Disease Clusters?

Groups of diseases that share a large number of curated genes with each other, computed via label propagation over the shared-gene similarity graph. See also Shared-Gene Disease Pairs for pairwise comparisons.

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Cluster 20

20 diseases · 58 shared-gene connections
20 Diseases
519 Unique genes
0.146 Avg. similarity score
Nonsyndromic hearing loss Most-connected disease (14 links)
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Disease Searched: Hearing loss Pinned (dragged)
Node size = connections within this cluster · edge thickness = similarity strength · hover an edge for its details · click a node to select it and show its pairs below (double-click or Ctrl/⌘-click opens the disease page) · drag a node to pin it in place · scroll/pinch to zoom.

Member diseases (most connected first ‐ the cluster's core)

Disease ⇵ Connections in cluster ⇵ Significant partners ⇵ Curated genes ⇵
Nonsyndromic hearing loss 14 14 118
Deafness 12 12 172
Isolated sensorineural deafness 12 12 119
Hereditary hearing loss 11 11 50
Hearing loss 9 9 387
nonsyndromic genetic hearing loss 9 9 82
Congenital ear anomaly 8 8 31
Usher syndrome 6 6 44
Meniere disease 5 5 67
Auditory neuropathy 4 4 31
Worster drought syndrome 4 4 1
autosomal recessive nonsyndromic hearing loss 102 4 4 1
autosomal recessive nonsyndromic hearing loss 63 4 4 1
hearing loss, autosomal recessive 120 4 4 1
Deafness-infertility syndrome 3 3 2
autosomal dominant nonsyndromic hearing loss 2 2 9
hearing loss, autosomal recessive 115 2 2 1
Cone rod dystrophy and hearing loss 1 1 2
Deafness dystonia syndrome 1 1 1
PDE6A-related retinopathy 1 1 1

Top shared genes (genes linked to 2+ member diseases ‐ top 100 shown, download for all)

