Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

← Back to all clusters

Cluster 156

9 diseases · 25 shared-gene connections
9 Diseases
29 Unique genes
0.473 Avg. similarity score
Congenital afibrinogenemia Most-connected disease (8 links)
Log in to save this analysis

Save This Analysis

Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Congenital afibrinogenemia 8 8 3
Afibrinogenemia 7 7 3
Congenital fibrinogen deficiency 7 7 3
Congenital hypofibrinogenemia 7 7 3
Dysfibrinogenemia 5 5 5
Hypofibrinogenemia 5 5 3
Thromboembolic pulmonary hypertension 5 5 9
Deep vein thrombosis 4 4 10
Cor pulmonale 2 2 15

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
FGA 9 / 9 Afibrinogenemia, Congenital afibrinogenemia, Congenital fibrinogen deficiency, Congenital hypofibrinogenemia and 5 more
FGG 8 / 9 Afibrinogenemia, Congenital afibrinogenemia, Congenital fibrinogen deficiency, Congenital hypofibrinogenemia and 4 more
FGB 7 / 9 Afibrinogenemia, Congenital afibrinogenemia, Congenital fibrinogen deficiency, Congenital hypofibrinogenemia and 3 more
ABO 2 / 9 Cor pulmonale, Thromboembolic pulmonary hypertension
F11 2 / 9 Cor pulmonale, Thromboembolic pulmonary hypertension
SLC44A2 2 / 9 Cor pulmonale, Thromboembolic pulmonary hypertension
TSPAN15 2 / 9 Cor pulmonale, Thromboembolic pulmonary hypertension
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Common Pathway of Fibrin Clot Formation
FGA, FGG, FGB, F2, F5, PROCR, PROC, PROS1, SERPINC1, SERPIND1
 Reactome 10 / 22 188× 7.43e-22 8.12e-19 ✓ sig.
Complement and coagulation cascades
F11, FGA, FGG, FGB, F2, F5, PROCR, PLAT, PLG, PROC, PROS1, SERPINC1
 KEGG 13 / 88 61.2× 4.30e-21 4.20e-18 ✓ sig.
Intrinsic Pathway of Fibrin Clot Formation
F11, F2, PROC, PROS1, SERPINC1, SERPIND1
 Reactome 6 / 23 108× 1.12e-11 1.98e-9 ✓ sig.
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
FGA, FGG, F2, F5, PLG, PROC, SERPINC1, SERPIND1
 Reactome 8 / 125 26.5× 3.93e-10 4.89e-8 ✓ sig.
Post-translational protein phosphorylation
FGA, FGG, F5, PROC, SERPINC1, SERPIND1
 Reactome 6 / 108 23.0× 1.85e-7 1.12e-5 ✓ sig.
Platelet degranulation
FGA, FGG, FGB, F5, PLG, PROS1
 Reactome 6 / 123 20.2× 4.00e-7 2.21e-5 ✓ sig.
Gamma-carboxylation of protein precursors
F2, PROC, PROS1
 Reactome 3 / 9 138× 1.05e-6 5.11e-5 ✓ sig.
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus
F2, PROC, PROS1
 Reactome 3 / 9 138× 1.05e-6 5.11e-5 ✓ sig.
Removal of aminoterminal propeptides from gamma-carboxylated proteins
F2, PROC, PROS1
 Reactome 3 / 10 124× 1.50e-6 6.93e-5 ✓ sig.
p130Cas linkage to MAPK signaling for integrins
FGA, FGG, FGB
 Reactome 3 / 15 82.8× 5.65e-6 2.10e-4 ✓ sig.
GRB2:SOS provides linkage to MAPK signaling for Integrins
FGA, FGG, FGB
 Reactome 3 / 15 82.8× 5.65e-6 2.10e-4 ✓ sig.
Platelet activation
FGA, FGG, FGB, F2, PLCG2
 KEGG 5 / 126 16.4× 1.14e-5 3.73e-4 ✓ sig.
Regulation of TLR by endogenous ligand
FGA, FGG, FGB
 Reactome 3 / 19 65.4× 1.20e-5 3.89e-4 ✓ sig.
Integrin signaling
FGA, FGG, FGB
 Reactome 3 / 23 54.0× 2.17e-5 6.39e-4 ✓ sig.
Cell surface interactions at the vascular wall
F2, PROCR, PROC, PROS1
 Reactome 4 / 84 19.7× 4.63e-5 1.20e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
hemostasis
F11, FGA, FGG, FGB, F2, F5, PROCR, PLG, PROC, PROS1, SERPINC1, SERPIND1
 GO:0007599 12 / 55 141× 5.82e-24 1.63e-20 ✓ sig.
blood coagulation
F11, FGA, FGG, FGB, F2, F5, PROCR, PLAT, PLG, PROC, PROS1, SERPINC1
 GO:0007596 13 / 106 79.0× 1.85e-22 4.29e-19 ✓ sig.
fibrinolysis
FGA, FGG, FGB, F2, PLAT, PLG, PROS1
 GO:0042730 7 / 19 237× 4.93e-16 4.09e-13 ✓ sig.
