Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs Other IDs Associated diseases
Entrez ID	51135
Gene name	Interleukin 1 receptor associated kinase 4
Gene symbol	IRAK4
Synonyms (NCBI Gene)	IMD67IPD1IRAK-4NY-REN-64REN64
Chromosome	12
Chromosome location	12q12
Summary	This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurre

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SNP ID	Visualize variation	Clinical significance	Consequence
rs114951157	C>T	Pathogenic	Coding sequence variant, stop gained, synonymous variant
rs121908002	C>T	Pathogenic	Coding sequence variant, stop gained, genic downstream transcript variant
rs377584435	C>T	Likely-pathogenic, pathogenic	Intron variant, missense variant, coding sequence variant, 5 prime UTR variant
rs758539498	G>A,T	Pathogenic	Genic downstream transcript variant, intron variant
rs944235493	A>G	Pathogenic	Genic downstream transcript variant, intron variant
rs1443126481	G>C,T	Pathogenic	5 prime UTR variant, stop gained, intron variant, coding sequence variant, missense variant
rs1555167566	G>-	Pathogenic	Frameshift variant, 5 prime UTR variant, coding sequence variant, intron variant
rs1555169270	G>T	Likely-pathogenic	Genic downstream transcript variant, splice acceptor variant
rs1565678077	T>-	Pathogenic	Genic downstream transcript variant, frameshift variant, coding sequence variant
rs1565688667	G>T	Pathogenic	Genic downstream transcript variant, splice acceptor variant

