Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 14

27 diseases · 98 shared-gene connections
27 Diseases
170 Unique genes
0.214 Avg. similarity score
Pituitary short stature Most-connected disease (22 links)
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Disease Searched: Hypogonadotropic hypogonadism 10 with or without anosmia Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Pituitary short stature 22 22 34
Kallmann syndrome 20 20 38
Sheehan syndrome 20 20 34
Growth hormone deficiency 19 19 35
Panhypopituitarism 17 17 43
Pituitary stalk interruption syndrome 8 8 32
Hypogonadism 7 7 76
Hypopituitarism 7 7 50
Hypogonadotropic hypogonadism 6 6 49
Pituitary dwarfism 6 6 43
Congenital hypogonadotrophic hypogonadism 5 5 1
Hypogonadotropic hypogonadism 10 with or without anosmia 5 5 1
Hypogonadotropic hypogonadism 15 with or without anosmia 5 5 1
Hypogonadotropic hypogonadism 17 with or without anosmia 5 5 1
Hypogonadotropic hypogonadism 19 with or without anosmia 5 5 1
Hypogonadotropic hypogonadism 20 with or without anosmia 5 5 1
Hypogonadotropic hypogonadism 21 with or without anosmia 5 5 1
Hypogonadotropic hypogonadism 22 with or without anosmia 5 5 1
Hypogonadotropic hypogonadism 9 with or without anosmia 5 5 1
Hypogonadotropic hypogonadism 13 with or without anosmia 4 4 1
Hypogonadotropic hypogonadism 18 with or without anosmia 4 4 1
Hypogonadotropic hypogonadism 4 with or without anosmia 4 4 1
Hypogonadotropic hypogonadism 3 with or without anosmia 3 3 1
Amyotrophic lateral sclerosis type 15 1 1 1
Brody myopathy 1 1 2
Cohen syndrome 1 1 1
Medulloblastoma predisposition 1 1 1

Top shared genes (genes linked to 2+ member diseases)

Gene ⇵ Member diseases ⇵ Linked diseases
IL17RD 10 / 27 Growth hormone deficiency, Hypogonadism, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 18 with or without anosmia and 6 more
KISS1R 10 / 27 Growth hormone deficiency, Hypogonadism, Hypogonadotropic hypogonadism, Hypopituitarism and 6 more
NSMF 10 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 9 with or without anosmia, Hypopituitarism and 6 more
PROKR2 10 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 3 with or without anosmia, Hypopituitarism and 6 more
TAC3 10 / 27 Growth hormone deficiency, Hypogonadism, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 10 with or without anosmia and 6 more
CHD7 9 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 5 more
DUSP6 9 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 19 with or without anosmia, Hypopituitarism and 5 more
FEZF1 9 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 22 with or without anosmia, Hypopituitarism and 5 more
FGF17 9 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 20 with or without anosmia, Hypopituitarism and 5 more
FLRT3 9 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 21 with or without anosmia, Hypopituitarism and 5 more
GNRH1 9 / 27 Growth hormone deficiency, Hypogonadism, Hypogonadotropic hypogonadism, Hypopituitarism and 5 more
GNRHR 9 / 27 Growth hormone deficiency, Hypogonadism, Hypogonadotropic hypogonadism, Hypopituitarism and 5 more
HS6ST1 9 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 15 with or without anosmia, Hypopituitarism and 5 more
KISS1 9 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 13 with or without anosmia, Hypopituitarism and 5 more
NDNF 9 / 27 Congenital hypogonadotrophic hypogonadism, Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism and 5 more
PROK2 9 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 4 with or without anosmia, Hypopituitarism and 5 more
