UGT2B10 (UDP glucuronosyltransferase family 2 member B10)

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Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 7365
• Gene name: UDP glucuronosyltransferase family 2 member B10
• Gene symbol: UGT2B10
• Synonyms (NCBI Gene): UDPGT2B10
• Chromosome: 4
• Chromosome location: 4q13.2

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs61750900	G>A,T	Drug-response	Intron variant, missense variant, coding sequence variant

miRNA Show/Hide all (26)

miRTarBase ID	miRNA	Experiments	Reference
MIRT551989	hsa-miR-890	PAR-CLIP	21572407
MIRT551988	hsa-miR-501-3p	PAR-CLIP	21572407
MIRT551987	hsa-miR-502-3p	PAR-CLIP	21572407
MIRT551986	hsa-miR-5690	PAR-CLIP	21572407
MIRT551985	hsa-miR-6804-3p	PAR-CLIP	21572407
MIRT551984	hsa-miR-4281	PAR-CLIP	21572407
MIRT551982	hsa-miR-7977	PAR-CLIP	21572407
MIRT551983	hsa-miR-500a-3p	PAR-CLIP	21572407
MIRT551981	hsa-miR-133a-3p	PAR-CLIP	21572407
MIRT735965	hsa-miR-485-5p	Luciferase reporter assay, qRT-PCR	31554697
MIRT551989	hsa-miR-890	PAR-CLIP	21572407
MIRT551988	hsa-miR-501-3p	PAR-CLIP	21572407
MIRT551987	hsa-miR-502-3p	PAR-CLIP	21572407
MIRT551986	hsa-miR-5690	PAR-CLIP	21572407
MIRT551985	hsa-miR-6804-3p	PAR-CLIP	21572407
MIRT551984	hsa-miR-4281	PAR-CLIP	21572407
MIRT551982	hsa-miR-7977	PAR-CLIP	21572407
MIRT551983	hsa-miR-500a-3p	PAR-CLIP	21572407
MIRT551981	hsa-miR-133a-3p	PAR-CLIP	21572407
MIRT1473622	hsa-miR-216b	CLIP-seq
MIRT1473623	hsa-miR-3921	CLIP-seq
MIRT1473624	hsa-miR-4255	CLIP-seq
MIRT1473625	hsa-miR-4446-5p	CLIP-seq
MIRT1473626	hsa-miR-4653-5p	CLIP-seq
MIRT1473627	hsa-miR-4755-5p	CLIP-seq
MIRT1473628	hsa-miR-4766-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0006629	Process	Lipid metabolic process	TAS	8333863
GO:0008194	Function	UDP-glycosyltransferase activity	IBA
GO:0008194	Function	UDP-glycosyltransferase activity	IEA
GO:0008210	Process	Estrogen metabolic process	IBA
GO:0015020	Function	Glucuronosyltransferase activity	IDA	8333863
GO:0016020	Component	Membrane	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016757	Function	Glycosyltransferase activity	IEA

Other IDs

• MIM: 600070
• HGNC: 12544
• e!Ensembl: ENSG00000109181

Protein

• UniProt ID: P36537
• Protein name: UDP-glucuronosyltransferase 2B10 (UDPGT 2B10) (EC 2.4.1.17)
• Protein function: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
• PDB: 7YF5
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00201	UDPGT	23 → 525	UDP-glucoronosyl and UDP-glucosyl transferase	Family

• Sequence:

  MALKWTTVLLIQLSFYFSSGSCGKVLVWAAEYSLWMNMKTILKELVQRGHEVTVLASSAS
  ILFDPNDSSTLKLEVYPTSLTKTEFENIIMQLVKRLSEIQKDTFWLPFSQEQEILWAIND
  IIRNFCKDVVSNKKLMKKLQESRFDIVFADAYLPCGELLAELFNIPFVYSHSFSPGYSFE
  RHSGGFIFPPSYVPVVMSKLSDQMTFMERVKNMLYVLYFDFWFQIFNMKKWDQFYSEVLG
  RPTTLSETMRKADIWLMRNSWNFKFPHPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGE
  NGVVVFSLGSMVSNMTEERANVIATALAKIPQKVLWRFDGNKPDALGLNTRLYKWIPQND
  LLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPLFFDQPDNIAHMKAKGAAVRVDFNTMS
  STDLLNALKTVINDPSYKENIMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAH
  NLTWFQYHSLDVIGFLLACVATVLFIITKCCLFCFWKFARKGKKGKRD

• Sequence length: 528

Pathways

KEGG Pathway	Reactome Pathway
Pentose and glucuronate interconversions	Glucuronidation
Ascorbate and aldarate metabolism
Steroid hormone biosynthesis
Retinol metabolism
Porphyrin metabolism
Metabolism of xenobiotics by cytochrome P450
Drug metabolism - cytochrome P450
Drug metabolism - other enzymes
Metabolic pathways
Biosynthesis of cofactors
Bile secretion
Chemical carcinogenesis - DNA adducts
Chemical carcinogenesis - receptor activation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (7)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
AUTISM SPECTRUM DISORDER	—	CTD	35663546	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EPILEPSY	—	GWAS catalog	40465716	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA MULTIFORME	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	36810956	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOGONADISM	—	GWAS catalog	40316537	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	CTD	21499247	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (9)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	29438977	Associate	★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	36199423	Associate	★☆☆☆☆ Found in Text Mining only
Hepatic Veno Occlusive Disease	Hepatic veno occlusive disease	Pubtator	31790828	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	31434609		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	27197298		★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	CTD_human_DG	21499247		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Melanoma	Pubtator	23110092	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostate carcinoma	Prostate cancer	BEFREE	31434609		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	28586067	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

