Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 3
65
Diseases
2,115
Unique genes
0.029
Avg. similarity score
Neurodevelopmental disorder
Most-connected disease (44 links)
Disease
Searched: Neurodevelopmental disorder with dysmorphic facies and variable seizures
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Neurodevelopmental disorder with dysmorphic facies and variable seizures
Neurodevelopmental disorder
Non-specific syndromic intellectual disability
Intellectual developmental disorder
Complex neurodevelopmental disorder
Intellectual disability
Global developmental delay
Developmental and epileptic encephalopathy
Developmental disorder
Developmental disability
Seizures
Epilepsy
Mental retardation, autosomal recessive 68
Neurodevelopmental disorder with hypotonia, seizures, and absent language
Usmani-riazuddin syndrome
Neurodevelopmental disorder with absent language and variable seizures
1q44 microdeletion syndrome
Congenital neurologic anomalies
Developmental delay
Neurodevelopmental disorder with language delay and behavioral abnormalities, with or without seizures
Developmental delay with variable neurological abnormalities
Neurodevelopmental disorder with or without autistic features and/or structural brain abnormalities
Intellectual developmental disorder, autosomal dominant 10
Macrocephaly, neurodevelopmental delay, and seizures
Epileptic encephalopathy, early infantile, 33
Fucosidosis
Intellectual developmental disorder, autosomal dominant 64
Jaberi-elahi syndrome
Dworschak-punetha neurodevelopmental syndrome
Neurodevelopmental disorder with behavioral, ear, and skeletal abnormalities
Neurodevelopmental disorder with poor growth, seizures, and brain abnormalities
Intellectual developmental disorder, autosomal dominant 73
Neurodevelopmental disorder with ataxia, hypotonia, and microcephaly
Epileptic encephalopathy, early infantile, 68
Intellectual developmental disorder, autosomal dominant 65
Neurodevelopmental disorder with brain abnormalities
Neurodevelopmental disorder with congenital anomalies
Cardiofacio-neurodevelopmental syndrome
Hypotonia, infantile, with psychomotor retardation and characteristic facies 2
Intellectual developmental disorder, autosomal recessive 80, with variant lissencephaly
Neurodevelopmental disorder with ataxic gait, absent speech, and decreased cortical white matter
Neurodevelopmental disorder with early-onset parkinsonism and behavioral abnormalities
Neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy
Neurodevelopmental disorder with hypotonia, dysmorphic facies, and skin abnormalities
Neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation
Neurodevelopmental disorder with microcephaly, cerebral atrophy, and visual impairment
Neurodevelopmental disorder with motor and speech delay and behavioural abnormalities
Neurodevelopmental disorder with or without brain abnormalities
Neurodevelopmental disorder with speech and motor delay and spasticity
Neurodevelopmental disorder with white matter abnormalities and gait disturbance
Suleiman-el-hattab syndrome
Aspartylglucosaminuria
Li-takada-miyake syndrome
Neurodevelopmental disorder with dysmorphic facies and behavioral abnormalities
Macrocephaly/megalencephaly syndrome, autosomal recessive
Neurodevelopmental disorder with eye movement abnormalities and ataxia
Kaya-barakat-masson syndrome
Neurodegeneration with developmental delay, early respiratory failure, myoclonic seizures, and brain abnormalities
Neurodevelopmental disorder with cataracts, poor growth, and dysmorphic facies
Neurodevelopmental disorder with growth retardation, dysmorphic facies, and corpus callosum abnormalities
Neurodevelopmental disorder with hyperkinetic movements, seizures and structural brain abnormalities
Neurodevelopmental disorder with hypotonia, poor growth, dysmorphic facies, and agammaglobulinemia