SPRY4 9 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypogonadotropic hypogonadism 17 with or without anosmia, Hypopituitarism and 5 more
TACR3 9 / 27 Growth hormone deficiency, Hypogonadism, Hypogonadotropic hypogonadism, Hypopituitarism and 5 more
WDR11 9 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 5 more
ANOS1 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
AXL 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
BTK 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
CCDC141 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
DNA2 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
FGF8 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
GH1 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
GHRHR 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
NHLH2 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
SEMA3A 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
SEMA3E 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
SOX10 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
SRA1 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
TCF12 8 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 4 more
FGFR1 7 / 27 Growth hormone deficiency, Hypogonadotropic hypogonadism, Hypopituitarism, Kallmann syndrome and 3 more
PROP1 4 / 27 Hypogonadism, Hypopituitarism, Panhypopituitarism, Pituitary dwarfism
HESX1 3 / 27 Kallmann syndrome, Panhypopituitarism, Pituitary stalk interruption syndrome
LHX4 3 / 27 Hypopituitarism, Panhypopituitarism, Pituitary stalk interruption syndrome
ATP2A1 2 / 27 Brody myopathy, Hypogonadism
CYP17A1 2 / 27 Hypogonadism, Hypopituitarism
CYP19A1 2 / 27 Hypogonadism, Hypopituitarism
FSHB 2 / 27 Hypogonadism, Hypogonadotropic hypogonadism
GPR161 2 / 27 Medulloblastoma predisposition, Pituitary stalk interruption syndrome
LHB 2 / 27 Hypogonadism, Hypogonadotropic hypogonadism
PNPLA6 2 / 27 Hypogonadotropic hypogonadism, Kallmann syndrome
POU1F1 2 / 27 Panhypopituitarism, Pituitary dwarfism
PRL 2 / 27 Hypogonadism, Hypopituitarism
RNPC3 2 / 27 Growth hormone deficiency, Pituitary dwarfism
ROBO1 2 / 27 Hypopituitarism, Pituitary stalk interruption syndrome
SOX11 2 / 27 Hypogonadotropic hypogonadism, Pituitary stalk interruption syndrome
UBQLN2 2 / 27 Amyotrophic lateral sclerosis type 15, Hypogonadism
VPS13B 2 / 27 Cohen syndrome, Pituitary stalk interruption syndrome
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Hormone ligand-binding receptors
FSHB, GNRH1, GNRHR, LHB, LHCGR
 Reactome 5 / 12 29.4× 3.92e-7 1.84e-5 ✓ sig.
Hormone signaling
FSHB, GNRH1, GNRHR, LEP, LEPR, LHB, PRL, GH1, GHRHR, GNAI2, GHR, CSHL1
 KEGG 13 / 219 4.2× 1.38e-5 3.80e-4 ✓ sig.
FGFR1c ligand binding and activation
ANOS1, FGF17, FGF8, FGFR1
 Reactome 4 / 12 23.5× 1.76e-5 4.68e-4 ✓ sig.
Neuroactive ligand-receptor interaction
FSHB, GNRH1, GNRHR, KISS1R, LEP, LEPR, LHB, PRL, TAC3, TACR3, GH1, GHRHR
 KEGG 16 / 370 3.1× 7.11e-5 1.44e-3 ✓ sig.
FGFR3b ligand binding and activation
FGF17, FGF8, FGFR3
 Reactome 3 / 7 30.3× 9.35e-5 1.80e-3 ✓ sig.
Downstream signaling of activated FGFR1
FGF17, FGF8, FGFR1, FLRT3
 Reactome 4 / 18 15.7× 1.02e-4 1.92e-3 ✓ sig.
Steroid hormone biosynthesis
AKR1C4, CYP17A1, CYP19A1, SRD5A2, UGT2B10, UGT2B15
 KEGG 6 / 63 6.7× 2.57e-4 3.99e-3 ✓ sig.
Axon guidance
PLXNA3, SEMA3A, SEMA3E, SEMA3F, GNAI2, ROBO1, DCC, PTCH1, RAF1, SEMA5A
 KEGG 10 / 183 3.9× 2.73e-4 4.19e-3 ✓ sig.
Androgen biosynthesis
CYP17A1, LHB, SRD5A2
 Reactome 3 / 11 19.3× 4.23e-4 5.87e-3 ✓ sig.
