Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

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What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Optic atrophy Retinitis pigmentosa
142 genes
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140 of 142 corroborated by 2+ sources
OPA3(7), ABCA4(6), ITM2B(2), COL2A1(2), CNGA3(2), CNGB3(2), PDE6C(2), PHYH(2), PRPH2(7), CACNA1F(2), ALMS1(2), ABHD12(2) +130 more
0.359 0.785 1.97e-207 8.51e-205 ✓ sig. Cluster 7 →
Psoriasis Ulcerative colitis
271 genes
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57 of 271 corroborated by 2+ sources
SH2B3(1), NOTCH1(1), IFIH1(3), BLTP1(1), ADGRL2(1), ANKRD55(1), ATXN2L(1), BANK1(2), BSN(1), BTNL2(2), CDKAL1(1), DAG1(1) +259 more
0.253 0.444 2.80e-207 1.19e-204 ✓ sig. Cluster 14 →
Cancer Squamous cell carcinoma
198 genes
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7 of 198 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(2), ARHGEF10L(1), ASIP(1), BAD(1) +186 more
0.232 0.759 4.13e-207 1.72e-204 ✓ sig. Cluster 21 →
Cancer Prostate cancer
208 genes
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16 of 208 corroborated by 2+ sources
ANKRD11(1), HNF1B(2), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +196 more
0.205 0.797 2.70e-206 1.10e-203 ✓ sig. Cluster 21 →
Endometrial cancer Non-hodgkins lymphoma
109 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +97 more
0.542 0.807 1.74e-204 6.98e-202 ✓ sig. Cluster 72 →
Ovarian serous carcinoma Squamous cell carcinoma
198 genes
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7 of 198 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(2), ARHGEF10L(1), ASIP(1), BAD(1) +186 more
0.230 0.733 6.24e-202 2.46e-199 ✓ sig. Cluster 21 →
Biliary tract cancer Cervical cancer
109 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +97 more
0.460 0.924 6.22e-201 2.40e-198 ✓ sig. Cluster 72 →
Biliary tract cancer Gastric cancer
108 genes
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1 of 108 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +96 more
0.472 0.915 2.24e-200 8.50e-198 ✓ sig. Cluster 72 →
Coronary artery disease Ischemic heart disease
170 genes
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101 of 170 corroborated by 2+ sources
PRDM16(3), APOA1(2), ACAT2(1), SH2B3(3), TERT(3), ARHGAP31(1), AMPD1(1), TP53(1), AHSG(1), ABCA1(2), ABCG8(3), ACE(2) +158 more
0.149 1.000 4.53e-198 1.69e-195 ✓ sig. —
Breast cancer Ovarian cancer
270 genes
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12 of 270 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(2), ABCA4(1), PDE4D(1), SH2B3(1), CHEK2(2), RTEL1(1), TERT(1), TP53(4) +258 more
0.214 0.579 2.28e-197 8.37e-195 ✓ sig. Cluster 21 →
Ovarian serous carcinoma Prostate cancer
205 genes
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14 of 205 corroborated by 2+ sources
ANKRD11(1), HNF1B(2), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +193 more
0.199 0.759 3.61e-195 1.30e-192 ✓ sig. Cluster 21 →
Estrogen-receptor negative breast cancer Prostate cancer
212 genes
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15 of 212 corroborated by 2+ sources
ANKRD11(1), HNF1B(2), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1) +200 more
0.202 0.716 8.71e-193 3.10e-190 ✓ sig. Cluster 21 →
Biliary tract cancer Cancer
109 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +97 more
0.402 0.924 3.37e-192 1.18e-189 ✓ sig. —
Breast cancer Ovarian serous carcinoma
209 genes
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5 of 209 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(2), PDE4D(1), SH2B3(1), RTEL1(1), TERT(1), TP53(4), ARHGEF10L(1), ASIP(1) +197 more
0.185 0.774 4.19e-192 1.44e-189 ✓ sig. Cluster 21 →
Cancer Colorectal cancer
201 genes
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3 of 201 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(3), ARHGEF10L(1), ASIP(1), BAD(1) +189 more
0.194 0.770 4.57e-192 1.55e-189 ✓ sig. Cluster 21 →
Cervical cancer Non-hodgkins lymphoma
111 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +99 more
0.440 0.822 9.03e-192 3.02e-189 ✓ sig. Cluster 72 →
Biliary tract cancer Pancreatic cancer
108 genes
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3 of 108 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(4), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +96 more
0.412 0.915 1.54e-191 5.08e-189 ✓ sig. Cluster 72 →
Gastric cancer Non-hodgkins lymphoma
109 genes
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1 of 109 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +97 more
0.445 0.807 6.82e-189 2.21e-186 ✓ sig. Cluster 72 →
Endometrial cancer Esophageal cancer
108 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +96 more
0.482 0.688 1.15e-188 3.68e-186 ✓ sig. Cluster 72 →
Colorectal cancer Ovarian serous carcinoma
202 genes
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3 of 202 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(3), ARHGEF10L(1), ASIP(1), BAD(1) +190 more
0.193 0.748 1.71e-188 5.37e-186 ✓ sig. Cluster 21 →
Cancer Non-hodgkins lymphoma
113 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +101 more
0.398 0.837 3.36e-188 1.04e-185 ✓ sig. —
Biliary tract cancer Ovarian serous carcinoma
108 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +96 more
0.384 0.915 3.93e-187 1.20e-184 ✓ sig. —
Non-hodgkins lymphoma Ovarian serous carcinoma
113 genes
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ANKRD11(1), HNF1B(1), MAP3K1(1), SH2B3(1), TERT(1), TP53(1), ARHGEF10L(1), ASIP(1), BAD(1), BNC2(1), CELF2(1), DCAF4(1) +101 more
0.386 0.837 4.81e-186 1.45e-183 ✓ sig. —
Colorectal cancer Estrogen-receptor negative breast cancer
208 genes
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4 of 208 corroborated by 2+ sources
ANKRD11(1), HNF1B(1), KANSL1(1), RREB1(1), MAP3K1(1), SH2B3(1), RTEL1(1), TERT(1), TP53(3), ARHGEF10L(1), ASIP(1), BAD(1) +196 more
0.195 0.703 1.09e-184 3.25e-182 ✓ sig. Cluster 21 →
Depression Major depressive disorder
245 genes
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66 of 245 corroborated by 2+ sources
APRT(1), COMT(1), SEC24C(1), SOX9(1), APP(1), CAT(3), TERT(1), GFAP(1), ACE(1), ADRA1A(1), ARSA(1), ATP7B(1) +233 more
0.123 0.878 4.04e-184 1.19e-181 ✓ sig. Cluster 2 →

Showing 25 of 22038 pairs, sorted by significance (ascending). Click a column header to sort.