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miRTarBase ID	miRNA	Experiments	Reference
MIRT024734	hsa-miR-215-5p	Microarray	19074876
MIRT026168	hsa-miR-192-5p	Microarray	19074876
MIRT438882	hsa-miR-132-3p	Luciferase reporter assay	23264652
MIRT438882	hsa-miR-132-3p	Luciferase reporter assay	23264652
MIRT438881	hsa-miR-212-3p	Luciferase reporter assay	23264652
MIRT438881	hsa-miR-212-3p	Luciferase reporter assay	23264652
MIRT438882	hsa-miR-132-3p	Luciferase reporter assay	23264652
MIRT438882	hsa-miR-132-3p	Luciferase reporter assay	23264652
MIRT438881	hsa-miR-212-3p	Luciferase reporter assay	23264652
MIRT438881	hsa-miR-212-3p	Luciferase reporter assay	23264652
MIRT690758	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT690757	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT690756	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT690755	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT690754	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT690753	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT690752	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT690751	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT690750	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT690749	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT690748	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT690747	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT690746	hsa-miR-302e	HITS-CLIP	23313552
MIRT690745	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT690744	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT690743	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT690742	hsa-miR-520b	HITS-CLIP	23313552
MIRT690741	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT690740	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT690739	hsa-miR-520e	HITS-CLIP	23313552
MIRT690738	hsa-miR-552-3p	HITS-CLIP	23313552
MIRT690737	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT690736	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT690735	hsa-miR-520h	HITS-CLIP	23313552
MIRT690734	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT690732	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT690733	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT690731	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT690730	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT690728	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT690729	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT690727	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT690726	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT690725	hsa-miR-5095	HITS-CLIP	23313552
MIRT690724	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT690723	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT643606	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT643604	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT661893	hsa-miR-7162-3p	HITS-CLIP	23824327
MIRT643605	hsa-miR-4327	HITS-CLIP	23824327
MIRT643603	hsa-miR-628-5p	HITS-CLIP	23824327
MIRT643602	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT643601	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT643606	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT643604	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT643605	hsa-miR-4327	HITS-CLIP	23824327
MIRT643603	hsa-miR-628-5p	HITS-CLIP	23824327
MIRT643602	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT643601	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT629367	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629366	hsa-miR-4308	HITS-CLIP	23824327
MIRT629365	hsa-miR-4292	HITS-CLIP	23824327
MIRT629364	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT629363	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629362	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT629361	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT629360	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT629359	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT629358	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT508612	hsa-miR-940	PAR-CLIP	20371350
MIRT515031	hsa-miR-3929	PAR-CLIP	20371350
MIRT515030	hsa-miR-4419b	PAR-CLIP	20371350
MIRT515029	hsa-miR-4478	PAR-CLIP	20371350
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT508609	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT508608	hsa-miR-1827	PAR-CLIP	20371350
MIRT515028	hsa-miR-485-5p	PAR-CLIP	20371350
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	20371350
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	20371350
MIRT515025	hsa-miR-665	PAR-CLIP	20371350
MIRT508615	hsa-miR-490-3p	PAR-CLIP	21572407
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	21572407
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT508612	hsa-miR-940	PAR-CLIP	21572407
MIRT515031	hsa-miR-3929	PAR-CLIP	21572407
MIRT515030	hsa-miR-4419b	PAR-CLIP	21572407
MIRT515029	hsa-miR-4478	PAR-CLIP	21572407
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT508608	hsa-miR-1827	PAR-CLIP	21572407
MIRT515028	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	21572407
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	21572407
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	21572407