Signaling by activated point mutants of FGFR1
FGF17, FGF8, FGFR1
 Reactome 3 / 11 19.3× 4.23e-4 5.87e-3 ✓ sig.
Negative regulation of FGFR1 signaling
ANOS1, FGF17, FGF8, FGFR1
 Reactome 4 / 26 10.9× 4.54e-4 6.20e-3 ✓ sig.
Glycoprotein hormones
CGB3, FSHB, LHB
 Reactome 3 / 12 17.7× 5.58e-4 7.28e-3 ✓ sig.
Prolactin receptor signaling
PRL, GH1, GHR
 Reactome 3 / 12 17.7× 5.58e-4 7.28e-3 ✓ sig.
Signaling by activated point mutants of FGFR3
FGF17, FGF8, FGFR3
 Reactome 3 / 12 17.7× 5.58e-4 7.28e-3 ✓ sig.
FGFR3 mutant receptor activation
FGF17, FGF8, FGFR3
 Reactome 3 / 12 17.7× 5.58e-4 7.28e-3 ✓ sig.

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
pituitary gland development
NR0B1, PROP1, HESX1, LHX3, SOX3, GLI2, PITX2, TBX19
 GO:0021983 8 / 30 29.3× 1.96e-10 5.59e-8 ✓ sig.
axon guidance
NOTCH3, OPHN1, ANOS1, FEZF1, FLRT3, PLXNA3, SEMA3A, SEMA3E, SEMA3F, ROBO1, DCC, OTX2
 GO:0007411 15 / 192 8.6× 2.50e-10 6.95e-8 ✓ sig.
mammary gland development
CYP19A1, PRL, GHRHR, GLI2, PTCH1, ARHGAP35
 GO:0030879 6 / 37 17.8× 9.55e-7 8.27e-5 ✓ sig.
negative chemotaxis
FLRT3, PLXNA3, SEMA3A, SEMA3E, SEMA3F, SEMA5A
 GO:0050919 6 / 40 16.5× 1.54e-6 1.23e-4 ✓ sig.
motor neuron axon guidance
FGF8, PLXNA3, SEMA3A, LHX3, LHX4
 GO:0008045 5 / 24 22.9× 2.17e-6 1.62e-4 ✓ sig.
hormone metabolic process
AKR1C4, CYP17A1, LEP, GHRHR, GHR
 GO:0042445 5 / 25 22.0× 2.69e-6 1.92e-4 ✓ sig.
somatotropin secreting cell differentiation
PROP1, LHX3, PITX2
 GO:0060126 3 / 4 82.4× 2.94e-6 2.06e-4 ✓ sig.
female gonad development
CYP19A1, BRCA2, FANCA, LHX9, LHCGR
 GO:0008585 5 / 27 20.4× 4.03e-6 2.67e-4 ✓ sig.
forebrain development
NOTCH3, FEZF1, SEMA3A, SEMA3E, HESX1, OTX2, ARHGAP35
 GO:0030900 7 / 76 10.1× 5.88e-6 3.60e-4 ✓ sig.
positive regulation of MAPK cascade
AR, LEP, FGF17, FGF8, FGFR1, GH1, ROBO1, GHR, CDON, FGFR3, RAF1
 GO:0043410 11 / 224 5.4× 6.68e-6 3.98e-4 ✓ sig.
positive regulation of cell differentiation
AR, SERPINF2, FGF8, FGFR1, GHR, ARID1B, SMARCA2
 GO:0045597 7 / 83 9.3× 1.06e-5 5.68e-4 ✓ sig.
male gonad development
AR, LHB, NR0B1, SRD5A2, NHLH2, FANCA, LHX9, LHCGR
 GO:0008584 8 / 117 7.5× 1.17e-5 6.13e-4 ✓ sig.
trigeminal nerve structural organization
PLXNA3, SEMA3A, SEMA3F
 GO:0021637 3 / 6 55.0× 1.45e-5 7.26e-4 ✓ sig.