Neurodevelopmental disorder with intracranial hemorrhage, seizures, and spasticity
Neurodevelopmental disorder with microcephaly, epilepsy, and brain atrophy
Neurodevelopmental disorder with speech delay and variable ocular anomalies
Member diseases (most connected first ‐ the cluster's core)
Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| GRIN2B | 10 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental delay, Developmental disability and 6 more |
| SCN8A | 10 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Epilepsy and 6 more |
| EEF1A2 | 9 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Epilepsy and 5 more |
| KCNQ2 | 9 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Epilepsy and 5 more |
| NBEA | 9 / 65 | Complex neurodevelopmental disorder, Developmental disability, Epilepsy, Global developmental delay and 5 more |
| PURA | 9 / 65 | Complex neurodevelopmental disorder, Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Epilepsy and 5 more |
| SCN2A | 9 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Epilepsy and 5 more |
| AP2M1 | 8 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 4 more |
| CDKL5 | 8 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Developmental delay, Epilepsy and 4 more |
| DYRK1A | 8 / 65 | Complex neurodevelopmental disorder, Epilepsy, Global developmental delay, Intellectual developmental disorder and 4 more |
| FOXG1 | 8 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Epilepsy, Global developmental delay and 4 more |
| KMT2E | 8 / 65 | Complex neurodevelopmental disorder, Epilepsy, Global developmental delay, Intellectual developmental disorder and 4 more |
| MECP2 | 8 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Developmental disability, Epilepsy and 4 more |
| SLC2A1 | 8 / 65 | Developmental and epileptic encephalopathy, Developmental delay, Developmental disability, Epilepsy and 4 more |
| SYNGAP1 | 8 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental disability, Epilepsy and 4 more |
| AGO1 | 7 / 65 | Complex neurodevelopmental disorder, Developmental disorder, Intellectual developmental disorder, Intellectual disability and 3 more |
| ARFGEF1 | 7 / 65 | Developmental disability, Epilepsy, Global developmental delay, Intellectual developmental disorder and 3 more |
| ATP1A3 | 7 / 65 | Developmental and epileptic encephalopathy, Developmental delay, Epilepsy, Global developmental delay and 3 more |
| ATP6V0A1 | 7 / 65 | Developmental and epileptic encephalopathy, Developmental disorder, Global developmental delay, Intellectual developmental disorder and 3 more |
| FLNA | 7 / 65 | Developmental and epileptic encephalopathy, Developmental delay, Epilepsy, Global developmental delay and 3 more |
| GABRB2 | 7 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Epilepsy, Intellectual developmental disorder and 3 more |
| GRIN2A | 7 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Epilepsy, Global developmental delay and 3 more |
| HNRNPU | 7 / 65 | 1q44 microdeletion syndrome, Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Epilepsy and 3 more |
| KCNQ3 | 7 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Intellectual disability and 3 more |
| POU3F3 | 7 / 65 | Complex neurodevelopmental disorder, Developmental disability, Global developmental delay, Intellectual developmental disorder and 3 more |
| PTEN | 7 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Developmental delay, Developmental disability and 3 more |
| RALA | 7 / 65 | Complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 3 more |
| RBFOX1 | 7 / 65 | Developmental and epileptic encephalopathy, Developmental disorder, Epilepsy, Global developmental delay and 3 more |
| SCAMP5 | 7 / 65 | Epilepsy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 3 more |