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	21572407
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	21572407
MIRT515025	hsa-miR-665	PAR-CLIP	21572407
MIRT508615	hsa-miR-490-3p	PAR-CLIP	23446348
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	23446348
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT508612	hsa-miR-940	PAR-CLIP	23446348
MIRT515031	hsa-miR-3929	PAR-CLIP	23446348
MIRT515030	hsa-miR-4419b	PAR-CLIP	23446348
MIRT515029	hsa-miR-4478	PAR-CLIP	23446348
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT508608	hsa-miR-1827	PAR-CLIP	23446348
MIRT515028	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	23446348
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	23446348
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	23446348
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	23446348
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	23446348
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	23446348
MIRT515025	hsa-miR-665	PAR-CLIP	23446348
MIRT508615	hsa-miR-490-3p	PAR-CLIP	23446348
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	23446348
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT508612	hsa-miR-940	PAR-CLIP	23446348
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT508609	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT508608	hsa-miR-1827	PAR-CLIP	23446348
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	23446348
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	23446348
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	23446348
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	23446348
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	23446348
MIRT735379	hsa-miR-146a-5p	qRT-PCR	31739406
MIRT736351	hsa-miR-378a-3p	Luciferase reporter assayWestern blottingMicroarrayqRT-PCRGFP reporter assay	33261009
MIRT690758	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT690757	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT690756	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT690755	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT690754	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT690753	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT690752	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT690751	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT690750	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT690749	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT690748	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT690747	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT690746	hsa-miR-302e	HITS-CLIP	23313552
MIRT690745	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT690744	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT690743	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT690742	hsa-miR-520b	HITS-CLIP	23313552
MIRT690741	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT690740	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT690739	hsa-miR-520e	HITS-CLIP	23313552
MIRT690738	hsa-miR-552-3p	HITS-CLIP	23313552
MIRT690737	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT690736	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT690735	hsa-miR-520h	HITS-CLIP	23313552
MIRT690734	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT690732	hsa-miR-1234-3p	HITS-CLIP	23313552
MIRT690733	hsa-miR-7107-5p	HITS-CLIP	23313552
MIRT690731	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT690730	hsa-miR-619-5p	HITS-CLIP	23313552
MIRT690728	hsa-miR-6506-5p	HITS-CLIP	23313552
MIRT690729	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT690727	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT690726	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT690725	hsa-miR-5095	HITS-CLIP	23313552
MIRT690724	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT690723	hsa-miR-5089-5p	HITS-CLIP	23313552
MIRT643606	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT643604	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT661893	hsa-miR-7162-3p	HITS-CLIP	23824327
MIRT643605	hsa-miR-4327	HITS-CLIP	23824327
MIRT643603	hsa-miR-628-5p	HITS-CLIP	23824327
MIRT643602	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT643601	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT643606	hsa-miR-370-3p	HITS-CLIP	23824327
MIRT643604	hsa-miR-6893-3p	HITS-CLIP	23824327
MIRT643605	hsa-miR-4327	HITS-CLIP	23824327
MIRT643603	hsa-miR-628-5p	HITS-CLIP	23824327
MIRT643602	hsa-miR-3074-5p	HITS-CLIP	23824327
MIRT643601	hsa-miR-7152-5p	HITS-CLIP	23824327
MIRT629367	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT629366	hsa-miR-4308	HITS-CLIP	23824327
MIRT629365	hsa-miR-4292	HITS-CLIP	23824327
MIRT629364	hsa-miR-6791-5p	HITS-CLIP	23824327
MIRT629363	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT629362	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT629361	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT629360	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT629359	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT629358	hsa-miR-218-1-3p	HITS-CLIP	23824327
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	20371350
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	20371350
MIRT508612	hsa-miR-940	PAR-CLIP	20371350
