Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
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Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Gliosarcoma Urologic neoplasms
2 genes
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1 of 2 corroborated by 2+ sources
TP53(2), VEGFA(1)
0.087 0.250 2.82e-5 1.31e-4 ✓ sig. —
Paraganglioma Pheochromocytoma
2 genes
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2 of 2 corroborated by 2+ sources
SDHB(3), SDHD(3)
0.087 0.250 2.82e-5 1.31e-4 ✓ sig. Cluster 81 →
Pheochromocytoma Pheochromocytoma/paraganglioma syndrome
2 genes
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2 of 2 corroborated by 2+ sources
SDHB(4), SDHD(4)
0.087 0.250 2.82e-5 1.31e-4 ✓ sig. Cluster 81 →
Rubinstein-taybi syndrome Vacterl association
2 genes
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DLX5(1), SMOC1(1)
0.087 0.250 2.82e-5 1.31e-4 ✓ sig. Cluster 249 →
Hepatic insufficiency Intestinal disease
2 genes
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2 of 2 corroborated by 2+ sources
NOS2(2), MAPK14(2)
0.091 0.222 2.75e-5 1.28e-4 ✓ sig. —
Granulomatosis with polyangiitis Irritant dermatitis
2 genes
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2 of 2 corroborated by 2+ sources
HLA-DPB1(4), HLA-DPA1(3)
0.091 0.222 2.75e-5 1.28e-4 ✓ sig. —
Endocrine system disease Hepatic insufficiency
2 genes
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2 of 2 corroborated by 2+ sources
NFE2L2(2), RELA(2)
0.091 0.222 2.75e-5 1.28e-4 ✓ sig. Cluster 153 →
Asperger syndrome Fatigue syndrome
2 genes
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2 of 2 corroborated by 2+ sources
DISC1(2), SLC6A4(2)
0.091 0.222 2.75e-5 1.28e-4 ✓ sig. Cluster 156 →
Bicuspid aortic valve Optic neuropathy
2 genes
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ATP6(1), ATP8(1)
0.091 0.222 2.75e-5 1.28e-4 ✓ sig. —
Cholangitis Intrahepatic cholestasis
2 genes
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2 of 2 corroborated by 2+ sources
EGR1(2), ABCB4(2)
0.091 0.222 2.75e-5 1.28e-4 ✓ sig. —
Metabolic bone disorder Vitamin deficiency disorder
2 genes
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2 of 2 corroborated by 2+ sources
GC(2), CYP2R1(2)
0.091 0.222 2.75e-5 1.28e-4 ✓ sig. —
Eye disease Ocular sarcoidosis
5 genes
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1 of 5 corroborated by 2+ sources
HLA-DQA1(1), HLA-DQB1(1), KCNH7(1), LRP2(3), STK32C(1)
0.034 0.086 2.70e-5 1.26e-4 ✓ sig. —
Osteolysis Uremia
2 genes
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2 of 2 corroborated by 2+ sources
SPP1(2), TNFRSF11B(2)
0.083 0.286 2.70e-5 1.26e-4 ✓ sig. —
Otosclerosis Uremia
3 genes
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3 of 3 corroborated by 2+ sources
SPP1(3), TGFB1(3), KDR(3)
0.045 0.167 2.70e-5 1.25e-4 ✓ sig. Cluster 180 →
Autoimmune polyendocrine syndrome Bronchitis
2 genes
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2 of 2 corroborated by 2+ sources
HLA-DQA1(2), HLA-DQB1(2)
0.056 0.500 2.67e-5 1.24e-4 ✓ sig. Cluster 1 →
Bronchitis Esophageal achalasia
2 genes
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2 of 2 corroborated by 2+ sources
HLA-DQA1(3), HLA-DQB1(3)
0.056 0.500 2.67e-5 1.24e-4 ✓ sig. Cluster 1 →
Bronchitis Oropharyngeal neoplasms
2 genes
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2 of 2 corroborated by 2+ sources
HLA-DQA1(2), HLA-DQB1(2)
0.056 0.500 2.67e-5 1.24e-4 ✓ sig. Cluster 1 →
Hemorrhagic disease Thrombocytosis
2 genes
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2 of 2 corroborated by 2+ sources
THPO(5), JAK2(4)
0.077 0.333 2.65e-5 1.23e-4 ✓ sig. —
Hemorrhagic disease Thrombocythemia
2 genes
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2 of 2 corroborated by 2+ sources
THPO(5), JAK2(5)
0.077 0.333 2.65e-5 1.23e-4 ✓ sig. —
Ataxia Choreoathetosis
2 genes
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2 of 2 corroborated by 2+ sources
SCN8A(2), SLC2A1(2)
0.077 0.333 2.65e-5 1.23e-4 ✓ sig. —
Cushing syndrome Penile disease
2 genes
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2 of 2 corroborated by 2+ sources
ATRX(2), POMC(2)
0.077 0.333 2.65e-5 1.23e-4 ✓ sig. —
Congenital heart disease Pelvic organ prolapse
9 genes
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5 of 9 corroborated by 2+ sources
FOXP2(1), NRP1(3), SORBS2(3), RXRA(2), SNAI1(3), KLF13(3), IQCJ(1), IQCJ-SCHIP1(1), LNPK(1)
0.030 0.065 2.60e-5 1.21e-4 ✓ sig. —
Periodic limb movement disorder Sleep disorder
2 genes
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BTBD9(1), MEIS1(1)
0.095 0.182 2.54e-5 1.19e-4 ✓ sig. —
Hematuria Infantile spasms
2 genes
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2 of 2 corroborated by 2+ sources
POMC(2), LMX1B(2)
0.095 0.182 2.54e-5 1.19e-4 ✓ sig. —
Demyelinating diseases Ductal carcinoma
2 genes
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2 of 2 corroborated by 2+ sources
TP53(2), MYC(2)
0.095 0.182 2.54e-5 1.19e-4 ✓ sig. —

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.