Shared-Gene Disease Pairs?
Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.
What do these columns mean?
- Shared genes
- Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
- Similarity score
- Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
- Overlap coefficient
- Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
- P-value / FDR q-value
- Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
- Shared cluster
- Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
| Disease A ⇵ | Disease B ⇵ | Shared genes ⇵ | Similarity score ⇵ | Overlap coefficient ⇵ | P-value ⇵ | FDR q-value ▲ | Shared cluster | |
|---|---|---|---|---|---|---|---|---|
| Rothmund-thomson syndrome | Ruptured abdominal aortic aneurysm |
2 genes
|
0.105 | 0.250 | 1.55e-5 | 7.48e-5 ✓ sig. | — | |
| Episodic ataxia | Lennox-gastaut syndrome |
2 genes
|
0.105 | 0.250 | 1.55e-5 | 7.48e-5 ✓ sig. | — | |
| Eye neoplasms | Prader-willi syndrome |
2 genes
|
0.105 | 0.250 | 1.55e-5 | 7.48e-5 ✓ sig. | Cluster 298 → | |
| Congenital nystagmus | Eye neoplasms |
2 genes
|
0.105 | 0.250 | 1.55e-5 | 7.48e-5 ✓ sig. | — | |
| Esophageal adenocarcinoma | Hyperlipidemia |
5 genes
|
0.029 | 0.143 | 1.56e-5 | 7.50e-5 ✓ sig. | — | |
| Ambiguous genitalia | Fraser syndrome |
2 genes
|
0.083 | 0.400 | 1.60e-5 | 7.68e-5 ✓ sig. | — | |
| Congenital diaphragmatic hernia | Diaphragmatic malformations |
2 genes
|
0.083 | 0.400 | 1.60e-5 | 7.68e-5 ✓ sig. | — | |
| Hepatic encephalopathy | Nausea |
2 genes
|
0.100 | 0.286 | 1.61e-5 | 7.71e-5 ✓ sig. | Cluster 57 → | |
| Bonnevie-ullrich syndrome | Hyperemia |
2 genes
|
0.100 | 0.286 | 1.61e-5 | 7.71e-5 ✓ sig. | — | |
| Angle closure glaucoma | Hepatic veno occlusive disease |
2 genes
|
0.100 | 0.286 | 1.61e-5 | 7.71e-5 ✓ sig. | — | |
| Testicular disease | Thyroid agenesis |
2 genes
|
0.100 | 0.286 | 1.61e-5 | 7.71e-5 ✓ sig. | Cluster 88 → | |
| Bicuspid aortic valve | Hereditary bundle branch system defect |
2 genes
|
0.100 | 0.286 | 1.61e-5 | 7.71e-5 ✓ sig. | — | |
| Bronchial hyperreactivity | Extravasation of diagnostic and therapeutic materials |
2 genes
|
0.100 | 0.286 | 1.61e-5 | 7.71e-5 ✓ sig. | — | |
| Arthritis | Autoimmune polyendocrine syndrome |
2 genes
|
0.069 | 0.500 | 1.64e-5 | 7.87e-5 ✓ sig. | Cluster 1 → | |
| Arthritis | Esophageal achalasia |
2 genes
|
0.069 | 0.500 | 1.64e-5 | 7.87e-5 ✓ sig. | Cluster 1 → | |
| Arthritis | Oropharyngeal neoplasms |
2 genes
|
0.069 | 0.500 | 1.64e-5 | 7.87e-5 ✓ sig. | Cluster 1 → | |
| Beta thalassemia | Diamond-blackfan anemia |
3 genes
|
0.054 | 0.143 | 1.65e-5 | 7.90e-5 ✓ sig. | — | |
| Arterial occlusive disease | Hematuria |
2 genes
|
0.105 | 0.222 | 1.67e-5 | 7.98e-5 ✓ sig. | — | |
| Optic neuropathy | Stomatitis |
2 genes
|
0.105 | 0.222 | 1.67e-5 | 7.98e-5 ✓ sig. | Cluster 32 → | |
| Anhydramnios | Fabry disease |
2 genes
|
0.105 | 0.222 | 1.67e-5 | 7.98e-5 ✓ sig. | — | |
| Esotropia | Tongue neoplasms |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | — | |
| Congenital skin anomaly | Ectrodactyly |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | — | |
| Ectrodactyly | Skin abnormalities |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | — | |
| Berylliosis | Vascular system injury |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | — | |
| Berylliosis | Intervertebral disc disease |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | Cluster 180 → |
0 selected
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Showing 25 of 20813 pairs, sorted by significance (ascending). Click a column header to sort.