Gene ⇵ Member diseases ⇵ Linked diseases
MYO7A 10 / 20 Auditory neuropathy, Congenital ear anomaly, Deafness, Hearing loss and 6 more
CDH23 9 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 5 more
PCDH15 9 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 5 more
MYO6 8 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 4 more
OTOF 8 / 20 Auditory neuropathy, Congenital ear anomaly, Deafness, Hearing loss and 4 more
TECTA 8 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 4 more
USH1C 8 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 4 more
WFS1 8 / 20 Auditory neuropathy, Deafness, Hearing loss, Hereditary hearing loss and 4 more
COCH 7 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 3 more
COL11A2 7 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more
ESPN 7 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 3 more
GJB2 7 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more
LHFPL5 7 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more
MARVELD2 7 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more
MYH14 7 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 3 more
MYO15A 7 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more
OTOA 7 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 3 more
PJVK 7 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more
STRC 7 / 20 Deafness, Deafness-infertility syndrome, Hearing loss, Hereditary hearing loss and 3 more
TMC1 7 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more
TMIE 7 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more
TMPRSS3 7 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 3 more
WHRN 7 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 3 more
ACTG1 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
ATP11A 6 / 20 Auditory neuropathy, autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss and 2 more
CDC14A 6 / 20 Congenital ear anomaly, Deafness, Hearing loss, Isolated sensorineural deafness and 2 more
CEACAM16 6 / 20 Congenital ear anomaly, Deafness, Hearing loss, Isolated sensorineural deafness and 2 more
CIB2 6 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 2 more
CLDN14 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
COL11A1 6 / 20 autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 2 more
ESRRB 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
EYA4 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
GRHL2 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
GSDME 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
HGF 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
KCNQ4 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
LOXHD1 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
LRTOMT 6 / 20 autosomal recessive nonsyndromic hearing loss 63, Deafness, Hearing loss, Hereditary hearing loss and 2 more
MYH9 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
MYO3A 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
OTOG 6 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, Meniere disease and 2 more
OTOGL 6 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, Meniere disease and 2 more
POU4F3 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
RDX 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
RIPOR2 6 / 20 autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 2 more
SERPINB6 6 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 2 more
SLC17A8 6 / 20 Auditory neuropathy, Deafness, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
SLC26A4 6 / 20 Congenital ear anomaly, Deafness, Hearing loss, Hereditary hearing loss and 2 more
TBC1D24 6 / 20 Auditory neuropathy, Deafness, Hearing loss, Isolated sensorineural deafness and 2 more
TNC 6 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, Meniere disease and 2 more
TPRN 6 / 20 Congenital ear anomaly, Deafness, Hearing loss, Isolated sensorineural deafness and 2 more
TRIOBP 6 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 2 more
ABCC1 5 / 20 autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 1 more
ADCY1 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
ADGRV1 5 / 20 Congenital ear anomaly, Deafness, Hearing loss, Meniere disease and 1 more
ATP2B2 5 / 20 autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 1 more
C10ORF105 5 / 20 Congenital ear anomaly, Deafness, Hearing loss, Meniere disease and 1 more
CABP2 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
CCDC50 5 / 20 Deafness, Hereditary hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
CLRN2 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
DCDC2 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
DIABLO 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
DIAPH1 5 / 20 Auditory neuropathy, Deafness, Hearing loss, Hereditary hearing loss and 1 more
DMXL2 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
ELMOD3 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
EPS8 5 / 20 autosomal recessive nonsyndromic hearing loss 102, Deafness, Hearing loss, Isolated sensorineural deafness and 1 more
EPS8L2 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, Meniere disease and 1 more
GIPC3 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
GJB3 5 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 1 more
GJB6 5 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 1 more
GRXCR1 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
GRXCR2 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
ILDR1 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
KARS1 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
LMX1A 5 / 20 autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 1 more
MET 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
MINAR2 5 / 20 Deafness, Hearing loss, hearing loss, autosomal recessive 120, Isolated sensorineural deafness and 1 more
MSRB3 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
PDE1C 5 / 20 autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 1 more
PLS1 5 / 20 autosomal dominant nonsyndromic hearing loss, Deafness, Hearing loss, Isolated sensorineural deafness and 1 more
PTPRQ 5 / 20 Congenital ear anomaly, Deafness, Hearing loss, Isolated sensorineural deafness and 1 more
S1PR2 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
SIX1 5 / 20 Deafness, Hearing loss, Hereditary hearing loss, Isolated sensorineural deafness and 1 more
SLC26A5 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
SLC44A4 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
SYNE4 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
TBCEL-TECTA 5 / 20 Congenital ear anomaly, Deafness, Hearing loss, Meniere disease and 1 more
TJP2 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss and 1 more
TMTC4 5 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic hearing loss and 1 more
AFG2B 4 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic hearing loss
BDP1 4 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss
CD164 4 / 20 autosomal dominant nonsyndromic hearing loss, Deafness, Isolated sensorineural deafness, Nonsyndromic hearing loss
CLIC5 4 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic hearing loss
CRYM 4 / 20 Deafness, Isolated sensorineural deafness, nonsyndromic genetic hearing loss, Nonsyndromic hearing loss
DIAPH3 4 / 20 Auditory neuropathy, Hearing loss, Isolated sensorineural deafness, Nonsyndromic hearing loss
FOXI1 4 / 20 Deafness, Hearing loss, Hereditary hearing loss, Nonsyndromic hearing loss
GPR156 4 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, Nonsyndromic hearing loss
GRAP 4 / 20 Deafness, Hearing loss, Isolated sensorineural deafness, nonsyndromic genetic hearing loss
HOMER2 4 / 20 Deafness, Isolated sensorineural deafness, nonsyndromic genetic hearing loss, Nonsyndromic hearing loss
KITLG 4 / 20 Deafness, Isolated sensorineural deafness, nonsyndromic genetic hearing loss, Nonsyndromic hearing loss
What do these columns mean?
Connections in cluster
How many other members this disease has a shared-gene link to (the node size in the network above). The most-connected diseases are the cluster's core.
Significant partners
How many of those links are statistically significant (FDR q < 0.05).
Curated genes
Distinct curated genes linked to that disease in GeDiPNet.
Member diseases (Top shared genes)
How many of this cluster's diseases are linked to the gene, out of the cluster's total. Genes shared by many members are the most direct explanation of why they group together.
Overlap genes (x / y)
x = genes shared between this cluster and the pathway/GO term; y = that pathway/GO term's total gene count. A higher x relative to y (and to the cluster's own size) means a tighter biological match.
Cluster gene count
Total distinct genes across every disease in this cluster -- the "n" used in the significance test below.
Fold enrichment
Observed overlap divided by the overlap expected by chance, given the cluster's gene count, the pathway/term's size and the gene universe tested. 5× means five times more shared genes than random. Tells strong hits apart when q-values are all vanishingly small.
P-value / FDR q-value
Is this pathway/GO term's overlap with the cluster more than chance? Upper-tail hypergeometric test, Benjamini-Hochberg corrected across every tested pathway/term (prefer the q-value -- it accounts for testing many at once).
Shared genes (Pairs within this cluster)
Number of curated genes the two diseases in that row have in common.
Similarity score (Pairs within this cluster)
Jaccard-based gene overlap between the two specific diseases in that row -- same metric as the main Shared-Gene Disease Pairs page.