MIRT515031	hsa-miR-3929	PAR-CLIP	20371350
MIRT515030	hsa-miR-4419b	PAR-CLIP	20371350
MIRT515029	hsa-miR-4478	PAR-CLIP	20371350
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	20371350
MIRT508609	hsa-miR-4649-3p	PAR-CLIP	20371350
MIRT508608	hsa-miR-1827	PAR-CLIP	20371350
MIRT515028	hsa-miR-485-5p	PAR-CLIP	20371350
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	20371350
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	20371350
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	20371350
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	20371350
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	20371350
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	20371350
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	20371350
MIRT515025	hsa-miR-665	PAR-CLIP	20371350
MIRT508615	hsa-miR-490-3p	PAR-CLIP	21572407
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	21572407
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	21572407
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	21572407
MIRT508612	hsa-miR-940	PAR-CLIP	21572407
MIRT515031	hsa-miR-3929	PAR-CLIP	21572407
MIRT515030	hsa-miR-4419b	PAR-CLIP	21572407
MIRT515029	hsa-miR-4478	PAR-CLIP	21572407
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	21572407
MIRT508608	hsa-miR-1827	PAR-CLIP	21572407
MIRT515028	hsa-miR-485-5p	PAR-CLIP	21572407
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	21572407
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	21572407
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	21572407
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	21572407
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	21572407
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	21572407
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	21572407
MIRT515025	hsa-miR-665	PAR-CLIP	21572407
MIRT508615	hsa-miR-490-3p	PAR-CLIP	23446348
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	23446348
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT508612	hsa-miR-940	PAR-CLIP	23446348
MIRT515031	hsa-miR-3929	PAR-CLIP	23446348
MIRT515030	hsa-miR-4419b	PAR-CLIP	23446348
MIRT515029	hsa-miR-4478	PAR-CLIP	23446348
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT508608	hsa-miR-1827	PAR-CLIP	23446348
MIRT515028	hsa-miR-485-5p	PAR-CLIP	23446348
MIRT515027	hsa-miR-6884-5p	PAR-CLIP	23446348
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	23446348
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	23446348
MIRT515026	hsa-miR-7160-5p	PAR-CLIP	23446348
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	23446348
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	23446348
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	23446348
MIRT515025	hsa-miR-665	PAR-CLIP	23446348
MIRT508615	hsa-miR-490-3p	PAR-CLIP	23446348
MIRT508614	hsa-miR-7851-3p	PAR-CLIP	23446348
MIRT508613	hsa-miR-6808-5p	PAR-CLIP	23446348
MIRT508611	hsa-miR-6893-5p	PAR-CLIP	23446348
MIRT508612	hsa-miR-940	PAR-CLIP	23446348
MIRT508610	hsa-miR-6783-5p	PAR-CLIP	23446348
MIRT508609	hsa-miR-4649-3p	PAR-CLIP	23446348
MIRT508608	hsa-miR-1827	PAR-CLIP	23446348
MIRT508607	hsa-miR-1909-3p	PAR-CLIP	23446348
MIRT508606	hsa-miR-6722-3p	PAR-CLIP	23446348
MIRT508605	hsa-miR-1207-5p	PAR-CLIP	23446348
MIRT508604	hsa-miR-4763-3p	PAR-CLIP	23446348
MIRT508603	hsa-miR-6716-5p	PAR-CLIP	23446348
MIRT1070559	hsa-miR-122	CLIP-seq
MIRT1070560	hsa-miR-1271	CLIP-seq
MIRT1070561	hsa-miR-1272	CLIP-seq
MIRT1070562	hsa-miR-1289	CLIP-seq
MIRT1070563	hsa-miR-1322	CLIP-seq
MIRT1070564	hsa-miR-182	CLIP-seq
MIRT1070565	hsa-miR-1909	CLIP-seq
MIRT1070566	hsa-miR-2114	CLIP-seq
MIRT1070567	hsa-miR-3134	CLIP-seq
MIRT1070568	hsa-miR-3135b	CLIP-seq
MIRT1070569	hsa-miR-3150a-3p	CLIP-seq
MIRT1070570	hsa-miR-3175	CLIP-seq
MIRT1070571	hsa-miR-3198	CLIP-seq
MIRT1070572	hsa-miR-320e	CLIP-seq
MIRT1070573	hsa-miR-345	CLIP-seq
MIRT1070574	hsa-miR-3652	CLIP-seq
MIRT1070575	hsa-miR-3664-5p	CLIP-seq
MIRT1070576	hsa-miR-4263	CLIP-seq
MIRT1070577	hsa-miR-4294	CLIP-seq
MIRT1070578	hsa-miR-4309	CLIP-seq
MIRT1070579	hsa-miR-4330	CLIP-seq
MIRT1070580	hsa-miR-4430	CLIP-seq
MIRT1070581	hsa-miR-4534	CLIP-seq
MIRT1070582	hsa-miR-4639-3p	CLIP-seq
MIRT1070583	hsa-miR-4667-5p	CLIP-seq
MIRT1070584	hsa-miR-4695-3p	CLIP-seq
MIRT1070585	hsa-miR-4700-5p	CLIP-seq
MIRT1070586	hsa-miR-4735-5p	CLIP-seq
MIRT1070587	hsa-miR-4775	CLIP-seq
MIRT1070588	hsa-miR-564	CLIP-seq
MIRT1070589	hsa-miR-590-3p	CLIP-seq
MIRT1070590	hsa-miR-939	CLIP-seq
MIRT1070591	hsa-miR-96	CLIP-seq
MIRT1070592	hsa-miR-106a	CLIP-seq
MIRT1070593	hsa-miR-106b	CLIP-seq
MIRT1070594	hsa-miR-1184	CLIP-seq
MIRT1070595	hsa-miR-1205	CLIP-seq
MIRT1070596	hsa-miR-1234	CLIP-seq
MIRT1070597	hsa-miR-1252	CLIP-seq
MIRT1070561	hsa-miR-1272	CLIP-seq
MIRT1070598	hsa-miR-1273g	CLIP-seq
MIRT1070599	hsa-miR-127-5p	CLIP-seq
MIRT1070562	hsa-miR-1289	CLIP-seq
MIRT1070563	hsa-miR-1322	CLIP-seq
MIRT1070600	hsa-miR-150	CLIP-seq
MIRT1070601	hsa-miR-17	CLIP-seq
MIRT1070602	hsa-miR-1972	CLIP-seq
MIRT1070603	hsa-miR-20a	CLIP-seq
MIRT1070604	hsa-miR-20b	CLIP-seq
MIRT1070605	hsa-miR-302a	CLIP-seq
MIRT1070606	hsa-miR-302b	CLIP-seq
MIRT1070607	hsa-miR-302c	CLIP-seq
MIRT1070608	hsa-miR-302d	CLIP-seq
MIRT1070567	hsa-miR-3134	CLIP-seq