| SCN1A | 7 / 65 | Developmental and epileptic encephalopathy, Epilepsy, Global developmental delay, Intellectual developmental disorder and 3 more |
| SNAP25 | 7 / 65 | Developmental and epileptic encephalopathy, Epilepsy, Global developmental delay, Intellectual developmental disorder and 3 more |
| STXBP1 | 7 / 65 | Developmental and epileptic encephalopathy, Developmental disability, Epilepsy, Global developmental delay and 3 more |
| TCF7L2 | 7 / 65 | Complex neurodevelopmental disorder, Developmental disorder, Global developmental delay, Intellectual developmental disorder and 3 more |
| UBE3A | 7 / 65 | Developmental and epileptic encephalopathy, Developmental delay, Developmental disability, Epilepsy and 3 more |
| ZMIZ1 | 7 / 65 | Complex neurodevelopmental disorder, Developmental disability, Global developmental delay, Intellectual disability and 3 more |
| ZNF292 | 7 / 65 | Complex neurodevelopmental disorder, Developmental disorder, Intellectual developmental disorder, Intellectual developmental disorder, autosomal dominant 64 and 3 more |
| ANKRD11 | 6 / 65 | Congenital neurologic anomalies, Developmental disability, Epilepsy, Global developmental delay and 2 more |
| AP1G1 | 6 / 65 | Complex neurodevelopmental disorder, Epilepsy, Intellectual disability, Neurodevelopmental disorder and 2 more |
| ARF3 | 6 / 65 | Global developmental delay, Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder and 2 more |
| ARHGEF9 | 6 / 65 | Developmental and epileptic encephalopathy, Developmental disability, Developmental disorder, Epilepsy and 2 more |
| BRSK2 | 6 / 65 | Complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| CACNA2D1 | 6 / 65 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| CACNA2D2 | 6 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Developmental delay, Epilepsy and 2 more |
| CAMK2B | 6 / 65 | Congenital neurologic anomalies, Developmental disability, Global developmental delay, Intellectual developmental disorder and 2 more |
| CASK | 6 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 2 more |
| CHD2 | 6 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Epilepsy, Intellectual developmental disorder and 2 more |
| CHD5 | 6 / 65 | Epilepsy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| CHD8 | 6 / 65 | Complex neurodevelopmental disorder, Developmental delay, Developmental disability, Intellectual developmental disorder and 2 more |
| CNTNAP2 | 6 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Epilepsy, Intellectual developmental disorder and 2 more |
| CTNNB1 | 6 / 65 | Congenital neurologic anomalies, Developmental disability, Global developmental delay, Intellectual developmental disorder and 2 more |
| CYFIP2 | 6 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 2 more |
| GRIA3 | 6 / 65 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| HECW2 | 6 / 65 | Complex neurodevelopmental disorder, Congenital neurologic anomalies, Developmental disability, Neurodevelopmental disorder and 2 more |
| IQSEC2 | 6 / 65 | Developmental and epileptic encephalopathy, Epilepsy, Intellectual developmental disorder, Intellectual disability and 2 more |
| KCNA2 | 6 / 65 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 2 more |
| KCNB1 | 6 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Epilepsy, Intellectual developmental disorder and 2 more |
| KDM4B | 6 / 65 | Developmental disability, Developmental disorder, Intellectual developmental disorder, Intellectual developmental disorder, autosomal dominant 65 and 2 more |
| MBD5 | 6 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 2 more |
| MEF2C | 6 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Epilepsy, Intellectual developmental disorder and 2 more |
| NAA15 | 6 / 65 | Developmental disability, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| NALCN | 6 / 65 | Congenital neurologic anomalies, Developmental disability, Global developmental delay, Intellectual developmental disorder and 2 more |