Enriched Pathways (why this cluster is grouped, biologically)

Pathway ⇵ Source ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
Cohesin Loading onto Chromatin
WAPL, NIPBL
 Reactome 2 / 10 48.0× 7.48e-4 1.12e-2 ✓ sig.
Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
PTGES, PTGS2
 Reactome 2 / 12 40.0× 1.09e-3 1.48e-2 ✓ sig.
Retinoid cycle disease events
LRAT, RBP4
 Reactome 2 / 13 37.0× 1.29e-3 1.68e-2 ✓ sig.
Aminoacyl-tRNA biosynthesis
AARS1, DARS2, AARS2
 KEGG 3 / 66 10.9× 2.58e-3 2.82e-2 ✓ sig.
The canonical retinoid cycle in rods (twilight vision)
LRAT, RBP4
 Reactome 2 / 20 24.0× 3.08e-3 3.18e-2 ✓ sig.
Mtb iron assimilation by chelation
LTF
 Reactome 1 / 1 240× 4.16e-3 3.93e-2 ✓ sig.
Biosynthesis of EPA-derived SPMs
PTGS2
 Reactome 1 / 1 240× 4.16e-3 3.93e-2 ✓ sig.
Biosynthesis of DPAn-3 SPMs
PTGS2
 Reactome 1 / 1 240× 4.16e-3 3.93e-2 ✓ sig.
Retinoid metabolism disease events
RBP4
 Reactome 1 / 1 240× 4.16e-3 3.93e-2 ✓ sig.
Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives
PTGS2
 Reactome 1 / 2 120× 8.31e-3 6.23e-2
ARL13B-mediated ciliary trafficking of INPP5E
INPP5E
 Reactome 1 / 3 80.1× 1.24e-2 8.00e-2
Biosynthesis of DHA-derived SPMs
PTGS2
 Reactome 1 / 3 80.1× 1.24e-2 8.00e-2
Retinoid metabolism and transport
LRAT, RBP4
 Reactome 2 / 41 11.7× 1.26e-2 8.07e-2
Biosynthesis of protectins
CYP1A1
 Reactome 1 / 4 60.1× 1.66e-2 9.50e-2
Ovarian steroidogenesis
CYP1A1, PTGS2
 KEGG 2 / 52 9.2× 1.97e-2 1.05e-1

Enriched GO Terms (Biological Process, a second line of biological evidence)

GO term ⇵ GO ID ⇵ Overlap genes ⇵ Fold enrichment ⇵ P-value ⇵ FDR q-value ⇵
embryonic hindlimb morphogenesis
TBX4, BMP4, PITX1, WNT3, RSPO2
 GO:0035116 5 / 29 64.4× 1.26e-8 2.06e-6 ✓ sig.
tRNA aminoacylation
AARS1, DARS2, AARS2
 GO:0043039 3 / 13 86.2× 5.06e-6 3.09e-4 ✓ sig.
response to hypoxia
MTHFR, CYP1A1, PLOD2, RYR1, TRPV4, EGR1
 GO:0001666 6 / 176 12.7× 7.22e-6 4.11e-4 ✓ sig.
alanyl-tRNA aminoacylation
AARS1, AARS2
 GO:0006419 2 / 3 249× 2.10e-5 9.48e-4 ✓ sig.
heart morphogenesis
BMP4, COL5A1, NIPBL, TBXT
 GO:0003007 4 / 61 24.5× 2.11e-5 9.52e-4 ✓ sig.
eye morphogenesis
COL5A1, NIPBL
 GO:0048592 2 / 4 187× 4.20e-5 1.61e-3 ✓ sig.
metanephric ascending thin limb development
PKD1, UMOD
 GO:0072218 2 / 4 187× 4.20e-5 1.61e-3 ✓ sig.
kidney development
BMP4, CC2D2A, PKD1, AGT, UMOD
 GO:0001822 5 / 146 12.8× 4.34e-5 1.65e-3 ✓ sig.
skeletal system development
BMP4, PITX1, HOXD12, HOXD13, BMP5
 GO:0001501 5 / 151 12.4× 5.10e-5 1.86e-3 ✓ sig.
regulation of branching involved in prostate gland morphogenesis
BMP4, HOXD13
 GO:0060687 2 / 5 149× 6.98e-5 2.37e-3 ✓ sig.
regulation of blood pressure
ATP2B1, AGT, PTGS2, UMOD
 GO:0008217 4 / 83 18.0× 7.13e-5 2.40e-3 ✓ sig.
heart development
BMP4, CC2D2A, PKD1, NIPBL, BMP5, RBP4
 GO:0007507 6 / 273 8.2× 8.53e-5 2.75e-3 ✓ sig.
embryonic forelimb morphogenesis
NIPBL, WNT3, RSPO2
 GO:0035115 3 / 33 34.0× 9.29e-5 2.93e-3 ✓ sig.
cartilage development
BMP4, PITX1, PKD1, BMP5
 GO:0051216 4 / 89 16.8× 9.36e-5 2.95e-3 ✓ sig.
digestive tract development
CYP1A1, PKD1, NIPBL
 GO:0048565 3 / 34 33.0× 1.02e-4 3.13e-3 ✓ sig.