MIRT1070609	hsa-miR-3158-5p	CLIP-seq
MIRT1070571	hsa-miR-3198	CLIP-seq
MIRT1070575	hsa-miR-3664-5p	CLIP-seq
MIRT1070610	hsa-miR-372	CLIP-seq
MIRT1070611	hsa-miR-373	CLIP-seq
MIRT1070577	hsa-miR-4294	CLIP-seq
MIRT1070578	hsa-miR-4309	CLIP-seq
MIRT1070612	hsa-miR-432	CLIP-seq
MIRT1070613	hsa-miR-4428	CLIP-seq
MIRT1070614	hsa-miR-4453	CLIP-seq
MIRT1070581	hsa-miR-4534	CLIP-seq
MIRT1070615	hsa-miR-4538	CLIP-seq
MIRT1070582	hsa-miR-4639-3p	CLIP-seq
MIRT1070616	hsa-miR-519d	CLIP-seq
MIRT1070617	hsa-miR-520g	CLIP-seq
MIRT1070618	hsa-miR-544	CLIP-seq
MIRT1070619	hsa-miR-552	CLIP-seq
MIRT1070620	hsa-miR-93	CLIP-seq
MIRT1070592	hsa-miR-106a	CLIP-seq
MIRT1070593	hsa-miR-106b	CLIP-seq
MIRT1070594	hsa-miR-1184	CLIP-seq
MIRT1070595	hsa-miR-1205	CLIP-seq
MIRT1070596	hsa-miR-1234	CLIP-seq
MIRT1070600	hsa-miR-150	CLIP-seq
MIRT1070601	hsa-miR-17	CLIP-seq
MIRT1070565	hsa-miR-1909	CLIP-seq
MIRT1070602	hsa-miR-1972	CLIP-seq
MIRT1070603	hsa-miR-20a	CLIP-seq
MIRT1070604	hsa-miR-20b	CLIP-seq
MIRT1070566	hsa-miR-2114	CLIP-seq
MIRT1070605	hsa-miR-302a	CLIP-seq
MIRT1070606	hsa-miR-302b	CLIP-seq
MIRT1070607	hsa-miR-302c	CLIP-seq
MIRT1070608	hsa-miR-302d	CLIP-seq
MIRT1070569	hsa-miR-3150a-3p	CLIP-seq
MIRT1070609	hsa-miR-3158-5p	CLIP-seq
MIRT1070570	hsa-miR-3175	CLIP-seq
MIRT1070610	hsa-miR-372	CLIP-seq
MIRT1070611	hsa-miR-373	CLIP-seq
MIRT1070621	hsa-miR-4661-5p	CLIP-seq
MIRT1070583	hsa-miR-4667-5p	CLIP-seq
MIRT1070585	hsa-miR-4700-5p	CLIP-seq
MIRT1070616	hsa-miR-519d	CLIP-seq
MIRT1070617	hsa-miR-520g	CLIP-seq
MIRT1070618	hsa-miR-544	CLIP-seq
MIRT1070619	hsa-miR-552	CLIP-seq
MIRT1070620	hsa-miR-93	CLIP-seq
MIRT1070590	hsa-miR-939	CLIP-seq
MIRT1070559	hsa-miR-122	CLIP-seq
MIRT1070561	hsa-miR-1272	CLIP-seq
MIRT1070562	hsa-miR-1289	CLIP-seq
MIRT1070563	hsa-miR-1322	CLIP-seq
MIRT1070566	hsa-miR-2114	CLIP-seq
MIRT1070567	hsa-miR-3134	CLIP-seq
MIRT1070568	hsa-miR-3135b	CLIP-seq
MIRT1070569	hsa-miR-3150a-3p	CLIP-seq
MIRT1070570	hsa-miR-3175	CLIP-seq
MIRT1070571	hsa-miR-3198	CLIP-seq
MIRT1070622	hsa-miR-323-5p	CLIP-seq
MIRT1070574	hsa-miR-3652	CLIP-seq
MIRT1070575	hsa-miR-3664-5p	CLIP-seq
MIRT1070577	hsa-miR-4294	CLIP-seq
MIRT1070578	hsa-miR-4309	CLIP-seq
MIRT1070580	hsa-miR-4430	CLIP-seq
MIRT1070623	hsa-miR-4438	CLIP-seq
MIRT1070581	hsa-miR-4534	CLIP-seq
MIRT1070582	hsa-miR-4639-3p	CLIP-seq
MIRT1070583	hsa-miR-4667-5p	CLIP-seq
MIRT1070585	hsa-miR-4700-5p	CLIP-seq
MIRT1070624	hsa-miR-4742-5p	CLIP-seq
MIRT1070588	hsa-miR-564	CLIP-seq
MIRT1070625	hsa-miR-582-5p	CLIP-seq
MIRT1070626	hsa-miR-876-3p	CLIP-seq
MIRT1070590	hsa-miR-939	CLIP-seq
MIRT2017341	hsa-miR-125a-3p	CLIP-seq
MIRT2017342	hsa-miR-142-5p	CLIP-seq
MIRT2017343	hsa-miR-186	CLIP-seq
MIRT2017344	hsa-miR-192	CLIP-seq
MIRT2017345	hsa-miR-215	CLIP-seq
MIRT2017346	hsa-miR-2467-5p	CLIP-seq
MIRT2017347	hsa-miR-3133	CLIP-seq
MIRT2017348	hsa-miR-3187-3p	CLIP-seq
MIRT2017349	hsa-miR-3188	CLIP-seq
MIRT2017350	hsa-miR-340	CLIP-seq
MIRT2017351	hsa-miR-3545-3p	CLIP-seq
MIRT2017352	hsa-miR-371b-5p	CLIP-seq
MIRT2017353	hsa-miR-3934	CLIP-seq
MIRT2017354	hsa-miR-3975	CLIP-seq
MIRT2017355	hsa-miR-4435	CLIP-seq
MIRT2017356	hsa-miR-4505	CLIP-seq
MIRT2017357	hsa-miR-4635	CLIP-seq
MIRT2017358	hsa-miR-4680-5p	CLIP-seq
MIRT2017359	hsa-miR-4701-5p	CLIP-seq
MIRT2017360	hsa-miR-4716-5p	CLIP-seq
MIRT2017361	hsa-miR-4755-3p	CLIP-seq
MIRT2017362	hsa-miR-4781-3p	CLIP-seq
MIRT2017363	hsa-miR-548s	CLIP-seq
MIRT2017364	hsa-miR-555	CLIP-seq
MIRT2017365	hsa-miR-588	CLIP-seq
MIRT2017366	hsa-miR-764	CLIP-seq
MIRT1070584	hsa-miR-4695-3p	CLIP-seq
MIRT2249249	hsa-miR-1264	CLIP-seq
MIRT2249250	hsa-miR-1227	CLIP-seq
MIRT2249251	hsa-miR-1285	CLIP-seq
MIRT2249252	hsa-miR-1908	CLIP-seq
MIRT1070565	hsa-miR-1909	CLIP-seq
MIRT1070566	hsa-miR-2114	CLIP-seq
MIRT2249253	hsa-miR-3120-3p	CLIP-seq
MIRT1070569	hsa-miR-3150a-3p	CLIP-seq
MIRT1070570	hsa-miR-3175	CLIP-seq
MIRT2249254	hsa-miR-3187-5p	CLIP-seq
MIRT2249255	hsa-miR-3192	CLIP-seq
MIRT2249256	hsa-miR-3612	CLIP-seq
MIRT2249257	hsa-miR-3616-5p	CLIP-seq
MIRT2249258	hsa-miR-3622b-5p	CLIP-seq
MIRT2249259	hsa-miR-3647-5p	CLIP-seq
MIRT2249260	hsa-miR-3689a-3p	CLIP-seq
MIRT2249261	hsa-miR-3689c	CLIP-seq
MIRT2249262	hsa-miR-3945	CLIP-seq
MIRT2249263	hsa-miR-4252	CLIP-seq
MIRT2249264	hsa-miR-4253	CLIP-seq
MIRT2249265	hsa-miR-4537	CLIP-seq
MIRT1070583	hsa-miR-4667-5p	CLIP-seq
MIRT2249266	hsa-miR-4670-3p	CLIP-seq
MIRT1070584	hsa-miR-4695-3p	CLIP-seq
MIRT1070585	hsa-miR-4700-5p	CLIP-seq
MIRT2249267	hsa-miR-4728-5p	CLIP-seq
MIRT2249268	hsa-miR-4793-3p	CLIP-seq
MIRT2249269	hsa-miR-508-5p	CLIP-seq
MIRT2249270	hsa-miR-545	CLIP-seq
MIRT2249271	hsa-miR-573	CLIP-seq
MIRT2249272	hsa-miR-612	CLIP-seq
MIRT2249273	hsa-miR-650	CLIP-seq
MIRT2249274	hsa-miR-661	CLIP-seq
MIRT2249275	hsa-miR-663	CLIP-seq
MIRT2249276	hsa-miR-766	CLIP-seq
MIRT1070590	hsa-miR-939	CLIP-seq
MIRT2451927	hsa-miR-128	CLIP-seq
MIRT2249251	hsa-miR-1285	CLIP-seq
MIRT2017342	hsa-miR-142-5p	CLIP-seq
MIRT2017343	hsa-miR-186	CLIP-seq
MIRT2017346	hsa-miR-2467-5p	CLIP-seq
MIRT2017347	hsa-miR-3133	CLIP-seq
MIRT2451928	hsa-miR-3147	CLIP-seq
MIRT2249254	hsa-miR-3187-5p	CLIP-seq
MIRT2017349	hsa-miR-3188	CLIP-seq
MIRT2017350	hsa-miR-340	CLIP-seq
MIRT2451929	hsa-miR-3613-3p	CLIP-seq
MIRT2249258	hsa-miR-3622b-5p	CLIP-seq
MIRT2451930	hsa-miR-3675-3p	CLIP-seq
