia
ANKRD1 2 / 46 Brugada syndrome, Left ventricular disease
AOPEP 2 / 46 Atrial flutter, Cardiac arrhythmia
ASAH1 2 / 46 Atrial flutter, Cardiac arrhythmia
C2ORF49 2 / 46 Arrhythmogenic right ventricular cardiomyopathy, Left ventricular noncompaction cardiomyopathy
CACNA1D 2 / 46 Long qt syndrome, Sick sinus syndrome
CAND2 2 / 46 Atrial flutter, Cardiac arrhythmia
CAV1 2 / 46 Atrial flutter, Cardiac arrhythmia
CAV3 2 / 46 Brugada syndrome, Long qt syndrome
CCDC141 2 / 46 Atrioventricular block, Sick sinus syndrome
CDKN1A 2 / 46 Atrial flutter, Hypertrophy
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Cytoskeleton in muscle cells
ACTN2, FLNC, LMNA, PKP2, DES, DSC2, DSG2, DSP, JUP, LDB3, MYBPC3, MYH7
 KEGG 52 / 232 6.5× 4.28e-28 9.70e-25 ✓ sig.
Adrenergic signaling in cardiomyocytes
AGT, CACNA1C, CALM1, CALM2, CALM3, KCNQ1, PLN, PPP1R1A, RYR2, SCN5A, MYH7, MYL3
 KEGG 37 / 154 7.0× 2.46e-21 2.08e-18 ✓ sig.
Hypertrophic cardiomyopathy
ACE, AGT, CACNA1C, EDN1, LMNA, RYR2, DES, MYBPC3, MYH7, MYL3, TGFB3, TTN
 KEGG 29 / 99 8.5× 1.51e-19 9.78e-17 ✓ sig.
Dilated cardiomyopathy
AGT, CACNA1C, LMNA, PLN, RYR2, DES, MYBPC3, MYH7, MYL3, TGFB3, TTN, ACTC1
 KEGG 27 / 105 7.4× 1.11e-16 4.53e-14 ✓ sig.
Oxytocin signaling pathway
CACNA1C, CALM1, CALM2, CALM3, KCNJ2, PTGS2, RYR2, CACNB2, RYR1, PRKAG2, CDKN1A, KCNJ5
 KEGG 30 / 154 5.6× 7.70e-15 2.29e-12 ✓ sig.
Striated Muscle Contraction
ACTN2, DES, MYBPC3, MYL3, TTN, ACTC1, DMD, MYH6, MYL2, TNNC1, TNNI3, TNNT2
 Reactome 16 / 36 12.9× 1.20e-14 3.40e-12 ✓ sig.
Phase 0 - rapid depolarisation
CACNA1C, CALM1, CALM2, CALM3, SCN5A, CACNB2, SCN10A, CACNA2D1, CAMK2D, RANGRF, SCN1B, SCN2B
 Reactome 17 / 44 11.2× 3.01e-14 7.99e-12 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy
ACTN2, CACNA1C, GJA1, LMNA, PKP2, RYR2, CDH2, CTNNA3, DES, DSC2, DSG2, DSP
 KEGG 22 / 86 7.4× 8.99e-14 2.24e-11 ✓ sig.
Cardiac muscle contraction
CACNA1C, CASQ2, RYR2, TRDN, MYH7, MYL3, ACTC1, CACNB2, MYH6, MYL2, TNNC1, TNNI3
 KEGG 21 / 87 7.0× 1.14e-12 2.30e-10 ✓ sig.
cGMP-PKG signaling pathway
CACNA1C, CALM1, CALM2, CALM3, KNG1, PLN, MYH7, MYH6, GNAI2, GATA4, KCNJ8, INS
 KEGG 27 / 166 4.7× 1.56e-11 2.54e-9 ✓ sig.
Proteoglycans in cancer
ANK2, CAV1, CDKN1A, PTK2, WNT8A, CAMK2D, CAV3, PRKCA, SOS1, TNF, CAV2, RAF1
 KEGG 29 / 204 4.1× 8.10e-11 1.13e-8 ✓ sig.
Renin secretion
ACE, AGT, CACNA1C, CALM1, CALM2, CALM3, EDN1, KCNJ2, GNAI2, CACNA1D, ITPR3, NPPA
 KEGG 17 / 69 7.1× 1.18e-10 1.59e-8 ✓ sig.
