Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 57

15 diseases · 25 shared-gene connections
15 Diseases
152 Unique genes
0.114 Avg. similarity score
Antisocial personality disorder Most-connected disease (7 links)
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Disease Searched: Separation anxiety disorder Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Antisocial personality disorder 7 7 4
Orthostatic hypotension 6 6 3
Colchicine resistance 5 5 1
Familial mediterranean fever 5 5 2
Hepatic encephalopathy 5 5 14
Congenital dyserythropoietic anemia 4 4 10
Conduct disorder 3 3 52
Hyperpituitarism 3 3 15
Brunner syndrome 2 2 1
Congenital brain dysgenesis due to glutamine synthetase deficiency 2 2 1
Huntington disease 2 2 61
Nausea 2 2 7
Separation anxiety disorder 2 2 1
severe combined immunodeficiency due to DNA-PKcs deficiency 1 1 1
severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
ABCB1 7 / 15 Antisocial personality disorder, Colchicine resistance, Congenital dyserythropoietic anemia, Familial mediterranean fever and 3 more
MAOA 4 / 15 Antisocial personality disorder, Brunner syndrome, Hepatic encephalopathy, Huntington disease
DRD4 3 / 15 Antisocial personality disorder, Conduct disorder, Separation anxiety disorder
GLUL 3 / 15 Congenital brain dysgenesis due to glutamine synthetase deficiency, Hepatic encephalopathy, Huntington disease
OPRM1 3 / 15 Hepatic encephalopathy, Nausea, Orthostatic hypotension
CNR1 2 / 15 Conduct disorder, Huntington disease
GATAD2B 2 / 15 Conduct disorder, severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome
HTR1B 2 / 15 Antisocial personality disorder, Conduct disorder
MAD1L1 2 / 15 Conduct disorder, Hyperpituitarism
MAOB 2 / 15 Hepatic encephalopathy, Huntington disease
PRKDC 2 / 15 Hepatic encephalopathy, severe combined immunodeficiency due to DNA-PKcs deficiency
TNF 2 / 15 Hepatic encephalopathy, Nausea
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Alcoholic liver disease
ADH1B, ADH1C, IRAK4, TNF, IL6, MAP3K5, PPARGC1A, PRKAA1, SIRT1, IFNA2
 KEGG 10 / 144 5.5× 1.41e-5 4.72e-4 ✓ sig.
Neuroactive ligand-receptor interaction
DRD4, HTR1B, CNR1, GABRA1, GABRB1, GABRG2, OPRM1, TSPO, GRIK2, GRIN2A, GRIN2B, NPY
 KEGG 15 / 370 3.2× 6.95e-5 1.74e-3 ✓ sig.
Synaptic adhesion-like molecules
PTPRD, PTPRF, GRIN2A, GRIN2B
 Reactome 4 / 21 15.1× 1.25e-4 2.77e-3 ✓ sig.
GABAergic synapse
SLC6A1, GLUL, GABRA1, GABRB1, GABRG2, ABAT, HAP1
 KEGG 7 / 89 6.2× 1.31e-4 2.88e-3 ✓ sig.
Nicotine addiction
GABRA1, GABRB1, GABRG2, GRIN2A, GRIN2B
 KEGG 5 / 41 9.6× 1.58e-4 3.33e-3 ✓ sig.
Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB
MAOA, MAOB
 Reactome 2 / 2 79.0× 1.59e-4 3.35e-3 ✓ sig.
Cocaine addiction
MAOA, MAOB, BDNF, GRIN2A, GRIN2B
 KEGG 5 / 49 8.1× 3.70e-4 6.54e-3 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
MAOA, OPRM1, TNF, IL6, IL6R, OPRD1, POMC
 Reactome 7 / 108 5.1× 4.34e-4 7.43e-3 ✓ sig.
Opioid Signalling
OPRM1, POMC
 Reactome 2 / 3 52.7× 4.73e-4 7.95e-3 ✓ sig.
GABA receptor activation
GABRA1, GABRB1, GABRG2
 Reactome 3 / 16 14.8× 9.86e-4 1.39e-2 ✓ sig.
Tyrosine metabolism
MAOA, ADH1B, ADH1C, MAOB
 KEGG 4 / 36 8.8× 1.06e-3 1.47e-2 ✓ sig.
Amphetamine addiction
MAOA, MAOB, GRIN2A, GRIN2B, SIRT1
 KEGG 5 / 69 5.7× 1.78e-3 2.18e-2 ✓ sig.
Adipocytokine signaling pathway
TNF, NPY, PPARGC1A, PRKAA1, POMC
 KEGG 5 / 70 5.6× 1.90e-3 2.28e-2 ✓ sig.
Assembly and cell surface presentation of NMDA receptors
GRIN2A, GRIN2B
 Reactome 2 / 6 26.3× 2.31e-3 2.63e-2 ✓ sig.
Necroptosis
GLUL, TNF, AIFM1, EIF2AK2, IFNA2, IFNG, TNFRSF10A
 KEGG 7 / 159 3.5× 4.07e-3 3.93e-2 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
positive regulation of apoptotic process
PAWR, ZBTB16, LTA, PRKDC, S100B, TNF, TSPO, AIFM1, DIABLO, GRIN2A, HTT, IL6
 GO:0043065 16 / 326 6.0× 1.03e-8 1.74e-6 ✓ sig.
cell surface receptor signaling pathway via STAT
CNTF, IGF1, IL6, IL6R, IFNA2, IFNG
 GO:0097696 6 / 28 26.3× 8.52e-8 1.07e-5 ✓ sig.
cellular response to hydrogen peroxide
AIFM1, AQP1, HSF1, IL6, MAP3K5, PRKAA1, SIRT1
 GO:0070301 7 / 69 12.5× 1.45e-6 1.15e-4 ✓ sig.
regulation of neuronal synaptic plasticity
S100B, GRIN2A, GRIN2B, JPH3, NOG
 GO:0048168 5 / 26 23.6× 1.91e-6 1.44e-4 ✓ sig.
chemical synaptic transmission
DRD4, HTR1B, ACP1, RIT2, SLC6A1, GABRG2, GRIK2, GRIN2A, GRIN2B, HAP1, NPY
 GO:0007268 11 / 236 5.7× 3.75e-6 2.46e-4 ✓ sig.
