Shared-Gene Disease Pairs?

Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.

Log in to save this analysis

Save This Analysis

What do these columns mean?
Shared genes
Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
Similarity score
Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
Overlap coefficient
Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
P-value / FDR q-value
Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
Shared cluster
Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
ⓘ Shows only pairs whose gene overlap is too large to be down to chance (FDR q-value below 0.05). These are the rows marked ✓ sig. in the table. ⓘ Shows only pairs where both diseases also belong to the same group on the Disease Clusters page. Two separate analyses agree they're related, so the link is stronger. These are the rows with a link in the Shared cluster column.
0 selected Clear
Disease A ⇵Disease B ⇵Shared genes ⇵Similarity score ⇵Overlap coefficient ⇵P-value ⇵FDR q-value ▲ Shared cluster
Cystic fibrosis-related diabetes Lewy body disease
2 genes
Show details
RAB7B(1), SLC26A9(1)
0.021 0.667 1.13e-4 3.93e-4 ✓ sig. —
Camos syndrome Sarcoidosis
2 genes
Show details
2 of 2 corroborated by 2+ sources
ZNF592(2), WDR73(4)
0.012 1.000 1.11e-4 3.93e-4 ✓ sig. —
Blepharoptosis Congenital epicanthus
2 genes
Show details
ANKRD11(1), PTPN11(1)
0.063 0.143 1.30e-4 3.94e-4 ✓ sig. —
Auricle malformation Strabismus
2 genes
Show details
KMT2D(1), PTPN11(1)
0.049 0.250 1.31e-4 3.98e-4 ✓ sig. —
Esophageal atresia Genetic predisposition to disease
3 genes
Show details
3 of 3 corroborated by 2+ sources
TERT(2), GSTM1(2), CACNA1C(2)
0.038 0.094 1.32e-4 4.00e-4 ✓ sig. —
Cystitis Nuclear cataract
2 genes
Show details
2 of 2 corroborated by 2+ sources
CRYBB2(2), CRYBB3(2)
0.063 0.133 1.34e-4 4.06e-4 ✓ sig. —
Amnesia Cystitis
2 genes
Show details
2 of 2 corroborated by 2+ sources
NGF(2), POMC(2)
0.063 0.133 1.34e-4 4.06e-4 ✓ sig. —
Eye abnormalities Loeys-dietz syndrome
2 genes
Show details
2 of 2 corroborated by 2+ sources
TGFB2(6), TGFBR2(7)
0.063 0.125 1.36e-4 4.12e-4 ✓ sig. —
Eye abnormalities Walker-warburg syndrome
2 genes
Show details
2 of 2 corroborated by 2+ sources
CRPPA(3), COL4A1(3)
0.063 0.125 1.36e-4 4.12e-4 ✓ sig. Cluster 14 →
Cone rod dystrophy and hearing loss Optic atrophy
2 genes
Show details
2 of 2 corroborated by 2+ sources
CEP78(5), CEP250(5)
0.011 1.000 1.37e-4 4.15e-4 ✓ sig. —
Conduct disorder Spondylosis
3 genes
Show details
LIG4(1), NALF1(1), PTPRD(1)
0.038 0.100 1.38e-4 4.18e-4 ✓ sig. —
Hepatic insufficiency Pancreatic ductal carcinoma
2 genes
Show details
NFE2L2(1), RELA(1)
0.051 0.222 1.40e-4 4.23e-4 ✓ sig. Cluster 153 →
Biliary atresia Haddad syndrome
2 genes
Show details
2 of 2 corroborated by 2+ sources
PAH(2), EDN3(2)
0.051 0.222 1.40e-4 4.23e-4 ✓ sig. Cluster 387 →
Biliary atresia Congenital central hypoventilation syndrome
2 genes
Show details
2 of 2 corroborated by 2+ sources
PAH(2), EDN3(4)
0.051 0.222 1.40e-4 4.23e-4 ✓ sig. Cluster 387 →
Epithelial ovarian carcinoma Keratosis
2 genes
Show details
2 of 2 corroborated by 2+ sources
TP53(2), GSTM1(2)
0.054 0.200 1.42e-4 4.30e-4 ✓ sig. —
Paraquat lung disease Pulmonary fibrosis
2 genes
Show details
2 of 2 corroborated by 2+ sources
SMAD7(2), SKIL(2)
0.018 0.667 1.43e-4 4.32e-4 ✓ sig. —
Congenital hydrocephalus Fraser syndrome
2 genes
Show details
1 of 2 corroborated by 2+ sources
WDR81(3), PTCH1(1)
0.061 0.143 1.44e-4 4.36e-4 ✓ sig. —
Congenital epicanthus Cryptorchidism
2 genes
Show details
ANKRD11(1), KAT6B(1)
0.061 0.143 1.44e-4 4.36e-4 ✓ sig. —
Cerebral arteriovenous malformations Costello syndrome
2 genes
Show details
2 of 2 corroborated by 2+ sources
BRAF(3), KRAS(4)
0.059 0.154 1.51e-4 4.55e-4 ✓ sig. —
Hypospadias Porphyria cutanea tarda
2 genes
Show details
GSTM1(1), CYP1A1(1)
0.042 0.286 1.51e-4 4.56e-4 ✓ sig. —
Glycosylphosphatidylinositol biosynthesis defect Uranostaphyloschisis
2 genes
Show details
1 of 2 corroborated by 2+ sources
MYO19(1), PIGW(2)
0.057 0.167 1.52e-4 4.59e-4 ✓ sig. —
Lipoma Uterine polyp
2 genes
Show details
TERT(1), ACTRT3(1)
0.057 0.167 1.52e-4 4.59e-4 ✓ sig. —
Urinary system neoplasms Uterine polyp
2 genes
Show details
TERT(1), ACTRT3(1)
0.057 0.167 1.52e-4 4.59e-4 ✓ sig. —
Loeys-dietz syndrome Thoracic aortic aneurysm
2 genes
Show details
2 of 2 corroborated by 2+ sources
FBN1(2), SMAD6(2)
0.061 0.125 1.53e-4 4.63e-4 ✓ sig. —
Melas syndrome Mitochondrial encephalomyopathy
2 genes
Show details
1 of 2 corroborated by 2+ sources
POLG(1), CYTB(2)
0.061 0.125 1.53e-4 4.63e-4 ✓ sig. —

Showing 25 of 20813 pairs, sorted by significance (ascending). Click a column header to sort.