Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
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Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▼ Shared cluster
Kallmann syndrome Pituitary short stature
34 genes
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21 of 34 corroborated by 2+ sources
FGF8(3), DUSP6(3), IL17RD(3), PROK2(4), TACR3(2), PROKR2(3), TCF12(2), GH1(1), CHD7(4), FGFR1(4), WDR11(3), SEMA3E(2) +22 more
0.872 1.000 9.56e-100 1.05e-97 ✓ sig. Cluster 54 →
Kallmann syndrome Sheehan syndrome
34 genes
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21 of 34 corroborated by 2+ sources
FGF8(3), DUSP6(3), IL17RD(3), PROK2(4), TACR3(2), PROKR2(3), TCF12(2), GH1(1), CHD7(4), FGFR1(4), WDR11(3), SEMA3E(2) +22 more
0.872 1.000 9.56e-100 1.05e-97 ✓ sig. Cluster 54 →
Hereditary hearing loss Nonsyndromic hearing loss
47 genes
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47 of 47 corroborated by 2+ sources
ESRRB(3), EYA4(3), MYO15A(3), OTOF(2), PCDH15(3), TMC1(4), HGF(3), RDX(2), GSDME(3), DIAPH1(3), MYO1A(2), GJB6(4) +35 more
0.385 0.940 1.77e-100 1.98e-98 ✓ sig. Cluster 26 →
Gastric cancer Hepatocellular carcinoma
115 genes
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14 of 115 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(2), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CDH13(2), CELF2(1) +103 more
0.153 0.528 9.93e-101 1.12e-98 ✓ sig. Cluster 67 →
Astrocytoma Glioma
138 genes
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4 of 138 corroborated by 2+ sources
NF1(1), ADNP(1), HMCN1(1), TEAD1(1), AGBL1(1), ARHGEF28(1), BRAF(1), C6orf118(1), CARD11(1), CTNNA3(1), DSCAM(1), EFL1(2) +126 more
0.150 0.458 8.08e-101 9.14e-99 ✓ sig. Cluster 284 →
Intellectual developmental disorder Non-specific syndromic intellectual disability
154 genes
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97 of 154 corroborated by 2+ sources
CHD8(3), CHRNA7(1), PSMD12(2), HNRNPU(1), JMJD1C(1), ACTL6A(2), VCP(1), CACNA1D(1), ACTL6B(2), ANK3(5), CAMK4(1), CAPZA2(1) +142 more
0.150 0.418 5.10e-101 5.80e-99 ✓ sig. Cluster 6 →
Peripheral nervous system disease Peripheral neuropathy
52 genes
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52 of 52 corroborated by 2+ sources
DPYD(2), SLC12A6(2), GFAP(2), ABCA1(2), CACNA1H(2), ERCC1(2), MMP3(2), TCF4(2), GSTP1(2), ICAM1(2), IGF1(2), IGF1R(2) +40 more
0.268 0.981 2.70e-101 3.08e-99 ✓ sig. Cluster 243 →
Age-related macular degeneration Atrophic macular degeneration
46 genes
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10 of 46 corroborated by 2+ sources
CFHR1(3), CFI(4), COL4A3(1), ABCA1(1), ALDH1A2(1), APOE(3), CNN2(1), EXOC3L2(1), LIPC(1), MARK4(1), PILRA(1), TRPM1(1) +34 more
0.489 0.821 2.54e-101 2.92e-99 ✓ sig. Cluster 187 →
Cardiovascular disease Coronary artery disease
190 genes
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57 of 190 corroborated by 2+ sources
CASZ1(1), PRDM16(3), ZFPM2(1), SH2B3(3), ABCG8(3), ACE(3), AGT(3), ALDH1A2(1), APOB(3), APOE(3), BCAS3(1), C1GALT1(1) +178 more
0.137 0.440 1.37e-101 1.58e-99 ✓ sig. Cluster 78 →
Diabetes mellitus type 1 Systemic lupus erythematosus
159 genes
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46 of 159 corroborated by 2+ sources
RERE(1), GATA4(1), CAT(2), NOTCH2(1), SH2B3(3), IFIH1(3), BLTP1(1), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), BANK1(4) +147 more
0.163 0.333 9.62e-102 1.12e-99 ✓ sig. Cluster 28 →
Arthrogryposis multiplex congenita Pena-shokeir syndrome
44 genes
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2 of 44 corroborated by 2+ sources
SCN4A(1), GBE1(1), BLTP1(1), ACTA1(1), NAGA(1), ASCC1(1), PRICKLE1(1), RAPSN(1), ROR2(1), SCN8A(1), SPAG16(1), DYNC1H1(1) +32 more
0.543 0.846 8.94e-102 1.05e-99 ✓ sig. —
Autoimmune disease Celiac disease
79 genes
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11 of 79 corroborated by 2+ sources
SH2B3(1), ARHGAP31(1), ADGRL2(1), AFF3(1), ANKRD55(1), ATXN2L(1), CTSH(1), DAG1(1), ELMO1(1), FUT2(1), ICOS(2), IGF2(1) +67 more
0.249 0.409 6.05e-102 7.11e-100 ✓ sig. Cluster 39 →