UGT2B15 2 shared diseasesEpilepsy, Hypogonadism 13 shared pathwaysPentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, Retinol metabolism, Porphyrin metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Biosynthesis of cofactors, Bile secretion, Chemical carcinogenesis - DNA adducts, Chemical carcinogenesis - receptor activation +1 more 2 shared evidence sourcesGWAS catalog (Epilepsy), GWAS catalog (Hypogonadism) Related via 13 shared pathways including Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism — evidence mostly GWAS catalog. UGT2B11 13 shared pathwaysPentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, Retinol metabolism, Porphyrin metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Biosynthesis of cofactors, Bile secretion, Chemical carcinogenesis - DNA adducts, Chemical carcinogenesis - receptor activation +1 more Related via 13 shared pathways including Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism. UGT2A1 13 shared pathwaysPentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, Retinol metabolism, Porphyrin metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Biosynthesis of cofactors, Bile secretion, Chemical carcinogenesis - DNA adducts, Chemical carcinogenesis - receptor activation +1 more Related via 13 shared pathways including Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism. UGT2B28 13 shared pathwaysPentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, Retinol metabolism, Porphyrin metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Biosynthesis of cofactors, Bile secretion, Chemical carcinogenesis - DNA adducts, Chemical carcinogenesis - receptor activation +1 more Related via 13 shared pathways including Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism. UGT1A10 13 shared pathwaysPentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, Retinol metabolism, Porphyrin metabolism, Metabolism of xenobiotics by cytochrome P450, Drug metabolism - cytochrome P450, Drug metabolism - other enzymes, Biosynthesis of cofactors, Bile secretion, Chemical carcinogenesis - DNA adducts, Chemical carcinogenesis - receptor activation +1 more Related via 13 shared pathways including Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
UGT2B15	2	["Epilepsy","Hypogonadism"]	13	["Pentose and glucuronate interconversions","Ascorbate and aldarate metabolism","Steroid hormone biosynthesis","Retinol metabolism","Porphyrin metabolism","Metabolism of xenobiotics by cytochrome P450","Drug metabolism - cytochrome P450","Drug metabolism - other enzymes","Biosynthesis of cofactors","Bile secretion","Chemical carcinogenesis - DNA adducts","Chemical carcinogenesis - receptor activation"]	2	["GWAS catalog (Epilepsy)","GWAS catalog (Hypogonadism)"]
UGT2B11	0	[]	13	["Pentose and glucuronate interconversions","Ascorbate and aldarate metabolism","Steroid hormone biosynthesis","Retinol metabolism","Porphyrin metabolism","Metabolism of xenobiotics by cytochrome P450","Drug metabolism - cytochrome P450","Drug metabolism - other enzymes","Biosynthesis of cofactors","Bile secretion","Chemical carcinogenesis - DNA adducts","Chemical carcinogenesis - receptor activation"]	0	[]
UGT2A1	0	[]	13	["Pentose and glucuronate interconversions","Ascorbate and aldarate metabolism","Steroid hormone biosynthesis","Retinol metabolism","Porphyrin metabolism","Metabolism of xenobiotics by cytochrome P450","Drug metabolism - cytochrome P450","Drug metabolism - other enzymes","Biosynthesis of cofactors","Bile secretion","Chemical carcinogenesis - DNA adducts","Chemical carcinogenesis - receptor activation"]	0	[]
UGT2B28	0	[]	13	["Pentose and glucuronate interconversions","Ascorbate and aldarate metabolism","Steroid hormone biosynthesis","Retinol metabolism","Porphyrin metabolism","Metabolism of xenobiotics by cytochrome P450","Drug metabolism - cytochrome P450","Drug metabolism - other enzymes","Biosynthesis of cofactors","Bile secretion","Chemical carcinogenesis - DNA adducts","Chemical carcinogenesis - receptor activation"]	0	[]
UGT1A10	0	[]	13	["Pentose and glucuronate interconversions","Ascorbate and aldarate metabolism","Steroid hormone biosynthesis","Retinol metabolism","Porphyrin metabolism","Metabolism of xenobiotics by cytochrome P450","Drug metabolism - cytochrome P450","Drug metabolism - other enzymes","Biosynthesis of cofactors","Bile secretion","Chemical carcinogenesis - DNA adducts","Chemical carcinogenesis - receptor activation"]	0	[]

Diseases Linked via Similar Genes

Hyperlipidemia Linked via 1 of 5 related genesUGT2B15 Metabolic syndrome Linked via 1 of 5 related genesUGT2B15 Prostatic neoplasms Linked via 1 of 5 related genesUGT2B15 Diverticular disease Linked via 1 of 5 related genesUGT2B11 Ovarian epithelial cancer Linked via 1 of 5 related genesUGT2A1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Hyperlipidemia	1	["UGT2B15"]
Metabolic syndrome	1	["UGT2B15"]
Prostatic neoplasms	1	["UGT2B15"]
Diverticular disease	1	["UGT2B11"]
Ovarian epithelial cancer	1	["UGT2A1"]