plasminogen activation
F11, FGA, FGG, FGB, PLAT
 GO:0031639 5 / 12 268× 4.92e-12 1.93e-9 ✓ sig.
platelet activation
DGKZ, FGA, FGG, FGB, F2, PLCG2, CD40LG
 GO:0030168 7 / 69 65.4× 1.00e-11 3.69e-9 ✓ sig.
blood coagulation, fibrin clot formation
FGA, FGG, FGB
 GO:0072378 3 / 9 215× 2.80e-7 2.88e-5 ✓ sig.
positive regulation of peptide hormone secretion
FGA, FGG, FGB
 GO:0090277 3 / 10 193× 4.00e-7 3.87e-5 ✓ sig.
regulation of blood coagulation
F11, F2, SERPINC1
 GO:0030193 3 / 11 176× 5.50e-7 5.07e-5 ✓ sig.
negative regulation of fibrinolysis
F2, PLAT, PLG
 GO:0051918 3 / 12 161× 7.32e-7 6.45e-5 ✓ sig.
positive regulation of heterotypic cell-cell adhesion
FGA, FGG, FGB
 GO:0034116 3 / 13 149× 9.51e-7 7.98e-5 ✓ sig.
protein polymerization
FGA, FGG, FGB
 GO:0051258 3 / 17 114× 2.25e-6 1.58e-4 ✓ sig.
trans-synaptic signaling by BDNF, modulating synaptic transmission
PLAT, PLG
 GO:0099183 2 / 3 430× 6.97e-6 3.91e-4 ✓ sig.
positive regulation of exocytosis
FGA, FGG, FGB
 GO:0045921 3 / 26 74.4× 8.53e-6 4.60e-4 ✓ sig.
positive regulation of vasoconstriction
FGA, FGG, FGB
 GO:0045907 3 / 27 71.6× 9.59e-6 5.05e-4 ✓ sig.
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
FGA, FGG, FGB
 GO:1902042 3 / 29 66.7× 1.19e-5 5.98e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Cor pulmonale Thromboembolic pulmonary hypertension 0.316 6 2.27e-17 4.00e-16 ✓ sig.
Afibrinogenemia Congenital fibrinogen deficiency 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Congenital hypofibrinogenemia Hypofibrinogenemia 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Congenital fibrinogen deficiency Hypofibrinogenemia 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Congenital fibrinogen deficiency Congenital hypofibrinogenemia 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Congenital afibrinogenemia Hypofibrinogenemia 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Congenital afibrinogenemia Congenital fibrinogen deficiency 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Afibrinogenemia Hypofibrinogenemia 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Afibrinogenemia Congenital hypofibrinogenemia 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Afibrinogenemia Congenital afibrinogenemia 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Congenital afibrinogenemia Congenital hypofibrinogenemia 0.750 3 1.64e-12 2.04e-11 ✓ sig.
Congenital afibrinogenemia Dysfibrinogenemia 0.500 3 1.64e-11 1.88e-10 ✓ sig.
Afibrinogenemia Dysfibrinogenemia 0.500 3 1.64e-11 1.88e-10 ✓ sig.
Congenital fibrinogen deficiency Dysfibrinogenemia 0.500 3 1.64e-11 1.88e-10 ✓ sig.
Congenital hypofibrinogenemia Dysfibrinogenemia 0.500 3 1.64e-11 1.88e-10 ✓ sig.
Dysfibrinogenemia Hypofibrinogenemia 0.500 3 1.64e-11 1.88e-10 ✓ sig.
Afibrinogenemia Thromboembolic pulmonary hypertension 0.182 2 9.11e-7 5.67e-6 ✓ sig.
Congenital hypofibrinogenemia Thromboembolic pulmonary hypertension 0.182 2 9.11e-7 5.67e-6 ✓ sig.
Congenital fibrinogen deficiency Thromboembolic pulmonary hypertension 0.182 2 9.11e-7 5.67e-6 ✓ sig.
Congenital afibrinogenemia Thromboembolic pulmonary hypertension 0.182 2 9.11e-7 5.67e-6 ✓ sig.
Afibrinogenemia Deep vein thrombosis 0.167 2 1.14e-6 6.99e-6 ✓ sig.
Congenital hypofibrinogenemia Deep vein thrombosis 0.167 2 1.14e-6 6.99e-6 ✓ sig.
Congenital fibrinogen deficiency Deep vein thrombosis 0.167 2 1.14e-6 6.99e-6 ✓ sig.
Congenital afibrinogenemia Deep vein thrombosis 0.167 2 1.14e-6 6.99e-6 ✓ sig.
Congenital afibrinogenemia Cor pulmonale 0.118 2 2.66e-6 1.53e-5 ✓ sig.