Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 18

22 diseases · 80 shared-gene connections
22 Diseases
11 Unique genes
0.443 Avg. similarity score
Cooleys anemia Most-connected disease (18 links)
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Disease Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Cooleys anemia 18 18 1
Dominant beta-thalassemia 17 17 1
Hemoglobin c disease 16 16 1
Hemoglobin c beta thalassemia 15 15 1
Hemoglobin d disease 14 14 1
Hemoglobin f disease 6 6 3
Lepore-beta-thalassemia syndrome 6 6 2
Cyanosis 5 5 5
Delta-beta thalassemia 5 5 4
Hemoglobin c-thalassemia disease 5 5 1
Hemoglobin e beta thalassemia 5 5 1
Hemoglobin sc disease 5 5 1
Hemoglobin sd disease 5 5 1
Hemoglobin se disease 5 5 1
Hemoglobinopathy 5 5 1
Thalassemia intermedia 5 5 1
beta-thalassemia HBB/LCRB 5 5 1
erythrocytosis, familial, 6 5 5 1
obsolete sickle cell disease and related diseases 5 5 1
Hemoglobin e disease 4 4 5
Hemoglobinopathy toms river 3 3 1
Angiocentric glioma 1 1 2

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
HBB 20 / 22 beta-thalassemia HBB/LCRB, Cooleys anemia, Cyanosis, Delta-beta thalassemia and 16 more
HBG2 4 / 22 Cyanosis, Delta-beta thalassemia, Hemoglobin f disease, Hemoglobinopathy toms river
HBD 3 / 22 Delta-beta thalassemia, Hemoglobin e disease, Lepore-beta-thalassemia syndrome
HBG1 2 / 22 Delta-beta thalassemia, Hemoglobin f disease
MYB 2 / 22 Angiocentric glioma, Hemoglobin e disease
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Factors involved in megakaryocyte development and platelet production
HBB, HBG2, HBD, HBG1
 Reactome 4 / 99 44.1× 1.37e-6 6.42e-5 ✓ sig.
Malaria
HBB, TGFB2
 KEGG 2 / 50 43.7× 9.12e-4 1.27e-2 ✓ sig.
Adrenaline signalling through Alpha-2 adrenergic receptor
ADRA2B
 Reactome 1 / 3 364× 2.75e-3 2.89e-2 ✓ sig.
Vitamin C (ascorbate) metabolism
CYB5R3
 Reactome 1 / 8 136× 7.31e-3 5.62e-2
Adrenoceptors
ADRA2B
 Reactome 1 / 9 121× 8.22e-3 6.07e-2
Erythrocytes take up oxygen and release carbon dioxide
HBB
 Reactome 1 / 9 121× 8.22e-3 6.07e-2
Scavenging of heme from plasma
HBB
 Reactome 1 / 13 84.0× 1.18e-2 7.60e-2
Erythrocytes take up carbon dioxide and release oxygen
HBB
 Reactome 1 / 13 84.0× 1.18e-2 7.60e-2
Biosynthesis of various nucleotide sugars
CYB5R3
 KEGG 1 / 15 72.8× 1.37e-2 8.23e-2
mRNA decay by 3' to 5' exoribonuclease
HBS1L
 Reactome 1 / 16 68.2× 1.46e-2 8.55e-2
Phase I - Functionalization of compounds
CYB5R3
 Reactome 1 / 21 52.0× 1.91e-2 1.00e-1
G alpha (z) signalling events
ADRA2B
 Reactome 1 / 33 33.1× 2.98e-2 1.28e-1
African trypanosomiasis
HBB
 KEGG 1 / 37 29.5× 3.34e-2 1.37e-1
Molecules associated with elastic fibres
TGFB2
 Reactome 1 / 38 28.7× 3.43e-2 1.39e-1
Legionellosis
HBS1L
 KEGG 1 / 56 19.5× 5.01e-2 1.72e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
carbon dioxide transport
HBB, HBG2, HBD, HBG1
 GO:0015670 4 / 13 523× 4.63e-11 1.44e-8 ✓ sig.
oxygen transport
HBB, HBG2, HBD, HBG1
 GO:0015671 4 / 17 400× 1.54e-10 4.24e-8 ✓ sig.
erythrocyte development
HBB, HBG2, HBD, HBG1
 GO:0048821 4 / 32 212× 2.32e-9 4.70e-7 ✓ sig.
embryonic digestive tract development
MYB, TGFB2
 GO:0048566 2 / 19 179× 5.36e-5 1.89e-3 ✓ sig.
positive regulation of miRNA transcription
MYB, TGFB2
 GO:1902895 2 / 56 60.7× 4.77e-4 9.29e-3 ✓ sig.
negative regulation of neuron remodeling
BCL11A
 GO:1904800 1 / 1 1,699× 5.89e-4 1.07e-2 ✓ sig.
negative regulation of branching morphogenesis of a nerve
BCL11A
 GO:2000173 1 / 1 1,699× 5.89e-4 1.07e-2 ✓ sig.
regulation of timing of catagen
TGFB2
 GO:0051794 1 / 1 1,699× 5.89e-4 1.07e-2 ✓ sig.
positive regulation of activation-induced cell death of T cells
TGFB2
 GO:0070237 1 / 1 1,699× 5.89e-4 1.07e-2 ✓ sig.
regulation of apoptotic process involved in outflow tract morphogenesis
TGFB2
 GO:1902256 1 / 1 1,699× 5.89e-4 1.07e-2 ✓ sig.
negative regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
TGFB2
 GO:1905006 1 / 1 1,699× 5.89e-4 1.07e-2 ✓ sig.
positive regulation of neuron apoptotic process
MYB, TGFB2
 GO:0043525 2 / 65 52.3× 6.42e-4 1.13e-2 ✓ sig.
regulation of macrophage differentiation
QKI
 GO:0045649 1 / 2 849× 1.18e-3 1.66e-2 ✓ sig.
regulation of cell development
QKI
 GO:0060284 1 / 2 849× 1.18e-3 1.66e-2 ✓ sig.
myofibroblast contraction
QKI
 GO:1990764 1 / 2 849× 1.18e-3 1.66e-2 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Delta-beta thalassemia Hemoglobin f disease 0.600 3 6.58e-12 7.74e-11 ✓ sig.
