Shared-Gene Disease Pairs?
Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.
What do these columns mean?
- Shared genes
- Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
- Similarity score
- Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
- Overlap coefficient
- Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
- P-value / FDR q-value
- Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
- Shared cluster
- Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
| Disease A ⇵ | Disease B ⇵ | Shared genes ⇵ | Similarity score ⇵ | Overlap coefficient ⇵ | P-value ⇵ | FDR q-value ▼ | Shared cluster | |
|---|---|---|---|---|---|---|---|---|
| Degenerative disorder | Splenomegaly |
3 genes
|
0.052 | 0.150 | 1.80e-5 | 8.57e-5 ✓ sig. | — | |
| Developmental delay | Mitochondrial encephalopathy |
2 genes
|
0.050 | 0.667 | 1.78e-5 | 8.48e-5 ✓ sig. | Cluster 32 → | |
| Bladder exstrophy and epispadias complex | Tetra-amelia syndrome |
2 genes
|
0.067 | 0.500 | 1.77e-5 | 8.46e-5 ✓ sig. | — | |
| Aneurysm | Coronary syndrome |
2 genes
|
0.067 | 0.500 | 1.77e-5 | 8.46e-5 ✓ sig. | — | |
| Aortic rupture | Bone neoplasms |
2 genes
|
0.080 | 0.400 | 1.77e-5 | 8.44e-5 ✓ sig. | — | |
| Aplasia cutis congenita | Epidermolysis bullosa |
2 genes
|
0.080 | 0.400 | 1.77e-5 | 8.44e-5 ✓ sig. | — | |
| Brain small vessel disease | Intracerebral hemorrhage |
2 genes
|
0.080 | 0.400 | 1.77e-5 | 8.44e-5 ✓ sig. | Cluster 198 → | |
| Asbestosis | Cervical disc degenerative disorder |
2 genes
|
0.091 | 0.333 | 1.72e-5 | 8.20e-5 ✓ sig. | — | |
| Diabetes microvascular complications | Substance-induced psychosis |
2 genes
|
0.091 | 0.333 | 1.72e-5 | 8.20e-5 ✓ sig. | — | |
| Degenerative disorder | Frontotemporal dementia |
4 genes
|
0.041 | 0.100 | 1.71e-5 | 8.19e-5 ✓ sig. | — | |
| Frontotemporal dementia | Generalized anxiety disorder |
4 genes
|
0.041 | 0.100 | 1.71e-5 | 8.19e-5 ✓ sig. | — | |
| Mastocytosis | Sickle cell anemia |
3 genes
|
0.056 | 0.107 | 1.71e-5 | 8.18e-5 ✓ sig. | Cluster 235 → | |
| Esotropia | Tongue neoplasms |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | — | |
| Congenital skin anomaly | Ectrodactyly |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | — | |
| Head and neck cancer | Tongue neoplasms |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | — | |
| Ectrodactyly | Skin abnormalities |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | — | |
| Berylliosis | Vascular system injury |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | — | |
| Berylliosis | Intervertebral disc disease |
2 genes
|
0.105 | 0.200 | 1.70e-5 | 8.15e-5 ✓ sig. | Cluster 180 → | |
| Arterial occlusive disease | Hematuria |
2 genes
|
0.105 | 0.222 | 1.67e-5 | 7.98e-5 ✓ sig. | — | |
| Anhydramnios | Fabry disease |
2 genes
|
0.105 | 0.222 | 1.67e-5 | 7.98e-5 ✓ sig. | — | |
| Optic neuropathy | Stomatitis |
2 genes
|
0.105 | 0.222 | 1.67e-5 | 7.98e-5 ✓ sig. | Cluster 32 → | |
| Beta thalassemia | Diamond-blackfan anemia |
3 genes
|
0.054 | 0.143 | 1.65e-5 | 7.90e-5 ✓ sig. | — | |
| Arthritis | Autoimmune polyendocrine syndrome |
2 genes
|
0.069 | 0.500 | 1.64e-5 | 7.87e-5 ✓ sig. | Cluster 1 → | |
| Arthritis | Esophageal achalasia |
2 genes
|
0.069 | 0.500 | 1.64e-5 | 7.87e-5 ✓ sig. | Cluster 1 → | |
| Arthritis | Oropharyngeal neoplasms |
2 genes
|
0.069 | 0.500 | 1.64e-5 | 7.87e-5 ✓ sig. | Cluster 1 → |
0 selected
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Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.