Calcium signaling pathway
CACNA1C, CALM1, CALM2, CALM3, CASQ2, HTR4, PLN, RYR2, TRDN, RYR1, TNNC1, FGF5
 KEGG 32 / 254 3.6× 2.06e-10 2.61e-8 ✓ sig.
Phase 2 - plateau phase
CACNA1C, KCNQ1, CACNB2, KCNE1, AKAP9, CACNA2D1, KCNE3, KCNE5, KCNE2, CACNA1D, CACNA1S
 Reactome 11 / 25 12.7× 2.12e-10 2.68e-8 ✓ sig.
Phase 3 - rapid repolarisation
KCNH2, KCNQ1, KCNE1, AKAP9, KCNE3, KCNE5, KCNE2
 Reactome 7 / 8 25.3× 4.35e-10 5.07e-8 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
regulation of heart rate by cardiac conduction
ACE, CACNA1C, KCNH2, KCNJ2, KCNQ1, PKP2, SCN5A, CTNNA3, DSC2, DSG2, DSP, JUP
 GO:0086091 34 / 43 35.6× 7.31e-49 1.50e-44 ✓ sig.
cardiac muscle contraction
CASQ2, KCNH2, KCNQ1, RYR2, SCN5A, MYBPC3, MYH7, MYL3, TTN, ACTC1, DMD, MYH6
 GO:0060048 31 / 43 32.5× 2.16e-42 2.66e-38 ✓ sig.
ventricular cardiac muscle cell action potential
KCNH2, KCNQ1, PKP2, RYR2, SCN5A, ANK2, KCNE1, GJA5, CAV3, GPD1L, KCNE3, KCNE5
 GO:0086005 15 / 17 39.7× 1.60e-23 4.21e-20 ✓ sig.
regulation of heart rate
CALM1, CALM2, CALM3, CASQ2, KCNQ1, RYR2, SCN5A, MYH7, ANK2, DMD, HCN4, MYH6
 GO:0002027 20 / 39 23.1× 2.53e-23 6.44e-20 ✓ sig.
regulation of ventricular cardiac muscle cell membrane repolarization
KCNH2, KCNQ1, SCN5A, ANK2, KCNE1, GJA5, AKAP9, CACNA2D1, CAV3, KCNE3, KCNE5, SCN1B
 GO:0060307 16 / 21 34.3× 4.83e-23 1.20e-19 ✓ sig.
muscle contraction
CACNA1C, TRDN, DES, MYH7, MYL3, TTN, DMD, HCN4, MYH6, RYR1, TACR2, KCND3
 GO:0006936 24 / 85 12.7× 2.76e-20 4.59e-17 ✓ sig.
membrane repolarization during ventricular cardiac muscle cell action potential
KCNH2, KCNQ1, KCNE1, KCNJ5, DLG1, KCND3, KCNE3, KCNE5, KCNJ8, SCN2B, KCNE2, KCNJ3
 GO:0098915 12 / 13 41.6× 1.57e-19 2.25e-16 ✓ sig.
sarcomere organization
ACTN2, FLNC, LDB3, MYBPC3, TTN, MYH6, MYOM1, TNNT2, TPM1, PLEC, PRKAR1A, OBSCN
 GO:0045214 18 / 43 18.8× 4.38e-19 6.00e-16 ✓ sig.
regulation of ventricular cardiac muscle cell action potential
CACNA1C, PKP2, RYR2, CTNNA3, DSC2, DSG2, DSP, JUP, TRPM4, CAV1, DLG1
 GO:0098911 11 / 11 45.0× 5.69e-19 7.71e-16 ✓ sig.
heart development
CACNA1C, EDN1, GJA1, KCNQ1, PKP2, LDB3, TGFB3, ABCC9, MYL2, TNNI3, PRKAR1A, CDKN1A
 GO:0007507 37 / 273 6.1× 9.02e-19 1.18e-15 ✓ sig.
regulation of cardiac muscle contraction
CALM1, CALM2, CALM3, RYR2, SCN5A, ANK2, HCN4, TNNI3K, GJA5, NKX2-5, SCN10A, CAV3
 GO:0055117 14 / 24 26.3× 9.15e-18 1.03e-14 ✓ sig.