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
DRD4, HTR1B, CNR1, OPRM1, NPY, OPRD1
 GO:0007187 6 / 54 13.7× 4.91e-6 3.04e-4 ✓ sig.
negative regulation of apoptotic process
TNFRSF18, YWHAZ, PRKDC, TNF, AQP1, ATF5, EIF2AK2, GDNF, HTT, IGF1, IL6, PRDM9
 GO:0043066 16 / 524 3.8× 5.95e-6 3.57e-4 ✓ sig.
protein destabilization
KLF1, PRKDC, HTT, PRKAA1, PRNP, SIRT1
 GO:0031648 6 / 60 12.3× 9.14e-6 5.04e-4 ✓ sig.
negative regulation of apoptotic signaling pathway
TNF, BDNF, IGF1, NOG, FAIM2
 GO:2001234 5 / 36 17.1× 1.03e-5 5.50e-4 ✓ sig.
vascular endothelial growth factor production
TNF, IL6, IL6R
 GO:0010573 3 / 6 61.5× 1.04e-5 5.55e-4 ✓ sig.
response to hypoxia
ABCB1, KCNA5, LTA, NOS1, TNF, ABAT, PRKAA1, TFAM, PSEN2
 GO:0001666 9 / 176 6.3× 1.41e-5 7.07e-4 ✓ sig.
positive regulation of glial cell proliferation
LTA, TNF, TSPO, IL6
 GO:0060252 4 / 22 22.4× 2.75e-5 1.18e-3 ✓ sig.
exploration behavior
ABAT, JPH3, NOG, BRINP1
 GO:0035640 4 / 25 19.7× 4.66e-5 1.77e-3 ✓ sig.
positive regulation of chemokine production
TNF, EIF2AK2, IL6, IL6R, IFNG
 GO:0032722 5 / 49 12.5× 4.76e-5 1.80e-3 ✓ sig.
negative regulation of neuron apoptotic process
LIG4, BDNF, CNTF, GDNF, GRIK2, PPARGC1A, SIRT1, FAIM2
 GO:0043524 8 / 160 6.1× 5.01e-5 1.87e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Nausea Orthostatic hypotension 0.222 2 5.31e-7 3.27e-6 ✓ sig.
Hepatic encephalopathy Nausea 0.100 2 1.61e-5 7.71e-5 ✓ sig.
Hepatic encephalopathy Huntington disease 0.041 3 2.09e-5 9.88e-5 ✓ sig.
Antisocial personality disorder Conduct disorder 0.036 2 6.68e-5 2.40e-4 ✓ sig.
Colchicine resistance Familial mediterranean fever 0.333 1 1.30e-4 3.93e-4 ✓ sig.
Colchicine resistance Orthostatic hypotension 0.250 1 1.95e-4 5.35e-4 ✓ sig.
Antisocial personality disorder Separation anxiety disorder 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Antisocial personality disorder Brunner syndrome 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Antisocial personality disorder Colchicine resistance 0.200 1 2.60e-4 6.51e-4 ✓ sig.
Familial mediterranean fever Orthostatic hypotension 0.200 1 3.90e-4 8.67e-4 ✓ sig.
Antisocial personality disorder Familial mediterranean fever 0.167 1 5.19e-4 1.06e-3 ✓ sig.
Colchicine resistance Congenital dyserythropoietic anemia 0.091 1 6.49e-4 1.24e-3 ✓ sig.
Antisocial personality disorder Orthostatic hypotension 0.143 1 7.79e-4 1.41e-3 ✓ sig.
Brunner syndrome Hepatic encephalopathy 0.067 1 9.09e-4 1.58e-3 ✓ sig.
Congenital brain dysgenesis due to glutamine synthetase deficiency Hepatic encephalopathy 0.067 1 9.09e-4 1.58e-3 ✓ sig.
Hepatic encephalopathy severe combined immunodeficiency due to DNA-PKcs deficiency 0.067 1 9.09e-4 1.58e-3 ✓ sig.
Colchicine resistance Hyperpituitarism 0.063 1 9.74e-4 1.67e-3 ✓ sig.
Congenital dyserythropoietic anemia Familial mediterranean fever 0.083 1 1.30e-3 2.06e-3 ✓ sig.
Congenital dyserythropoietic anemia Orthostatic hypotension 0.077 1 1.95e-3 2.83e-3 ✓ sig.
Familial mediterranean fever Hyperpituitarism 0.059 1 1.95e-3 2.83e-3 ✓ sig.
Antisocial personality disorder Congenital dyserythropoietic anemia 0.071 1 2.60e-3 3.51e-3 ✓ sig.
Hyperpituitarism Orthostatic hypotension 0.056 1 2.92e-3 3.88e-3 ✓ sig.
Conduct disorder Separation anxiety disorder 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Conduct disorder severe intellectual disability-poor language-strabismus-grimacing face-long fingers syndrome 0.019 1 3.38e-3 4.37e-3 ✓ sig.
Congenital brain dysgenesis due to glutamine synthetase deficiency Huntington disease 0.016 1 3.96e-3 5.02e-3 ✓ sig.