MIRT2451931	hsa-miR-371-5p	CLIP-seq
MIRT2017352	hsa-miR-371b-5p	CLIP-seq
MIRT2249262	hsa-miR-3945	CLIP-seq
MIRT2017354	hsa-miR-3975	CLIP-seq
MIRT2249264	hsa-miR-4253	CLIP-seq
MIRT2451932	hsa-miR-4260	CLIP-seq
MIRT2451933	hsa-miR-4283	CLIP-seq
MIRT2451934	hsa-miR-4425	CLIP-seq
MIRT2451935	hsa-miR-4432	CLIP-seq
MIRT2451936	hsa-miR-4489	CLIP-seq
MIRT2017356	hsa-miR-4505	CLIP-seq
MIRT2451937	hsa-miR-451b	CLIP-seq
MIRT2451938	hsa-miR-4684-5p	CLIP-seq
MIRT2451939	hsa-miR-4696	CLIP-seq
MIRT2451940	hsa-miR-548c-3p	CLIP-seq
MIRT2017364	hsa-miR-555	CLIP-seq
MIRT2249272	hsa-miR-612	CLIP-seq
MIRT2552788	hsa-miR-1207-3p	CLIP-seq
MIRT1070559	hsa-miR-122	CLIP-seq
MIRT2552789	hsa-miR-1244	CLIP-seq
MIRT2451927	hsa-miR-128	CLIP-seq
MIRT2249251	hsa-miR-1285	CLIP-seq
MIRT1070562	hsa-miR-1289	CLIP-seq
MIRT2017342	hsa-miR-142-5p	CLIP-seq
MIRT2017343	hsa-miR-186	CLIP-seq
MIRT2552790	hsa-miR-190	CLIP-seq
MIRT2552791	hsa-miR-190b	CLIP-seq
MIRT2017346	hsa-miR-2467-5p	CLIP-seq
MIRT2552792	hsa-miR-297	CLIP-seq
MIRT2249253	hsa-miR-3120-3p	CLIP-seq
MIRT2552793	hsa-miR-3132	CLIP-seq
MIRT2017347	hsa-miR-3133	CLIP-seq
MIRT1070568	hsa-miR-3135b	CLIP-seq
MIRT2552794	hsa-miR-3149	CLIP-seq
MIRT2552795	hsa-miR-3158-3p	CLIP-seq
MIRT2249254	hsa-miR-3187-5p	CLIP-seq
MIRT2017349	hsa-miR-3188	CLIP-seq
MIRT1070571	hsa-miR-3198	CLIP-seq
MIRT2017350	hsa-miR-340	CLIP-seq
MIRT2451929	hsa-miR-3613-3p	CLIP-seq
MIRT2249258	hsa-miR-3622b-5p	CLIP-seq
MIRT1070574	hsa-miR-3652	CLIP-seq
MIRT2552796	hsa-miR-3659	CLIP-seq
MIRT2451930	hsa-miR-3675-3p	CLIP-seq
MIRT2552797	hsa-miR-3681	CLIP-seq
MIRT2552798	hsa-miR-3692	CLIP-seq
MIRT2451931	hsa-miR-371-5p	CLIP-seq
MIRT2017352	hsa-miR-371b-5p	CLIP-seq
MIRT2552799	hsa-miR-378g	CLIP-seq
MIRT2552800	hsa-miR-383	CLIP-seq
MIRT2552801	hsa-miR-3942-3p	CLIP-seq
MIRT2249262	hsa-miR-3945	CLIP-seq
MIRT2017354	hsa-miR-3975	CLIP-seq
MIRT2249263	hsa-miR-4252	CLIP-seq
MIRT2249264	hsa-miR-4253	CLIP-seq
MIRT1070577	hsa-miR-4294	CLIP-seq
MIRT1070578	hsa-miR-4309	CLIP-seq
MIRT1070580	hsa-miR-4430	CLIP-seq
MIRT2451935	hsa-miR-4432	CLIP-seq
MIRT2552802	hsa-miR-4446-3p	CLIP-seq
MIRT2552803	hsa-miR-4464	CLIP-seq
MIRT2017356	hsa-miR-4505	CLIP-seq
MIRT2552804	hsa-miR-4506	CLIP-seq
MIRT2451937	hsa-miR-451b	CLIP-seq
MIRT2451938	hsa-miR-4684-5p	CLIP-seq
MIRT2552805	hsa-miR-4690-3p	CLIP-seq
MIRT1070584	hsa-miR-4695-3p	CLIP-seq
MIRT2451939	hsa-miR-4696	CLIP-seq
MIRT1070586	hsa-miR-4735-5p	CLIP-seq
MIRT2552806	hsa-miR-4748	CLIP-seq
MIRT1070587	hsa-miR-4775	CLIP-seq
MIRT2249268	hsa-miR-4793-3p	CLIP-seq
MIRT2249269	hsa-miR-508-5p	CLIP-seq
MIRT2249270	hsa-miR-545	CLIP-seq
MIRT2451940	hsa-miR-548c-3p	CLIP-seq
MIRT2017364	hsa-miR-555	CLIP-seq
MIRT1070588	hsa-miR-564	CLIP-seq
MIRT2552807	hsa-miR-567	CLIP-seq
MIRT1070589	hsa-miR-590-3p	CLIP-seq
MIRT2552808	hsa-miR-595	CLIP-seq
MIRT2249272	hsa-miR-612	CLIP-seq
MIRT2552809	hsa-miR-646	CLIP-seq
MIRT2249274	hsa-miR-661	CLIP-seq
MIRT2552810	hsa-miR-759	CLIP-seq
MIRT2552811	hsa-miR-760	CLIP-seq
MIRT2249276	hsa-miR-766	CLIP-seq
MIRT2552788	hsa-miR-1207-3p	CLIP-seq
MIRT1070559	hsa-miR-122	CLIP-seq
MIRT2249250	hsa-miR-1227	CLIP-seq
MIRT2552789	hsa-miR-1244	CLIP-seq
MIRT2451927	hsa-miR-128	CLIP-seq
MIRT2249251	hsa-miR-1285	CLIP-seq
MIRT1070562	hsa-miR-1289	CLIP-seq
MIRT2017342	hsa-miR-142-5p	CLIP-seq
MIRT2017343	hsa-miR-186	CLIP-seq
MIRT2552790	hsa-miR-190	CLIP-seq
MIRT2552791	hsa-miR-190b	CLIP-seq
MIRT2017346	hsa-miR-2467-5p	CLIP-seq
MIRT2552792	hsa-miR-297	CLIP-seq
MIRT2249253	hsa-miR-3120-3p	CLIP-seq
MIRT2552793	hsa-miR-3132	CLIP-seq
MIRT2017347	hsa-miR-3133	CLIP-seq
MIRT1070568	hsa-miR-3135b	CLIP-seq
MIRT2552795	hsa-miR-3158-3p	CLIP-seq
MIRT2249254	hsa-miR-3187-5p	CLIP-seq
MIRT2017349	hsa-miR-3188	CLIP-seq
MIRT1070571	hsa-miR-3198	CLIP-seq
MIRT2017350	hsa-miR-340	CLIP-seq
MIRT2451929	hsa-miR-3613-3p	CLIP-seq
MIRT2249258	hsa-miR-3622b-5p	CLIP-seq
MIRT1070574	hsa-miR-3652	CLIP-seq
MIRT2552796	hsa-miR-3659	CLIP-seq
MIRT2451930	hsa-miR-3675-3p	CLIP-seq
MIRT2552797	hsa-miR-3681	CLIP-seq
MIRT2451931	hsa-miR-371-5p	CLIP-seq
MIRT2017352	hsa-miR-371b-5p	CLIP-seq
MIRT2552799	hsa-miR-378g	CLIP-seq
MIRT2552800	hsa-miR-383	CLIP-seq
MIRT2552801	hsa-miR-3942-3p	CLIP-seq
MIRT2249262	hsa-miR-3945	CLIP-seq
MIRT2017354	hsa-miR-3975	CLIP-seq
MIRT2249263	hsa-miR-4252	CLIP-seq
MIRT2249264	hsa-miR-4253	CLIP-seq
MIRT1070577	hsa-miR-4294	CLIP-seq
MIRT1070578	hsa-miR-4309	CLIP-seq
MIRT1070580	hsa-miR-4430	CLIP-seq
MIRT2451935	hsa-miR-4432	CLIP-seq
MIRT2552802	hsa-miR-4446-3p	CLIP-seq
MIRT2682906	hsa-miR-4476	CLIP-seq
MIRT2682907	hsa-miR-4493	CLIP-seq
MIRT2017356	hsa-miR-4505	CLIP-seq
MIRT2552804	hsa-miR-4506	CLIP-seq
MIRT2451937	hsa-miR-451b	CLIP-seq
MIRT2451938	hsa-miR-4684-5p	CLIP-seq
MIRT1070584	hsa-miR-4695-3p	CLIP-seq
MIRT2451939	hsa-miR-4696	CLIP-seq
MIRT2249268	hsa-miR-4793-3p	CLIP-seq
MIRT2249269	hsa-miR-508-5p	CLIP-seq
MIRT2249270	hsa-miR-545	CLIP-seq
MIRT2451940	hsa-miR-548c-3p	CLIP-seq
MIRT2017364	hsa-miR-555	CLIP-seq
MIRT1070588	hsa-miR-564	CLIP-seq
MIRT2552807	hsa-miR-567	CLIP-seq
MIRT2552808	hsa-miR-595	CLIP-seq
MIRT2249272	hsa-miR-612	CLIP-seq
MIRT2552809	hsa-miR-646	CLIP-seq
MIRT2249274	hsa-miR-661	CLIP-seq
MIRT2552810	hsa-miR-759	CLIP-seq
MIRT2552811	hsa-miR-760	CLIP-seq
MIRT2249276	hsa-miR-766	CLIP-seq

