Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
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Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Ductal carcinoma of breast Esotropia
2 genes
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2 of 2 corroborated by 2+ sources
SOD2(2), PTGS2(2)
0.095 0.200 2.50e-5 1.17e-4 ✓ sig. —
Ductal carcinoma of breast Tongue neoplasms
2 genes
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SOD2(1), PTGS2(1)
0.095 0.200 2.50e-5 1.17e-4 ✓ sig. Cluster 269 →
Dwarfism Ear, patella, short stature syndrome
2 genes
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2 of 2 corroborated by 2+ sources
ORC1(3), DONSON(2)
0.095 0.200 2.50e-5 1.17e-4 ✓ sig. Cluster 171 →
Common migraine Trigeminal neuralgia
2 genes
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2 of 2 corroborated by 2+ sources
TNF(2), CALCA(2)
0.095 0.200 2.50e-5 1.17e-4 ✓ sig. —
Bone resorption Cachexia
2 genes
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PTHLH(1), GHRL(1)
0.095 0.200 2.50e-5 1.17e-4 ✓ sig. —
Wagr syndrome Wilms tumor
2 genes
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2 of 2 corroborated by 2+ sources
WT1(7), PAX6(4)
0.057 0.500 2.50e-5 1.17e-4 ✓ sig. Cluster 35 →
Hepatoblastoma Wilms tumor
2 genes
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1 of 2 corroborated by 2+ sources
IGF2(3), CTNNB1(1)
0.057 0.500 2.50e-5 1.17e-4 ✓ sig. —
Cleft lip and cleft of alveolar process of maxilla Ectodermal dysplasia
2 genes
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TP63(1), NECTIN1(1)
0.057 0.500 2.50e-5 1.17e-4 ✓ sig. —
Ectodermal dysplasia Pachyonychia congenita
2 genes
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2 of 2 corroborated by 2+ sources
KRT17(6), KRT16(6)
0.057 0.500 2.50e-5 1.17e-4 ✓ sig. —
Conotruncal cardiac defect Ventricular septal defect
4 genes
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4 of 4 corroborated by 2+ sources
TBX1(5), NKX2-6(5), NKX2-5(5), GATA6(5)
0.039 0.095 2.53e-5 1.18e-4 ✓ sig. —
Demyelinating diseases Ductal carcinoma
2 genes
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2 of 2 corroborated by 2+ sources
TP53(2), MYC(2)
0.095 0.182 2.54e-5 1.19e-4 ✓ sig. —
Ductal carcinoma Prostatic intraepithelial neoplasia
2 genes
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PTEN(1), CDH1(1)
0.095 0.182 2.54e-5 1.19e-4 ✓ sig. —
Periodic limb movement disorder Sleep disorder
2 genes
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BTBD9(1), MEIS1(1)
0.095 0.182 2.54e-5 1.19e-4 ✓ sig. —
Hematuria Infantile spasms
2 genes
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2 of 2 corroborated by 2+ sources
POMC(2), LMX1B(2)
0.095 0.182 2.54e-5 1.19e-4 ✓ sig. —
Autoimmune lymphoproliferative disorder Melanocytic nevus
2 genes
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2 of 2 corroborated by 2+ sources
NRAS(4), CASP8(5)
0.095 0.182 2.54e-5 1.19e-4 ✓ sig. Cluster 18 →
Dyslipidemias Promyelocytic leukemia
3 genes
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3 of 3 corroborated by 2+ sources
PPARG(2), RARA(2), PML(2)
0.045 0.167 2.54e-5 1.19e-4 ✓ sig. —
Congenital heart disease Pelvic organ prolapse
9 genes
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5 of 9 corroborated by 2+ sources
FOXP2(1), NRP1(3), SORBS2(3), RXRA(2), SNAI1(3), KLF13(3), IQCJ(1), IQCJ-SCHIP1(1), LNPK(1)
0.030 0.065 2.60e-5 1.21e-4 ✓ sig. —
Ataxia Choreoathetosis
2 genes
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2 of 2 corroborated by 2+ sources
SCN8A(2), SLC2A1(2)
0.077 0.333 2.65e-5 1.23e-4 ✓ sig. —
Cushing syndrome Penile disease
2 genes
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2 of 2 corroborated by 2+ sources
ATRX(2), POMC(2)
0.077 0.333 2.65e-5 1.23e-4 ✓ sig. —
Hemorrhagic disease Thrombocytosis
2 genes
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2 of 2 corroborated by 2+ sources
THPO(5), JAK2(4)
0.077 0.333 2.65e-5 1.23e-4 ✓ sig. —
Hemorrhagic disease Thrombocythemia
2 genes
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2 of 2 corroborated by 2+ sources
THPO(5), JAK2(5)
0.077 0.333 2.65e-5 1.23e-4 ✓ sig. —
Autoimmune polyendocrine syndrome Bronchitis
2 genes
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2 of 2 corroborated by 2+ sources
HLA-DQA1(2), HLA-DQB1(2)
0.056 0.500 2.67e-5 1.24e-4 ✓ sig. Cluster 1 →
Bronchitis Esophageal achalasia
2 genes
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2 of 2 corroborated by 2+ sources
HLA-DQA1(3), HLA-DQB1(3)
0.056 0.500 2.67e-5 1.24e-4 ✓ sig. Cluster 1 →
Bronchitis Oropharyngeal neoplasms
2 genes
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2 of 2 corroborated by 2+ sources
HLA-DQA1(2), HLA-DQB1(2)
0.056 0.500 2.67e-5 1.24e-4 ✓ sig. Cluster 1 →
Otosclerosis Uremia
3 genes
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3 of 3 corroborated by 2+ sources
SPP1(3), TGFB1(3), KDR(3)
0.045 0.167 2.70e-5 1.25e-4 ✓ sig. Cluster 180 →

Showing 25 of 20813 pairs, sorted by significance (ascending). Click a column header to sort.