Disease Clusters?
Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.
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Cluster 6
57
Diseases
650
Unique genes
0.053
Avg. similarity score
Isolated sensorineural deafness
Most-connected disease (43 links)
Disease
Searched: Auditory neuropathy, autosomal dominant, 1
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Auditory neuropathy, autosomal dominant, 1
Isolated sensorineural deafness
Nonsyndromic genetic hearing loss
Nonsyndromic hearing loss
Deafness
Hearing loss
Hereditary hearing loss
Nonsyndromic intellectual disability
Congenital ear anomaly
Meniere disease
Usher syndrome
Auditory neuropathy
Autosomal dominant nonsyndromic hearing loss
Deafness, autosomal dominant 21
Deafness, autosomal dominant 25
Deafness, autosomal dominant 2a
Deafness, autosomal dominant 44
Deafness, autosomal recessive 106
Deafness, autosomal recessive 117
Deafness, autosomal recessive 15
Deafness, autosomal recessive 18b
Deafness, autosomal recessive 22
Deafness, autosomal recessive 25
Deafness, autosomal recessive 35
Deafness, autosomal recessive 49
Deafness, autosomal recessive 61
Deafness, autosomal recessive 67
Deafness, autosomal recessive 76
Deafness, autosomal recessive 79
Deafness, autosomal recessive 93
Deafness, autosomal dominant 40
Deafness, autosomal dominant 41
Deafness, autosomal dominant 68
Deafness, autosomal dominant, 70
Deafness, autosomal recessive 108
Deafness, autosomal recessive 111
Deafness, autosomal recessive 68
Deafness, autosomal recessive 77
Deafness, autosomal recessive 91
Hearing loss, autosomal recessive 120
Worster drought syndrome
Deafness, autosomal dominant 64
Deafness, autosomal recessive 103
Deafness, autosomal recessive 109
Deafness, autosomal recessive 74
Pancreas adenocarcinoma
Deafness, autosomal dominant, 77
Deafness, autosomal dominant, 79
Hearing loss, autosomal recessive 115
Retinitis pigmentosa-deafness syndrome
Al-raqad syndrome
Deafness, autosomal dominant 50
Deafness, autosomal dominant 7
Mental retardation, autosomal recessive 56
Neurodevelopmental disorder with cerebral atrophy and variable facial dysmorphism
Neurodevelopmental disorder with hypotonia and gross motor and speech delay
Otofacial neurodevelopmental syndrome
Member diseases (most connected first ‐ the cluster's core)
Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)
| Gene ⇵ | Member diseases ⇵ | Linked diseases |
|---|---|---|
| MYO7A | 11 / 57 | Auditory neuropathy, Congenital ear anomaly, Deafness, Hearing loss and 7 more |
| CDH23 | 10 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 6 more |
| PCDH15 | 10 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 6 more |
| LHFPL5 | 9 / 57 | Congenital ear anomaly, Deafness, Deafness, autosomal recessive 67, Hearing loss and 5 more |
| OTOF | 9 / 57 | Auditory neuropathy, Congenital ear anomaly, Deafness, Hearing loss and 5 more |
| WFS1 | 9 / 57 | Auditory neuropathy, Autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss and 5 more |
| LOXHD1 | 8 / 57 | Deafness, Deafness, autosomal recessive 77, Hearing loss, Hereditary hearing loss and 4 more |
| MARVELD2 | 8 / 57 | Congenital ear anomaly, Deafness, Deafness, autosomal recessive 49, Hearing loss and 4 more |
| MYO6 | 8 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 4 more |
| OTOA | 8 / 57 | Deafness, Deafness, autosomal recessive 22, Hearing loss, Hereditary hearing loss and 4 more |
| SERPINB6 | 8 / 57 | Deafness, Deafness, autosomal recessive 91, Hearing loss, Isolated sensorineural deafness and 4 more |
| SLC17A8 | 8 / 57 | Auditory neuropathy, Deafness, Deafness, autosomal dominant 25, Hearing loss and 4 more |
| TECTA | 8 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 4 more |
| TMC1 | 8 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 4 more |
| TMPRSS3 | 8 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 4 more |
| TPRN | 8 / 57 | Congenital ear anomaly, Deafness, Deafness, autosomal recessive 79, Hearing loss and 4 more |
| USH1C | 8 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 4 more |
| WHRN | 8 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 4 more |
| ACTG1 | 7 / 57 | Autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Hereditary hearing loss and 3 more |