Show/Hide all (56)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0002224	Process	Toll-like receptor signaling pathway	TAS	21269878
GO:0002376	Process	Immune system process	IEA
GO:0002446	Process	Neutrophil mediated immunity	IMP	19663824
GO:0002755	Process	MyD88-dependent toll-like receptor signaling pathway	TAS	21269878
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	EXP	11960013
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	11960013
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS
GO:0005149	Function	Interleukin-1 receptor binding	IEA
GO:0005515	Function	Protein binding	IPI	12496252, 12860405, 19264966, 20485341, 21903422, 23376919, 24316379, 25502805, 25910212, 26871637, 28514442, 31515488, 32296183, 33238146, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005615	Component	Extracellular space	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IC	20485341
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007254	Process	JNK cascade	IEA
GO:0008063	Process	Toll signaling pathway	IBA
GO:0009986	Component	Cell surface	IDA	22851693
GO:0010008	Component	Endosome membrane	TAS
GO:0016301	Function	Kinase activity	IDA	11960013
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IBA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0019221	Process	Cytokine-mediated signaling pathway	IEA
GO:0019897	Component	Extrinsic component of plasma membrane	IC	20485341
GO:0019901	Function	Protein kinase binding	IPI	33238146
GO:0031349	Process	Positive regulation of defense response	IEA
GO:0031663	Process	Lipopolysaccharide-mediated signaling pathway	IBA
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IC	35977521
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IDA	7479976, 17878161, 25355951, 25371197, 26189595
GO:0034162	Process	Toll-like receptor 9 signaling pathway	TAS
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0038061	Process	Non-canonical NF-kappaB signal transduction	IDA	12048232, 26189595
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IDA	20532808
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IDA	11960013
GO:0038172	Process	Interleukin-33-mediated signaling pathway	IMP	31435003
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IMP	22158417
GO:0045087	Process	Innate immune response	IEA
GO:0045087	Process	Innate immune response	TAS	21269878
GO:0048661	Process	Positive regulation of smooth muscle cell proliferation	IEA
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IDA	14625308
GO:0070498	Process	Interleukin-1-mediated signaling pathway	IDA	20485341
GO:0070498	Process	Interleukin-1-mediated signaling pathway	TAS
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1990266	Process	Neutrophil migration	IMP	19663824