cardiac muscle cell action potential involved in contraction
CACNA1C, KCNJ2, PKP2, SCN5A, KCNE1, SCN10A, CACNA2D1, SCN1B, SCN2B, SCN3B, KCNE2, CACNA1D
 GO:0086002 14 / 24 26.3× 9.15e-18 1.03e-14 ✓ sig.
striated muscle contraction
CASQ2, RYR2, MYH7, TTN, MYH6, RYR1, TNNI3, TNNT2, DTNA, GAA, MYLK2, CACNA1S
 GO:0006941 12 / 24 22.5× 2.61e-14 1.54e-11 ✓ sig.
cardiac muscle cell development
ACTN2, TTN, MYH6, PLEC, LRRC10, NKX2-5, CAV3, MYO18B, MTOR, MYH11, ALPK3, TCAP
 GO:0055013 12 / 25 21.6× 4.92e-14 2.80e-11 ✓ sig.
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
CACNA1C, CALM1, CALM2, CALM3, CASQ2, PLN, RYR2, TRDN, ANK2, DMD, CAMK2D, HRC
 GO:0010881 12 / 25 21.6× 4.92e-14 2.80e-11 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Hypertrophy Left ventricular disease 0.349 30 6.46e-62 4.07e-60 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Left ventricular noncompaction cardiomyopathy 0.379 25 8.23e-56 4.72e-54 ✓ sig.
Atrial flutter Cardiac arrhythmia 0.216 32 5.29e-51 2.83e-49 ✓ sig.
Long qt syndrome Ventricular fibrillation 0.219 25 7.92e-48 3.93e-46 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Long qt syndrome 0.202 26 3.05e-44 1.41e-42 ✓ sig.
Brugada syndrome Long qt syndrome 0.194 27 1.42e-43 6.50e-42 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Long qt syndrome 0.171 18 2.33e-38 9.38e-37 ✓ sig.
Long qt syndrome Wolff-parkinson-white syndrome 0.176 23 9.13e-38 3.60e-36 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Wolff-parkinson-white syndrome 0.224 19 1.17e-35 4.34e-34 ✓ sig.
Cardiac arrhythmia Long qt syndrome 0.149 26 1.88e-35 6.91e-34 ✓ sig.
Brugada syndrome Ventricular fibrillation 0.220 18 6.10e-35 2.20e-33 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Polymorphic catecholaminergic ventricular tachycardia 0.500 12 1.55e-34 5.51e-33 ✓ sig.
Left ventricular disease Left ventricular noncompaction cardiomyopathy 0.207 18 5.92e-34 2.08e-32 ✓ sig.
Brugada syndrome Wolff-parkinson-white syndrome 0.198 19 9.19e-34 3.19e-32 ✓ sig.
Conduction disorder of the heart Wolff-parkinson-white syndrome 0.246 15 8.30e-33 2.80e-31 ✓ sig.
Ventricular fibrillation Wolff-parkinson-white syndrome 0.222 16 1.06e-31 3.41e-30 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Arrhythmogenic right ventricular dysplasia 0.236 13 1.52e-31 4.88e-30 ✓ sig.
Long qt syndrome Polymorphic catecholaminergic ventricular tachycardia 0.135 14 1.85e-30 5.72e-29 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Conduction disorder of the heart 0.222 14 7.06e-30 2.15e-28 ✓ sig.
Conduction disorder of the heart Ventricular fibrillation 0.271 13 1.30e-29 3.91e-28 ✓ sig.
Cardiac arrest Ventricular fibrillation 0.260 13 5.40e-29 1.60e-27 ✓ sig.
Left ventricular noncompaction cardiomyopathy Wolff-parkinson-white syndrome 0.200 15 9.52e-29 2.79e-27 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Left ventricular disease 0.167 17 1.16e-28 3.37e-27 ✓ sig.
Cardiac arrhythmia Wolff-parkinson-white syndrome 0.136 18 1.33e-27 3.72e-26 ✓ sig.
Brugada syndrome Cardiac arrhythmia 0.133 19 1.44e-27 4.02e-26 ✓ sig.