Pairs within this cluster, by significance

Disease A ⇵ Disease B ⇵ Similarity score ⇵ Shared genes ⇵ P-value ⇵ FDR q-value ⇵
Deafness Isolated sensorineural deafness 0.640 114 1.05e-236 6.45e-234 ✓ sig.
Isolated sensorineural deafness Nonsyndromic hearing loss 0.737 101 1.93e-222 9.57e-220 ✓ sig.
Deafness Nonsyndromic hearing loss 0.582 107 2.99e-213 1.32e-210 ✓ sig.
Deafness Hearing loss 0.308 132 1.31e-183 3.59e-181 ✓ sig.
Isolated sensorineural deafness nonsyndromic genetic hearing loss 0.629 78 8.37e-174 2.03e-171 ✓ sig.
Deafness nonsyndromic genetic hearing loss 0.449 79 3.04e-159 6.09e-157 ✓ sig.
Hearing loss Isolated sensorineural deafness 0.261 105 1.18e-157 2.34e-155 ✓ sig.
nonsyndromic genetic hearing loss Nonsyndromic hearing loss 0.558 72 6.64e-153 1.27e-150 ✓ sig.
Hearing loss Nonsyndromic hearing loss 0.237 97 1.09e-138 1.82e-136 ✓ sig.
Hearing loss nonsyndromic genetic hearing loss 0.181 72 1.17e-106 1.48e-104 ✓ sig.
Hereditary hearing loss Nonsyndromic hearing loss 0.385 47 1.77e-100 1.98e-98 ✓ sig.
Deafness Hereditary hearing loss 0.267 47 3.60e-91 3.33e-89 ✓ sig.
Hereditary hearing loss Isolated sensorineural deafness 0.349 44 2.08e-90 1.89e-88 ✓ sig.
Hereditary hearing loss nonsyndromic genetic hearing loss 0.415 39 1.46e-83 1.21e-81 ✓ sig.
Hearing loss Hereditary hearing loss 0.117 46 3.59e-70 2.57e-68 ✓ sig.
Congenital ear anomaly Deafness 0.146 26 4.02e-47 1.97e-45 ✓ sig.
Congenital ear anomaly Nonsyndromic hearing loss 0.163 21 2.38e-38 9.55e-37 ✓ sig.
Congenital ear anomaly Isolated sensorineural deafness 0.162 21 2.89e-38 1.16e-36 ✓ sig.
Congenital ear anomaly nonsyndromic genetic hearing loss 0.200 19 8.95e-37 3.47e-35 ✓ sig.
Congenital ear anomaly Hereditary hearing loss 0.262 17 5.92e-36 2.22e-34 ✓ sig.
Deafness Usher syndrome 0.085 17 1.55e-22 3.29e-21 ✓ sig.
Meniere disease Nonsyndromic hearing loss 0.094 16 4.01e-20 7.70e-19 ✓ sig.
Isolated sensorineural deafness Meniere disease 0.094 16 4.62e-20 8.83e-19 ✓ sig.
autosomal dominant nonsyndromic hearing loss Nonsyndromic hearing loss 0.076 9 6.68e-20 1.27e-18 ✓ sig.
autosomal dominant nonsyndromic hearing loss Isolated sensorineural deafness 0.075 9 7.23e-20 1.37e-18 ✓ sig.
Meniere disease nonsyndromic genetic hearing loss 0.087 12 1.07e-15 1.60e-14 ✓ sig.
Hereditary hearing loss Meniere disease 0.093 10 1.08e-14 1.52e-13 ✓ sig.
nonsyndromic genetic hearing loss Usher syndrome 0.085 10 2.23e-14 3.05e-13 ✓ sig.
Congenital ear anomaly Meniere disease 0.088 8 6.08e-13 7.46e-12 ✓ sig.
