Shared-Gene Disease Pairs?
Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.
What do these columns mean?
- Shared genes
- Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
- Similarity score
- Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
- Overlap coefficient
- Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
- P-value / FDR q-value
- Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
- Shared cluster
- Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
| Disease A ⇵ | Disease B ⇵ | Shared genes ⇵ | Similarity score ⇵ | Overlap coefficient ⇵ | P-value ⇵ | FDR q-value ▼ | Shared cluster | |
|---|---|---|---|---|---|---|---|---|
| Angina pectoris | Brain edema |
3 genes
|
0.150 | 0.300 | 4.33e-8 | 3.23e-7 ✓ sig. | — | |
| Hemolytic anemia | Rh deficiency syndrome |
3 genes
|
0.054 | 1.000 | 4.31e-8 | 3.22e-7 ✓ sig. | — | |
| Coach syndrome | Cystic kidney disease |
3 genes
|
0.103 | 0.600 | 4.26e-8 | 3.19e-7 ✓ sig. | — | |
| Sarcoma | Thyroid neoplasms |
5 genes
|
0.067 | 0.152 | 4.24e-8 | 3.17e-7 ✓ sig. | — | |
| Cholangiocarcinoma | Hereditary breast and ovarian cancer syndrome |
4 genes
|
0.080 | 0.267 | 4.22e-8 | 3.16e-7 ✓ sig. | — | |
| Chronic obstructive pulmonary disease | Emphysema |
5 genes
|
0.068 | 0.139 | 4.18e-8 | 3.13e-7 ✓ sig. | Cluster 119 → | |
| Congenital hypoplasia of kidney | Renal agenesis |
3 genes
|
0.143 | 0.375 | 4.18e-8 | 3.12e-7 ✓ sig. | Cluster 152 → | |
| Haddad syndrome | Hirschsprung disease |
4 genes
|
0.055 | 0.444 | 4.06e-8 | 3.04e-7 ✓ sig. | Cluster 387 → | |
| Congenital central hypoventilation syndrome | Hirschsprung disease |
4 genes
|
0.055 | 0.444 | 4.06e-8 | 3.04e-7 ✓ sig. | Cluster 387 → | |
| Congenital microcephaly | Seckel syndrome |
4 genes
|
0.087 | 0.222 | 4.03e-8 | 3.02e-7 ✓ sig. | Cluster 101 → | |
| Brachycephaly | Craniosynostosis |
4 genes
|
0.061 | 0.400 | 4.01e-8 | 3.01e-7 ✓ sig. | — | |
| Female infertility | Hypogonadism |
8 genes
|
0.047 | 0.105 | 3.94e-8 | 2.95e-7 ✓ sig. | — | |
| Erythrocytosis | Polycythemia vera |
3 genes
|
0.150 | 0.333 | 3.94e-8 | 2.95e-7 ✓ sig. | — | |
| Congenital arteriovenous malformation | Costello syndrome |
3 genes
|
0.150 | 0.333 | 3.94e-8 | 2.95e-7 ✓ sig. | — | |
| Genetic steroid-resistant nephrotic syndrome | Nephrotic syndrome, idiopathic, steroid-resistant |
3 genes
|
0.083 | 0.750 | 3.93e-8 | 2.95e-7 ✓ sig. | — | |
| Congenital neutropenia | Shwachman-diamond syndrome |
3 genes
|
0.136 | 0.429 | 3.90e-8 | 2.93e-7 ✓ sig. | — | |
| Gallbladder neoplasms | Nasopharyngeal carcinoma |
4 genes
|
0.091 | 0.182 | 3.88e-8 | 2.91e-7 ✓ sig. | — | |
| Cervical disc degenerative disorder | Oral submucous fibrosis |
3 genes
|
0.125 | 0.500 | 3.74e-8 | 2.81e-7 ✓ sig. | — | |
| Learning disorders | Neurodegenerative disorder |
5 genes
|
0.068 | 0.139 | 3.69e-8 | 2.77e-7 ✓ sig. | — | |
| Multinodular goiter | Thyroid disease |
5 genes
|
0.065 | 0.179 | 3.69e-8 | 2.77e-7 ✓ sig. | — | |
| Pulmonary hypertension | Sleep apnea |
6 genes
|
0.057 | 0.122 | 3.68e-8 | 2.77e-7 ✓ sig. | — | |
| Aplastic anemia | Asbestosis |
4 genes
|
0.087 | 0.235 | 3.59e-8 | 2.70e-7 ✓ sig. | — | |
| Chloracne | Delta-beta thalassemia |
3 genes
|
0.086 | 0.750 | 3.58e-8 | 2.70e-7 ✓ sig. | — | |
| Carcinogenesis | Lymphatic metastasis |
4 genes
|
0.089 | 0.222 | 3.51e-8 | 2.65e-7 ✓ sig. | — | |
| Nystagmus | Strabismus |
5 genes
|
0.068 | 0.147 | 3.50e-8 | 2.64e-7 ✓ sig. | — |
0 selected
·
Loading clusters...
Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.