MIM	HGNC	e!Ensembl
606883	17967	ENSG00000198001

Q9NWZ3

Protein name

Interleukin-1 receptor-associated kinase 4 (IRAK-4) (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-64)

Protein function

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the

PDB

2NRU , 2NRY , 2O8Y , 2OIB , 2OIC , 2OID , 3MOP , 4RMZ , 4U97 , 4U9A , 4XS2 , 4Y73 , 4YO6 , 4YP8 , 4ZTL , 4ZTM , 4ZTN , 5K72 , 5K75 , 5K76 , 5K7G , 5K7I , 5KX7 , 5KX8 , 5T1S , 5T1T , 5UIQ , 5UIR , 5UIS , 5UIT , 5UIU , 5W84 , 5W85 , 6EG9 , 6EGA , 6EGD , 6EGE , 6EGF , 6F3D , 6F3E , 6F3G , 6F3I , 6LXY , 6MOM , 6N8G , 6O8U , 6O94 , 6O95 , 6O9D , 6RFI , 6RFJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07714	PK_Tyr_Ser-Thr	187 → 454	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS

Sequence length

460

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (4)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Congenital dyserythropoietic anemia	Likely pathogenic	rs2540412301	RCV003326055	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Immunodeficiency 67	Likely pathogenic; Pathogenic	rs753106997, rs1007276082, rs1429128979, rs2137931667, rs766515269, rs2540488916, rs766102187, rs1565678077, rs121908002, rs1421444086, rs1565688667, rs944235493, rs1333654771, rs1266375962, rs2540426135 View all (14 more)	RCV001381892 RCV001949238 RCV001970197 RCV001964704 RCV002468721 View all (24 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Invasive pneumococcal disease, recurrent isolated	Likely pathogenic	rs944235493	RCV001815160	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
IRAK4-related disorder	Pathogenic	rs121908002	RCV003390639	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Familial cancer of breast	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUPUS ERYTHEMATOSUS, SYSTEMIC	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATIC NEOPLASMS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (92)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adult Diffuse Large B-Cell Lymphoma	B-cell Lymphoma	BEFREE	29172502, 31622099		★★★★★ ★☆☆☆☆ Found in Text Mining only
Allergic rhinitis (disorder)	Allergic rhinitis	BEFREE	21738793		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anemia	Anemia	Pubtator	37744344	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	27702822, 29363544		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anoxia-Ischemia, Brain	Anorexia	CTD_human_DG	21925238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anoxia-Ischemia, Cerebral	Anorexia	CTD_human_DG	21925238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Anoxic-Ischemic Encephalopathy	Anoxic-Ischemic Encephalopathy	CTD_human_DG	21925238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	18190779, 20375592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	19254290, 20375592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	18190779, 20375592		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	28295231, 28947151, 30076215, 31312412		★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	36234844	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet disease	Pubtator	26785681	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet Syndrome	BEFREE	28780618		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	19706770	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36234844	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Burkitt Lymphoma	Burkitt lymphoma	Pubtator	29088270	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Camurati-Engelmann Syndrome	Diaphyseal dysplasia	BEFREE	18591412		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	30112356	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	36234844	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebral Hypoxia-Ischemia	Cerebral Hypoxia-Ischemia	CTD_human_DG	21925238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic granulomatous disease	Granulomatous Disease	BEFREE	28684198		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	30537114, 31197259		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	28536249		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	39328405	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	31527315		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36234844	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Common Variable Immunodeficiency	Common variable immunodeficiency	Pubtator	32047491	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Craniosynostosis	Craniosynostosis	BEFREE	19254290		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cryopyrin-Associated Periodic Syndromes	Cryopyrin-Associated Periodic Syndromes	BEFREE	20353899		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	27062898		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	27062898		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diffuse Large B-Cell Lymphoma	Diffuse Lymphoma	BEFREE	29172502, 31622099		★★★★★ ★☆☆☆☆ Found in Text Mining only
Encephalitis	Encephalitis	Pubtator	36205835	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Familial lichen amyloidosis	Lichen amyloidosis	BEFREE	23657238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gingivitis	Gingival diseases	Pubtator	31448244	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	23595970		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glomerulonephritis	Glomerulonephritis	BEFREE	28295231		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hematologic Diseases	Hematologic disease	Pubtator	37102608	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxia-Ischemia, Brain	Ischemic Encephalopathy	CTD_human_DG	21925238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoxic-Ischemic Encephalopathy	Hypoxic-Ischemic Encephalopathy	CTD_human_DG	21925238		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immune System Diseases	Immune system disease	Pubtator	27895398, 40397075	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency	Immunodeficiency	Orphanet			★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	26250868		★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory abnormality of the eye	Inflammatory abnormality of the eye	BEFREE	28609207		★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	30997787	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Interleukin 2 Receptor Alpha Deficiency of	Interleukin 2 receptor deficiency	Pubtator	26825884, 32532880	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Interleukin 2 Receptor Alpha Deficiency of	Interleukin 2 receptor deficiency	Pubtator	26825884, 32532880	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
IRAK4 Deficiency	IRAK4 Deficiency	UNIPROT_DG	12637671, 12925671, 17878374, 19663824, 21057262, 24316379		★★★★★ ★☆☆☆☆ Found in Text Mining only
IRAK4 Deficiency	IRAK4 Deficiency	BEFREE	23519847		★★★★★ ★☆☆☆☆ Found in Text Mining only
IRAK4 Deficiency	IRAK4 Deficiency	CTD_human_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
IRAK4 Deficiency	IRAK4 Deficiency	ORPHANET_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	30229835		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	36040792, 37172199	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	31484791, 36040792, 37172199	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	31011167		★★★★★ ★☆☆☆☆ Found in Text Mining only
Libman-Sacks Disease	Nonbacterial verrucal endocardiosis	CTD_human_DG	28003376		★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29483095, 30112356		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus	Lupus Erythematosus	BEFREE	28003376, 28295231		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	23497717	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus Systemic	Systemic lupus erythematosus	Pubtator	34419106	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Discoid	Lupus Erythematosus	BEFREE	28003376, 28295231		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	20375592, 28003376, 28295231, 30355354		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lupus Erythematosus, Systemic	Lupus Erythematosus	CTD_human_DG	28003376		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lupus Vulgaris	Lupus Vulgaris	BEFREE	28003376, 28295231		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	29363544		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	16537705		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	CTD_human_DG	16537705		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27702822, 29363544, 30679311, 30818109, 31011167		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mucocutaneous Lymph Node Syndrome	Kawasaki disease	Pubtator	34193364	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
MYD88 Deficiency	MYD88 Deficiency	BEFREE	21057262, 24316379		★★★★★ ★☆☆☆☆ Found in Text Mining only
MYELODYSPLASTIC SYNDROME	Myelodysplastic Syndrome	BEFREE	31011167		★★★★★ ★☆☆☆☆ Found in Text Mining only
Myelodysplastic Syndromes	Myelodysplastic syndrome	Pubtator	31011167, 36040792, 36216757, 37102608, 37172199, 40397075	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Necrotizing enterocolitis in fetus OR newborn	Necrotizing Enterocolitis	BEFREE	29784900		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	19826413, 27702822, 29363544, 31197259		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nephritis, Tubulointerstitial	Nephritis	BEFREE	29739813		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neutropenia	Neutropenia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	29363544		★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic Ductal Adenocarcinoma	Pancreatic adenocarcinoma	BEFREE	27702822		★★★★★ ★☆☆☆☆ Found in Text Mining only
Primary immune deficiency disorder	immunodeficiency	BEFREE	25232776		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	16537705		★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic Neoplasms	CTD_human_DG	16537705		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	23657238	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	31012109		★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhinitis Allergic	Rhinitis	Pubtator	21738793	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Seizures	Seizures	Pubtator	37744344	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	18286571, 22901274		★★★★★ ★☆☆☆☆ Found in Text Mining only
Splenomegaly	Splenomegaly	Pubtator	37744344	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Uveomeningoencephalitic Syndrome	Uveomeningoencephalitic syndrome	Pubtator	24690905	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Waldenstrom Macroglobulinemia	Waldenstrom`s Macroglobulinemia	BEFREE	23477936		★★★★★ ★☆☆☆☆ Found in Text Mining only
Waldenstrom Macroglobulinemia	Waldenstrom macroglobulinemia	Pubtator	23836557, 36234844	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

IRAK4 (interleukin 1 receptor associated kinase 4)