gonadotrophin-releasing hormone neuronal migration to the hypothalamus
NDNF, PLXNA3, SEMA3E
 GO:0021828 3 / 6 55.0× 1.45e-5 7.26e-4 ✓ sig.
nervous system development
VPS13B, NR2F6, OPHN1, PROP1, ZC4H2, AXL, FEZF1, FGF17, NDNF, SEMA3A, SEMA3E, SOX11
 GO:0007399 18 / 631 3.1× 1.86e-5 8.75e-4 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Pituitary short stature Sheehan syndrome 0.971 34 1.06e-104 4.62e-103 ✓ sig.
Growth hormone deficiency Pituitary short stature 0.944 34 3.72e-103 1.59e-101 ✓ sig.
Growth hormone deficiency Sheehan syndrome 0.944 34 3.72e-103 1.59e-101 ✓ sig.
Kallmann syndrome Sheehan syndrome 0.872 34 7.84e-100 3.27e-98 ✓ sig.
Kallmann syndrome Pituitary short stature 0.872 34 7.84e-100 3.27e-98 ✓ sig.
Growth hormone deficiency Kallmann syndrome 0.850 34 2.74e-98 1.13e-96 ✓ sig.
Panhypopituitarism Pituitary short stature 0.773 34 5.99e-96 2.41e-94 ✓ sig.
Panhypopituitarism Sheehan syndrome 0.773 34 5.99e-96 2.41e-94 ✓ sig.
Kallmann syndrome Panhypopituitarism 0.745 35 2.94e-95 1.18e-93 ✓ sig.
Growth hormone deficiency Panhypopituitarism 0.756 34 2.09e-94 8.32e-93 ✓ sig.
Growth hormone deficiency Pituitary dwarfism 0.756 34 2.09e-94 8.32e-93 ✓ sig.
Hypogonadotropic hypogonadism Sheehan syndrome 0.680 34 1.67e-92 6.54e-91 ✓ sig.
Hypogonadotropic hypogonadism Pituitary short stature 0.680 34 1.67e-92 6.54e-91 ✓ sig.
Hypopituitarism Sheehan syndrome 0.667 34 5.23e-92 2.03e-90 ✓ sig.
Hypopituitarism Pituitary short stature 0.667 34 5.23e-92 2.03e-90 ✓ sig.
Hypogonadotropic hypogonadism Kallmann syndrome 0.660 35 1.37e-91 5.30e-90 ✓ sig.
Pituitary dwarfism Sheehan syndrome 0.733 33 3.14e-91 1.21e-89 ✓ sig.
Pituitary dwarfism Pituitary short stature 0.733 33 3.14e-91 1.21e-89 ✓ sig.
Panhypopituitarism Pituitary dwarfism 0.673 35 5.04e-91 1.94e-89 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 0.667 34 5.85e-91 2.25e-89 ✓ sig.
Hypopituitarism Panhypopituitarism 0.621 36 1.68e-90 6.43e-89 ✓ sig.
Growth hormone deficiency Hypopituitarism 0.654 34 1.83e-90 6.98e-89 ✓ sig.
Hypopituitarism Kallmann syndrome 0.618 34 3.84e-87 1.43e-85 ✓ sig.
Kallmann syndrome Pituitary dwarfism 0.673 33 4.63e-87 1.72e-85 ✓ sig.
Hypogonadotropic hypogonadism Panhypopituitarism 0.576 34 9.35e-84 3.42e-82 ✓ sig.
Hypogonadism Hypopituitarism 0.085 10 3.85e-14 4.45e-13 ✓ sig.
Panhypopituitarism Pituitary stalk interruption syndrome 0.101 7 2.43e-12 2.54e-11 ✓ sig.
Hypopituitarism Pituitary stalk interruption syndrome 0.092 7 7.47e-12 7.56e-11 ✓ sig.
Hypogonadism Hypogonadotropic hypogonadism 0.068 8 8.84e-11 8.32e-10 ✓ sig.