| NCKAP1 | 6 / 65 | Complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| NOVA2 | 6 / 65 | Complex neurodevelopmental disorder, Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder and 2 more |
| NRXN1 | 6 / 65 | Complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| PACS2 | 6 / 65 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| PNKP | 6 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Developmental disability, Global developmental delay and 2 more |
| PPP2CA | 6 / 65 | Complex neurodevelopmental disorder, Global developmental delay, Intellectual disability, Neurodevelopmental disorder and 2 more |
| PPP2R5D | 6 / 65 | Complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| PRRT2 | 6 / 65 | Epilepsy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| SETBP1 | 6 / 65 | Complex neurodevelopmental disorder, Congenital neurologic anomalies, Developmental disability, Intellectual developmental disorder and 2 more |
| SLC6A1 | 6 / 65 | Developmental and epileptic encephalopathy, Epilepsy, Global developmental delay, Intellectual developmental disorder and 2 more |
| SMARCA5 | 6 / 65 | Complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| SMC1A | 6 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Epilepsy, Global developmental delay and 2 more |
| ST3GAL3 | 6 / 65 | Complex neurodevelopmental disorder, Developmental and epileptic encephalopathy, Intellectual developmental disorder, Intellectual disability and 2 more |
| TCF4 | 6 / 65 | Developmental disability, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| TNRC6B | 6 / 65 | Complex neurodevelopmental disorder, Developmental disability, Global developmental delay, Intellectual disability and 2 more |
| TRIM8 | 6 / 65 | Developmental and epileptic encephalopathy, Epilepsy, Global developmental delay, Intellectual disability and 2 more |
| TRMT1 | 6 / 65 | Complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| TSC2 | 6 / 65 | Congenital neurologic anomalies, Epilepsy, Intellectual developmental disorder, Intellectual disability and 2 more |
| UFSP2 | 6 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Epilepsy, Intellectual developmental disorder and 2 more |
| UPF1 | 6 / 65 | Developmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 2 more |
| WASF1 | 6 / 65 | Developmental and epileptic encephalopathy, Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder and 2 more |
| WWOX | 6 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Developmental delay, Epilepsy and 2 more |
| ZNF142 | 6 / 65 | Global developmental delay, Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder and 2 more |
| ACTL6A | 5 / 65 | Developmental delay, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 1 more |
| ADGRL1 | 5 / 65 | Complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| ALDH7A1 | 5 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Epilepsy, Intellectual developmental disorder and 1 more |
| ALG13 | 5 / 65 | Developmental and epileptic encephalopathy, Epilepsy, Intellectual developmental disorder, Intellectual disability and 1 more |
| ANK2 | 5 / 65 | Complex neurodevelopmental disorder, Epilepsy, Intellectual developmental disorder, Neurodevelopmental disorder and 1 more |
| AP4S1 | 5 / 65 | Developmental delay, Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder and 1 more |
| ARID1B | 5 / 65 | Developmental disability, Epilepsy, Global developmental delay, Intellectual developmental disorder and 1 more |
| ATRX | 5 / 65 | Congenital neurologic anomalies, Developmental disability, Global developmental delay, Intellectual developmental disorder and 1 more |
| BLOC1S1 | 5 / 65 | Epilepsy, Global developmental delay, Intellectual disability, Neurodevelopmental disorder and 1 more |