| CABP2 | 7 / 57 | Deafness, Deafness, autosomal recessive 93, Hearing loss, Isolated sensorineural deafness and 3 more |
| CCDC50 | 7 / 57 | Deafness, Deafness, autosomal dominant 44, Hearing loss, Hereditary hearing loss and 3 more |
| COCH | 7 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 3 more |
| COL11A2 | 7 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more |
| ESPN | 7 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 3 more |
| ESRRB | 7 / 57 | Deafness, Deafness, autosomal recessive 35, Hearing loss, Hereditary hearing loss and 3 more |
| GJB2 | 7 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more |
| KCNQ4 | 7 / 57 | Deafness, Deafness, autosomal dominant 2a, Hearing loss, Hereditary hearing loss and 3 more |
| MSRB3 | 7 / 57 | Deafness, Deafness, autosomal recessive 74, Hearing loss, Isolated sensorineural deafness and 3 more |
| MYH14 | 7 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 3 more |
| MYO15A | 7 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more |
| OTOG | 7 / 57 | Deafness, Deafness, autosomal recessive 18b, Hearing loss, Isolated sensorineural deafness and 3 more |
| OTOGL | 7 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Meniere disease and 3 more |
| PJVK | 7 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more |
| RIPOR2 | 7 / 57 | Autosomal dominant nonsyndromic hearing loss, Deafness, Deafness, autosomal dominant 21, Hearing loss and 3 more |
| S1PR2 | 7 / 57 | Deafness, Deafness, autosomal recessive 68, Hearing loss, Isolated sensorineural deafness and 3 more |
| SLC26A5 | 7 / 57 | Deafness, Deafness, autosomal recessive 61, Hearing loss, Isolated sensorineural deafness and 3 more |
| SYNE4 | 7 / 57 | Deafness, Deafness, autosomal recessive 76, Hearing loss, Isolated sensorineural deafness and 3 more |
| TBC1D24 | 7 / 57 | Auditory neuropathy, Deafness, Hearing loss, Isolated sensorineural deafness and 3 more |
| TMIE | 7 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more |
| ABCC1 | 6 / 57 | Autosomal dominant nonsyndromic hearing loss, Deafness, Deafness, autosomal dominant, 77, Hearing loss and 2 more |
| ATP11A | 6 / 57 | Auditory neuropathy, Autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss and 2 more |
| C10ORF105 | 6 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Meniere disease and 2 more |
| CDC14A | 6 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Isolated sensorineural deafness and 2 more |
| CEACAM16 | 6 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Isolated sensorineural deafness and 2 more |
| CIB2 | 6 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 2 more |
| CLDN14 | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| CLRN2 | 6 / 57 | Deafness, Deafness, autosomal recessive 117, Hearing loss, Isolated sensorineural deafness and 2 more |
| COL11A1 | 6 / 57 | Autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 2 more |
| DCDC2 | 6 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 2 more |
| DIABLO | 6 / 57 | Deafness, Deafness, autosomal dominant 64, Hearing loss, Isolated sensorineural deafness and 2 more |
| ELMOD3 | 6 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 2 more |
| EPS8L2 | 6 / 57 | Deafness, Deafness, autosomal recessive 106, Hearing loss, Isolated sensorineural deafness and 2 more |
| EYA4 | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| GIPC3 | 6 / 57 | Deafness, Deafness, autosomal recessive 15, Hearing loss, Isolated sensorineural deafness and 2 more |
| GRHL2 | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| GRXCR1 | 6 / 57 | Deafness, Deafness, autosomal recessive 25, Hearing loss, Isolated sensorineural deafness and 2 more |
| GSDME | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| HGF | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| KARS1 | 6 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 2 more |
| LMX1A | 6 / 57 | Autosomal dominant nonsyndromic hearing loss, Deafness, Deafness, autosomal dominant 7, Hearing loss and 2 more |
| LRTOMT | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| MET | 6 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 2 more |
| MYH9 | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| MYO3A | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| POU4F3 | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| PTPRQ | 6 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Isolated sensorineural deafness and 2 more |