Hereditary hearing loss Usher syndrome 0.092 8 1.11e-12 1.34e-11 ✓ sig.
Auditory neuropathy Nonsyndromic hearing loss 0.064 9 1.17e-12 1.41e-11 ✓ sig.
Congenital ear anomaly Usher syndrome 0.101 7 2.36e-12 2.71e-11 ✓ sig.
Auditory neuropathy Hereditary hearing loss 0.065 5 4.69e-8 3.49e-7 ✓ sig.
Auditory neuropathy Congenital ear anomaly 0.068 4 4.07e-7 2.56e-6 ✓ sig.
Cone rod dystrophy and hearing loss Usher syndrome 0.044 2 7.98e-6 4.00e-5 ✓ sig.
Auditory neuropathy Deafness dystonia syndrome 0.031 1 2.01e-3 2.90e-3 ✓ sig.
PDE6A-related retinopathy Usher syndrome 0.022 1 2.86e-3 3.80e-3 ✓ sig.
autosomal recessive nonsyndromic hearing loss 63 Hereditary hearing loss 0.020 1 3.25e-3 4.24e-3 ✓ sig.
Deafness-infertility syndrome Hereditary hearing loss 0.019 1 6.48e-3 7.74e-3 ✓ sig.
hearing loss, autosomal recessive 120 Nonsyndromic hearing loss 0.008 1 7.66e-3 8.95e-3 ✓ sig.
Nonsyndromic hearing loss Worster drought syndrome 0.008 1 7.66e-3 8.95e-3 ✓ sig.
autosomal recessive nonsyndromic hearing loss 102 Nonsyndromic hearing loss 0.008 1 7.66e-3 8.95e-3 ✓ sig.
autosomal recessive nonsyndromic hearing loss 63 Nonsyndromic hearing loss 0.008 1 7.66e-3 8.95e-3 ✓ sig.
autosomal recessive nonsyndromic hearing loss 63 Isolated sensorineural deafness 0.008 1 7.73e-3 9.01e-3 ✓ sig.
Isolated sensorineural deafness Worster drought syndrome 0.008 1 7.73e-3 9.01e-3 ✓ sig.
autosomal recessive nonsyndromic hearing loss 102 Isolated sensorineural deafness 0.008 1 7.73e-3 9.01e-3 ✓ sig.
hearing loss, autosomal recessive 120 Isolated sensorineural deafness 0.008 1 7.73e-3 9.01e-3 ✓ sig.
Deafness-infertility syndrome nonsyndromic genetic hearing loss 0.012 1 1.06e-2 1.20e-2 ✓ sig.
autosomal recessive nonsyndromic hearing loss 63 Deafness 0.006 1 1.12e-2 1.26e-2 ✓ sig.
autosomal recessive nonsyndromic hearing loss 102 Deafness 0.006 1 1.12e-2 1.26e-2 ✓ sig.
Deafness hearing loss, autosomal recessive 115 0.006 1 1.12e-2 1.26e-2 ✓ sig.
Deafness hearing loss, autosomal recessive 120 0.006 1 1.12e-2 1.26e-2 ✓ sig.
Deafness Worster drought syndrome 0.006 1 1.12e-2 1.26e-2 ✓ sig.
Deafness-infertility syndrome Nonsyndromic hearing loss 0.008 1 1.53e-2 1.69e-2 ✓ sig.
Hearing loss hearing loss, autosomal recessive 115 0.003 1 2.51e-2 2.69e-2 ✓ sig.
autosomal recessive nonsyndromic hearing loss 102 Hearing loss 0.003 1 2.51e-2 2.69e-2 ✓ sig.
Hearing loss hearing loss, autosomal recessive 120 0.003 1 2.51e-2 2.69e-2 ✓ sig.
Hearing loss Worster drought syndrome 0.003 1 2.51e-2 2.69e-2 ✓ sig.