| BRWD3 | 5 / 65 | Developmental delay, Intellectual developmental disorder, Intellectual disability, Neurodevelopmental disorder and 1 more |
| CACNA1A | 5 / 65 | Congenital neurologic anomalies, Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder and 1 more |
| CACNA1B | 5 / 65 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual disability, Neurodevelopmental disorder and 1 more |
| CACNA1E | 5 / 65 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual disability, Neurodevelopmental disorder and 1 more |
| CACNG2 | 5 / 65 | Complex neurodevelopmental disorder, Intellectual developmental disorder, Intellectual developmental disorder, autosomal dominant 10, Neurodevelopmental disorder and 1 more |
| CAMK2A | 5 / 65 | Complex neurodevelopmental disorder, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 1 more |
| CAMK2G | 5 / 65 | Developmental and epileptic encephalopathy, Global developmental delay, Intellectual developmental disorder, Intellectual disability and 1 more |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Nicotine addiction | KEGG | 26 / 41 | 3.6× | 8.75e-11 | 1.04e-8 ✓ sig. |
| Glutamatergic synapse | KEGG | 50 / 116 | 2.4× | 1.20e-10 | 1.37e-8 ✓ sig. |
| Unblocking of NMDA receptors, glutamate binding and activation | Reactome | 16 / 22 | 4.1× | 2.07e-8 | 1.41e-6 ✓ sig. |
| Dopaminergic synapse | KEGG | 50 / 132 | 2.2× | 2.34e-8 | 1.57e-6 ✓ sig. |
| Cholinergic synapse | KEGG | 45 / 115 | 2.2× | 3.73e-8 | 2.37e-6 ✓ sig. |
| GABAergic synapse | KEGG | 37 / 89 | 2.4× | 9.60e-8 | 5.40e-6 ✓ sig. |
| Amphetamine addiction | KEGG | 31 / 69 | 2.6× | 1.27e-7 | 6.90e-6 ✓ sig. |
| Long-term depression | KEGG | 28 / 60 | 2.6× | 1.92e-7 | 9.88e-6 ✓ sig. |
| Serotonin Neurotransmitter Release Cycle | Reactome | 13 / 18 | 4.1× | 5.37e-7 | 2.43e-5 ✓ sig. |
| Long-term potentiation | KEGG | 29 / 67 | 2.5× | 8.42e-7 | 3.58e-5 ✓ sig. |
| RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known | Reactome | 20 / 38 | 3.0× | 9.81e-7 | 4.10e-5 ✓ sig. |
| cAMP signaling pathway | KEGG | 69 / 226 | 1.7× | 1.17e-6 | 4.79e-5 ✓ sig. |
| Glutamate Neurotransmitter Release Cycle | Reactome | 15 / 24 | 3.5× | 1.22e-6 | 4.95e-5 ✓ sig. |
| Circadian entrainment | KEGG | 37 / 97 | 2.2× | 1.25e-6 | 5.04e-5 ✓ sig. |
| Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | KEGG | 17 / 30 | 3.2× | 1.65e-6 | 6.44e-5 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| nervous system development | GO:0007399 | 207 / 631 | 2.9× | 6.99e-49 | 1.33e-44 ✓ sig. |
| chemical synaptic transmission | GO:0007268 | 96 / 236 | 3.6× | 2.28e-31 | 1.47e-27 ✓ sig. |
| chromatin organization | GO:0006325 | 135 / 449 | 2.7× | 1.06e-27 | 4.69e-24 ✓ sig. |
| brain development | GO:0007420 | 89 / 244 | 3.2× | 4.13e-25 | 1.30e-21 ✓ sig. |
| chromatin remodeling | GO:0006338 | 104 / 320 | 2.9× | 1.68e-24 | 4.79e-21 ✓ sig. |
| monoatomic ion transmembrane transport | GO:0034220 | 112 / 404 | 2.4× | 4.59e-20 | 7.37e-17 ✓ sig. |
| synapse organization | GO:0050808 | 40 / 72 | 4.9× | 7.35e-20 | 1.15e-16 ✓ sig. |
| monoatomic ion transport | GO:0006811 | 155 / 667 | 2.1× | 5.03e-19 | 6.96e-16 ✓ sig. |
| positive regulation of DNA-templated transcription | GO:0045893 | 166 / 778 | 1.9× | 1.68e-16 | 1.57e-13 ✓ sig. |
| neuron migration | GO:0001764 | 51 / 132 | 3.4× | 3.61e-16 | 3.17e-13 ✓ sig. |
| cerebral cortex development | GO:0021987 | 40 / 88 | 4.0× | 7.53e-16 | 6.29e-13 ✓ sig. |
| axon guidance | GO:0007411 | 62 / 192 | 2.9× | 5.46e-15 | 3.92e-12 ✓ sig. |
| neuron projection development | GO:0031175 | 55 / 161 | 3.0× | 1.28e-14 | 8.62e-12 ✓ sig. |
| positive regulation of excitatory postsynaptic potential | GO:2000463 | 22 / 32 | 6.1× | 2.87e-14 | 1.82e-11 ✓ sig. |
| positive regulation of transcription by RNA polymerase II | GO:0045944 | 221 / 1,208 | 1.6× | 9.35e-14 | 5.40e-11 ✓ sig. |