Arrhythmogenic right ventricular dysplasia Left ventricular noncompaction cardiomyopathy 0.256 11 5.67e-27 1.54e-25 ✓ sig.
Left ventricular disease Wolff-parkinson-white syndrome 0.157 16 1.16e-26 3.14e-25 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Restrictive cardiomyopathy 0.188 12 7.36e-25 1.79e-23 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Cardiac arrest 0.179 12 5.22e-24 1.21e-22 ✓ sig.
Conduction disorder of the heart Left ventricular noncompaction cardiomyopathy 0.212 11 1.02e-23 2.33e-22 ✓ sig.
Brugada syndrome Conduction disorder of the heart 0.158 12 1.88e-23 4.24e-22 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Wolff-parkinson-white syndrome 0.180 11 2.72e-23 6.08e-22 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Conduction disorder of the heart 0.250 9 1.63e-21 3.30e-20 ✓ sig.
Left ventricular noncompaction cardiomyopathy Restrictive cardiomyopathy 0.192 10 2.57e-21 5.20e-20 ✓ sig.
Left ventricular disease Restrictive cardiomyopathy 0.139 11 4.85e-21 9.70e-20 ✓ sig.
Brugada syndrome Cardiac arrest 0.139 11 1.58e-20 3.10e-19 ✓ sig.
Arrhythmogenic right ventricular dysplasia Conduction disorder of the heart 0.250 8 6.01e-20 1.15e-18 ✓ sig.
Restrictive cardiomyopathy Wolff-parkinson-white syndrome 0.136 9 1.80e-17 3.02e-16 ✓ sig.
Polymorphic catecholaminergic ventricular tachycardia Wolff-parkinson-white syndrome 0.136 8 5.15e-17 8.43e-16 ✓ sig.
Conduction disorder of the heart Polymorphic catecholaminergic ventricular tachycardia 0.212 7 5.43e-17 8.89e-16 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Cardiac conduction disease 0.127 7 1.18e-16 1.89e-15 ✓ sig.
Brugada syndrome Hereditary atrial fibrillation 0.114 9 2.21e-16 3.47e-15 ✓ sig.
Conduction disorder of the heart Restrictive cardiomyopathy 0.171 7 2.05e-15 3.03e-14 ✓ sig.
Cardiac arrest Conduction disorder of the heart 0.159 7 5.50e-15 7.89e-14 ✓ sig.
Atrial flutter Sick sinus syndrome 0.087 8 1.72e-14 2.38e-13 ✓ sig.
Sick sinus syndrome Wolff-parkinson-white syndrome 0.111 7 8.81e-14 1.15e-12 ✓ sig.
Conduction disorder of the heart Hereditary bundle branch system defect 0.185 5 1.24e-13 1.59e-12 ✓ sig.
Cardiac arrest Catecholaminergic polymorphic ventricular tachycardia 0.146 6 4.75e-13 5.94e-12 ✓ sig.
Hereditary bundle branch system defect Ventricular fibrillation 0.128 5 1.09e-12 1.33e-11 ✓ sig.
Arrhythmogenic right ventricular dysplasia Catecholaminergic polymorphic ventricular tachycardia 0.161 5 6.41e-12 7.23e-11 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Paroxysmal familial ventricular fibrillation 0.182 4 1.03e-11 1.14e-10 ✓ sig.
Hereditary atrial fibrillation Ventricular fibrillation 0.109 6 1.38e-11 1.51e-10 ✓ sig.
Cardiac arrest Paroxysmal familial ventricular fibrillation 0.143 4 3.19e-11 3.35e-10 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia Hereditary bundle branch system defect 0.167 4 7.22e-11 7.33e-10 ✓ sig.
Atrial flutter Wolff-parkinson-white syndrome 0.064 8 2.18e-10 2.12e-9 ✓ sig.
Cardiac conduction disease Conduction disorder of the heart 0.133 4 5.69e-10 5.29e-9 ✓ sig.
Arrhythmogenic right ventricular dysplasia Polymorphic catecholaminergic ventricular tachycardia 0.148 4 7.91e-10 7.26e-9 ✓ sig.
Atrioventricular block Sick sinus syndrome 0.125 4 3.08e-9 2.67e-8 ✓ sig.