| RDX | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| SLC26A4 | 6 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 2 more |
| SLC44A4 | 6 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 2 more |
| STRC | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| TNC | 6 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Meniere disease and 2 more |
| TRIOBP | 6 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more |
| ADCY1 | 5 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 1 more |
| ADGRV1 | 5 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Meniere disease and 1 more |
| ATP2B2 | 5 / 57 | Autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 1 more |
| CLIC5 | 5 / 57 | Deafness, Deafness, autosomal recessive 103, Hearing loss, Isolated sensorineural deafness and 1 more |
| CRYM | 5 / 57 | Deafness, Deafness, autosomal dominant 40, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 1 more |
| DIAPH1 | 5 / 57 | Auditory neuropathy, Deafness, Hearing loss, Hereditary hearing loss and 1 more |
| DIAPH3 | 5 / 57 | Auditory neuropathy, Auditory neuropathy, autosomal dominant, 1, Hearing loss, Isolated sensorineural deafness and 1 more |
| DMXL2 | 5 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 1 more |
| GJB3 | 5 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 1 more |
| GJB6 | 5 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 1 more |
| GRXCR2 | 5 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 1 more |
| HOMER2 | 5 / 57 | Deafness, Deafness, autosomal dominant 68, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 1 more |
| ILDR1 | 5 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 1 more |
| MCM2 | 5 / 57 | Deafness, Deafness, autosomal dominant, 70, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 1 more |
| MINAR2 | 5 / 57 | Deafness, Hearing loss, Hearing loss, autosomal recessive 120, Isolated sensorineural deafness and 1 more |
| MPZL2 | 5 / 57 | Deafness, Deafness, autosomal recessive 111, Hearing loss, Isolated sensorineural deafness and 1 more |
| P2RX2 | 5 / 57 | Deafness, Deafness, autosomal dominant 41, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 1 more |
| PDE1C | 5 / 57 | Autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 1 more |
| PLS1 | 5 / 57 | Autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 1 more |
| PNPT1 | 5 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic hearing loss and 1 more |
| ROR1 | 5 / 57 | Deafness, Deafness, autosomal recessive 108, Hearing loss, Isolated sensorineural deafness and 1 more |
| SIX1 | 5 / 57 | Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 1 more |
| TBCEL-TECTA | 5 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Meniere disease and 1 more |
| TJP2 | 5 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss and 1 more |
| TMTC4 | 5 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic hearing loss and 1 more |
| USH2A | 5 / 57 | Congenital ear anomaly, Deafness, Hearing loss, Retinitis pigmentosa-deafness syndrome and 1 more |
| AFG2B | 4 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic hearing loss |
| BDP1 | 4 / 57 | Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic genetic hearing loss |
What do these columns mean?
- Connections in cluster
- How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
- Significant partners
- How many of those links are statistically significant (FDR q < 0.05).
- Curated genes
- Distinct curated genes linked to that disease in GeDiPNet.
- Member diseases (Top shared genes)
- How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
- Overlap genes (x / y)
- x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
- Cluster gene count
- Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
- Fold enrichment
- Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
- P-value / FDR q-value
- Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
- Shared genes (Pairs within this cluster)
- Number of curated genes the two diseases in that row have in common.
- Similarity score (Pairs within this cluster)
- Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.
