Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Cancer Lung cancer
199 genes
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1 of 199 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +187 more
0.279 0.762 1.61e-228 8.84e-226 ✓ sig. Cluster 20 →
Intellectual developmental disorder Neurodevelopmental disorder
354 genes
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263 of 354 corroborated by 2+ sources
CHD8(5), FOXG1(2), UBE3A(1), CHRNA7(2), SIN3A(2), USP7(1), ANKRD11(2), RAI1(2), BPTF(4), PSMD12(1), NFIX(1), SKI(1) +342 more
0.254 0.438 2.71e-231 1.53e-228 ✓ sig. Cluster 6 →
Juvenile arthritis Juvenile idiopathic arthritis
127 genes
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127 of 127 corroborated by 2+ sources
RERE(2), GP1BB(2), JMJD1C(2), WWOX(3), ETV6(2), ASAP1(2), AVL9(2), CAMSAP1(2), CLU(2), FOXP1(3), GMPR(2), HBEGF(2) +115 more
0.470 0.977 1.22e-234 7.03e-232 ✓ sig. Cluster 311 →
Biliary tract cancer Non-hodgkins lymphoma
108 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +96 more
0.740 0.915 1.96e-236 1.16e-233 ✓ sig. Cluster 67 →
Deafness Isolated sensorineural deafness
114 genes
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110 of 114 corroborated by 2+ sources
CEACAM16(3), CLIC5(3), COL11A1(2), ESRRB(3), EYA4(3), GIPC3(3), GRAP(2), LMX1A(3), MYO15A(3), NARS2(2), OTOF(3), OTOGL(3) +102 more
0.640 0.958 1.05e-236 6.45e-234 ✓ sig. Cluster 26 →
Attention deficit hyperactivity disorder Autism
499 genes
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130 of 499 corroborated by 2+ sources
SOX5(3), RAI1(3), NFIX(1), NFIA(1), RERE(2), FGF8(1), COMT(2), JMJD1C(3), HDAC4(1), ZFPM2(1), ATP2A2(1), BRWD1(2) +487 more
0.241 0.452 2.00e-238 1.26e-235 ✓ sig. Cluster 2 →
Crohn disease Sclerosing cholangitis
200 genes
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29 of 200 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ANKRD55(1), BANK1(1), BSN(1), CDKAL1(1), EMSY(1), ERN1(1), ETS1(1), FAM177A1(1), FIBP(1) +188 more
0.277 0.870 1.10e-246 7.13e-244 ✓ sig. Cluster 28 →
Major depressive disorder Schizophrenia
905 genes
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308 of 905 corroborated by 2+ sources
SOX5(2), PAFAH1B1(2), HNF1B(1), KANSL1(1), RERE(1), COMT(3), HDAC4(2), WWOX(2), ZFPM2(1), SMARCAD1(1), COL2A1(1), PDE4D(1) +893 more
0.252 0.462 1.92e-248 1.29e-245 ✓ sig. Cluster 2 →
Ankylosing spondylitis Crohn disease
228 genes
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44 of 228 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), BANK1(1), BSN(1), CDKAL1(1), DAG1(1), EMSY(1), ERN1(1) +216 more
0.294 0.728 7.26e-249 5.04e-246 ✓ sig. Cluster 28 →
Ankylosing spondylitis Psoriasis
232 genes
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35 of 232 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(3), ADGRL2(1), ANKRD55(1), ATXN2L(1), BANK1(2), BSN(1), CDKAL1(1), DAG1(1), EMSY(1), ERN1(1) +220 more
0.285 0.741 1.06e-249 7.64e-247 ✓ sig. Cluster 28 →
Sclerosing cholangitis Ulcerative colitis
198 genes
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24 of 198 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ANKRD55(1), BANK1(1), BSN(1), CDKAL1(1), EMSY(1), ERN1(1), ETS1(1), FAM177A1(1), FIBP(1) +186 more
0.307 0.861 1.60e-254 1.19e-251 ✓ sig. Cluster 28 →
Psoriasis Sclerosing cholangitis
206 genes
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21 of 206 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(3), ANKRD55(1), BANK1(2), BSN(1), CDKAL1(1), EMSY(1), ERN1(1), ETS1(1), FAM177A1(1), FIBP(1) +194 more
0.272 0.896 1.03e-254 7.92e-252 ✓ sig. Cluster 28 →
Cancer Ovarian cancer
198 genes
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ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +186 more