Cardiac conduction disease Hereditary bundle branch system defect 0.214 3 4.83e-9 4.09e-8 ✓ sig.
Arrhythmogenic right ventricular dysplasia Paroxysmal familial ventricular fibrillation 0.167 3 7.47e-9 6.23e-8 ✓ sig.
Hereditary atrial fibrillation Sick sinus syndrome 0.103 4 1.37e-8 1.09e-7 ✓ sig.
Conduction disorder of the heart Sick sinus syndrome 0.103 4 1.37e-8 1.09e-7 ✓ sig.
Cardiac conduction disease Sick sinus syndrome 0.120 3 1.12e-7 7.83e-7 ✓ sig.
Hereditary atrial fibrillation Hereditary bundle branch system defect 0.103 3 1.16e-7 8.09e-7 ✓ sig.
Hereditary bundle branch system defect Paroxysmal familial ventricular fibrillation 0.182 2 1.77e-6 9.99e-6 ✓ sig.
Cardiac conduction disease Paroxysmal familial ventricular fibrillation 0.154 2 3.03e-6 1.64e-5 ✓ sig.
Atrioventricular block Hereditary bundle branch system defect 0.087 2 2.40e-5 1.13e-4 ✓ sig.
Atrioventricular block Cardiac conduction disease 0.080 2 4.11e-5 1.88e-4 ✓ sig.
Bronchial disease Cardiac conduction disease 0.077 2 4.62e-5 2.10e-4 ✓ sig.
Arrhythmogenic right ventricular dysplasia Myofibrillar myopathy 0.077 2 5.81e-5 2.32e-4 ✓ sig.
Atrial tachyarrhythmia, infra-hisian cardiac conduction disease Cardiac conduction disease 0.100 1 5.84e-4 1.15e-3 ✓ sig.
dilated cardiomyopathy 1HH Myofibrillar myopathy 0.077 1 7.79e-4 1.40e-3 ✓ sig.
dilated cardiomyopathy 1I Myofibrillar myopathy 0.077 1 7.79e-4 1.40e-3 ✓ sig.
Myofibrillar myopathy myofibrillar myopathy 8 0.077 1 7.79e-4 1.40e-3 ✓ sig.
Arrhythmogenic right ventricular dysplasia dilated cardiomyopathy 1BB 0.063 1 9.74e-4 1.66e-3 ✓ sig.
Arrhythmogenic right ventricular dysplasia dilated cardiomyopathy 1HH 0.063 1 9.74e-4 1.66e-3 ✓ sig.
Arrhythmogenic right ventricular dysplasia familial isolated arrhythmogenic right ventricular dysplasia 0.063 1 9.74e-4 1.66e-3 ✓ sig.
Atrioventricular block dilated cardiomyopathy 1HH 0.056 1 1.10e-3 1.82e-3 ✓ sig.
Atrioventricular block dilated cardiomyopathy 1I 0.056 1 1.10e-3 1.82e-3 ✓ sig.
Atrial tachyarrhythmia, infra-hisian cardiac conduction disease Bronchial disease 0.053 1 1.17e-3 1.89e-3 ✓ sig.
Bronchial disease Vici syndrome 0.053 1 1.17e-3 1.89e-3 ✓ sig.
Sick sinus syndrome sick sinus syndrome 2, autosomal dominant 0.053 1 1.17e-3 1.89e-3 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia dilated cardiomyopathy 1BB 0.048 1 1.30e-3 2.06e-3 ✓ sig.
Catecholaminergic polymorphic ventricular tachycardia dilated cardiomyopathy 1JJ 0.048 1 1.30e-3 2.06e-3 ✓ sig.
dilated cardiomyopathy 1I Restrictive cardiomyopathy 0.042 1 1.49e-3 2.31e-3 ✓ sig.
Conduction disorder of the heart dilated cardiomyopathy 1BB 0.040 1 1.56e-3 2.37e-3 ✓ sig.
Cardiac arrest dilated cardiomyopathy 1BB 0.037 1 1.69e-3 2.53e-3 ✓ sig.
Cardiac arrest intrinsic cardiomyopathy 0.037 1 1.69e-3 2.53e-3 ✓ sig.
Cardiac arrest lissencephaly 10 0.037 1 1.69e-3 2.53e-3 ✓ sig.