Kallmann syndrome Pituitary stalk interruption syndrome 0.092 6 1.25e-10 1.16e-9 ✓ sig.
Hypogonadism Pituitary dwarfism 0.062 7 1.44e-9 1.23e-8 ✓ sig.
Hypogonadism Panhypopituitarism 0.062 7 1.44e-9 1.23e-8 ✓ sig.
Pituitary short stature Pituitary stalk interruption syndrome 0.081 5 7.24e-9 5.87e-8 ✓ sig.
Hypogonadism Pituitary short stature 0.057 6 1.38e-8 1.08e-7 ✓ sig.
Cohen syndrome Pituitary stalk interruption syndrome 0.030 1 2.07e-3 2.79e-3 ✓ sig.
Medulloblastoma predisposition Pituitary stalk interruption syndrome 0.030 1 2.07e-3 2.79e-3 ✓ sig.
Hypogonadotropic hypogonadism 9 with or without anosmia Pituitary stalk interruption syndrome 0.030 1 2.07e-3 2.79e-3 ✓ sig.
Hypogonadotropic hypogonadism 3 with or without anosmia Pituitary stalk interruption syndrome 0.030 1 2.07e-3 2.79e-3 ✓ sig.
Hypogonadotropic hypogonadism 21 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 17 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 20 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 20 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 9 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 9 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 21 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 4 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 4 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 22 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 3 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 3 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 22 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 19 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Congenital hypogonadotrophic hypogonadism Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Congenital hypogonadotrophic hypogonadism Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 10 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 10 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 13 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 13 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 15 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 15 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 17 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 18 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 18 with or without anosmia Sheehan syndrome 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Hypogonadotropic hypogonadism 19 with or without anosmia Pituitary short stature 0.029 1 2.20e-3 2.92e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 15 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 22 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 17 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 21 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 13 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 10 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 18 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 4 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Congenital hypogonadotrophic hypogonadism Growth hormone deficiency 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 20 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 19 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Growth hormone deficiency Hypogonadotropic hypogonadism 9 with or without anosmia 0.028 1 2.26e-3 2.99e-3 ✓ sig.
Hypogonadotropic hypogonadism 19 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 4 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Congenital hypogonadotrophic hypogonadism Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 10 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 13 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 15 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 17 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 18 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 20 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 21 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 22 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 9 with or without anosmia Kallmann syndrome 0.026 1 2.45e-3 3.19e-3 ✓ sig.
Hypogonadotropic hypogonadism 19 with or without anosmia Panhypopituitarism 0.023 1 2.78e-3 3.56e-3 ✓ sig.
Hypogonadotropic hypogonadism 20 with or without anosmia Panhypopituitarism 0.023 1 2.78e-3 3.56e-3 ✓ sig.
Hypogonadotropic hypogonadism 17 with or without anosmia Panhypopituitarism 0.023 1 2.78e-3 3.56e-3 ✓ sig.
Hypogonadotropic hypogonadism 15 with or without anosmia Panhypopituitarism 0.023 1 2.78e-3 3.56e-3 ✓ sig.
Hypogonadotropic hypogonadism 21 with or without anosmia Panhypopituitarism 0.023 1 2.78e-3 3.56e-3 ✓ sig.
Hypogonadotropic hypogonadism 10 with or without anosmia Panhypopituitarism 0.023 1 2.78e-3 3.56e-3 ✓ sig.
Hypogonadotropic hypogonadism 22 with or without anosmia Panhypopituitarism 0.023 1 2.78e-3 3.56e-3 ✓ sig.
Congenital hypogonadotrophic hypogonadism Panhypopituitarism 0.023 1 2.78e-3 3.56e-3 ✓ sig.
Amyotrophic lateral sclerosis type 15 Hypogonadism 0.013 1 4.91e-3 5.89e-3 ✓ sig.
Brody myopathy Hypogonadism 0.013 1 9.79e-3 1.10e-2 ✓ sig.