Shared-Gene Disease Pairs?
Disease pairs ranked by curated gene overlap — a data-driven way to spot diseases that aren't normally considered related but share a large number of underlying genes. Looking for groups of more than two? See Disease Clusters.
What do these columns mean?
- Shared genes
- Curated genes linked to both diseases (disease_gdp). The line below it shows how many of those are "corroborated" -- backed by 2+ independent database sources combined across both diseases, not resting on a single source's say-so.
- Similarity score
- Jaccard-based: shared genes ÷ the union of both diseases' entire gene sets, with a small boost from users who bookmarked both diseases. Treats both diseases symmetrically.
- Overlap coefficient
- Shared genes ÷ the smaller disease's own total gene count. Complements the similarity score above for asymmetric pairs -- e.g. a rare disease almost entirely "contained" in a common disease's much larger gene set scores low on Jaccard but high here.
- P-value / FDR q-value
- Is this gene overlap more than chance? An upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pair (the q-value is the one that accounts for testing thousands of pairs at once -- prefer it over the raw p-value).
- Shared cluster
- Links to a multi-disease cluster (see Disease Clusters) if both diseases of this pair were independently grouped together by that separate analysis.
| Disease A ⇵ | Disease B ⇵ | Shared genes ⇵ | Similarity score ⇵ | Overlap coefficient ⇵ | P-value ⇵ | FDR q-value ▼ | Shared cluster | |
|---|---|---|---|---|---|---|---|---|
| Glycogen storage disease | Ventricular dysfunction |
3 genes
|
0.037 | 0.081 | 1.81e-4 | 5.35e-4 ✓ sig. | — | |
| Dyslipidemias | Osteopetrosis |
2 genes
|
0.059 | 0.118 | 1.74e-4 | 5.23e-4 ✓ sig. | — | |
| Gastroparesis | Internet addiction disorder |
2 genes
|
0.053 | 0.182 | 1.74e-4 | 5.23e-4 ✓ sig. | — | |
| Brain infarction | Ventricular dysfunction |
3 genes
|
0.038 | 0.083 | 1.66e-4 | 5.01e-4 ✓ sig. | — | |
| Combined immunodeficiency disease | Tubular aggregate myopathy |
2 genes
|
0.040 | 0.286 | 1.66e-4 | 5.00e-4 ✓ sig. | — | |
| Amblyopia | Eye neoplasms |
2 genes
|
0.056 | 0.167 | 1.65e-4 | 4.98e-4 ✓ sig. | — | |
| Esophageal disease | Esotropia |
2 genes
|
0.051 | 0.200 | 1.64e-4 | 4.93e-4 ✓ sig. | — | |
| Cerebellar ataxia | Diencephalic mesencephalic junction dysplasia |
2 genes
|
0.017 | 0.667 | 1.62e-4 | 4.89e-4 ✓ sig. | — | |
| B-cell chronic lymphocytic leukemia | Diamond-blackfan anemia |
2 genes
|
0.045 | 0.250 | 1.56e-4 | 4.70e-4 ✓ sig. | — | |
| Lymphoid leukemia | Ocular sarcoidosis |
3 genes
|
0.036 | 0.107 | 1.55e-4 | 4.68e-4 ✓ sig. | — | |
| Hyperopia | Vertebral, cardiac, renal, and limb defects syndrome |
2 genes
|
0.024 | 0.500 | 1.55e-4 | 4.67e-4 ✓ sig. | Cluster 386 → | |
| Loeys-dietz syndrome | Thoracic aortic aneurysm |
2 genes
|
0.061 | 0.125 | 1.53e-4 | 4.63e-4 ✓ sig. | — | |
| Gliosarcoma | Hemangiosarcoma |
2 genes
|
0.061 | 0.125 | 1.53e-4 | 4.63e-4 ✓ sig. | — | |
| Body weight | Diabetic nephropathy type 2 |
2 genes
|
0.061 | 0.125 | 1.53e-4 | 4.63e-4 ✓ sig. | Cluster 73 → | |
| Melas syndrome | Mitochondrial encephalomyopathy |
2 genes
|
0.061 | 0.125 | 1.53e-4 | 4.63e-4 ✓ sig. | — | |
| Glycosylphosphatidylinositol biosynthesis defect | Uranostaphyloschisis |
2 genes
|
0.057 | 0.167 | 1.52e-4 | 4.59e-4 ✓ sig. | — | |
| Lipoma | Uterine polyp |
2 genes
|
0.057 | 0.167 | 1.52e-4 | 4.59e-4 ✓ sig. | — | |
| Urinary system neoplasms | Uterine polyp |
2 genes
|
0.057 | 0.167 | 1.52e-4 | 4.59e-4 ✓ sig. | — | |
| Hypospadias | Porphyria cutanea tarda |
2 genes
|
0.042 | 0.286 | 1.51e-4 | 4.56e-4 ✓ sig. | — | |
| Cerebral arteriovenous malformations | Costello syndrome |
2 genes
|
0.059 | 0.154 | 1.51e-4 | 4.55e-4 ✓ sig. | — | |
| Congenital epicanthus | Cryptorchidism |
2 genes
|
0.061 | 0.143 | 1.44e-4 | 4.36e-4 ✓ sig. | — | |
| Congenital hydrocephalus | Fraser syndrome |
2 genes
|
0.061 | 0.143 | 1.44e-4 | 4.36e-4 ✓ sig. | — | |
| Paraquat lung disease | Pulmonary fibrosis |
2 genes
|
0.018 | 0.667 | 1.43e-4 | 4.32e-4 ✓ sig. | — | |
| Epithelial ovarian carcinoma | Keratosis |
2 genes
|
0.054 | 0.200 | 1.42e-4 | 4.30e-4 ✓ sig. | — | |
| Hepatic insufficiency | Pancreatic ductal carcinoma |
2 genes
|
0.051 | 0.222 | 1.40e-4 | 4.23e-4 ✓ sig. | Cluster 153 → |
0 selected
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Showing 25 of 20813 pairs, sorted by significance (descending). Click a column header to sort.