Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 250

7 diseases · 11 shared-gene connections
7 Diseases
32 Unique genes
0.156 Avg. similarity score
Extravasation of diagnostic and therapeutic materials Most-connected disease (5 links)
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Disease Searched: Hereditary angioedema Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Extravasation of diagnostic and therapeutic materials 5 5 7
Congenital high-molecular-weight kininogen deficiency 4 4 1
Hyperesthesia 4 4 1
Occupational dermatitis 4 4 8
Hereditary angioedema 2 2 7
Hyperemia 2 2 14
Bladder disease 1 1 3

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
KNG1 6 / 7 Congenital high-molecular-weight kininogen deficiency, Extravasation of diagnostic and therapeutic materials, Hereditary angioedema, Hyperemia and 2 more
BDKRB2 3 / 7 Extravasation of diagnostic and therapeutic materials, Hyperemia, Occupational dermatitis
HRH1 2 / 7 Bladder disease, Extravasation of diagnostic and therapeutic materials
TAC1 2 / 7 Extravasation of diagnostic and therapeutic materials, Hyperemia
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Pertussis
IL10, SERPING1, C1S, IL1B, NOS2
 KEGG 5 / 78 24.1× 1.78e-6 8.60e-5 ✓ sig.
Leishmaniasis
HLA-DMA, IL10, IL1B, NOS2, PTGS2
 KEGG 5 / 78 24.1× 1.78e-6 8.60e-5 ✓ sig.
Complement and coagulation cascades
KNG1, BDKRB2, F12, SERPING1, C1S
 KEGG 5 / 88 21.3× 3.24e-6 1.43e-4 ✓ sig.
Neuroactive ligand-receptor interaction
HRH1, KNG1, BDKRB2, TAC1, ADCYAP1, ADRB1, AGT, CNR2
 KEGG 8 / 370 8.1× 4.14e-6 1.75e-4 ✓ sig.
Interleukin-10 signaling
IL10, IL1RN, IL1B, PTGS2
 Reactome 4 / 47 31.9× 6.83e-6 2.61e-4 ✓ sig.
Acetylation
NAT1, NAT2
 Reactome 2 / 2 375× 6.88e-6 2.62e-4 ✓ sig.
Chagas disease
KNG1, BDKRB2, IL10, IL1B, NOS2
 KEGG 5 / 103 18.2× 7.05e-6 2.67e-4 ✓ sig.
Inflammatory bowel disease
FOXP3, HLA-DMA, IL10, IL1B
 KEGG 4 / 66 22.7× 2.66e-5 7.99e-4 ✓ sig.
Intrinsic Pathway of Fibrin Clot Formation
KNG1, F12, SERPING1
 Reactome 3 / 23 49.0× 2.93e-5 8.63e-4 ✓ sig.
G alpha (q) signalling events
HRH1, KNG1, BDKRB2, TAC1, AGT
 Reactome 5 / 172 10.9× 8.37e-5 2.02e-3 ✓ sig.
Caffeine metabolism
NAT1, NAT2
 KEGG 2 / 6 125× 1.02e-4 2.37e-3 ✓ sig.
African trypanosomiasis
KNG1, IL10, IL1B
 KEGG 3 / 37 30.4× 1.26e-4 2.78e-3 ✓ sig.
Inflammatory mediator regulation of TRP channels
HRH1, KNG1, BDKRB2, IL1B
 KEGG 4 / 99 15.2× 1.31e-4 2.87e-3 ✓ sig.
Interleukin-4 and Interleukin-13 signaling
IL10, IL1B, NOS2, PTGS2
 Reactome 4 / 108 13.9× 1.83e-4 3.75e-3 ✓ sig.