Enriched Pathways (why this cluster is grouped, biologically)
| Pathway ⇵ | Source ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| Trafficking of AMPA receptors | Reactome | 7 / 17 | 7.6× | 1.59e-5 | 4.30e-4 ✓ sig. |
| NCAM1 interactions | Reactome | 7 / 21 | 6.2× | 7.86e-5 | 1.56e-3 ✓ sig. |
| Unblocking of NMDA receptors, glutamate binding and activation | Reactome | 7 / 22 | 5.9× | 1.10e-4 | 2.05e-3 ✓ sig. |
| Cytoskeleton in muscle cells | KEGG | 27 / 232 | 2.2× | 1.41e-4 | 2.49e-3 ✓ sig. |
| Signaling by PDGF | Reactome | 8 / 33 | 4.5× | 2.93e-4 | 4.43e-3 ✓ sig. |
| Collagen chain trimerization | Reactome | 9 / 44 | 3.8× | 4.85e-4 | 6.52e-3 ✓ sig. |
| Glutamatergic synapse | KEGG | 16 / 116 | 2.5× | 4.98e-4 | 6.67e-3 ✓ sig. |
| MET activates PTK2 signaling | Reactome | 7 / 30 | 4.3× | 8.99e-4 | 1.05e-2 ✓ sig. |
| Leishmaniasis | KEGG | 12 / 78 | 2.8× | 9.27e-4 | 1.07e-2 ✓ sig. |
| Allograft rejection | KEGG | 8 / 39 | 3.8× | 9.74e-4 | 1.11e-2 ✓ sig. |
| RAF/MAP kinase cascade | Reactome | 16 / 124 | 2.4× | 1.04e-3 | 1.17e-2 ✓ sig. |
| Recycling pathway of L1 | Reactome | 8 / 40 | 3.7× | 1.16e-3 | 1.27e-2 ✓ sig. |
| Integrin cell surface interactions | Reactome | 12 / 81 | 2.7× | 1.30e-3 | 1.39e-2 ✓ sig. |
| Cytosolic tRNA aminoacylation | Reactome | 6 / 24 | 4.6× | 1.43e-3 | 1.48e-2 ✓ sig. |
| Non-integrin membrane-ECM interactions | Reactome | 6 / 24 | 4.6× | 1.43e-3 | 1.48e-2 ✓ sig. |
Enriched GO Terms (Biological Process, a second line of biological evidence)
| GO term ⇵ | GO ID ⇵ | Overlap genes ⇵ | Fold enrichment ⇵ | P-value ⇵ | FDR q-value ⇵ |
|---|---|---|---|---|---|
| sensory perception of sound | GO:0007605 | 95 / 162 | 16.9× | 1.08e-96 | 2.06e-91 ✓ sig. |
| auditory receptor cell stereocilium organization | GO:0060088 | 16 / 19 | 24.2× | 3.37e-21 | 6.62e-18 ✓ sig. |
| inner ear morphogenesis | GO:0042472 | 22 / 65 | 9.7× | 1.71e-16 | 1.60e-13 ✓ sig. |
| inner ear auditory receptor cell differentiation | GO:0042491 | 13 / 19 | 19.7× | 2.17e-15 | 1.67e-12 ✓ sig. |
| inner ear receptor cell differentiation | GO:0060113 | 9 / 9 | 28.7× | 7.06e-14 | 4.19e-11 ✓ sig. |
| inner ear development | GO:0048839 | 18 / 54 | 9.6× | 1.33e-13 | 7.44e-11 ✓ sig. |
| detection of mechanical stimulus involved in sensory perception of sound | GO:0050910 | 11 / 18 | 17.6× | 2.12e-12 | 9.45e-10 ✓ sig. |
| visual perception | GO:0007601 | 32 / 215 | 4.3× | 3.65e-12 | 1.54e-9 ✓ sig. |
| photoreceptor cell maintenance | GO:0045494 | 15 / 45 | 9.6× | 1.47e-11 | 5.42e-9 ✓ sig. |
| sensory perception of light stimulus | GO:0050953 | 9 / 13 | 19.9× | 4.46e-11 | 1.48e-8 ✓ sig. |
| inner ear receptor cell stereocilium organization | GO:0060122 | 11 / 25 | 12.6× | 2.37e-10 | 6.64e-8 ✓ sig. |
| equilibrioception | GO:0050957 | 6 / 6 | 28.7× | 1.73e-9 | 3.75e-7 ✓ sig. |
| auditory receptor cell development | GO:0060117 | 6 / 8 | 21.6× | 4.57e-8 | 6.57e-6 ✓ sig. |
| olfactory behavior | GO:0042048 | 6 / 9 | 19.2× | 1.33e-7 | 1.61e-5 ✓ sig. |
| cochlea development | GO:0090102 | 10 / 35 | 8.2× | 2.02e-7 | 2.28e-5 ✓ sig. |