Delta-beta thalassemia Lepore-beta-thalassemia syndrome 0.400 2 5.06e-8 3.92e-7 ✓ sig.
Hemoglobin e disease Lepore-beta-thalassemia syndrome 0.333 2 8.44e-8 6.27e-7 ✓ sig.
Cyanosis Hemoglobin f disease 0.286 2 2.53e-7 1.75e-6 ✓ sig.
Delta-beta thalassemia Hemoglobin e disease 0.250 2 5.06e-7 3.32e-6 ✓ sig.
Cyanosis Delta-beta thalassemia 0.250 2 5.06e-7 3.32e-6 ✓ sig.
Hemoglobin c beta thalassemia Hemoglobin se disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c disease Hemoglobinopathy 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c disease Hemoglobin se disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Hemoglobin se disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Hemoglobin se disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin d disease Hemoglobin sd disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c beta thalassemia Hemoglobin sd disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c disease Hemoglobin sd disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Hemoglobin sd disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Hemoglobin sd disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin d disease Hemoglobin sc disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c beta thalassemia Hemoglobin sc disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c disease Hemoglobin sc disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Hemoglobin sc disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Hemoglobin sc disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin d disease Hemoglobin se disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Hemoglobinopathy 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Hemoglobinopathy 0.500 1 6.49e-5 2.34e-4 ✓ sig.
beta-thalassemia HBB/LCRB Cooleys anemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c beta thalassemia Hemoglobinopathy 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin d disease Hemoglobinopathy 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia obsolete sickle cell disease and related diseases 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia obsolete sickle cell disease and related diseases 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c disease obsolete sickle cell disease and related diseases 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c beta thalassemia obsolete sickle cell disease and related diseases 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin d disease obsolete sickle cell disease and related diseases 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Thalassemia intermedia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Thalassemia intermedia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c disease Thalassemia intermedia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c beta thalassemia Thalassemia intermedia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin d disease Thalassemia intermedia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Hemoglobin d disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
erythrocytosis, familial, 6 Hemoglobin c disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia erythrocytosis, familial, 6 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia erythrocytosis, familial, 6 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Hemoglobin e beta thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Hemoglobin d disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Hemoglobin c beta thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Hemoglobin c disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Hemoglobin e beta thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c-thalassemia disease Hemoglobin d disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Hemoglobin c beta thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Hemoglobin c disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Dominant beta-thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
beta-thalassemia HBB/LCRB Hemoglobin d disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
beta-thalassemia HBB/LCRB Hemoglobin c beta thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
beta-thalassemia HBB/LCRB Hemoglobin c disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
beta-thalassemia HBB/LCRB Dominant beta-thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
erythrocytosis, familial, 6 Hemoglobin d disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c beta thalassemia Hemoglobin c disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c beta thalassemia Hemoglobin d disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c beta thalassemia Hemoglobin e beta thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c disease Hemoglobin d disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c disease Hemoglobin e beta thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin d disease Hemoglobin e beta thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c beta thalassemia Hemoglobin c-thalassemia disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Hemoglobin c disease Hemoglobin c-thalassemia disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Hemoglobin c-thalassemia disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Cooleys anemia Hemoglobin c-thalassemia disease 0.500 1 6.49e-5 2.34e-4 ✓ sig.
erythrocytosis, familial, 6 Hemoglobin c beta thalassemia 0.500 1 6.49e-5 2.34e-4 ✓ sig.
Dominant beta-thalassemia Lepore-beta-thalassemia syndrome 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Hemoglobin c beta thalassemia Lepore-beta-thalassemia syndrome 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Hemoglobin c disease Lepore-beta-thalassemia syndrome 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Cooleys anemia Lepore-beta-thalassemia syndrome 0.333 1 1.30e-4 3.90e-4 ✓ sig.
Hemoglobin f disease Hemoglobinopathy toms river 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Hemoglobin c disease Hemoglobin f disease 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Dominant beta-thalassemia Hemoglobin f disease 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Cooleys anemia Hemoglobin f disease 0.250 1 1.95e-4 5.28e-4 ✓ sig.
Delta-beta thalassemia Hemoglobinopathy toms river 0.200 1 2.60e-4 6.40e-4 ✓ sig.
Cyanosis Hemoglobinopathy toms river 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Cooleys anemia Cyanosis 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Cooleys anemia Hemoglobin e disease 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Cyanosis Dominant beta-thalassemia 0.167 1 3.25e-4 7.58e-4 ✓ sig.
Angiocentric glioma Hemoglobin e disease 0.143 1 6.49e-4 1.22e-3 ✓ sig.