Renin secretion
ADCYAP1, ADRB1, AGT
 KEGG 3 / 69 16.3× 7.99e-4 1.19e-2 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
inflammatory response
HRH1, KNG1, BDKRB2, FOXP3, IL1RN, NR1H4, TAC1, CNR2, IL1B, NOS2
 GO:0006954 10 / 467 12.5× 3.40e-9 6.60e-7 ✓ sig.
response to lipopolysaccharide
FOXP3, IL10, TAC1, CNR2, IL1B, NOS2
 GO:0032496 6 / 161 21.8× 2.80e-7 2.96e-5 ✓ sig.
negative regulation of heterotypic cell-cell adhesion
IL10, IL1RN, ADIPOQ
 GO:0034115 3 / 11 159× 7.46e-7 6.67e-5 ✓ sig.
negative regulation of inflammatory response
FOXP3, IL10, NR1H4, ADA, ADIPOQ
 GO:0050728 5 / 152 19.2× 5.62e-6 3.41e-4 ✓ sig.
response to inactivity
IL10, CAT
 GO:0014854 2 / 3 389× 8.51e-6 4.77e-4 ✓ sig.
negative regulation of tumor necrosis factor production
FOXP3, IL10, NR1H4, ADIPOQ
 GO:0032720 4 / 81 28.8× 1.07e-5 5.71e-4 ✓ sig.
positive regulation of fever generation
IL1B, PTGS2
 GO:0031622 2 / 4 292× 1.70e-5 8.16e-4 ✓ sig.
brown fat cell differentiation
ADIPOQ, ADRB1, PTGS2
 GO:0050873 3 / 32 54.7× 2.19e-5 9.95e-4 ✓ sig.
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
BDKRB2, PTGS2
 GO:1902219 2 / 5 234× 2.83e-5 1.21e-3 ✓ sig.
prostaglandin secretion
NOS2, PTGS2
 GO:0032310 2 / 5 234× 2.83e-5 1.21e-3 ✓ sig.
blood coagulation
KNG1, F12, SERPING1, ANGPT1
 GO:0007596 4 / 106 22.0× 3.11e-5 1.30e-3 ✓ sig.
positive regulation of immature T cell proliferation in thymus
FOXP3, IL1B
 GO:0033092 2 / 6 195× 4.24e-5 1.65e-3 ✓ sig.
blood circulation
BDKRB2, SERPING1, MYOF
 GO:0008015 3 / 41 42.7× 4.65e-5 1.77e-3 ✓ sig.
negative regulation of type II interferon production
FOXP3, IL10, NR1H4
 GO:0032689 3 / 44 39.8× 5.76e-5 2.06e-3 ✓ sig.
regulation of circadian sleep/wake cycle, sleep
ADA, ADRB1
 GO:0045187 2 / 7 167× 5.93e-5 2.11e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Extravasation of diagnostic and therapeutic materials Hyperemia 0.158 3 2.09e-8 1.63e-7 ✓ sig.
Extravasation of diagnostic and therapeutic materials Occupational dermatitis 0.143 2 4.95e-6 2.57e-5 ✓ sig.
Hyperemia Occupational dermatitis 0.095 2 2.14e-5 1.01e-4 ✓ sig.
Congenital high-molecular-weight kininogen deficiency Hyperesthesia 0.500 1 6.49e-5 2.33e-4 ✓ sig.
Congenital high-molecular-weight kininogen deficiency Extravasation of diagnostic and therapeutic materials 0.125 1 4.55e-4 9.73e-4 ✓ sig.
Congenital high-molecular-weight kininogen deficiency Hereditary angioedema 0.125 1 4.55e-4 9.73e-4 ✓ sig.
Extravasation of diagnostic and therapeutic materials Hyperesthesia 0.125 1 4.55e-4 9.73e-4 ✓ sig.
Hereditary angioedema Hyperesthesia 0.125 1 4.55e-4 9.73e-4 ✓ sig.
Congenital high-molecular-weight kininogen deficiency Occupational dermatitis 0.111 1 5.20e-4 1.06e-3 ✓ sig.
Hyperesthesia Occupational dermatitis 0.111 1 5.20e-4 1.06e-3 ✓ sig.
Bladder disease Extravasation of diagnostic and therapeutic materials 0.100 1 1.36e-3 2.15e-3 ✓ sig.