Cardiac arrest sick sinus syndrome 2, autosomal dominant 0.037 1 1.69e-3 2.53e-3 ✓ sig.
Cardiac and skeletal myopathy Ventricular fibrillation 0.027 1 2.34e-3 3.24e-3 ✓ sig.
cardiomyopathy, dilated, 2e Ventricular fibrillation 0.027 1 2.34e-3 3.24e-3 ✓ sig.
Congenital right-sided heart lesions Ventricular fibrillation 0.027 1 2.34e-3 3.24e-3 ✓ sig.
dilated cardiomyopathy 1BB Ventricular fibrillation 0.027 1 2.34e-3 3.24e-3 ✓ sig.
Barth syndrome Left ventricular noncompaction cardiomyopathy 0.026 1 2.47e-3 3.37e-3 ✓ sig.
Cardiac and skeletal myopathy Left ventricular noncompaction cardiomyopathy 0.026 1 2.47e-3 3.37e-3 ✓ sig.
cardiomyopathy, dilated, 2e Left ventricular noncompaction cardiomyopathy 0.026 1 2.47e-3 3.37e-3 ✓ sig.
dilated cardiomyopathy 1CC Left ventricular noncompaction cardiomyopathy 0.026 1 2.47e-3 3.37e-3 ✓ sig.
dilated cardiomyopathy 1JJ Left ventricular noncompaction cardiomyopathy 0.026 1 2.47e-3 3.37e-3 ✓ sig.
dilated cardiomyopathy 1Y Left ventricular noncompaction cardiomyopathy 0.026 1 2.47e-3 3.37e-3 ✓ sig.
Left ventricular noncompaction cardiomyopathy sick sinus syndrome 2, autosomal dominant 0.026 1 2.47e-3 3.37e-3 ✓ sig.
Cardiac and skeletal myopathy Wolff-parkinson-white syndrome 0.019 1 3.31e-3 4.31e-3 ✓ sig.
dilated cardiomyopathy 1JJ Wolff-parkinson-white syndrome 0.019 1 3.31e-3 4.31e-3 ✓ sig.
FNIP1-associated syndrome Wolff-parkinson-white syndrome 0.019 1 3.31e-3 4.31e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy Atrial tachyarrhythmia, infra-hisian cardiac conduction disease 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy dilated cardiomyopathy 1CC 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy dilated cardiomyopathy 1JJ 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy dilated cardiomyopathy 1Y 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy dilated cardiomyopathy 1Z 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy familial isolated arrhythmogenic right ventricular dysplasia 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy intrinsic cardiomyopathy 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Arrhythmogenic right ventricular cardiomyopathy lissencephaly 10 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Cirrhosis Sick sinus syndrome 0.048 1 3.50e-3 4.52e-3 ✓ sig.
Brugada syndrome dilated cardiomyopathy 1JJ 0.016 1 4.09e-3 5.16e-3 ✓ sig.
Brugada syndrome hypokalemic alkalosis, familial, with specific renal tubulopathy 0.016 1 4.09e-3 5.16e-3 ✓ sig.
Barth syndrome Left ventricular disease 0.015 1 4.29e-3 5.38e-3 ✓ sig.
cardiomyopathy, dilated, 2e Left ventricular disease 0.015 1 4.29e-3 5.38e-3 ✓ sig.
dilated cardiomyopathy 1CC Left ventricular disease 0.015 1 4.29e-3 5.38e-3 ✓ sig.
dilated cardiomyopathy 1Y Left ventricular disease 0.015 1 4.29e-3 5.38e-3 ✓ sig.
familial isolated arrhythmogenic right ventricular dysplasia Left ventricular disease 0.015 1 4.29e-3 5.38e-3 ✓ sig.
5-oxoprolinase deficiency Atrial flutter 0.012 1 5.26e-3 6.42e-3 ✓ sig.
Cardiac arrhythmia intrinsic cardiomyopathy 0.010 1 6.36e-3 7.63e-3 ✓ sig.
dilated cardiomyopathy 1CC Long qt syndrome 0.010 1 6.62e-3 7.89e-3 ✓ sig.
familial isolated arrhythmogenic right ventricular dysplasia Long qt syndrome 0.010 1 6.62e-3 7.89e-3 ✓ sig.