Dilated cardiomyopathy Hypertrophic cardiomyopathy
94 genes
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53 of 94 corroborated by 2+ sources
ABCC9(7), ACTN2(7), BRAF(1), CACNB2(1), DMD(6), DSG2(7), FERMT2(1), FHOD3(3), GNPNAT1(1), JUP(1), MYPN(7), PKP2(2) +82 more
0.216 0.367 3.68e-102 4.35e-100 ✓ sig. Cluster 369 →
Inflammatory skin disease Psoriasis
76 genes
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13 of 76 corroborated by 2+ sources
IFIH1(3), BLTP1(1), ANO3(1), CSMD1(3), EBF1(1), ELMO1(1), EMSY(1), MGMT(1), PTPRN2(1), RAP1GAP2(1), RASIP1(1), SMARCA4(1) +64 more
0.104 1.000 5.45e-103 6.48e-101 ✓ sig. —
Aplasia of the vermis Joubert syndrome
43 genes
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40 of 43 corroborated by 2+ sources
KIF7(1), CPLANE1(6), CC2D2A(5), HYLS1(3), RPGRIP1L(5), NPHP3(1), TMEM67(6), ARL3(5), NPHP1(6), SUFU(5), CEP290(6), TMEM138(6) +31 more
0.614 0.796 1.57e-103 1.88e-101 ✓ sig. Cluster 8 →
Atrial fibrillation Atrial flutter
81 genes
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52 of 81 corroborated by 2+ sources
UBE4B(3), JMJD1C(1), OPLAH(1), BRWD1(1), PRRX1(3), AKAP6(3), ESR2(3), FBXO11(1), GORAB(1), KCNN3(3), KDM1B(3), MAPT(3) +69 more
0.094 1.000 1.10e-103 1.32e-101 ✓ sig. —
Pituitary short stature Sheehan syndrome
34 genes
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FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(1), CHD7(1), FGFR1(1), WDR11(1), SEMA3E(1) +22 more
0.971 1.000 1.29e-104 1.57e-102 ✓ sig. Cluster 54 →
Growth hormone deficiency Pituitary short stature
34 genes
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FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(1), CHD7(1), FGFR1(1), WDR11(1), SEMA3E(1) +22 more
0.971 1.000 1.29e-104 1.57e-102 ✓ sig. Cluster 54 →
Growth hormone deficiency Sheehan syndrome
34 genes
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FGF8(1), DUSP6(1), IL17RD(1), PROK2(1), TACR3(1), PROKR2(1), TCF12(1), GH1(1), CHD7(1), FGFR1(1), WDR11(1), SEMA3E(1) +22 more
0.971 1.000 1.29e-104 1.57e-102 ✓ sig. Cluster 54 →
Anorexia nervosa Bipolar disorder
154 genes
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35 of 154 corroborated by 2+ sources
SOX5(1), RERE(1), WWOX(1), ATP2A2(1), ZSWIM6(1), ALMS1(1), AKAP6(2), BANK1(1), BRAF(1), BSN(1), C8orf90(1), CACNB2(2) +142 more
0.117 0.614 5.96e-106 7.33e-104 ✓ sig. —
Inflammatory bowel disease Rheumatoid arthritis
191 genes
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61 of 191 corroborated by 2+ sources
SH2B3(1), RBPJ(3), BLTP1(1), ABT1(1), AFF3(3), ANKRD55(3), BSN(1), BTNL2(2), CCRL2(1), DLGAP2(1), ELMO1(1), EMSY(1) +179 more
0.164 0.289 4.56e-106 5.64e-104 ✓ sig. Cluster 28 →
Hypothyroidism Rheumatoid arthritis
148 genes
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30 of 148 corroborated by 2+ sources
SH2B3(1), RBPJ(3), BTNL2(2), ELMO1(1), ERBB3(1), ETS1(1), FADS1(1), FADS2(1), FAM76B(1), FKBPL(1), GABBR1(1), GLIS3(1) +136 more
0.166 0.396 3.98e-106 4.96e-104 ✓ sig. Cluster 28 →
Autoimmune thyroid disease Diabetes mellitus type 1
93 genes
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20 of 93 corroborated by 2+ sources
RERE(1), SH2B3(3), IFIH1(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), BANK1(1), BTNL2(1), CAMK4(1), DAG1(1), ERBB3(1), FAM76B(1) +81 more
0.176 0.646 3.53e-106 4.42e-104 ✓ sig. —
Hearing loss nonsyndromic genetic hearing loss
72 genes
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72 of 72 corroborated by 2+ sources
CEACAM16(4), ESRRB(3), EYA4(3), GIPC3(3), GRAP(4), MYO15A(3), NARS2(5), OTOF(3), OTOGL(3), PCDH15(4), OTOG(3), TMC1(2) +60 more
0.181 0.878 1.17e-106 1.47e-104 ✓ sig. Cluster 26 →
Myocardial infarction Myocardial ischemia
144 genes
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84 of 144 corroborated by 2+ sources
PRDM16(2), APOA1(1), SH2B3(3), TP53(1), SERPINA1(1), ABCG8(2), ACE(2), AGT(2), APOB(2), APOC1(1), APOE(3), CDH13(1) +132 more
0.174 0.368 1.10e-106 1.39e-104 ✓ sig. —

Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.