0.374 0.759 1.63e-261 1.31e-258 ✓ sig. Cluster 20 →
Estrogen-receptor negative breast cancer Ovarian cancer
207 genes
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ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +195 more
0.372 0.699 1.23e-261 1.03e-258 ✓ sig. Cluster 20 →
Ankylosing spondylitis Ulcerative colitis
228 genes
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41 of 228 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), BANK1(1), BSN(1), CDKAL1(1), DAG1(1), EMSY(1), ERN1(1) +216 more
0.327 0.728 1.73e-263 1.50e-260 ✓ sig. Cluster 28 →
Congestive heart failure Heart failure
173 genes
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137 of 173 corroborated by 2+ sources
INS(2), HMGCS2(2), EDNRB(2), CAT(2), ACACA(2), ATP2A2(2), AMPD1(1), TP53(1), SCD(1), GATM(2), ATP1A3(2), ACE(2) +161 more
0.363 0.966 1.01e-267 9.17e-265 ✓ sig. —
Juvenile arthritis Oligoarticular juvenile idiopathic arthritis
126 genes
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126 of 126 corroborated by 2+ sources
RERE(2), GP1BB(2), WWOX(2), ETV6(2), ASAP1(2), AVL9(2), CAMSAP1(2), CLU(2), FOXP1(2), GMPR(2), HBEGF(2), HSPA6(2) +114 more
0.720 0.969 1.23e-268 1.16e-265 ✓ sig. Cluster 311 →
Ischemic heart disease Myocardial ischemia
170 genes
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44 of 170 corroborated by 2+ sources
PRDM16(1), APOA1(1), ACAT2(1), SH2B3(2), TERT(1), ARHGAP31(1), AMPD1(1), TP53(1), AHSG(1), ABCA1(1), ABCG8(2), ACE(1) +158 more
0.434 1.000 1.83e-290 1.81e-287 ✓ sig. Cluster 139 →
Biliary cholangitis Biliary cirrhosis
128 genes
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16 of 128 corroborated by 2+ sources
SH2B3(1), POU2AF1(3), DDX6(1), DEAF1(1), DGKQ(1), ELMO1(1), ETS1(1), HLA-DQA1(1), HLA-DRA(1), ITGB8(1), MACIR(1), RARB(1) +116 more
0.865 1.000 2.44e-297 2.54e-294 ✓ sig. —
Estrogen-receptor negative breast cancer Ovarian serous carcinoma
196 genes
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ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +184 more
0.528 0.726 6.32e-307 6.93e-304 ✓ sig. Cluster 20 →
Bipolar disorder Schizophrenia
751 genes
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232 of 751 corroborated by 2+ sources
SOX5(2), CHRNA7(1), YWHAE(2), HNF1B(1), NFIX(2), RERE(1), COMT(3), HDAC4(2), WWOX(2), ZFPM2(1), SMARCAD1(1), COL2A1(1) +739 more
0.249 0.616 1.24e-309 1.43e-306 ✓ sig. Cluster 2 →
Cancer Estrogen-receptor negative breast cancer
197 genes
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ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +185 more
0.546 0.755 8.86e-315 1.08e-311 ✓ sig. Cluster 20 →
Breast cancer Estrogen-receptor negative breast cancer
281 genes
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5 of 281 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(2), ZFPM2(1), SH2B3(1), RTEL1(1), TERT(1), TP53(4), ARHGEF10L(1), ARL17B(1) +269 more
0.260 0.949 7.99e-319 1.04e-315 ✓ sig. Cluster 20 →
Juvenile idiopathic arthritis Oligoarticular juvenile idiopathic arthritis
168 genes
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16 of 168 corroborated by 2+ sources
RERE(1), GP1BB(1), WWOX(2), SLC26A2(1), ETV6(1), RUNX1(1), ANKRD55(2), ASAP1(1), AVL9(1), CAMSAP1(1), CLIC4(1), CLU(1) +156 more
0.625 0.988 1.53e-322 2.13e-319 ✓ sig. Cluster 311 →
Ankylosing spondylitis Sclerosing cholangitis
195 genes
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19 of 195 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(1), ANKRD55(1), BANK1(1), BSN(1), CDKAL1(1), EMSY(1), ERN1(1), ETS1(1), FAM177A1(1), FIBP(1) +183 more
0.559 0.848 2.96e-323 4.41e-320 ✓ sig. Cluster 28 →

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.